Translocon-associated protein subunit alpha

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translocon-associated protein (TRAP), alpha subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWZ6_LEIDO

TriTrypDb:

LdBPK_220130.1 , LdCL_220007400 , LDHU3_22.0400

Length:

282

Annotations

Annotations by Jardim et al.

Translation, translocon-associated (TRAP), alpha subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WWZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	272	274	PF00675	0.502
CLV_NRD_NRD_1	5	7	PF00675	0.614
CLV_PCSK_FUR_1	270	274	PF00082	0.400
CLV_PCSK_KEX2_1	272	274	PF00082	0.550
CLV_PCSK_SKI1_1	125	129	PF00082	0.533
CLV_PCSK_SKI1_1	187	191	PF00082	0.476
CLV_PCSK_SKI1_1	214	218	PF00082	0.337
CLV_PCSK_SKI1_1	6	10	PF00082	0.617
CLV_PCSK_SKI1_1	61	65	PF00082	0.467
DOC_CYCLIN_RxL_1	55	69	PF00134	0.348
DOC_MAPK_gen_1	125	135	PF00069	0.322
DOC_MAPK_gen_1	6	13	PF00069	0.530
DOC_MAPK_MEF2A_6	80	87	PF00069	0.356
DOC_PP1_RVXF_1	59	65	PF00149	0.285
DOC_PP2B_LxvP_1	105	108	PF13499	0.337
DOC_USP7_MATH_1	171	175	PF00917	0.299
DOC_USP7_MATH_1	29	33	PF00917	0.444
DOC_USP7_MATH_1	57	61	PF00917	0.313
DOC_WW_Pin1_4	137	142	PF00397	0.234
DOC_WW_Pin1_4	274	279	PF00397	0.699
LIG_14-3-3_CanoR_1	187	193	PF00244	0.312
LIG_BIR_II_1	1	5	PF00653	0.478
LIG_BRCT_BRCA1_1	146	150	PF00533	0.361
LIG_BRCT_BRCA1_1	68	72	PF00533	0.327
LIG_EH1_1	98	106	PF00400	0.301
LIG_eIF4E_1	58	64	PF01652	0.356
LIG_FHA_1	130	136	PF00498	0.330
LIG_FHA_1	138	144	PF00498	0.319
LIG_FHA_1	164	170	PF00498	0.282
LIG_FHA_1	173	179	PF00498	0.234
LIG_FHA_2	241	247	PF00498	0.630
LIG_LIR_Gen_1	147	158	PF02991	0.255
LIG_LIR_Gen_1	191	198	PF02991	0.319
LIG_LIR_Nem_3	147	153	PF02991	0.255
LIG_LIR_Nem_3	191	196	PF02991	0.319
LIG_LIR_Nem_3	69	75	PF02991	0.326
LIG_Pex14_2	168	172	PF04695	0.262
LIG_Pex14_2	9	13	PF04695	0.480
LIG_SH2_GRB2like	249	252	PF00017	0.668
LIG_SH2_NCK_1	245	249	PF00017	0.685
LIG_SH2_SRC	245	248	PF00017	0.682
LIG_SH2_SRC	249	252	PF00017	0.668
LIG_SH2_SRC	46	49	PF00017	0.231
LIG_SH2_STAT5	137	140	PF00017	0.276
LIG_SH2_STAT5	157	160	PF00017	0.281
LIG_SH2_STAT5	167	170	PF00017	0.287
LIG_SH2_STAT5	192	195	PF00017	0.312
LIG_SH2_STAT5	204	207	PF00017	0.284
LIG_SH2_STAT5	249	252	PF00017	0.572
LIG_SH2_STAT5	36	39	PF00017	0.488
LIG_SH2_STAT5	58	61	PF00017	0.320
LIG_SUMO_SIM_par_1	174	180	PF11976	0.235
LIG_TRAF2_1	38	41	PF00917	0.533
LIG_TYR_ITIM	190	195	PF00017	0.319
LIG_UBA3_1	215	223	PF00899	0.515
LIG_WRC_WIRS_1	72	77	PF05994	0.300
MOD_CDC14_SPxK_1	277	280	PF00782	0.670
MOD_CDK_SPK_2	274	279	PF00069	0.735
MOD_CDK_SPxK_1	274	280	PF00069	0.720
MOD_CDK_SPxxK_3	274	281	PF00069	0.722
MOD_CK1_1	226	232	PF00069	0.489
MOD_CK1_1	68	74	PF00069	0.315
MOD_CK2_1	35	41	PF00069	0.518
MOD_GlcNHglycan	1	4	PF01048	0.600
MOD_GlcNHglycan	146	149	PF01048	0.563
MOD_GlcNHglycan	160	163	PF01048	0.429
MOD_GlcNHglycan	228	231	PF01048	0.313
MOD_GlcNHglycan	274	277	PF01048	0.568
MOD_GlcNHglycan	37	40	PF01048	0.734
MOD_GSK3_1	127	134	PF00069	0.261
MOD_GSK3_1	163	170	PF00069	0.269
MOD_GSK3_1	181	188	PF00069	0.279
MOD_GSK3_1	219	226	PF00069	0.540
MOD_GSK3_1	264	271	PF00069	0.655
MOD_LATS_1	221	227	PF00433	0.537
MOD_LATS_1	263	269	PF00433	0.697
MOD_N-GLC_1	116	121	PF02516	0.451
MOD_N-GLC_1	163	168	PF02516	0.461
MOD_N-GLC_1	172	177	PF02516	0.451
MOD_N-GLC_1	226	231	PF02516	0.330
MOD_N-GLC_1	65	70	PF02516	0.537
MOD_NEK2_1	17	22	PF00069	0.536
MOD_NEK2_1	172	177	PF00069	0.252
MOD_NEK2_1	219	224	PF00069	0.540
MOD_NEK2_1	266	271	PF00069	0.673
MOD_NEK2_1	65	70	PF00069	0.298
MOD_PIKK_1	66	72	PF00454	0.337
MOD_PIKK_1	92	98	PF00454	0.317
MOD_PKA_1	264	270	PF00069	0.655
MOD_PKA_1	272	278	PF00069	0.695
MOD_PKA_2	272	278	PF00069	0.702
MOD_PKB_1	270	278	PF00069	0.605
MOD_Plk_1	116	122	PF00069	0.262
MOD_Plk_1	163	169	PF00069	0.265
MOD_Plk_1	172	178	PF00069	0.243
MOD_Plk_1	92	98	PF00069	0.321
MOD_Plk_4	163	169	PF00069	0.268
MOD_Plk_4	17	23	PF00069	0.537
MOD_Plk_4	172	178	PF00069	0.233
MOD_Plk_4	188	194	PF00069	0.267
MOD_ProDKin_1	137	143	PF00069	0.234
MOD_ProDKin_1	274	280	PF00069	0.701
TRG_ENDOCYTIC_2	192	195	PF00928	0.319
TRG_ER_diArg_1	270	273	PF00400	0.712
TRG_ER_diLys_1	279	282	PF00400	0.692

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H4	Leptomonas seymouri	66%	100%
A0A0S4JN42	Bodo saltans	31%	100%
A0A1X0NT38	Trypanosomatidae	43%	100%
A0A3R7KKR8	Trypanosoma rangeli	44%	99%
A4HC76	Leishmania braziliensis	73%	98%
A4HZQ3	Leishmania infantum	100%	100%
C9ZSE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AVK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QBX0	Leishmania major	94%	100%
Q54R45	Dictyostelium discoideum	28%	100%
Q5R4X4	Pongo abelii	25%	97%
V5AVS0	Trypanosoma cruzi	42%	100%