LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Guide RNA associated protein, GAP2, putative

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guide RNA associated protein, GAP2, putative
Gene product:
guide RNA associated protein, GAP2, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WX47_LEIDO
TriTrypDb:
LdBPK_220520.1 , LdCL_220011500 , LDHU3_22.0850
Length:
500

Annotations

Annotations by Jardim et al.

Nucleic acid binding, guide RNA associated Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 22
NetGPI no yes: 0, no: 22
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 3
GO:0005739 mitochondrion 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7WX47
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX47

Function

Biological processes
Term Name Level Count
GO:0000959 mitochondrial RNA metabolic process 6 2
GO:0000963 mitochondrial RNA processing 6 2
GO:0006139 nucleobase-containing compound metabolic process 3 2
GO:0006396 RNA processing 6 2
GO:0006725 cellular aromatic compound metabolic process 3 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0009451 RNA modification 5 1
GO:0009987 cellular process 1 2
GO:0010467 gene expression 4 2
GO:0016070 RNA metabolic process 5 2
GO:0016071 mRNA metabolic process 6 1
GO:0016556 mRNA modification 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0043170 macromolecule metabolic process 3 2
GO:0043412 macromolecule modification 4 1
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0046483 heterocycle metabolic process 3 2
GO:0071704 organic substance metabolic process 2 2
GO:0090304 nucleic acid metabolic process 4 2
GO:0140053 mitochondrial gene expression 5 2
GO:1901360 organic cyclic compound metabolic process 3 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003723 RNA binding 4 2
GO:0003729 mRNA binding 5 2
GO:0005488 binding 1 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 209 213 PF00656 0.487
CLV_NRD_NRD_1 105 107 PF00675 0.521
CLV_PCSK_KEX2_1 105 107 PF00082 0.521
CLV_PCSK_KEX2_1 316 318 PF00082 0.373
CLV_PCSK_KEX2_1 424 426 PF00082 0.335
CLV_PCSK_PC1ET2_1 316 318 PF00082 0.381
CLV_PCSK_PC1ET2_1 424 426 PF00082 0.291
CLV_PCSK_SKI1_1 247 251 PF00082 0.397
CLV_PCSK_SKI1_1 316 320 PF00082 0.466
CLV_PCSK_SKI1_1 356 360 PF00082 0.322
CLV_PCSK_SKI1_1 57 61 PF00082 0.402
CLV_PCSK_SKI1_1 84 88 PF00082 0.482
DEG_APCC_DBOX_1 424 432 PF00400 0.364
DEG_Nend_UBRbox_3 1 3 PF02207 0.423
DEG_SPOP_SBC_1 191 195 PF00917 0.561
DOC_CDC14_PxL_1 485 493 PF14671 0.401
DOC_CKS1_1 249 254 PF01111 0.329
DOC_CYCLIN_RxL_1 244 251 PF00134 0.334
DOC_CYCLIN_yCln2_LP_2 249 255 PF00134 0.327
DOC_MAPK_gen_1 14 23 PF00069 0.429
DOC_MAPK_gen_1 316 326 PF00069 0.341
DOC_MAPK_gen_1 421 431 PF00069 0.354
DOC_MAPK_HePTP_8 314 326 PF00069 0.240
DOC_MAPK_MEF2A_6 317 326 PF00069 0.339
DOC_MAPK_MEF2A_6 424 431 PF00069 0.377
DOC_MAPK_MEF2A_6 439 448 PF00069 0.412
DOC_MAPK_MEF2A_6 46 54 PF00069 0.516
DOC_PP1_RVXF_1 221 228 PF00149 0.355
DOC_USP7_MATH_1 186 190 PF00917 0.486
DOC_USP7_MATH_1 260 264 PF00917 0.343
DOC_USP7_MATH_1 363 367 PF00917 0.529
DOC_USP7_MATH_1 53 57 PF00917 0.704
DOC_WW_Pin1_4 248 253 PF00397 0.330
LIG_14-3-3_CanoR_1 190 200 PF00244 0.423
LIG_14-3-3_CanoR_1 308 312 PF00244 0.449
LIG_14-3-3_CanoR_1 33 42 PF00244 0.612
LIG_14-3-3_CanoR_1 7 11 PF00244 0.682
LIG_BIR_III_4 212 216 PF00653 0.502
LIG_deltaCOP1_diTrp_1 338 346 PF00928 0.449
LIG_deltaCOP1_diTrp_1 64 70 PF00928 0.396
LIG_FHA_1 16 22 PF00498 0.427
LIG_FHA_1 212 218 PF00498 0.471
LIG_FHA_1 240 246 PF00498 0.436
LIG_FHA_1 491 497 PF00498 0.455
LIG_FHA_1 56 62 PF00498 0.602
LIG_FHA_2 346 352 PF00498 0.468
LIG_FHA_2 39 45 PF00498 0.532
LIG_LIR_Gen_1 219 229 PF02991 0.326
LIG_LIR_Gen_1 274 284 PF02991 0.417
LIG_LIR_Gen_1 338 346 PF02991 0.325
LIG_LIR_Gen_1 371 381 PF02991 0.379
LIG_LIR_Gen_1 405 416 PF02991 0.363
LIG_LIR_Nem_3 193 199 PF02991 0.450
LIG_LIR_Nem_3 219 224 PF02991 0.368
LIG_LIR_Nem_3 274 280 PF02991 0.434
LIG_LIR_Nem_3 297 303 PF02991 0.344
LIG_LIR_Nem_3 310 314 PF02991 0.301
LIG_LIR_Nem_3 338 342 PF02991 0.340
LIG_LIR_Nem_3 371 376 PF02991 0.426
LIG_LIR_Nem_3 405 411 PF02991 0.343
LIG_NRBOX 472 478 PF00104 0.277
LIG_SH2_CRK 221 225 PF00017 0.333
LIG_SH2_CRK 373 377 PF00017 0.349
LIG_SH2_NCK_1 373 377 PF00017 0.349
LIG_SH2_SRC 110 113 PF00017 0.457
LIG_SH2_SRC 442 445 PF00017 0.252
LIG_SH2_SRC 63 66 PF00017 0.333
LIG_SH2_STAP1 221 225 PF00017 0.373
LIG_SH2_STAP1 277 281 PF00017 0.343
LIG_SH2_STAP1 63 67 PF00017 0.494
LIG_SH2_STAT3 265 268 PF00017 0.349
LIG_SH2_STAT5 110 113 PF00017 0.445
LIG_SH2_STAT5 206 209 PF00017 0.479
LIG_SH2_STAT5 265 268 PF00017 0.405
LIG_SH2_STAT5 277 280 PF00017 0.412
LIG_SH2_STAT5 373 376 PF00017 0.507
LIG_SH2_STAT5 399 402 PF00017 0.328
LIG_SH3_3 194 200 PF00018 0.452
LIG_SH3_3 347 353 PF00018 0.520
LIG_SH3_3 386 392 PF00018 0.389
LIG_SH3_3 443 449 PF00018 0.352
LIG_SUMO_SIM_anti_2 320 326 PF11976 0.461
LIG_SUMO_SIM_par_1 377 385 PF11976 0.483
LIG_SUMO_SIM_par_1 427 437 PF11976 0.413
LIG_SUMO_SIM_par_1 465 472 PF11976 0.423
LIG_TYR_ITIM 309 314 PF00017 0.220
LIG_TYR_ITIM 61 66 PF00017 0.499
LIG_TYR_ITSM 217 224 PF00017 0.301
MOD_CK1_1 113 119 PF00069 0.472
MOD_CK1_1 137 143 PF00069 0.618
MOD_CK1_1 211 217 PF00069 0.340
MOD_CK1_1 263 269 PF00069 0.350
MOD_CK1_1 451 457 PF00069 0.586
MOD_CK1_1 55 61 PF00069 0.561
MOD_CK1_1 9 15 PF00069 0.717
MOD_CK2_1 179 185 PF00069 0.532
MOD_CK2_1 345 351 PF00069 0.464
MOD_CK2_1 398 404 PF00069 0.372
MOD_CMANNOS 67 70 PF00535 0.343
MOD_GlcNHglycan 115 118 PF01048 0.510
MOD_GlcNHglycan 262 265 PF01048 0.454
MOD_GlcNHglycan 285 288 PF01048 0.435
MOD_GlcNHglycan 365 368 PF01048 0.519
MOD_GlcNHglycan 450 453 PF01048 0.534
MOD_GlcNHglycan 47 50 PF01048 0.617
MOD_GSK3_1 15 22 PF00069 0.525
MOD_GSK3_1 186 193 PF00069 0.371
MOD_GSK3_1 200 207 PF00069 0.390
MOD_GSK3_1 271 278 PF00069 0.373
MOD_GSK3_1 34 41 PF00069 0.567
MOD_GSK3_1 341 348 PF00069 0.317
MOD_GSK3_1 398 405 PF00069 0.339
MOD_GSK3_1 444 451 PF00069 0.512
MOD_GSK3_1 467 474 PF00069 0.452
MOD_GSK3_1 492 499 PF00069 0.570
MOD_GSK3_1 6 13 PF00069 0.607
MOD_N-GLC_1 191 196 PF02516 0.407
MOD_N-GLC_1 402 407 PF02516 0.470
MOD_NEK2_1 10 15 PF00069 0.633
MOD_NEK2_1 177 182 PF00069 0.390
MOD_NEK2_1 271 276 PF00069 0.476
MOD_NEK2_1 28 33 PF00069 0.670
MOD_NEK2_1 358 363 PF00069 0.336
MOD_NEK2_2 6 11 PF00069 0.436
MOD_PKA_2 15 21 PF00069 0.686
MOD_PKA_2 219 225 PF00069 0.315
MOD_PKA_2 307 313 PF00069 0.430
MOD_PKA_2 369 375 PF00069 0.441
MOD_PKA_2 420 426 PF00069 0.452
MOD_PKA_2 45 51 PF00069 0.744
MOD_PKA_2 6 12 PF00069 0.694
MOD_Plk_1 137 143 PF00069 0.616
MOD_Plk_1 191 197 PF00069 0.420
MOD_Plk_1 239 245 PF00069 0.457
MOD_Plk_1 471 477 PF00069 0.286
MOD_Plk_4 275 281 PF00069 0.332
MOD_Plk_4 472 478 PF00069 0.454
MOD_ProDKin_1 248 254 PF00069 0.322
MOD_SUMO_for_1 330 333 PF00179 0.315
MOD_SUMO_for_1 61 64 PF00179 0.524
TRG_DiLeu_BaEn_1 244 249 PF01217 0.450
TRG_DiLeu_BaEn_1 393 398 PF01217 0.367
TRG_DiLeu_BaEn_1 472 477 PF01217 0.488
TRG_DiLeu_BaEn_4 435 441 PF01217 0.418
TRG_DiLeu_BaEn_4 64 70 PF01217 0.326
TRG_DiLeu_BaLyEn_6 424 429 PF01217 0.344
TRG_ENDOCYTIC_2 221 224 PF00928 0.339
TRG_ENDOCYTIC_2 277 280 PF00928 0.340
TRG_ENDOCYTIC_2 311 314 PF00928 0.218
TRG_ENDOCYTIC_2 373 376 PF00928 0.507
TRG_ENDOCYTIC_2 63 66 PF00928 0.497
TRG_ER_diArg_1 104 106 PF00400 0.519
TRG_ER_diArg_1 359 362 PF00400 0.333
TRG_NES_CRM1_1 320 333 PF08389 0.448

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK37 Leptomonas seymouri 73% 100%
A0A0N1IKX3 Leptomonas seymouri 28% 92%
A0A0S4IN88 Bodo saltans 43% 93%
A0A0S4JQR1 Bodo saltans 30% 93%
A0A1X0NRA1 Trypanosomatidae 28% 98%
A0A1X0NTQ0 Trypanosomatidae 57% 100%
A0A3Q8II17 Leishmania donovani 28% 100%
A0A422NDT8 Trypanosoma rangeli 57% 100%
A0A422NKD3 Trypanosoma rangeli 28% 100%
A4HCA9 Leishmania braziliensis 88% 100%
A4HLY4 Leishmania braziliensis 29% 100%
A4HZU2 Leishmania infantum 100% 100%
A4I9B3 Leishmania infantum 28% 100%
C9ZJB1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZRN1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9AVP7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9B4B3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
Q4Q3R2 Leishmania major 28% 100%
Q4QBT2 Leishmania major 95% 100%
V5BAI0 Trypanosoma cruzi 28% 100%
V5BVS4 Trypanosoma cruzi 57% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS