LeishMANIAdb
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Prefoldin_5-like_protein/GeneDB:LmjF.22.0670

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Prefoldin_5-like_protein/GeneDB:LmjF.22.0670
Gene product:
prefoldin 5-like protein
Species:
Leishmania donovani
UniProt:
A0A3S7WX60_LEIDO
TriTrypDb:
LdBPK_220540.1 , LdCL_220011700 , LDHU3_22.0870
Length:
157

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, Prefoldin 5-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016272 prefoldin complex 2 11
GO:0032991 protein-containing complex 1 11
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7WX60
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX60

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 11
GO:0009987 cellular process 1 11
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0051082 unfolded protein binding 3 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 18 22 PF00656 0.563
CLV_PCSK_SKI1_1 106 110 PF00082 0.415
LIG_BIR_II_1 1 5 PF00653 0.588
LIG_BRCT_BRCA1_1 72 76 PF00533 0.613
LIG_FHA_1 123 129 PF00498 0.625
LIG_FHA_1 70 76 PF00498 0.576
LIG_FHA_2 27 33 PF00498 0.573
LIG_Integrin_isoDGR_2 36 38 PF01839 0.582
LIG_LIR_Nem_3 29 34 PF02991 0.483
LIG_SH2_CRK 31 35 PF00017 0.501
LIG_SH2_CRK 51 55 PF00017 0.425
LIG_SH2_CRK 6 10 PF00017 0.594
LIG_SH2_STAT5 107 110 PF00017 0.525
LIG_SH2_STAT5 95 98 PF00017 0.550
LIG_SUMO_SIM_par_1 87 93 PF11976 0.532
LIG_TRAF2_1 63 66 PF00917 0.587
MOD_CK1_1 26 32 PF00069 0.512
MOD_GSK3_1 77 84 PF00069 0.627
MOD_NEK2_1 71 76 PF00069 0.553
MOD_PKA_2 77 83 PF00069 0.613
MOD_Plk_1 122 128 PF00069 0.613
MOD_Plk_1 97 103 PF00069 0.602
MOD_Plk_4 122 128 PF00069 0.609
MOD_Plk_4 71 77 PF00069 0.576
MOD_SUMO_for_1 59 62 PF00179 0.594
TRG_ENDOCYTIC_2 31 34 PF00928 0.474
TRG_ENDOCYTIC_2 51 54 PF00928 0.425
TRG_ER_diArg_1 38 41 PF00400 0.549

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJL6 Leptomonas seymouri 84% 100%
A0A0S4IRG2 Bodo saltans 49% 100%
A0A1X0NUY3 Trypanosomatidae 43% 91%
A0A422NDH7 Trypanosoma rangeli 43% 95%
A4HCB2 Leishmania braziliensis 90% 100%
A4HZU4 Leishmania infantum 100% 100%
C9ZSF4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 92%
E9AVP9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O94307 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
P57742 Arabidopsis thaliana 33% 100%
Q04493 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 96%
Q21993 Caenorhabditis elegans 24% 100%
Q4QBT0 Leishmania major 99% 100%
Q54V55 Dictyostelium discoideum 25% 98%
Q5RAY0 Pongo abelii 34% 100%
Q8HYI9 Bos taurus 33% 100%
Q99471 Homo sapiens 34% 100%
Q9VCZ8 Drosophila melanogaster 27% 93%
Q9WU28 Mus musculus 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS