LeishMANIAdb
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3'a2rel-related protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
3'a2rel-related protein
Gene product:
3'a2rel-related protein
Species:
Leishmania donovani
UniProt:
A0A3S7WX43_LEIDO
TriTrypDb:
LdBPK_220560.1 , LdCL_220014100 , LDHU3_22.1120
Length:
615

Annotations

LeishMANIAdb annotations

A very special family of kinetoplastid proteins, carrying multiply amyloid-like segments on their disordered extracellular domain, alongside with RGD motifs. Duplicated in Leishmaniids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 4, no: 5
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A0A3S7WX43
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX43

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 383 387 PF00656 0.688
CLV_C14_Caspase3-7 538 542 PF00656 0.823
CLV_NRD_NRD_1 175 177 PF00675 0.707
CLV_NRD_NRD_1 215 217 PF00675 0.704
CLV_NRD_NRD_1 246 248 PF00675 0.458
CLV_NRD_NRD_1 251 253 PF00675 0.461
CLV_NRD_NRD_1 331 333 PF00675 0.539
CLV_NRD_NRD_1 336 338 PF00675 0.496
CLV_PCSK_FUR_1 249 253 PF00082 0.448
CLV_PCSK_FUR_1 334 338 PF00082 0.520
CLV_PCSK_KEX2_1 175 177 PF00082 0.707
CLV_PCSK_KEX2_1 215 217 PF00082 0.704
CLV_PCSK_KEX2_1 246 248 PF00082 0.458
CLV_PCSK_KEX2_1 251 253 PF00082 0.461
CLV_PCSK_KEX2_1 333 335 PF00082 0.517
CLV_PCSK_KEX2_1 336 338 PF00082 0.505
CLV_PCSK_PC1ET2_1 251 253 PF00082 0.458
CLV_PCSK_PC1ET2_1 333 335 PF00082 0.517
CLV_PCSK_PC7_1 247 253 PF00082 0.442
CLV_PCSK_PC7_1 332 338 PF00082 0.519
CLV_PCSK_SKI1_1 176 180 PF00082 0.625
CLV_PCSK_SKI1_1 221 225 PF00082 0.592
CLV_PCSK_SKI1_1 25 29 PF00082 0.633
CLV_PCSK_SKI1_1 252 256 PF00082 0.496
CLV_PCSK_SKI1_1 461 465 PF00082 0.540
CLV_PCSK_SKI1_1 513 517 PF00082 0.488
DEG_APCC_DBOX_1 220 228 PF00400 0.388
DEG_Nend_UBRbox_4 1 3 PF02207 0.661
DEG_SCF_FBW7_1 151 157 PF00400 0.475
DEG_SPOP_SBC_1 128 132 PF00917 0.528
DEG_SPOP_SBC_1 154 158 PF00917 0.518
DEG_SPOP_SBC_1 201 205 PF00917 0.540
DEG_SPOP_SBC_1 437 441 PF00917 0.727
DOC_CKS1_1 151 156 PF01111 0.475
DOC_CKS1_1 43 48 PF01111 0.606
DOC_CYCLIN_RxL_1 173 182 PF00134 0.427
DOC_CYCLIN_RxL_1 249 262 PF00134 0.721
DOC_CYCLIN_RxL_1 458 468 PF00134 0.644
DOC_CYCLIN_yCln2_LP_2 230 236 PF00134 0.441
DOC_CYCLIN_yCln2_LP_2 80 86 PF00134 0.556
DOC_MAPK_gen_1 215 222 PF00069 0.442
DOC_MAPK_gen_1 249 259 PF00069 0.710
DOC_MAPK_gen_1 330 340 PF00069 0.720
DOC_MAPK_gen_1 69 78 PF00069 0.511
DOC_MAPK_MEF2A_6 215 224 PF00069 0.448
DOC_MAPK_MEF2A_6 25 32 PF00069 0.526
DOC_MAPK_MEF2A_6 69 78 PF00069 0.554
DOC_PP2B_LxvP_1 178 181 PF13499 0.421
DOC_PP2B_LxvP_1 230 233 PF13499 0.441
DOC_PP2B_LxvP_1 555 558 PF13499 0.785
DOC_PP2B_LxvP_1 71 74 PF13499 0.530
DOC_PP2B_LxvP_1 76 79 PF13499 0.501
DOC_SPAK_OSR1_1 301 305 PF12202 0.722
DOC_USP7_MATH_1 124 128 PF00917 0.601
DOC_USP7_MATH_1 129 133 PF00917 0.568
DOC_USP7_MATH_1 15 19 PF00917 0.602
DOC_USP7_MATH_1 154 158 PF00917 0.499
DOC_USP7_MATH_1 165 169 PF00917 0.485
DOC_USP7_MATH_1 170 174 PF00917 0.467
DOC_USP7_MATH_1 202 206 PF00917 0.576
DOC_USP7_MATH_1 402 406 PF00917 0.792
DOC_USP7_MATH_1 410 414 PF00917 0.754
DOC_USP7_MATH_1 423 427 PF00917 0.774
DOC_USP7_MATH_1 437 441 PF00917 0.680
DOC_USP7_MATH_1 490 494 PF00917 0.782
DOC_USP7_MATH_1 507 511 PF00917 0.656
DOC_USP7_UBL2_3 251 255 PF12436 0.669
DOC_WW_Pin1_4 11 16 PF00397 0.677
DOC_WW_Pin1_4 134 139 PF00397 0.585
DOC_WW_Pin1_4 150 155 PF00397 0.484
DOC_WW_Pin1_4 214 219 PF00397 0.432
DOC_WW_Pin1_4 286 291 PF00397 0.678
DOC_WW_Pin1_4 360 365 PF00397 0.760
DOC_WW_Pin1_4 42 47 PF00397 0.641
LIG_14-3-3_CanoR_1 16 23 PF00244 0.632
LIG_14-3-3_CanoR_1 166 174 PF00244 0.517
LIG_14-3-3_CanoR_1 175 179 PF00244 0.485
LIG_14-3-3_CanoR_1 568 575 PF00244 0.764
LIG_EVH1_2 208 212 PF00568 0.532
LIG_FHA_1 38 44 PF00498 0.576
LIG_FHA_1 409 415 PF00498 0.811
LIG_FHA_1 437 443 PF00498 0.729
LIG_FHA_1 457 463 PF00498 0.629
LIG_FHA_1 52 58 PF00498 0.422
LIG_FHA_1 75 81 PF00498 0.533
LIG_FHA_2 568 574 PF00498 0.765
LIG_Integrin_isoDGR_2 141 143 PF01839 0.718
LIG_Integrin_RGD_1 47 49 PF01839 0.652
LIG_Integrin_RGD_1 536 538 PF01839 0.587
LIG_LIR_Apic_2 598 602 PF02991 0.634
LIG_LIR_Gen_1 281 290 PF02991 0.759
LIG_LIR_Gen_1 35 43 PF02991 0.591
LIG_LIR_Gen_1 514 524 PF02991 0.773
LIG_LIR_Nem_3 281 285 PF02991 0.754
LIG_LIR_Nem_3 316 322 PF02991 0.664
LIG_LIR_Nem_3 514 519 PF02991 0.768
LIG_MYND_1 79 83 PF01753 0.472
LIG_NRBOX 28 34 PF00104 0.541
LIG_SH2_GRB2like 455 458 PF00017 0.748
LIG_SH2_SRC 611 614 PF00017 0.714
LIG_SH2_STAT5 455 458 PF00017 0.748
LIG_SH2_STAT5 467 470 PF00017 0.669
LIG_SH2_STAT5 611 614 PF00017 0.714
LIG_SH3_3 148 154 PF00018 0.482
LIG_SH3_3 40 46 PF00018 0.604
LIG_SH3_3 473 479 PF00018 0.794
LIG_SH3_3 506 512 PF00018 0.740
LIG_SH3_3 607 613 PF00018 0.679
LIG_SH3_3 81 87 PF00018 0.549
LIG_SUMO_SIM_anti_2 185 191 PF11976 0.554
LIG_SUMO_SIM_par_1 187 193 PF11976 0.556
LIG_TRAF2_1 119 122 PF00917 0.532
LIG_TRAF2_1 379 382 PF00917 0.797
LIG_WRC_WIRS_1 108 113 PF05994 0.507
LIG_WRC_WIRS_1 33 38 PF05994 0.531
LIG_WRC_WIRS_1 519 524 PF05994 0.689
MOD_CDK_SPK_2 11 16 PF00069 0.610
MOD_CDK_SPK_2 42 47 PF00069 0.533
MOD_CDK_SPxK_1 286 292 PF00069 0.678
MOD_CDK_SPxxK_3 214 221 PF00069 0.405
MOD_CK1_1 127 133 PF00069 0.590
MOD_CK1_1 134 140 PF00069 0.547
MOD_CK1_1 157 163 PF00069 0.588
MOD_CK1_1 169 175 PF00069 0.503
MOD_CK1_1 363 369 PF00069 0.733
MOD_CK1_1 37 43 PF00069 0.552
MOD_CK1_1 441 447 PF00069 0.838
MOD_CK2_1 375 381 PF00069 0.825
MOD_CK2_1 495 501 PF00069 0.766
MOD_CK2_1 511 517 PF00069 0.636
MOD_CK2_1 567 573 PF00069 0.766
MOD_GlcNHglycan 121 125 PF01048 0.818
MOD_GlcNHglycan 133 136 PF01048 0.716
MOD_GlcNHglycan 168 171 PF01048 0.743
MOD_GlcNHglycan 181 184 PF01048 0.656
MOD_GlcNHglycan 204 207 PF01048 0.788
MOD_GlcNHglycan 365 368 PF01048 0.567
MOD_GlcNHglycan 394 397 PF01048 0.571
MOD_GlcNHglycan 404 407 PF01048 0.511
MOD_GlcNHglycan 426 429 PF01048 0.611
MOD_GlcNHglycan 470 473 PF01048 0.632
MOD_GlcNHglycan 480 483 PF01048 0.565
MOD_GlcNHglycan 497 500 PF01048 0.509
MOD_GlcNHglycan 503 506 PF01048 0.558
MOD_GlcNHglycan 547 550 PF01048 0.555
MOD_GlcNHglycan 57 60 PF01048 0.740
MOD_GlcNHglycan 606 609 PF01048 0.554
MOD_GlcNHglycan 91 94 PF01048 0.729
MOD_GSK3_1 11 18 PF00069 0.681
MOD_GSK3_1 120 127 PF00069 0.536
MOD_GSK3_1 130 137 PF00069 0.527
MOD_GSK3_1 150 157 PF00069 0.474
MOD_GSK3_1 165 172 PF00069 0.477
MOD_GSK3_1 286 293 PF00069 0.685
MOD_GSK3_1 37 44 PF00069 0.595
MOD_GSK3_1 382 389 PF00069 0.738
MOD_GSK3_1 437 444 PF00069 0.786
MOD_GSK3_1 507 514 PF00069 0.689
MOD_GSK3_1 51 58 PF00069 0.432
MOD_GSK3_1 600 607 PF00069 0.679
MOD_N-GLC_1 11 16 PF02516 0.723
MOD_N-GLC_1 259 264 PF02516 0.552
MOD_N-GLC_1 456 461 PF02516 0.576
MOD_NEK2_1 120 125 PF00069 0.517
MOD_NEK2_1 174 179 PF00069 0.563
MOD_NEK2_1 259 264 PF00069 0.752
MOD_NEK2_1 32 37 PF00069 0.575
MOD_NEK2_1 456 461 PF00069 0.721
MOD_NEK2_1 55 60 PF00069 0.536
MOD_NEK2_2 170 175 PF00069 0.512
MOD_NEK2_2 490 495 PF00069 0.738
MOD_PIKK_1 109 115 PF00454 0.506
MOD_PIKK_1 600 606 PF00454 0.678
MOD_PK_1 511 517 PF00069 0.634
MOD_PKA_2 142 148 PF00069 0.561
MOD_PKA_2 15 21 PF00069 0.631
MOD_PKA_2 165 171 PF00069 0.540
MOD_PKA_2 174 180 PF00069 0.466
MOD_PKA_2 245 251 PF00069 0.661
MOD_PKA_2 300 306 PF00069 0.721
MOD_PKA_2 465 471 PF00069 0.667
MOD_PKA_2 539 545 PF00069 0.688
MOD_PKA_2 567 573 PF00069 0.766
MOD_PKA_2 604 610 PF00069 0.720
MOD_Plk_1 315 321 PF00069 0.689
MOD_Plk_1 457 463 PF00069 0.672
MOD_Plk_1 490 496 PF00069 0.673
MOD_Plk_2-3 567 573 PF00069 0.766
MOD_Plk_4 410 416 PF00069 0.796
MOD_Plk_4 438 444 PF00069 0.726
MOD_Plk_4 511 517 PF00069 0.646
MOD_ProDKin_1 11 17 PF00069 0.667
MOD_ProDKin_1 134 140 PF00069 0.584
MOD_ProDKin_1 150 156 PF00069 0.485
MOD_ProDKin_1 214 220 PF00069 0.426
MOD_ProDKin_1 286 292 PF00069 0.681
MOD_ProDKin_1 360 366 PF00069 0.762
MOD_ProDKin_1 42 48 PF00069 0.643
TRG_DiLeu_BaLyEn_6 76 81 PF01217 0.471
TRG_ER_diArg_1 174 176 PF00400 0.515
TRG_ER_diArg_1 246 249 PF00400 0.664
TRG_ER_diArg_1 334 337 PF00400 0.722
TRG_ER_diArg_1 560 563 PF00400 0.695
TRG_NLS_MonoExtC_3 250 255 PF00514 0.662
TRG_NLS_MonoExtC_3 331 336 PF00514 0.720
TRG_NLS_MonoExtN_4 249 256 PF00514 0.662
TRG_NLS_MonoExtN_4 330 337 PF00514 0.720

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ILH2 Leishmania donovani 99% 100%
A4HCB1 Leishmania braziliensis 63% 100%
A4HDA2 Leishmania braziliensis 57% 100%
E9AGZ2 Leishmania infantum 98% 100%
E9AGZ3 Leishmania infantum 98% 100%
E9AVQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4QBR2 Leishmania major 89% 100%
Q4QBS8 Leishmania major 89% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS