Uncharacterized protein family UPF0066, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family UPF0066, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WX66_LEIDO

TriTrypDb:

LdBPK_220460.1 , LdCL_220010900 , LDHU3_22.0780

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WX66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX66

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	465	469	PF00656	0.535
CLV_NRD_NRD_1	108	110	PF00675	0.591
CLV_NRD_NRD_1	116	118	PF00675	0.609
CLV_NRD_NRD_1	317	319	PF00675	0.652
CLV_NRD_NRD_1	378	380	PF00675	0.481
CLV_PCSK_FUR_1	112	116	PF00082	0.416
CLV_PCSK_KEX2_1	114	116	PF00082	0.652
CLV_PCSK_KEX2_1	377	379	PF00082	0.483
CLV_PCSK_KEX2_1	48	50	PF00082	0.614
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.633
CLV_PCSK_PC7_1	112	118	PF00082	0.619
CLV_PCSK_SKI1_1	121	125	PF00082	0.517
CLV_PCSK_SKI1_1	401	405	PF00082	0.349
CLV_PCSK_SKI1_1	66	70	PF00082	0.490
DEG_COP1_1	134	145	PF00400	0.537
DEG_SCF_FBW7_1	22	28	PF00400	0.534
DEG_SCF_TRCP1_1	157	162	PF00400	0.574
DEG_SPOP_SBC_1	132	136	PF00917	0.612
DOC_CKS1_1	22	27	PF01111	0.556
DOC_MAPK_gen_1	191	200	PF00069	0.492
DOC_MAPK_gen_1	205	215	PF00069	0.347
DOC_MAPK_gen_1	86	93	PF00069	0.439
DOC_MAPK_MEF2A_6	193	202	PF00069	0.490
DOC_PP1_RVXF_1	182	189	PF00149	0.380
DOC_PP2B_LxvP_1	91	94	PF13499	0.520
DOC_PP4_FxxP_1	304	307	PF00568	0.549
DOC_USP7_MATH_1	13	17	PF00917	0.783
DOC_USP7_MATH_1	132	136	PF00917	0.612
DOC_USP7_MATH_1	307	311	PF00917	0.563
DOC_USP7_MATH_1	326	330	PF00917	0.556
DOC_USP7_MATH_1	372	376	PF00917	0.538
DOC_USP7_UBL2_3	124	128	PF12436	0.544
DOC_USP7_UBL2_3	474	478	PF12436	0.595
DOC_WW_Pin1_4	1	6	PF00397	0.759
DOC_WW_Pin1_4	133	138	PF00397	0.585
DOC_WW_Pin1_4	147	152	PF00397	0.669
DOC_WW_Pin1_4	15	20	PF00397	0.736
DOC_WW_Pin1_4	21	26	PF00397	0.758
DOC_WW_Pin1_4	233	238	PF00397	0.475
DOC_WW_Pin1_4	347	352	PF00397	0.692
DOC_WW_Pin1_4	405	410	PF00397	0.287
DOC_WW_Pin1_4	438	443	PF00397	0.317
LIG_14-3-3_CanoR_1	193	200	PF00244	0.544
LIG_14-3-3_CanoR_1	232	236	PF00244	0.559
LIG_14-3-3_CanoR_1	488	492	PF00244	0.657
LIG_APCC_ABBA_1	213	218	PF00400	0.432
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_BIR_III_4	468	472	PF00653	0.510
LIG_deltaCOP1_diTrp_1	294	304	PF00928	0.344
LIG_deltaCOP1_diTrp_1	397	404	PF00928	0.403
LIG_EH1_1	56	64	PF00400	0.493
LIG_FHA_1	1	7	PF00498	0.591
LIG_FHA_1	193	199	PF00498	0.549
LIG_FHA_1	219	225	PF00498	0.440
LIG_FHA_1	272	278	PF00498	0.432
LIG_FHA_1	388	394	PF00498	0.266
LIG_FHA_1	439	445	PF00498	0.287
LIG_FHA_1	481	487	PF00498	0.513
LIG_FHA_2	136	142	PF00498	0.682
LIG_FHA_2	192	198	PF00498	0.403
LIG_FHA_2	22	28	PF00498	0.768
LIG_FHA_2	279	285	PF00498	0.455
LIG_HCF-1_HBM_1	476	479	PF13415	0.473
LIG_LIR_Apic_2	303	307	PF02991	0.491
LIG_LIR_Apic_2	61	67	PF02991	0.345
LIG_LIR_Gen_1	294	305	PF02991	0.348
LIG_LIR_Nem_3	294	300	PF02991	0.357
LIG_LIR_Nem_3	397	403	PF02991	0.428
LIG_NBox_RRM_1	220	230	PF00076	0.400
LIG_Pex14_1	400	404	PF04695	0.403
LIG_Pex14_2	293	297	PF04695	0.336
LIG_Pex14_2	300	304	PF04695	0.365
LIG_REV1ctd_RIR_1	186	195	PF16727	0.406
LIG_SH2_NCK_1	216	220	PF00017	0.430
LIG_SH2_SRC	216	219	PF00017	0.410
LIG_SH2_STAP1	216	220	PF00017	0.370
LIG_SH2_STAP1	243	247	PF00017	0.521
LIG_SH2_STAT3	479	482	PF00017	0.505
LIG_SH2_STAT5	187	190	PF00017	0.494
LIG_SH2_STAT5	449	452	PF00017	0.287
LIG_SH2_STAT5	56	59	PF00017	0.408
LIG_SH3_3	166	172	PF00018	0.680
LIG_SH3_3	2	8	PF00018	0.661
LIG_SH3_3	259	265	PF00018	0.431
LIG_SH3_3	406	412	PF00018	0.287
LIG_SH3_3	445	451	PF00018	0.287
LIG_SH3_3	68	74	PF00018	0.362
LIG_SH3_3	90	96	PF00018	0.439
LIG_TRAF2_1	194	197	PF00917	0.433
LIG_UBA3_1	122	128	PF00899	0.420
LIG_WRC_WIRS_1	373	378	PF05994	0.522
LIG_WW_3	393	397	PF00397	0.287
MOD_CDC14_SPxK_1	236	239	PF00782	0.461
MOD_CDC14_SPxK_1	408	411	PF00782	0.287
MOD_CDK_SPxK_1	233	239	PF00069	0.474
MOD_CDK_SPxK_1	405	411	PF00069	0.287
MOD_CK1_1	135	141	PF00069	0.636
MOD_CK1_1	18	24	PF00069	0.730
MOD_CK1_1	9	15	PF00069	0.792
MOD_CK2_1	135	141	PF00069	0.680
MOD_CK2_1	191	197	PF00069	0.436
MOD_CK2_1	278	284	PF00069	0.453
MOD_CK2_1	360	366	PF00069	0.611
MOD_GlcNHglycan	157	160	PF01048	0.596
MOD_GlcNHglycan	161	164	PF01048	0.576
MOD_GlcNHglycan	309	312	PF01048	0.620
MOD_GlcNHglycan	325	329	PF01048	0.558
MOD_GlcNHglycan	335	338	PF01048	0.746
MOD_GlcNHglycan	368	371	PF01048	0.647
MOD_GlcNHglycan	468	472	PF01048	0.475
MOD_GSK3_1	131	138	PF00069	0.700
MOD_GSK3_1	155	162	PF00069	0.742
MOD_GSK3_1	17	24	PF00069	0.700
MOD_GSK3_1	173	180	PF00069	0.628
MOD_GSK3_1	324	331	PF00069	0.601
MOD_GSK3_1	338	345	PF00069	0.671
MOD_GSK3_1	9	16	PF00069	0.758
MOD_NEK2_1	161	166	PF00069	0.590
MOD_NEK2_1	300	305	PF00069	0.364
MOD_NEK2_1	467	472	PF00069	0.462
MOD_NEK2_2	313	318	PF00069	0.631
MOD_NEK2_2	372	377	PF00069	0.440
MOD_PIKK_1	218	224	PF00454	0.444
MOD_PIKK_1	478	484	PF00454	0.506
MOD_PKA_2	192	198	PF00069	0.493
MOD_PKA_2	231	237	PF00069	0.540
MOD_Plk_1	211	217	PF00069	0.440
MOD_Plk_4	211	217	PF00069	0.434
MOD_Plk_4	250	256	PF00069	0.370
MOD_Plk_4	387	393	PF00069	0.310
MOD_ProDKin_1	1	7	PF00069	0.757
MOD_ProDKin_1	133	139	PF00069	0.586
MOD_ProDKin_1	147	153	PF00069	0.669
MOD_ProDKin_1	15	21	PF00069	0.736
MOD_ProDKin_1	233	239	PF00069	0.474
MOD_ProDKin_1	347	353	PF00069	0.690
MOD_ProDKin_1	405	411	PF00069	0.287
MOD_ProDKin_1	438	444	PF00069	0.317
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.538
TRG_ENDOCYTIC_2	449	452	PF00928	0.282
TRG_ENDOCYTIC_2	56	59	PF00928	0.524
TRG_ER_diArg_1	114	117	PF00400	0.499
TRG_ER_diArg_1	277	280	PF00400	0.470
TRG_ER_diArg_1	376	379	PF00400	0.497
TRG_ER_diArg_1	50	53	PF00400	0.482
TRG_ER_diArg_1	87	90	PF00400	0.465
TRG_NLS_MonoExtC_3	46	51	PF00514	0.607
TRG_NLS_MonoExtN_4	47	52	PF00514	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB52	Leptomonas seymouri	67%	100%
A0A3R7K8Q3	Trypanosoma rangeli	49%	100%
A4HCA4	Leishmania braziliensis	78%	100%
A4HZT6	Leishmania infantum	100%	100%
C9ZRM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AVP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QBT8	Leishmania major	91%	99%
V5DMI0	Trypanosoma cruzi	48%	100%