WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

F-box and WD40 domain containing protein

Species:

Leishmania donovani

UniProt:

A0A3S7WX75_LEIDO

TriTrypDb:

LdBPK_220800.1 , LdCL_220015400 , LDHU3_22.1310

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0032991	protein-containing complex	1	4
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	4
GO:0043228	non-membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043232	intracellular non-membrane-bounded organelle	4	4
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	4
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	4
GO:0005840	ribosome	5	3

Expansion

Sequence features

A0A3S7WX75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX75

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.563
CLV_C14_Caspase3-7	309	313	PF00656	0.662
CLV_C14_Caspase3-7	68	72	PF00656	0.729
CLV_NRD_NRD_1	253	255	PF00675	0.573
CLV_NRD_NRD_1	270	272	PF00675	0.568
CLV_NRD_NRD_1	400	402	PF00675	0.644
CLV_PCSK_KEX2_1	253	255	PF00082	0.584
CLV_PCSK_KEX2_1	270	272	PF00082	0.568
CLV_PCSK_KEX2_1	631	633	PF00082	0.480
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.552
CLV_PCSK_SKI1_1	151	155	PF00082	0.488
CLV_PCSK_SKI1_1	187	191	PF00082	0.539
CLV_PCSK_SKI1_1	253	257	PF00082	0.585
CLV_PCSK_SKI1_1	259	263	PF00082	0.576
CLV_PCSK_SKI1_1	649	653	PF00082	0.466
DEG_APCC_DBOX_1	150	158	PF00400	0.501
DEG_APCC_DBOX_1	186	194	PF00400	0.527
DEG_Nend_Nbox_1	1	3	PF02207	0.779
DEG_SPOP_SBC_1	415	419	PF00917	0.767
DOC_CYCLIN_yClb1_LxF_4	523	528	PF00134	0.511
DOC_MAPK_DCC_7	354	364	PF00069	0.704
DOC_MAPK_DCC_7	365	374	PF00069	0.541
DOC_MAPK_FxFP_2	635	638	PF00069	0.557
DOC_MAPK_gen_1	251	258	PF00069	0.499
DOC_MAPK_gen_1	365	372	PF00069	0.567
DOC_MAPK_HePTP_8	362	374	PF00069	0.614
DOC_MAPK_MEF2A_6	182	190	PF00069	0.530
DOC_MAPK_MEF2A_6	205	213	PF00069	0.521
DOC_MAPK_MEF2A_6	281	288	PF00069	0.535
DOC_MAPK_MEF2A_6	365	374	PF00069	0.495
DOC_MAPK_MEF2A_6	656	663	PF00069	0.494
DOC_PP1_RVXF_1	523	529	PF00149	0.508
DOC_PP2B_LxvP_1	357	360	PF13499	0.743
DOC_PP4_FxxP_1	61	64	PF00568	0.779
DOC_PP4_FxxP_1	635	638	PF00568	0.557
DOC_PP4_MxPP_1	477	480	PF00568	0.543
DOC_SPAK_OSR1_1	281	285	PF12202	0.458
DOC_USP7_MATH_1	140	144	PF00917	0.516
DOC_USP7_MATH_1	22	26	PF00917	0.740
DOC_USP7_MATH_1	345	349	PF00917	0.653
DOC_USP7_MATH_1	35	39	PF00917	0.521
DOC_USP7_MATH_1	360	364	PF00917	0.550
DOC_USP7_MATH_1	397	401	PF00917	0.564
DOC_USP7_UBL2_3	402	406	PF12436	0.626
DOC_WW_Pin1_4	293	298	PF00397	0.590
DOC_WW_Pin1_4	578	583	PF00397	0.562
LIG_14-3-3_CanoR_1	525	529	PF00244	0.492
LIG_14-3-3_CanoR_1	656	662	PF00244	0.471
LIG_BIR_III_4	76	80	PF00653	0.702
LIG_deltaCOP1_diTrp_1	120	124	PF00928	0.509
LIG_EH1_1	182	190	PF00400	0.530
LIG_FHA_1	121	127	PF00498	0.473
LIG_FHA_1	225	231	PF00498	0.485
LIG_FHA_1	39	45	PF00498	0.602
LIG_FHA_1	579	585	PF00498	0.525
LIG_FHA_1	588	594	PF00498	0.361
LIG_FHA_1	609	615	PF00498	0.495
LIG_FHA_1	653	659	PF00498	0.478
LIG_FHA_1	677	683	PF00498	0.539
LIG_FHA_1	92	98	PF00498	0.554
LIG_FHA_2	144	150	PF00498	0.544
LIG_FHA_2	460	466	PF00498	0.453
LIG_FHA_2	550	556	PF00498	0.546
LIG_FHA_2	63	69	PF00498	0.632
LIG_FHA_2	97	103	PF00498	0.611
LIG_GBD_Chelix_1	184	192	PF00786	0.494
LIG_LIR_Apic_2	340	345	PF02991	0.596
LIG_LIR_Apic_2	58	64	PF02991	0.781
LIG_LIR_Gen_1	120	126	PF02991	0.509
LIG_LIR_Gen_1	166	175	PF02991	0.557
LIG_LIR_Gen_1	204	214	PF02991	0.501
LIG_LIR_Gen_1	299	306	PF02991	0.600
LIG_LIR_Gen_1	387	398	PF02991	0.486
LIG_LIR_Gen_1	527	536	PF02991	0.485
LIG_LIR_Gen_1	604	615	PF02991	0.504
LIG_LIR_Nem_3	120	125	PF02991	0.498
LIG_LIR_Nem_3	166	170	PF02991	0.543
LIG_LIR_Nem_3	204	209	PF02991	0.509
LIG_LIR_Nem_3	299	304	PF02991	0.603
LIG_LIR_Nem_3	387	393	PF02991	0.457
LIG_LIR_Nem_3	527	531	PF02991	0.457
LIG_LIR_Nem_3	556	562	PF02991	0.482
LIG_LIR_Nem_3	604	610	PF02991	0.515
LIG_LYPXL_SIV_4	636	644	PF13949	0.495
LIG_PDZ_Class_1	701	706	PF00595	0.565
LIG_SH2_CRK	122	126	PF00017	0.484
LIG_SH2_CRK	301	305	PF00017	0.614
LIG_SH2_CRK	607	611	PF00017	0.491
LIG_SH2_GRB2like	163	166	PF00017	0.550
LIG_SH2_NCK_1	607	611	PF00017	0.491
LIG_SH2_PTP2	206	209	PF00017	0.516
LIG_SH2_PTP2	559	562	PF00017	0.480
LIG_SH2_STAP1	122	126	PF00017	0.484
LIG_SH2_STAP1	88	92	PF00017	0.511
LIG_SH2_STAT5	122	125	PF00017	0.453
LIG_SH2_STAT5	206	209	PF00017	0.533
LIG_SH2_STAT5	301	304	PF00017	0.646
LIG_SH2_STAT5	323	326	PF00017	0.436
LIG_SH2_STAT5	390	393	PF00017	0.434
LIG_SH2_STAT5	407	410	PF00017	0.601
LIG_SH2_STAT5	547	550	PF00017	0.432
LIG_SH2_STAT5	559	562	PF00017	0.424
LIG_SH3_3	367	373	PF00018	0.563
LIG_SH3_3	42	48	PF00018	0.747
LIG_SH3_3	473	479	PF00018	0.583
LIG_SH3_4	402	409	PF00018	0.624
LIG_SUMO_SIM_anti_2	285	290	PF11976	0.484
LIG_SUMO_SIM_anti_2	493	500	PF11976	0.349
LIG_SUMO_SIM_anti_2	527	533	PF11976	0.484
LIG_SUMO_SIM_anti_2	549	558	PF11976	0.489
LIG_SUMO_SIM_par_1	457	462	PF11976	0.499
LIG_SUMO_SIM_par_1	493	500	PF11976	0.470
LIG_SUMO_SIM_par_1	659	665	PF11976	0.466
LIG_TRAF2_1	65	68	PF00917	0.781
LIG_TYR_ITSM	297	304	PF00017	0.596
LIG_TYR_ITSM	603	610	PF00017	0.477
LIG_UBA3_1	97	101	PF00899	0.604
MOD_CK1_1	143	149	PF00069	0.589
MOD_CK1_1	38	44	PF00069	0.696
MOD_CK1_1	416	422	PF00069	0.780
MOD_CK1_1	500	506	PF00069	0.542
MOD_CK1_1	601	607	PF00069	0.502
MOD_CK1_1	662	668	PF00069	0.340
MOD_CK2_1	1	7	PF00069	0.694
MOD_CK2_1	143	149	PF00069	0.474
MOD_CK2_1	459	465	PF00069	0.432
MOD_CK2_1	52	58	PF00069	0.693
MOD_CK2_1	549	555	PF00069	0.515
MOD_CK2_1	62	68	PF00069	0.603
MOD_GlcNHglycan	127	130	PF01048	0.505
MOD_GlcNHglycan	158	161	PF01048	0.408
MOD_GlcNHglycan	334	338	PF01048	0.474
MOD_GlcNHglycan	351	354	PF01048	0.459
MOD_GlcNHglycan	37	40	PF01048	0.693
MOD_GlcNHglycan	418	421	PF01048	0.689
MOD_GlcNHglycan	453	456	PF01048	0.573
MOD_GlcNHglycan	499	502	PF01048	0.471
MOD_GlcNHglycan	516	519	PF01048	0.552
MOD_GlcNHglycan	520	523	PF01048	0.561
MOD_GlcNHglycan	532	535	PF01048	0.500
MOD_GlcNHglycan	562	565	PF01048	0.417
MOD_GSK3_1	18	25	PF00069	0.687
MOD_GSK3_1	217	224	PF00069	0.504
MOD_GSK3_1	245	252	PF00069	0.528
MOD_GSK3_1	296	303	PF00069	0.523
MOD_GSK3_1	306	313	PF00069	0.453
MOD_GSK3_1	329	336	PF00069	0.508
MOD_GSK3_1	345	352	PF00069	0.547
MOD_GSK3_1	35	42	PF00069	0.537
MOD_GSK3_1	416	423	PF00069	0.741
MOD_GSK3_1	514	521	PF00069	0.644
MOD_GSK3_1	574	581	PF00069	0.526
MOD_GSK3_1	583	590	PF00069	0.488
MOD_GSK3_1	59	66	PF00069	0.705
MOD_GSK3_1	594	601	PF00069	0.427
MOD_N-GLC_1	518	523	PF02516	0.673
MOD_NEK2_1	1	6	PF00069	0.742
MOD_NEK2_1	249	254	PF00069	0.559
MOD_NEK2_1	306	311	PF00069	0.612
MOD_NEK2_1	490	495	PF00069	0.516
MOD_NEK2_1	532	537	PF00069	0.587
MOD_NEK2_1	554	559	PF00069	0.581
MOD_NEK2_1	652	657	PF00069	0.442
MOD_NEK2_1	701	706	PF00069	0.554
MOD_NEK2_2	217	222	PF00069	0.493
MOD_NEK2_2	360	365	PF00069	0.580
MOD_PIKK_1	140	146	PF00454	0.587
MOD_PIKK_1	306	312	PF00454	0.602
MOD_PIKK_1	63	69	PF00454	0.786
MOD_PIKK_1	91	97	PF00454	0.580
MOD_PKA_2	413	419	PF00069	0.706
MOD_PKA_2	490	496	PF00069	0.480
MOD_PKA_2	524	530	PF00069	0.497
MOD_Plk_1	245	251	PF00069	0.470
MOD_Plk_1	464	470	PF00069	0.549
MOD_Plk_1	554	560	PF00069	0.562
MOD_Plk_1	595	601	PF00069	0.515
MOD_Plk_1	640	646	PF00069	0.539
MOD_Plk_2-3	81	87	PF00069	0.652
MOD_Plk_4	120	126	PF00069	0.596
MOD_Plk_4	296	302	PF00069	0.470
MOD_Plk_4	337	343	PF00069	0.541
MOD_Plk_4	39	45	PF00069	0.687
MOD_Plk_4	490	496	PF00069	0.454
MOD_Plk_4	524	530	PF00069	0.488
MOD_Plk_4	532	538	PF00069	0.530
MOD_Plk_4	549	555	PF00069	0.311
MOD_Plk_4	640	646	PF00069	0.557
MOD_ProDKin_1	293	299	PF00069	0.585
MOD_ProDKin_1	578	584	PF00069	0.556
TRG_DiLeu_BaEn_2	119	125	PF01217	0.508
TRG_DiLeu_BaLyEn_6	677	682	PF01217	0.548
TRG_ENDOCYTIC_2	122	125	PF00928	0.527
TRG_ENDOCYTIC_2	206	209	PF00928	0.498
TRG_ENDOCYTIC_2	301	304	PF00928	0.619
TRG_ENDOCYTIC_2	323	326	PF00928	0.536
TRG_ENDOCYTIC_2	390	393	PF00928	0.393
TRG_ENDOCYTIC_2	559	562	PF00928	0.463
TRG_ENDOCYTIC_2	607	610	PF00928	0.499
TRG_ENDOCYTIC_2	615	618	PF00928	0.483
TRG_ER_diArg_1	253	255	PF00400	0.608
TRG_ER_diArg_1	265	268	PF00400	0.377
TRG_ER_diArg_1	270	272	PF00400	0.373
TRG_ER_diArg_1	364	367	PF00400	0.569
TRG_ER_diArg_1	575	578	PF00400	0.557
TRG_ER_FFAT_2	545	552	PF00635	0.498
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	680	685	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E7	Leptomonas seymouri	44%	72%
A0A422N3Q2	Trypanosoma rangeli	28%	100%
A4HCB8	Leishmania braziliensis	74%	97%
A4HZX1	Leishmania infantum	100%	100%
C9ZSK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AVT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QBP9	Leishmania major	95%	100%
V5DMK2	Trypanosoma cruzi	27%	100%