Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WX26_LEIDO

TriTrypDb:

LdBPK_220650.1 , LdCL_220012600 , LDHU3_22.0940 , LDHU3_22.1090

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WX26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX26

PDB structure(s): 7ane_an

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.646
CLV_NRD_NRD_1	186	188	PF00675	0.509
CLV_NRD_NRD_1	20	22	PF00675	0.379
CLV_NRD_NRD_1	250	252	PF00675	0.496
CLV_NRD_NRD_1	5	7	PF00675	0.386
CLV_PCSK_KEX2_1	150	152	PF00082	0.646
CLV_PCSK_KEX2_1	185	187	PF00082	0.547
CLV_PCSK_KEX2_1	20	22	PF00082	0.379
CLV_PCSK_KEX2_1	5	7	PF00082	0.386
CLV_PCSK_KEX2_1	71	73	PF00082	0.440
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.440
CLV_PCSK_SKI1_1	115	119	PF00082	0.401
CLV_PCSK_SKI1_1	12	16	PF00082	0.383
CLV_PCSK_SKI1_1	89	93	PF00082	0.566
DEG_Nend_UBRbox_2	1	3	PF02207	0.431
DEG_SCF_FBW7_2	240	246	PF00400	0.471
DOC_CKS1_1	240	245	PF01111	0.477
DOC_CKS1_1	63	68	PF01111	0.388
DOC_CYCLIN_RxL_1	228	236	PF00134	0.586
DOC_CYCLIN_yCln2_LP_2	237	243	PF00134	0.427
DOC_PP1_RVXF_1	120	127	PF00149	0.328
DOC_PP2B_LxvP_1	237	240	PF13499	0.417
DOC_USP7_MATH_1	138	142	PF00917	0.482
DOC_USP7_UBL2_3	115	119	PF12436	0.382
DOC_WW_Pin1_4	239	244	PF00397	0.463
DOC_WW_Pin1_4	62	67	PF00397	0.381
DOC_WW_Pin1_4	80	85	PF00397	0.377
LIG_14-3-3_CanoR_1	202	208	PF00244	0.505
LIG_14-3-3_CanoR_1	48	52	PF00244	0.522
LIG_Actin_WH2_2	56	73	PF00022	0.425
LIG_FHA_1	228	234	PF00498	0.556
LIG_FHA_2	134	140	PF00498	0.450
LIG_FHA_2	240	246	PF00498	0.433
LIG_LIR_Apic_2	133	138	PF02991	0.511
LIG_LIR_Gen_1	232	243	PF02991	0.538
LIG_LIR_Gen_1	25	36	PF02991	0.395
LIG_LIR_Nem_3	133	137	PF02991	0.450
LIG_LIR_Nem_3	2	7	PF02991	0.398
LIG_LIR_Nem_3	232	238	PF02991	0.550
LIG_LIR_Nem_3	25	31	PF02991	0.391
LIG_PTB_Apo_2	128	135	PF02174	0.434
LIG_PTB_Apo_2	34	41	PF02174	0.389
LIG_PTB_Phospho_1	34	40	PF10480	0.388
LIG_SH2_CRK	4	8	PF00017	0.379
LIG_SH2_NCK_1	135	139	PF00017	0.504
LIG_SH2_SRC	95	98	PF00017	0.434
LIG_SH2_STAP1	40	44	PF00017	0.381
LIG_SH2_STAT3	40	43	PF00017	0.393
LIG_SH2_STAT5	135	138	PF00017	0.466
LIG_SH2_STAT5	212	215	PF00017	0.442
LIG_SH2_STAT5	241	244	PF00017	0.450
LIG_SH2_STAT5	34	37	PF00017	0.408
LIG_SH3_3	237	243	PF00018	0.478
MOD_CK1_1	141	147	PF00069	0.454
MOD_CK1_1	266	272	PF00069	0.570
MOD_CK2_1	133	139	PF00069	0.445
MOD_NEK2_2	203	208	PF00069	0.461
MOD_PKA_2	47	53	PF00069	0.516
MOD_Plk_1	138	144	PF00069	0.463
MOD_Plk_2-3	133	139	PF00069	0.458
MOD_Plk_2-3	152	158	PF00069	0.572
MOD_Plk_4	263	269	PF00069	0.536
MOD_Plk_4	47	53	PF00069	0.516
MOD_ProDKin_1	239	245	PF00069	0.457
MOD_ProDKin_1	62	68	PF00069	0.383
MOD_ProDKin_1	80	86	PF00069	0.375
MOD_SUMO_rev_2	107	113	PF00179	0.484
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.410
TRG_ENDOCYTIC_2	114	117	PF00928	0.381
TRG_ENDOCYTIC_2	241	244	PF00928	0.424
TRG_ENDOCYTIC_2	4	7	PF00928	0.381
TRG_ER_diArg_1	149	151	PF00400	0.621
TRG_ER_diArg_1	184	187	PF00400	0.449
TRG_ER_diArg_1	20	22	PF00400	0.376
TRG_ER_diArg_1	220	223	PF00400	0.518
TRG_ER_diArg_1	4	6	PF00400	0.383
TRG_ER_diArg_1	72	75	PF00400	0.446
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	231	236	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB7	Leptomonas seymouri	81%	100%
A0A0S4IJG6	Bodo saltans	58%	93%
A0A1X0NT90	Trypanosomatidae	71%	99%
A0A381MHF5	Leishmania infantum	100%	100%
A0A3Q8IAP3	Leishmania donovani	100%	100%
A0A422NDI7	Trypanosoma rangeli	73%	100%
A4HCB5	Leishmania braziliensis	93%	98%
C9ZSF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AVQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4QBR4	Leishmania major	98%	100%
V5DMI7	Trypanosoma cruzi	71%	90%