Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WX05_LEIDO

TriTrypDb:

LdBPK_220430.1 , LdCL_220010600 , LDHU3_22.0740

Length:

889

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A0A3S7WX05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX05

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	18
GO:0007018	microtubule-based movement	3	18
GO:0009987	cellular process	1	18
GO:0006810	transport	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003774	cytoskeletal motor activity	1	18
GO:0003777	microtubule motor activity	2	18
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	18
GO:0005515	protein binding	2	18
GO:0005524	ATP binding	5	18
GO:0008017	microtubule binding	5	18
GO:0008092	cytoskeletal protein binding	3	18
GO:0015631	tubulin binding	4	18
GO:0016787	hydrolase activity	2	10
GO:0017076	purine nucleotide binding	4	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:0140657	ATP-dependent activity	1	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18
GO:0008574	plus-end-directed microtubule motor activity	3	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.588
CLV_NRD_NRD_1	300	302	PF00675	0.583
CLV_NRD_NRD_1	458	460	PF00675	0.531
CLV_NRD_NRD_1	476	478	PF00675	0.596
CLV_NRD_NRD_1	773	775	PF00675	0.663
CLV_PCSK_FUR_1	428	432	PF00082	0.395
CLV_PCSK_KEX2_1	300	302	PF00082	0.629
CLV_PCSK_KEX2_1	430	432	PF00082	0.395
CLV_PCSK_KEX2_1	773	775	PF00082	0.517
CLV_PCSK_KEX2_1	815	817	PF00082	0.462
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.395
CLV_PCSK_PC1ET2_1	815	817	PF00082	0.457
CLV_PCSK_SKI1_1	147	151	PF00082	0.297
CLV_PCSK_SKI1_1	313	317	PF00082	0.339
CLV_PCSK_SKI1_1	335	339	PF00082	0.292
CLV_PCSK_SKI1_1	354	358	PF00082	0.190
CLV_PCSK_SKI1_1	430	434	PF00082	0.300
CLV_PCSK_SKI1_1	459	463	PF00082	0.506
CLV_PCSK_SKI1_1	472	476	PF00082	0.484
CLV_PCSK_SKI1_1	532	536	PF00082	0.508
DEG_SCF_FBW7_2	409	414	PF00400	0.395
DOC_CYCLIN_RxL_1	456	466	PF00134	0.501
DOC_MAPK_gen_1	428	438	PF00069	0.385
DOC_MAPK_gen_1	813	822	PF00069	0.443
DOC_MAPK_gen_1	823	831	PF00069	0.412
DOC_MAPK_MEF2A_6	104	113	PF00069	0.390
DOC_MAPK_MEF2A_6	240	249	PF00069	0.261
DOC_MAPK_MEF2A_6	815	824	PF00069	0.433
DOC_MIT_MIM_1	694	702	PF04212	0.561
DOC_PP1_RVXF_1	789	795	PF00149	0.403
DOC_USP7_MATH_1	173	177	PF00917	0.411
DOC_USP7_MATH_1	412	416	PF00917	0.336
DOC_USP7_MATH_1	498	502	PF00917	0.718
DOC_USP7_MATH_1	760	764	PF00917	0.563
DOC_USP7_UBL2_3	316	320	PF12436	0.263
DOC_USP7_UBL2_3	854	858	PF12436	0.456
DOC_WW_Pin1_4	102	107	PF00397	0.381
DOC_WW_Pin1_4	174	179	PF00397	0.392
DOC_WW_Pin1_4	184	189	PF00397	0.329
DOC_WW_Pin1_4	407	412	PF00397	0.323
DOC_WW_Pin1_4	494	499	PF00397	0.654
LIG_14-3-3_CanoR_1	170	178	PF00244	0.459
LIG_14-3-3_CanoR_1	227	234	PF00244	0.284
LIG_14-3-3_CanoR_1	246	250	PF00244	0.420
LIG_14-3-3_CanoR_1	284	292	PF00244	0.696
LIG_14-3-3_CanoR_1	365	373	PF00244	0.366
LIG_14-3-3_CanoR_1	420	424	PF00244	0.263
LIG_14-3-3_CanoR_1	567	571	PF00244	0.536
LIG_14-3-3_CanoR_1	617	626	PF00244	0.546
LIG_14-3-3_CanoR_1	701	709	PF00244	0.589
LIG_APCC_ABBA_1	139	144	PF00400	0.308
LIG_APCC_ABBA_1	381	386	PF00400	0.278
LIG_APCC_ABBAyCdc20_2	127	133	PF00400	0.395
LIG_BIR_III_4	154	158	PF00653	0.263
LIG_FHA_1	179	185	PF00498	0.280
LIG_FHA_1	373	379	PF00498	0.329
LIG_FHA_1	388	394	PF00498	0.308
LIG_FHA_1	401	407	PF00498	0.308
LIG_FHA_1	408	414	PF00498	0.283
LIG_FHA_1	456	462	PF00498	0.527
LIG_FHA_1	464	470	PF00498	0.520
LIG_FHA_1	555	561	PF00498	0.492
LIG_FHA_1	57	63	PF00498	0.267
LIG_FHA_1	571	577	PF00498	0.525
LIG_FHA_1	650	656	PF00498	0.536
LIG_FHA_1	694	700	PF00498	0.409
LIG_FHA_2	272	278	PF00498	0.653
LIG_FHA_2	359	365	PF00498	0.411
LIG_FHA_2	534	540	PF00498	0.454
LIG_FHA_2	56	62	PF00498	0.381
LIG_FHA_2	706	712	PF00498	0.599
LIG_FHA_2	749	755	PF00498	0.546
LIG_Integrin_RGD_1	659	661	PF01839	0.469
LIG_LIR_Gen_1	115	122	PF02991	0.274
LIG_LIR_Gen_1	132	142	PF02991	0.289
LIG_LIR_Gen_1	401	409	PF02991	0.266
LIG_LIR_Gen_1	48	57	PF02991	0.304
LIG_LIR_Gen_1	680	688	PF02991	0.470
LIG_LIR_Gen_1	94	102	PF02991	0.333
LIG_LIR_Nem_3	115	120	PF02991	0.274
LIG_LIR_Nem_3	132	138	PF02991	0.352
LIG_LIR_Nem_3	195	201	PF02991	0.351
LIG_LIR_Nem_3	380	384	PF02991	0.283
LIG_LIR_Nem_3	401	405	PF02991	0.266
LIG_LIR_Nem_3	48	52	PF02991	0.304
LIG_LIR_Nem_3	680	684	PF02991	0.471
LIG_LIR_Nem_3	725	731	PF02991	0.489
LIG_LIR_Nem_3	94	98	PF02991	0.314
LIG_NRBOX	145	151	PF00104	0.277
LIG_NRBOX	388	394	PF00104	0.323
LIG_NRBOX	726	732	PF00104	0.489
LIG_PCNA_yPIPBox_3	143	151	PF02747	0.384
LIG_SH2_CRK	681	685	PF00017	0.589
LIG_SH2_NCK_1	221	225	PF00017	0.395
LIG_SH2_NCK_1	53	57	PF00017	0.250
LIG_SH2_SRC	221	224	PF00017	0.204
LIG_SH2_SRC	53	56	PF00017	0.381
LIG_SH2_STAP1	221	225	PF00017	0.276
LIG_SH2_STAP1	479	483	PF00017	0.606
LIG_SH2_STAP1	53	57	PF00017	0.295
LIG_SH2_STAP1	63	67	PF00017	0.244
LIG_SH2_STAT3	142	145	PF00017	0.244
LIG_SH2_STAT3	479	482	PF00017	0.613
LIG_SH2_STAT5	201	204	PF00017	0.273
LIG_SH2_STAT5	254	257	PF00017	0.620
LIG_SH2_STAT5	468	471	PF00017	0.469
LIG_SH2_STAT5	663	666	PF00017	0.446
LIG_SH2_STAT5	95	98	PF00017	0.261
LIG_SH3_3	879	885	PF00018	0.476
LIG_SUMO_SIM_anti_2	215	221	PF11976	0.249
LIG_SUMO_SIM_par_1	189	195	PF11976	0.280
LIG_SxIP_EBH_1	375	385	PF03271	0.250
LIG_TRAF2_1	212	215	PF00917	0.338
LIG_TRAF2_1	273	276	PF00917	0.689
LIG_TRAF2_1	628	631	PF00917	0.525
LIG_TRAF2_2	742	747	PF00917	0.542
LIG_UBA3_1	844	851	PF00899	0.514
LIG_WRC_WIRS_1	378	383	PF05994	0.204
MOD_CK1_1	165	171	PF00069	0.477
MOD_CK1_1	174	180	PF00069	0.395
MOD_CK1_1	226	232	PF00069	0.305
MOD_CK1_1	238	244	PF00069	0.299
MOD_CK1_1	287	293	PF00069	0.751
MOD_CK1_1	3	9	PF00069	0.429
MOD_CK1_1	355	361	PF00069	0.292
MOD_CK1_1	368	374	PF00069	0.253
MOD_CK1_1	387	393	PF00069	0.330
MOD_CK1_1	419	425	PF00069	0.274
MOD_CK1_1	494	500	PF00069	0.650
MOD_CK1_1	501	507	PF00069	0.648
MOD_CK1_1	569	575	PF00069	0.532
MOD_CK1_1	665	671	PF00069	0.378
MOD_CK1_1	705	711	PF00069	0.469
MOD_CK1_1	781	787	PF00069	0.626
MOD_CK1_1	91	97	PF00069	0.323
MOD_CK2_1	134	140	PF00069	0.323
MOD_CK2_1	189	195	PF00069	0.278
MOD_CK2_1	209	215	PF00069	0.164
MOD_CK2_1	270	276	PF00069	0.666
MOD_CK2_1	33	39	PF00069	0.276
MOD_CK2_1	412	418	PF00069	0.364
MOD_CK2_1	489	495	PF00069	0.503
MOD_CK2_1	5	11	PF00069	0.435
MOD_CK2_1	533	539	PF00069	0.565
MOD_CK2_1	55	61	PF00069	0.342
MOD_CK2_1	587	593	PF00069	0.494
MOD_CK2_1	617	623	PF00069	0.490
MOD_CK2_1	781	787	PF00069	0.509
MOD_Cter_Amidation	298	301	PF01082	0.556
MOD_GlcNHglycan	164	167	PF01048	0.474
MOD_GlcNHglycan	173	176	PF01048	0.252
MOD_GlcNHglycan	184	187	PF01048	0.176
MOD_GlcNHglycan	228	231	PF01048	0.294
MOD_GlcNHglycan	292	295	PF01048	0.634
MOD_GlcNHglycan	414	417	PF01048	0.299
MOD_GlcNHglycan	500	503	PF01048	0.664
MOD_GlcNHglycan	731	734	PF01048	0.557
MOD_GlcNHglycan	780	783	PF01048	0.612
MOD_GlcNHglycan	90	93	PF01048	0.323
MOD_GSK3_1	173	180	PF00069	0.484
MOD_GSK3_1	245	252	PF00069	0.359
MOD_GSK3_1	283	290	PF00069	0.733
MOD_GSK3_1	354	361	PF00069	0.309
MOD_GSK3_1	368	375	PF00069	0.278
MOD_GSK3_1	412	419	PF00069	0.348
MOD_GSK3_1	494	501	PF00069	0.684
MOD_GSK3_1	562	569	PF00069	0.572
MOD_GSK3_1	693	700	PF00069	0.613
MOD_GSK3_1	718	725	PF00069	0.451
MOD_GSK3_1	748	755	PF00069	0.666
MOD_GSK3_1	98	105	PF00069	0.328
MOD_N-GLC_1	102	107	PF02516	0.343
MOD_N-GLC_1	352	357	PF02516	0.308
MOD_N-GLC_1	489	494	PF02516	0.494
MOD_N-GLC_1	705	710	PF02516	0.446
MOD_N-GLC_1	79	84	PF02516	0.302
MOD_NEK2_1	292	297	PF00069	0.546
MOD_NEK2_1	392	397	PF00069	0.260
MOD_NEK2_1	455	460	PF00069	0.527
MOD_NEK2_1	570	575	PF00069	0.556
MOD_NEK2_1	584	589	PF00069	0.549
MOD_NEK2_1	642	647	PF00069	0.452
MOD_NEK2_1	677	682	PF00069	0.572
MOD_NEK2_1	702	707	PF00069	0.458
MOD_NEK2_1	722	727	PF00069	0.464
MOD_NEK2_1	98	103	PF00069	0.308
MOD_NEK2_2	189	194	PF00069	0.405
MOD_NEK2_2	748	753	PF00069	0.551
MOD_NEK2_2	79	84	PF00069	0.355
MOD_NEK2_2	862	867	PF00069	0.448
MOD_PIKK_1	271	277	PF00454	0.729
MOD_PIKK_1	285	291	PF00454	0.731
MOD_PIKK_1	570	576	PF00454	0.574
MOD_PIKK_1	584	590	PF00454	0.626
MOD_PIKK_1	642	648	PF00454	0.463
MOD_PIKK_1	679	685	PF00454	0.418
MOD_PIKK_1	693	699	PF00454	0.378
MOD_PIKK_1	735	741	PF00454	0.629
MOD_PIKK_1	752	758	PF00454	0.462
MOD_PIKK_1	852	858	PF00454	0.466
MOD_PKA_1	773	779	PF00069	0.526
MOD_PKA_2	226	232	PF00069	0.305
MOD_PKA_2	23	29	PF00069	0.657
MOD_PKA_2	245	251	PF00069	0.270
MOD_PKA_2	283	289	PF00069	0.735
MOD_PKA_2	384	390	PF00069	0.308
MOD_PKA_2	419	425	PF00069	0.261
MOD_PKA_2	455	461	PF00069	0.549
MOD_PKA_2	566	572	PF00069	0.533
MOD_PKA_2	697	703	PF00069	0.460
MOD_PKA_2	718	724	PF00069	0.447
MOD_PKA_2	752	758	PF00069	0.588
MOD_PKA_2	773	779	PF00069	0.526
MOD_Plk_1	249	255	PF00069	0.334
MOD_Plk_1	32	38	PF00069	0.430
MOD_Plk_1	352	358	PF00069	0.300
MOD_Plk_1	489	495	PF00069	0.494
MOD_Plk_1	665	671	PF00069	0.485
MOD_Plk_1	705	711	PF00069	0.458
MOD_Plk_2-3	257	263	PF00069	0.603
MOD_Plk_2-3	33	39	PF00069	0.395
MOD_Plk_4	134	140	PF00069	0.286
MOD_Plk_4	358	364	PF00069	0.291
MOD_Plk_4	377	383	PF00069	0.278
MOD_Plk_4	463	469	PF00069	0.474
MOD_Plk_4	501	507	PF00069	0.639
MOD_Plk_4	511	517	PF00069	0.589
MOD_Plk_4	718	724	PF00069	0.539
MOD_Plk_4	79	85	PF00069	0.332
MOD_Plk_4	93	99	PF00069	0.301
MOD_ProDKin_1	102	108	PF00069	0.381
MOD_ProDKin_1	174	180	PF00069	0.392
MOD_ProDKin_1	184	190	PF00069	0.329
MOD_ProDKin_1	407	413	PF00069	0.323
MOD_ProDKin_1	494	500	PF00069	0.619
MOD_SUMO_rev_2	529	536	PF00179	0.524
MOD_SUMO_rev_2	600	607	PF00179	0.599
MOD_SUMO_rev_2	807	814	PF00179	0.465
TRG_DiLeu_BaEn_1	621	626	PF01217	0.448
TRG_DiLeu_BaEn_4	529	535	PF01217	0.548
TRG_DiLeu_BaEn_4	631	637	PF01217	0.530
TRG_DiLeu_BaLyEn_6	650	655	PF01217	0.458
TRG_DiLeu_BaLyEn_6	726	731	PF01217	0.470
TRG_ENDOCYTIC_2	681	684	PF00928	0.587
TRG_ENDOCYTIC_2	95	98	PF00928	0.278
TRG_ER_diArg_1	14	17	PF00400	0.354
TRG_ER_diArg_1	788	791	PF00400	0.524
TRG_ER_diArg_1	875	878	PF00400	0.600
TRG_NES_CRM1_1	662	675	PF08389	0.418
TRG_NES_CRM1_1	818	833	PF08389	0.417
TRG_NLS_Bipartite_1	300	322	PF00514	0.507
TRG_NLS_MonoExtN_4	316	322	PF00514	0.263
TRG_NLS_MonoExtN_4	428	434	PF00514	0.395
TRG_Pf-PMV_PEXEL_1	599	604	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	793	797	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM1	Leptomonas seymouri	65%	96%
A0A0S4INA4	Bodo saltans	41%	100%
A0A1X0NUN6	Trypanosomatidae	41%	95%
A0A3Q8IG88	Leishmania donovani	30%	100%
A0A3R7NW09	Trypanosoma rangeli	30%	85%
A0A422N2N4	Trypanosoma rangeli	42%	100%
A4H4I4	Leishmania braziliensis	25%	100%
A4H8S6	Leishmania braziliensis	25%	86%
A4HCA1	Leishmania braziliensis	78%	100%
A4HZT3	Leishmania infantum	100%	100%
A4IBA7	Leishmania infantum	30%	100%
E9AF32	Leishmania major	29%	100%
E9AVN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B687	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q4QBU1	Leishmania major	92%	100%
V5BLH7	Trypanosoma cruzi	42%	100%