Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WX10_LEIDO

TriTrypDb:

LdBPK_220240.1 , LdCL_220008500 , LDHU3_22.0510

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WX10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.702
CLV_NRD_NRD_1	144	146	PF00675	0.600
CLV_NRD_NRD_1	156	158	PF00675	0.362
CLV_NRD_NRD_1	186	188	PF00675	0.510
CLV_NRD_NRD_1	291	293	PF00675	0.760
CLV_NRD_NRD_1	92	94	PF00675	0.480
CLV_PCSK_KEX2_1	143	145	PF00082	0.601
CLV_PCSK_KEX2_1	156	158	PF00082	0.408
CLV_PCSK_KEX2_1	186	188	PF00082	0.510
CLV_PCSK_KEX2_1	268	270	PF00082	0.674
CLV_PCSK_KEX2_1	291	293	PF00082	0.760
CLV_PCSK_KEX2_1	92	94	PF00082	0.480
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.550
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.674
CLV_PCSK_PC7_1	264	270	PF00082	0.651
CLV_PCSK_SKI1_1	187	191	PF00082	0.459
CLV_PCSK_SKI1_1	76	80	PF00082	0.629
CLV_Separin_Metazoa	52	56	PF03568	0.549
DEG_APCC_DBOX_1	155	163	PF00400	0.564
DEG_APCC_DBOX_1	54	62	PF00400	0.528
DOC_CYCLIN_RxL_1	71	82	PF00134	0.568
DOC_MAPK_DCC_7	164	172	PF00069	0.427
DOC_MAPK_gen_1	305	313	PF00069	0.636
DOC_MAPK_gen_1	71	80	PF00069	0.437
DOC_MAPK_gen_1	92	100	PF00069	0.475
DOC_USP7_MATH_1	210	214	PF00917	0.710
DOC_USP7_UBL2_3	227	231	PF12436	0.715
DOC_WW_Pin1_4	292	297	PF00397	0.689
DOC_WW_Pin1_4	45	50	PF00397	0.650
LIG_14-3-3_CanoR_1	156	160	PF00244	0.431
LIG_14-3-3_CanoR_1	186	190	PF00244	0.522
LIG_14-3-3_CanoR_1	281	289	PF00244	0.732
LIG_14-3-3_CanoR_1	291	295	PF00244	0.623
LIG_14-3-3_CanoR_1	55	59	PF00244	0.483
LIG_14-3-3_CanoR_1	74	79	PF00244	0.478
LIG_Actin_WH2_2	51	68	PF00022	0.532
LIG_APCC_ABBAyCdc20_2	187	193	PF00400	0.597
LIG_BRCT_BRCA1_1	102	106	PF00533	0.366
LIG_FHA_1	23	29	PF00498	0.653
LIG_FHA_1	261	267	PF00498	0.529
LIG_FHA_1	48	54	PF00498	0.574
LIG_FHA_1	75	81	PF00498	0.572
LIG_FHA_1	86	92	PF00498	0.385
LIG_FHA_2	135	141	PF00498	0.564
LIG_LIR_Gen_1	205	214	PF02991	0.639
LIG_LIR_Nem_3	166	171	PF02991	0.493
LIG_LIR_Nem_3	174	179	PF02991	0.464
LIG_LIR_Nem_3	205	209	PF02991	0.631
LIG_LYPXL_S_1	167	171	PF13949	0.394
LIG_LYPXL_yS_3	168	171	PF13949	0.396
LIG_PDZ_Class_2	337	342	PF00595	0.546
LIG_REV1ctd_RIR_1	174	182	PF16727	0.576
LIG_SH2_SRC	97	100	PF00017	0.478
LIG_SH2_STAP1	330	334	PF00017	0.596
LIG_SH2_STAT3	258	261	PF00017	0.669
LIG_SH2_STAT5	97	100	PF00017	0.542
LIG_SH3_2	257	262	PF14604	0.475
LIG_SH3_3	254	260	PF00018	0.455
LIG_SH3_3	296	302	PF00018	0.650
LIG_SUMO_SIM_anti_2	238	245	PF11976	0.611
LIG_SUMO_SIM_anti_2	56	62	PF11976	0.444
LIG_SUMO_SIM_par_1	168	174	PF11976	0.510
LIG_SUMO_SIM_par_1	76	82	PF11976	0.527
LIG_TRAF2_1	139	142	PF00917	0.555
LIG_TRAF2_1	49	52	PF00917	0.609
LIG_TYR_ITIM	95	100	PF00017	0.472
LIG_WRC_WIRS_1	203	208	PF05994	0.622
MOD_CDK_SPxxK_3	294	301	PF00069	0.654
MOD_CK1_1	19	25	PF00069	0.714
MOD_CK1_1	205	211	PF00069	0.609
MOD_CK1_1	297	303	PF00069	0.678
MOD_CK1_1	47	53	PF00069	0.554
MOD_CK2_1	134	140	PF00069	0.587
MOD_CK2_1	45	51	PF00069	0.726
MOD_Cter_Amidation	266	269	PF01082	0.647
MOD_Cter_Amidation	289	292	PF01082	0.661
MOD_GlcNHglycan	16	19	PF01048	0.671
MOD_GlcNHglycan	212	215	PF01048	0.653
MOD_GlcNHglycan	275	278	PF01048	0.668
MOD_GlcNHglycan	330	333	PF01048	0.664
MOD_GlcNHglycan	9	12	PF01048	0.628
MOD_GSK3_1	151	158	PF00069	0.629
MOD_GSK3_1	19	26	PF00069	0.689
MOD_GSK3_1	273	280	PF00069	0.618
MOD_GSK3_1	290	297	PF00069	0.541
MOD_GSK3_1	40	47	PF00069	0.688
MOD_GSK3_1	70	77	PF00069	0.568
MOD_NEK2_1	107	112	PF00069	0.561
MOD_NEK2_1	134	139	PF00069	0.553
MOD_NEK2_1	23	28	PF00069	0.621
MOD_NEK2_1	39	44	PF00069	0.660
MOD_NEK2_1	65	70	PF00069	0.519
MOD_NEK2_1	7	12	PF00069	0.608
MOD_NEK2_2	151	156	PF00069	0.577
MOD_PIKK_1	300	306	PF00454	0.673
MOD_PIKK_1	65	71	PF00454	0.578
MOD_PKA_2	134	140	PF00069	0.492
MOD_PKA_2	14	20	PF00069	0.714
MOD_PKA_2	155	161	PF00069	0.579
MOD_PKA_2	185	191	PF00069	0.523
MOD_PKA_2	280	286	PF00069	0.601
MOD_PKA_2	290	296	PF00069	0.627
MOD_PKA_2	300	306	PF00069	0.466
MOD_PKA_2	54	60	PF00069	0.600
MOD_PKA_2	65	71	PF00069	0.512
MOD_PKA_2	7	13	PF00069	0.633
MOD_Plk_1	151	157	PF00069	0.521
MOD_Plk_1	23	29	PF00069	0.653
MOD_Plk_1	40	46	PF00069	0.607
MOD_Plk_4	2	8	PF00069	0.571
MOD_Plk_4	202	208	PF00069	0.618
MOD_Plk_4	23	29	PF00069	0.697
MOD_ProDKin_1	292	298	PF00069	0.688
MOD_ProDKin_1	45	51	PF00069	0.643
TRG_ENDOCYTIC_2	168	171	PF00928	0.428
TRG_ENDOCYTIC_2	97	100	PF00928	0.401
TRG_ER_diArg_1	155	157	PF00400	0.581
TRG_ER_diArg_1	185	187	PF00400	0.500
TRG_ER_diArg_1	91	93	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	76	81	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVH6	Leptomonas seymouri	44%	97%
A4HC85	Leishmania braziliensis	70%	100%
A4HZR4	Leishmania infantum	98%	100%
E9AVM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QBV9	Leishmania major	90%	100%