tRNA binding domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative tRNA binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WX09_LEIDO

TriTrypDb:

LdBPK_220350.1 , LdCL_220009800 , LDHU3_22.0660

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WX09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX09

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	11
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	3
GO:0004812	aminoacyl-tRNA ligase activity	4	3
GO:0016874	ligase activity	2	3
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	3
GO:0140098	catalytic activity, acting on RNA	3	3
GO:0140101	catalytic activity, acting on a tRNA	4	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.622
CLV_C14_Caspase3-7	383	387	PF00656	0.630
CLV_MEL_PAP_1	255	261	PF00089	0.435
CLV_NRD_NRD_1	211	213	PF00675	0.640
CLV_NRD_NRD_1	266	268	PF00675	0.434
CLV_NRD_NRD_1	58	60	PF00675	0.654
CLV_PCSK_KEX2_1	210	212	PF00082	0.644
CLV_PCSK_KEX2_1	266	268	PF00082	0.413
CLV_PCSK_KEX2_1	330	332	PF00082	0.430
CLV_PCSK_KEX2_1	58	60	PF00082	0.685
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.430
CLV_PCSK_SKI1_1	243	247	PF00082	0.855
CLV_PCSK_SKI1_1	349	353	PF00082	0.504
CLV_PCSK_SKI1_1	67	71	PF00082	0.595
CLV_Separin_Metazoa	207	211	PF03568	0.657
DEG_Nend_UBRbox_3	1	3	PF02207	0.572
DOC_ANK_TNKS_1	38	45	PF00023	0.539
DOC_MAPK_gen_1	313	320	PF00069	0.662
DOC_MAPK_gen_1	330	337	PF00069	0.662
DOC_MAPK_RevD_3	196	212	PF00069	0.699
DOC_PP1_RVXF_1	347	353	PF00149	0.621
DOC_PP2B_LxvP_1	23	26	PF13499	0.611
DOC_USP7_MATH_1	101	105	PF00917	0.664
DOC_USP7_MATH_1	173	177	PF00917	0.644
DOC_USP7_MATH_1	18	22	PF00917	0.607
DOC_USP7_MATH_1	196	200	PF00917	0.754
DOC_USP7_MATH_1	229	233	PF00917	0.682
DOC_USP7_UBL2_3	215	219	PF12436	0.622
DOC_USP7_UBL2_3	243	247	PF12436	0.807
DOC_WW_Pin1_4	231	236	PF00397	0.790
DOC_WW_Pin1_4	60	65	PF00397	0.659
LIG_14-3-3_CanoR_1	133	137	PF00244	0.525
LIG_14-3-3_CanoR_1	39	43	PF00244	0.604
LIG_14-3-3_CanoR_1	58	64	PF00244	0.510
LIG_Actin_WH2_2	43	60	PF00022	0.601
LIG_FHA_1	150	156	PF00498	0.620
LIG_FHA_1	283	289	PF00498	0.620
LIG_FHA_1	302	308	PF00498	0.607
LIG_FHA_1	373	379	PF00498	0.546
LIG_FHA_2	127	133	PF00498	0.571
LIG_FHA_2	192	198	PF00498	0.710
LIG_FHA_2	246	252	PF00498	0.696
LIG_FHA_2	381	387	PF00498	0.531
LIG_KLC1_Yacidic_2	272	277	PF13176	0.613
LIG_LIR_Apic_2	168	173	PF02991	0.552
LIG_LIR_Apic_2	197	203	PF02991	0.821
LIG_LIR_LC3C_4	304	309	PF02991	0.662
LIG_LIR_Nem_3	46	50	PF02991	0.621
LIG_PCNA_PIPBox_1	374	383	PF02747	0.552
LIG_SH2_NCK_1	110	114	PF00017	0.648
LIG_SH2_NCK_1	142	146	PF00017	0.588
LIG_SH2_PTP2	200	203	PF00017	0.790
LIG_SH2_STAP1	142	146	PF00017	0.588
LIG_SH2_STAP1	356	360	PF00017	0.661
LIG_SH2_STAT5	127	130	PF00017	0.631
LIG_SH2_STAT5	170	173	PF00017	0.550
LIG_SH2_STAT5	200	203	PF00017	0.790
LIG_SH2_STAT5	275	278	PF00017	0.578
LIG_SH2_STAT5	296	299	PF00017	0.622
LIG_SH3_3	95	101	PF00018	0.651
LIG_SUMO_SIM_anti_2	72	81	PF11976	0.643
LIG_TRAF2_1	203	206	PF00917	0.659
MOD_CAAXbox	412	415	PF01239	0.617
MOD_CDK_SPxxK_3	231	238	PF00069	0.816
MOD_CDK_SPxxK_3	60	67	PF00069	0.658
MOD_CK1_1	149	155	PF00069	0.616
MOD_CK1_1	21	27	PF00069	0.584
MOD_CK2_1	108	114	PF00069	0.667
MOD_CK2_1	126	132	PF00069	0.395
MOD_CK2_1	191	197	PF00069	0.894
MOD_CK2_1	201	207	PF00069	0.614
MOD_Cter_Amidation	241	244	PF01082	0.858
MOD_GlcNHglycan	148	151	PF01048	0.573
MOD_GlcNHglycan	176	179	PF01048	0.623
MOD_GlcNHglycan	185	188	PF01048	0.785
MOD_GlcNHglycan	231	234	PF01048	0.782
MOD_GlcNHglycan	235	238	PF01048	0.822
MOD_GlcNHglycan	289	292	PF01048	0.382
MOD_GlcNHglycan	369	372	PF01048	0.527
MOD_GlcNHglycan	399	402	PF01048	0.706
MOD_GSK3_1	118	125	PF00069	0.682
MOD_GSK3_1	128	135	PF00069	0.502
MOD_GSK3_1	174	181	PF00069	0.622
MOD_GSK3_1	229	236	PF00069	0.806
MOD_GSK3_1	245	252	PF00069	0.659
MOD_GSK3_1	372	379	PF00069	0.610
MOD_N-GLC_1	146	151	PF02516	0.606
MOD_N-GLC_1	183	188	PF02516	0.712
MOD_N-GLC_1	5	10	PF02516	0.555
MOD_NEK2_1	117	122	PF00069	0.613
MOD_NEK2_1	146	151	PF00069	0.605
MOD_NEK2_1	250	255	PF00069	0.658
MOD_NEK2_1	301	306	PF00069	0.592
MOD_NEK2_1	318	323	PF00069	0.540
MOD_NEK2_1	57	62	PF00069	0.572
MOD_PIKK_1	245	251	PF00454	0.599
MOD_PIKK_1	301	307	PF00454	0.674
MOD_PIKK_1	319	325	PF00454	0.450
MOD_PKA_1	243	249	PF00069	0.788
MOD_PKA_2	132	138	PF00069	0.517
MOD_PKA_2	174	180	PF00069	0.719
MOD_PKA_2	38	44	PF00069	0.636
MOD_PKA_2	57	63	PF00069	0.344
MOD_Plk_1	196	202	PF00069	0.731
MOD_Plk_1	250	256	PF00069	0.634
MOD_Plk_1	5	11	PF00069	0.550
MOD_Plk_2-3	132	138	PF00069	0.642
MOD_Plk_4	18	24	PF00069	0.522
MOD_Plk_4	196	202	PF00069	0.770
MOD_Plk_4	313	319	PF00069	0.602
MOD_Plk_4	6	12	PF00069	0.577
MOD_Plk_4	75	81	PF00069	0.642
MOD_ProDKin_1	231	237	PF00069	0.792
MOD_ProDKin_1	60	66	PF00069	0.654
MOD_SUMO_for_1	218	221	PF00179	0.722
MOD_SUMO_rev_2	236	245	PF00179	0.864
MOD_SUMO_rev_2	332	338	PF00179	0.630
TRG_DiLeu_BaEn_1	75	80	PF01217	0.628
TRG_DiLeu_BaEn_2	64	70	PF01217	0.647
TRG_ENDOCYTIC_2	110	113	PF00928	0.617
TRG_ER_diArg_1	209	212	PF00400	0.643
TRG_ER_diArg_1	265	267	PF00400	0.634
TRG_ER_diArg_1	57	59	PF00400	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P301	Leptomonas seymouri	66%	98%
A0A0S4IJF4	Bodo saltans	39%	99%
A0A1X0NUW2	Trypanosomatidae	45%	100%
A0A3R7KNR3	Trypanosoma rangeli	44%	100%
A4HC93	Leishmania braziliensis	77%	100%
A4HZS5	Leishmania infantum	100%	100%
C9ZRK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	98%
E9AVN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QBU9	Leishmania major	86%	100%