Zinc_finger_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WX90_LEIDO

TriTrypDb:

LdBPK_220570.1 , LdCL_220012900 , LDHU3_22.0980

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WX90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX90

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.471
CLV_NRD_NRD_1	173	175	PF00675	0.376
CLV_NRD_NRD_1	287	289	PF00675	0.561
CLV_NRD_NRD_1	29	31	PF00675	0.374
CLV_NRD_NRD_1	62	64	PF00675	0.504
CLV_PCSK_KEX2_1	173	175	PF00082	0.376
CLV_PCSK_KEX2_1	287	289	PF00082	0.561
CLV_PCSK_SKI1_1	173	177	PF00082	0.381
CLV_PCSK_SKI1_1	180	184	PF00082	0.422
CLV_PCSK_SKI1_1	235	239	PF00082	0.386
CLV_PCSK_SKI1_1	287	291	PF00082	0.592
CLV_PCSK_SKI1_1	30	34	PF00082	0.361
CLV_PCSK_SKI1_1	534	538	PF00082	0.604
DEG_APCC_DBOX_1	46	54	PF00400	0.372
DEG_SPOP_SBC_1	267	271	PF00917	0.638
DEG_SPOP_SBC_1	492	496	PF00917	0.586
DOC_CYCLIN_RxL_1	27	36	PF00134	0.426
DOC_MAPK_gen_1	480	490	PF00069	0.593
DOC_MAPK_MEF2A_6	483	490	PF00069	0.574
DOC_PP2B_LxvP_1	148	151	PF13499	0.477
DOC_PP2B_LxvP_1	32	35	PF13499	0.347
DOC_PP2B_LxvP_1	394	397	PF13499	0.588
DOC_PP2B_LxvP_1	488	491	PF13499	0.580
DOC_SPAK_OSR1_1	483	487	PF12202	0.504
DOC_USP7_MATH_1	136	140	PF00917	0.493
DOC_USP7_MATH_1	151	155	PF00917	0.384
DOC_USP7_MATH_1	206	210	PF00917	0.391
DOC_USP7_MATH_1	323	327	PF00917	0.603
DOC_USP7_MATH_1	351	355	PF00917	0.615
DOC_USP7_MATH_1	367	371	PF00917	0.563
DOC_USP7_MATH_1	374	378	PF00917	0.600
DOC_USP7_MATH_1	386	390	PF00917	0.540
DOC_USP7_MATH_1	491	495	PF00917	0.600
DOC_USP7_MATH_1	519	523	PF00917	0.636
DOC_WW_Pin1_4	244	249	PF00397	0.507
DOC_WW_Pin1_4	280	285	PF00397	0.494
DOC_WW_Pin1_4	300	305	PF00397	0.592
DOC_WW_Pin1_4	430	435	PF00397	0.516
DOC_WW_Pin1_4	465	470	PF00397	0.572
DOC_WW_Pin1_4	513	518	PF00397	0.629
LIG_14-3-3_CanoR_1	10	15	PF00244	0.408
LIG_14-3-3_CanoR_1	165	171	PF00244	0.388
LIG_14-3-3_CanoR_1	189	193	PF00244	0.491
LIG_14-3-3_CanoR_1	288	294	PF00244	0.506
LIG_14-3-3_CanoR_1	309	313	PF00244	0.592
LIG_14-3-3_CanoR_1	483	489	PF00244	0.583
LIG_14-3-3_CanoR_1	80	89	PF00244	0.462
LIG_Actin_WH2_2	97	112	PF00022	0.519
LIG_BRCT_BRCA1_1	418	422	PF00533	0.552
LIG_FHA_1	167	173	PF00498	0.393
LIG_FHA_1	248	254	PF00498	0.601
LIG_FHA_1	27	33	PF00498	0.378
LIG_FHA_1	34	40	PF00498	0.373
LIG_FHA_1	430	436	PF00498	0.619
LIG_FHA_1	494	500	PF00498	0.616
LIG_FHA_2	21	27	PF00498	0.381
LIG_FHA_2	236	242	PF00498	0.401
LIG_FHA_2	281	287	PF00498	0.572
LIG_FHA_2	92	98	PF00498	0.460
LIG_IBAR_NPY_1	551	553	PF08397	0.560
LIG_LIR_Apic_2	578	584	PF02991	0.572
LIG_LIR_Gen_1	227	237	PF02991	0.357
LIG_LIR_Gen_1	311	318	PF02991	0.590
LIG_LIR_Gen_1	74	81	PF02991	0.364
LIG_LIR_Nem_3	157	163	PF02991	0.357
LIG_LIR_Nem_3	227	233	PF02991	0.348
LIG_LIR_Nem_3	311	316	PF02991	0.592
LIG_LIR_Nem_3	419	425	PF02991	0.504
LIG_LIR_Nem_3	578	583	PF02991	0.505
LIG_LIR_Nem_3	74	78	PF02991	0.360
LIG_NRBOX	171	177	PF00104	0.370
LIG_SH2_CRK	581	585	PF00017	0.573
LIG_SH2_SRC	149	152	PF00017	0.418
LIG_SH2_STAT5	149	152	PF00017	0.418
LIG_SH2_STAT5	168	171	PF00017	0.404
LIG_SH2_STAT5	38	41	PF00017	0.399
LIG_SH2_STAT5	381	384	PF00017	0.644
LIG_SH2_STAT5	417	420	PF00017	0.615
LIG_SH2_STAT5	553	556	PF00017	0.629
LIG_SH3_2	304	309	PF14604	0.590
LIG_SH3_3	179	185	PF00018	0.575
LIG_SH3_3	21	27	PF00018	0.348
LIG_SH3_3	301	307	PF00018	0.590
LIG_SH3_3	433	439	PF00018	0.605
MOD_CDK_SPxxK_3	280	287	PF00069	0.499
MOD_CK1_1	209	215	PF00069	0.437
MOD_CK1_1	247	253	PF00069	0.726
MOD_CK1_1	268	274	PF00069	0.615
MOD_CK1_1	298	304	PF00069	0.590
MOD_CK1_1	311	317	PF00069	0.584
MOD_CK1_1	345	351	PF00069	0.583
MOD_CK1_1	370	376	PF00069	0.765
MOD_CK1_1	454	460	PF00069	0.589
MOD_CK1_1	467	473	PF00069	0.626
MOD_CK1_1	494	500	PF00069	0.563
MOD_CK1_1	508	514	PF00069	0.582
MOD_CK1_1	528	534	PF00069	0.674
MOD_CK1_1	543	549	PF00069	0.537
MOD_CK2_1	151	157	PF00069	0.434
MOD_GlcNHglycan	129	132	PF01048	0.660
MOD_GlcNHglycan	185	188	PF01048	0.396
MOD_GlcNHglycan	207	211	PF01048	0.442
MOD_GlcNHglycan	270	273	PF01048	0.593
MOD_GlcNHglycan	297	300	PF01048	0.740
MOD_GlcNHglycan	325	328	PF01048	0.570
MOD_GlcNHglycan	344	347	PF01048	0.532
MOD_GlcNHglycan	372	375	PF01048	0.627
MOD_GlcNHglycan	384	387	PF01048	0.616
MOD_GlcNHglycan	390	393	PF01048	0.700
MOD_GlcNHglycan	412	415	PF01048	0.615
MOD_GlcNHglycan	422	425	PF01048	0.525
MOD_GlcNHglycan	443	446	PF01048	0.578
MOD_GlcNHglycan	460	463	PF01048	0.664
MOD_GlcNHglycan	469	472	PF01048	0.587
MOD_GlcNHglycan	476	479	PF01048	0.521
MOD_GlcNHglycan	58	61	PF01048	0.340
MOD_GSK3_1	111	118	PF00069	0.484
MOD_GSK3_1	123	130	PF00069	0.510
MOD_GSK3_1	261	268	PF00069	0.729
MOD_GSK3_1	275	282	PF00069	0.541
MOD_GSK3_1	308	315	PF00069	0.607
MOD_GSK3_1	345	352	PF00069	0.652
MOD_GSK3_1	370	377	PF00069	0.766
MOD_GSK3_1	382	389	PF00069	0.615
MOD_GSK3_1	416	423	PF00069	0.506
MOD_GSK3_1	454	461	PF00069	0.695
MOD_GSK3_1	491	498	PF00069	0.527
MOD_GSK3_1	504	511	PF00069	0.593
MOD_GSK3_1	519	526	PF00069	0.541
MOD_GSK3_1	528	535	PF00069	0.517
MOD_GSK3_1	539	546	PF00069	0.558
MOD_GSK3_1	553	560	PF00069	0.581
MOD_GSK3_1	80	87	PF00069	0.448
MOD_N-GLC_1	193	198	PF02516	0.531
MOD_N-GLC_1	275	280	PF02516	0.608
MOD_N-GLC_1	451	456	PF02516	0.686
MOD_N-GLC_1	464	469	PF02516	0.558
MOD_N-GLC_1	508	513	PF02516	0.656
MOD_NEK2_1	109	114	PF00069	0.532
MOD_NEK2_1	115	120	PF00069	0.531
MOD_NEK2_1	156	161	PF00069	0.469
MOD_NEK2_1	193	198	PF00069	0.549
MOD_NEK2_1	20	25	PF00069	0.394
MOD_NEK2_1	265	270	PF00069	0.620
MOD_NEK2_1	289	294	PF00069	0.722
MOD_NEK2_1	382	387	PF00069	0.698
MOD_NEK2_1	418	423	PF00069	0.562
MOD_NEK2_1	451	456	PF00069	0.577
MOD_NEK2_1	476	481	PF00069	0.544
MOD_NEK2_1	484	489	PF00069	0.520
MOD_NEK2_1	505	510	PF00069	0.599
MOD_NEK2_1	523	528	PF00069	0.688
MOD_NEK2_1	532	537	PF00069	0.534
MOD_NEK2_1	539	544	PF00069	0.482
MOD_NEK2_1	56	61	PF00069	0.342
MOD_NEK2_2	151	156	PF00069	0.440
MOD_PIKK_1	33	39	PF00454	0.425
MOD_PIKK_1	349	355	PF00454	0.581
MOD_PIKK_1	534	540	PF00454	0.605
MOD_PIKK_1	80	86	PF00454	0.439
MOD_PKA_2	109	115	PF00069	0.587
MOD_PKA_2	164	170	PF00069	0.390
MOD_PKA_2	188	194	PF00069	0.490
MOD_PKA_2	308	314	PF00069	0.633
MOD_PKA_2	374	380	PF00069	0.574
MOD_PKA_2	46	52	PF00069	0.386
MOD_PKA_2	484	490	PF00069	0.583
MOD_Plk_1	137	143	PF00069	0.509
MOD_Plk_4	151	157	PF00069	0.443
MOD_Plk_4	20	26	PF00069	0.343
MOD_Plk_4	289	295	PF00069	0.501
MOD_Plk_4	308	314	PF00069	0.590
MOD_Plk_4	336	342	PF00069	0.582
MOD_Plk_4	359	365	PF00069	0.648
MOD_ProDKin_1	244	250	PF00069	0.517
MOD_ProDKin_1	280	286	PF00069	0.497
MOD_ProDKin_1	300	306	PF00069	0.591
MOD_ProDKin_1	430	436	PF00069	0.516
MOD_ProDKin_1	465	471	PF00069	0.574
MOD_ProDKin_1	513	519	PF00069	0.629
MOD_SUMO_for_1	558	561	PF00179	0.566
MOD_SUMO_rev_2	226	231	PF00179	0.365
TRG_DiLeu_BaEn_1	390	395	PF01217	0.646
TRG_DiLeu_BaEn_2	225	231	PF01217	0.366
TRG_DiLeu_BaEn_4	226	232	PF01217	0.359
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.362
TRG_DiLeu_LyEn_5	390	395	PF01217	0.646
TRG_ENDOCYTIC_2	160	163	PF00928	0.333
TRG_ER_diArg_1	172	174	PF00400	0.374
TRG_ER_diArg_1	221	224	PF00400	0.390
TRG_ER_diArg_1	287	289	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	393	398	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6L3	Leptomonas seymouri	51%	100%
A4HCC9	Leishmania braziliensis	80%	100%
E9AVQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QBS3	Leishmania major	93%	100%