Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WX82_LEIDO

TriTrypDb:

LdBPK_221070.1 , LdCL_220018100 , LDHU3_22.1580

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

A0A3S7WX82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX82

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.641
CLV_NRD_NRD_1	325	327	PF00675	0.693
CLV_NRD_NRD_1	94	96	PF00675	0.423
CLV_PCSK_KEX2_1	325	327	PF00082	0.693
CLV_PCSK_KEX2_1	94	96	PF00082	0.423
CLV_PCSK_SKI1_1	325	329	PF00082	0.639
CLV_PCSK_SKI1_1	384	388	PF00082	0.563
CLV_PCSK_SKI1_1	406	410	PF00082	0.405
CLV_PCSK_SKI1_1	424	428	PF00082	0.528
DEG_Nend_Nbox_1	1	3	PF02207	0.397
DEG_SPOP_SBC_1	181	185	PF00917	0.374
DOC_ANK_TNKS_1	258	265	PF00023	0.562
DOC_CYCLIN_RxL_1	109	120	PF00134	0.387
DOC_CYCLIN_RxL_1	370	382	PF00134	0.389
DOC_PP1_RVXF_1	373	380	PF00149	0.366
DOC_PP2B_LxvP_1	114	117	PF13499	0.374
DOC_PP2B_LxvP_1	252	255	PF13499	0.539
DOC_PP4_FxxP_1	238	241	PF00568	0.405
DOC_USP7_MATH_1	117	121	PF00917	0.528
DOC_USP7_MATH_1	207	211	PF00917	0.362
DOC_USP7_MATH_1	255	259	PF00917	0.640
DOC_USP7_MATH_1	287	291	PF00917	0.650
DOC_USP7_MATH_1	342	346	PF00917	0.334
DOC_USP7_MATH_1	49	53	PF00917	0.524
DOC_WW_Pin1_4	16	21	PF00397	0.381
DOC_WW_Pin1_4	418	423	PF00397	0.383
LIG_14-3-3_CanoR_1	180	190	PF00244	0.365
LIG_14-3-3_CanoR_1	209	214	PF00244	0.397
LIG_14-3-3_CanoR_1	230	236	PF00244	0.472
LIG_BRCT_BRCA1_1	14	18	PF00533	0.369
LIG_BRCT_BRCA1_1	289	293	PF00533	0.535
LIG_CSL_BTD_1	114	117	PF09270	0.374
LIG_DLG_GKlike_1	209	217	PF00625	0.437
LIG_FHA_1	164	170	PF00498	0.456
LIG_FHA_1	181	187	PF00498	0.397
LIG_FHA_1	352	358	PF00498	0.286
LIG_FHA_1	37	43	PF00498	0.370
LIG_FHA_1	400	406	PF00498	0.430
LIG_FHA_1	443	449	PF00498	0.517
LIG_FHA_1	8	14	PF00498	0.391
LIG_FHA_2	160	166	PF00498	0.549
LIG_FHA_2	183	189	PF00498	0.383
LIG_FHA_2	199	205	PF00498	0.449
LIG_FHA_2	22	28	PF00498	0.542
LIG_FHA_2	232	238	PF00498	0.474
LIG_FHA_2	32	38	PF00498	0.322
LIG_FHA_2	385	391	PF00498	0.395
LIG_FHA_2	427	433	PF00498	0.364
LIG_FHA_2	79	85	PF00498	0.469
LIG_LIR_Apic_2	236	241	PF02991	0.417
LIG_LIR_Gen_1	74	82	PF02991	0.445
LIG_LIR_Nem_3	74	80	PF02991	0.445
LIG_Pex14_1	439	443	PF04695	0.391
LIG_Pex14_2	349	353	PF04695	0.341
LIG_SH2_CRK	297	301	PF00017	0.506
LIG_SH2_CRK	77	81	PF00017	0.477
LIG_SH2_SRC	147	150	PF00017	0.355
LIG_SH2_STAT5	147	150	PF00017	0.355
LIG_SH2_STAT5	373	376	PF00017	0.398
LIG_SH2_STAT5	77	80	PF00017	0.477
LIG_SH3_3	14	20	PF00018	0.343
LIG_SH3_3	187	193	PF00018	0.406
LIG_SH3_3	243	249	PF00018	0.414
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.303
LIG_SUMO_SIM_par_1	244	250	PF11976	0.424
LIG_SUMO_SIM_par_1	384	393	PF11976	0.356
MOD_CDC14_SPxK_1	421	424	PF00782	0.481
MOD_CDK_SPxK_1	418	424	PF00069	0.455
MOD_CK1_1	182	188	PF00069	0.366
MOD_CK1_1	267	273	PF00069	0.703
MOD_CK1_1	288	294	PF00069	0.602
MOD_CK1_1	389	395	PF00069	0.356
MOD_CK1_1	418	424	PF00069	0.390
MOD_CK2_1	153	159	PF00069	0.582
MOD_CK2_1	198	204	PF00069	0.341
MOD_CK2_1	21	27	PF00069	0.506
MOD_CK2_1	231	237	PF00069	0.480
MOD_CK2_1	390	396	PF00069	0.358
MOD_GlcNHglycan	103	106	PF01048	0.373
MOD_GlcNHglycan	130	133	PF01048	0.570
MOD_GlcNHglycan	138	141	PF01048	0.372
MOD_GlcNHglycan	155	158	PF01048	0.580
MOD_GlcNHglycan	249	252	PF01048	0.497
MOD_GlcNHglycan	266	269	PF01048	0.544
MOD_GlcNHglycan	287	290	PF01048	0.590
MOD_GlcNHglycan	317	320	PF01048	0.830
MOD_GlcNHglycan	34	37	PF01048	0.423
MOD_GlcNHglycan	417	420	PF01048	0.392
MOD_GSK3_1	12	19	PF00069	0.342
MOD_GSK3_1	123	130	PF00069	0.579
MOD_GSK3_1	149	156	PF00069	0.457
MOD_GSK3_1	159	166	PF00069	0.551
MOD_GSK3_1	194	201	PF00069	0.415
MOD_GSK3_1	3	10	PF00069	0.407
MOD_GSK3_1	310	317	PF00069	0.648
MOD_GSK3_1	32	39	PF00069	0.362
MOD_GSK3_1	386	393	PF00069	0.480
MOD_GSK3_1	414	421	PF00069	0.361
MOD_GSK3_1	71	78	PF00069	0.499
MOD_GSK3_1	80	87	PF00069	0.447
MOD_N-GLC_1	220	225	PF02516	0.534
MOD_NEK2_1	151	156	PF00069	0.415
MOD_NEK2_1	179	184	PF00069	0.381
MOD_NEK2_1	219	224	PF00069	0.541
MOD_NEK2_1	30	35	PF00069	0.364
MOD_NEK2_1	414	419	PF00069	0.376
MOD_NEK2_1	426	431	PF00069	0.435
MOD_PIKK_1	49	55	PF00454	0.457
MOD_PKA_1	325	331	PF00069	0.628
MOD_PKA_2	123	129	PF00069	0.572
MOD_PKA_2	179	185	PF00069	0.420
MOD_PKA_2	325	331	PF00069	0.657
MOD_Plk_1	220	226	PF00069	0.530
MOD_Plk_1	351	357	PF00069	0.277
MOD_Plk_1	37	43	PF00069	0.391
MOD_Plk_1	390	396	PF00069	0.358
MOD_Plk_1	84	90	PF00069	0.469
MOD_Plk_2-3	159	165	PF00069	0.504
MOD_Plk_4	12	18	PF00069	0.365
MOD_Plk_4	75	81	PF00069	0.516
MOD_ProDKin_1	16	22	PF00069	0.392
MOD_ProDKin_1	418	424	PF00069	0.390
MOD_SUMO_rev_2	378	386	PF00179	0.464
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.460
TRG_ENDOCYTIC_2	297	300	PF00928	0.507
TRG_ENDOCYTIC_2	77	80	PF00928	0.477
TRG_ER_diArg_1	324	326	PF00400	0.699
TRG_ER_diArg_1	93	95	PF00400	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM43	Leptomonas seymouri	68%	100%
A4HCG2	Leishmania braziliensis	83%	100%
E9AGZ5	Leishmania infantum	100%	100%
E9AVV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBM2	Leishmania major	94%	100%