Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WX76_LEIDO

TriTrypDb:

LdBPK_220980.1 , LdCL_220017200 , LDHU3_22.1490

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WX76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.758
CLV_NRD_NRD_1	19	21	PF00675	0.555
CLV_PCSK_KEX2_1	102	104	PF00082	0.758
CLV_PCSK_KEX2_1	19	21	PF00082	0.555
CLV_PCSK_KEX2_1	65	67	PF00082	0.504
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.561
CLV_PCSK_SKI1_1	298	302	PF00082	0.467
CLV_PCSK_SKI1_1	320	324	PF00082	0.540
CLV_PCSK_SKI1_1	410	414	PF00082	0.593
CLV_PCSK_SKI1_1	87	91	PF00082	0.692
DEG_APCC_DBOX_1	21	29	PF00400	0.609
DOC_CKS1_1	88	93	PF01111	0.700
DOC_CYCLIN_RxL_1	292	305	PF00134	0.491
DOC_CYCLIN_yClb5_NLxxxL_5	54	63	PF00134	0.456
DOC_CYCLIN_yCln2_LP_2	182	188	PF00134	0.668
DOC_MAPK_gen_1	261	269	PF00069	0.647
DOC_PP1_RVXF_1	198	204	PF00149	0.493
DOC_USP7_MATH_1	117	121	PF00917	0.756
DOC_USP7_MATH_1	122	126	PF00917	0.776
DOC_USP7_MATH_1	174	178	PF00917	0.619
DOC_USP7_MATH_1	252	256	PF00917	0.732
DOC_WW_Pin1_4	123	128	PF00397	0.782
DOC_WW_Pin1_4	134	139	PF00397	0.659
DOC_WW_Pin1_4	275	280	PF00397	0.523
DOC_WW_Pin1_4	341	346	PF00397	0.522
DOC_WW_Pin1_4	366	371	PF00397	0.513
DOC_WW_Pin1_4	87	92	PF00397	0.634
LIG_14-3-3_CanoR_1	113	117	PF00244	0.744
LIG_14-3-3_CanoR_1	133	138	PF00244	0.770
LIG_14-3-3_CanoR_1	205	209	PF00244	0.593
LIG_14-3-3_CanoR_1	275	279	PF00244	0.487
LIG_14-3-3_CanoR_1	338	342	PF00244	0.557
LIG_14-3-3_CanoR_1	423	428	PF00244	0.625
LIG_14-3-3_CanoR_1	432	437	PF00244	0.571
LIG_BIR_II_1	1	5	PF00653	0.720
LIG_FHA_1	16	22	PF00498	0.552
LIG_FHA_1	163	169	PF00498	0.443
LIG_FHA_1	204	210	PF00498	0.628
LIG_FHA_1	302	308	PF00498	0.511
LIG_FHA_1	37	43	PF00498	0.613
LIG_FHA_1	375	381	PF00498	0.487
LIG_FHA_1	411	417	PF00498	0.580
LIG_FHA_1	49	55	PF00498	0.491
LIG_FHA_1	9	15	PF00498	0.608
LIG_FHA_2	297	303	PF00498	0.504
LIG_FHA_2	31	37	PF00498	0.695
LIG_FHA_2	404	410	PF00498	0.617
LIG_FHA_2	433	439	PF00498	0.589
LIG_FHA_2	88	94	PF00498	0.702
LIG_GBD_Chelix_1	209	217	PF00786	0.599
LIG_LIR_Apic_2	232	236	PF02991	0.642
LIG_LIR_Apic_2	273	279	PF02991	0.404
LIG_LIR_Apic_2	340	345	PF02991	0.572
LIG_LIR_Apic_2	51	55	PF02991	0.396
LIG_LIR_Gen_1	435	444	PF02991	0.622
LIG_LIR_Nem_3	216	222	PF02991	0.532
LIG_LIR_Nem_3	360	365	PF02991	0.482
LIG_LIR_Nem_3	435	439	PF02991	0.583
LIG_LIR_Nem_3	51	56	PF02991	0.418
LIG_PALB2_WD40_1	48	56	PF16756	0.543
LIG_Pex14_2	362	366	PF04695	0.447
LIG_PTB_Apo_2	232	239	PF02174	0.619
LIG_PTB_Apo_2	55	62	PF02174	0.484
LIG_PTB_Phospho_1	232	238	PF10480	0.627
LIG_PTB_Phospho_1	55	61	PF10480	0.480
LIG_SH2_CRK	233	237	PF00017	0.632
LIG_SH2_CRK	276	280	PF00017	0.440
LIG_SH2_GRB2like	150	153	PF00017	0.624
LIG_SH2_NCK_1	276	280	PF00017	0.440
LIG_SH2_STAP1	436	440	PF00017	0.689
LIG_SH2_STAT5	150	153	PF00017	0.664
LIG_SH2_STAT5	238	241	PF00017	0.568
LIG_SH2_STAT5	27	30	PF00017	0.674
LIG_SH2_STAT5	276	279	PF00017	0.448
LIG_SH2_STAT5	365	368	PF00017	0.471
LIG_SH2_STAT5	61	64	PF00017	0.571
LIG_SH3_3	26	32	PF00018	0.609
LIG_SH3_3	342	348	PF00018	0.539
LIG_SH3_3	368	374	PF00018	0.468
LIG_SH3_3	85	91	PF00018	0.700
LIG_UBA3_1	226	234	PF00899	0.550
LIG_WRC_WIRS_1	424	429	PF05994	0.508
MOD_CDC14_SPxK_1	130	133	PF00782	0.690
MOD_CDK_SPxK_1	127	133	PF00069	0.692
MOD_CK1_1	126	132	PF00069	0.748
MOD_CK1_1	136	142	PF00069	0.677
MOD_CK1_1	2	8	PF00069	0.775
MOD_CK1_1	260	266	PF00069	0.695
MOD_CK1_1	343	349	PF00069	0.522
MOD_CK1_1	403	409	PF00069	0.606
MOD_CK1_1	41	47	PF00069	0.577
MOD_CK2_1	136	142	PF00069	0.779
MOD_CK2_1	174	180	PF00069	0.526
MOD_CK2_1	357	363	PF00069	0.566
MOD_CK2_1	408	414	PF00069	0.585
MOD_CK2_1	432	438	PF00069	0.636
MOD_CK2_1	87	93	PF00069	0.682
MOD_GlcNHglycan	119	122	PF01048	0.718
MOD_GlcNHglycan	239	242	PF01048	0.525
MOD_GlcNHglycan	254	257	PF01048	0.693
MOD_GlcNHglycan	315	318	PF01048	0.449
MOD_GlcNHglycan	4	7	PF01048	0.751
MOD_GlcNHglycan	402	405	PF01048	0.616
MOD_GSK3_1	122	129	PF00069	0.751
MOD_GSK3_1	132	139	PF00069	0.654
MOD_GSK3_1	209	216	PF00069	0.528
MOD_GSK3_1	270	277	PF00069	0.504
MOD_GSK3_1	296	303	PF00069	0.525
MOD_GSK3_1	337	344	PF00069	0.540
MOD_GSK3_1	37	44	PF00069	0.538
MOD_N-GLC_1	313	318	PF02516	0.471
MOD_NEK2_1	112	117	PF00069	0.751
MOD_NEK2_1	209	214	PF00069	0.534
MOD_NEK2_1	300	305	PF00069	0.537
MOD_NEK2_1	332	337	PF00069	0.542
MOD_NEK2_2	189	194	PF00069	0.473
MOD_PIKK_1	270	276	PF00454	0.479
MOD_PK_1	103	109	PF00069	0.764
MOD_PK_1	225	231	PF00069	0.507
MOD_PKA_2	112	118	PF00069	0.751
MOD_PKA_2	132	138	PF00069	0.770
MOD_PKA_2	15	21	PF00069	0.586
MOD_PKA_2	204	210	PF00069	0.585
MOD_PKA_2	274	280	PF00069	0.530
MOD_PKA_2	337	343	PF00069	0.556
MOD_Plk_1	313	319	PF00069	0.475
MOD_Plk_1	383	389	PF00069	0.513
MOD_Plk_1	408	414	PF00069	0.580
MOD_Plk_1	92	98	PF00069	0.679
MOD_Plk_2-3	357	363	PF00069	0.566
MOD_Plk_4	103	109	PF00069	0.718
MOD_Plk_4	154	160	PF00069	0.479
MOD_Plk_4	162	168	PF00069	0.391
MOD_Plk_4	174	180	PF00069	0.337
MOD_Plk_4	204	210	PF00069	0.585
MOD_Plk_4	296	302	PF00069	0.453
MOD_Plk_4	332	338	PF00069	0.544
MOD_Plk_4	357	363	PF00069	0.438
MOD_Plk_4	374	380	PF00069	0.226
MOD_Plk_4	383	389	PF00069	0.489
MOD_Plk_4	48	54	PF00069	0.405
MOD_ProDKin_1	123	129	PF00069	0.781
MOD_ProDKin_1	134	140	PF00069	0.658
MOD_ProDKin_1	275	281	PF00069	0.518
MOD_ProDKin_1	341	347	PF00069	0.518
MOD_ProDKin_1	366	372	PF00069	0.522
MOD_ProDKin_1	87	93	PF00069	0.638
MOD_SUMO_for_1	291	294	PF00179	0.502
MOD_SUMO_rev_2	228	236	PF00179	0.554
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.610
TRG_ENDOCYTIC_2	27	30	PF00928	0.674
TRG_ENDOCYTIC_2	424	427	PF00928	0.539
TRG_ENDOCYTIC_2	436	439	PF00928	0.538
TRG_ER_diArg_1	19	22	PF00400	0.593
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P811	Leptomonas seymouri	81%	100%
A0A0S4JBD1	Bodo saltans	48%	100%
A0A3R7MFR3	Trypanosoma rangeli	54%	100%
A4HCF8	Leishmania braziliensis	88%	99%
A4HZY7	Leishmania infantum	100%	100%
E9AVU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
Q4QBN1	Leishmania major	94%	100%
V5BVW6	Trypanosoma cruzi	53%	100%