Acetyltransferase_(GNAT)_family_putative/Pfam:PF0 0583

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acetyltransferase (GNAT) family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWZ5_LEIDO

TriTrypDb:

LdBPK_220330.1 , LdCL_220009600 , LDHU3_22.0640

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031248	protein acetyltransferase complex	3	1
GO:0031414	N-terminal protein acetyltransferase complex	4	1
GO:0031417	NatC complex	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902493	acetyltransferase complex	4	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WWZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWZ5

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	10
GO:0006474	N-terminal protein amino acid acetylation	5	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0017196	N-terminal peptidyl-methionine acetylation	6	10
GO:0018193	peptidyl-amino acid modification	5	10
GO:0018206	peptidyl-methionine modification	6	10
GO:0019538	protein metabolic process	3	10
GO:0031365	N-terminal protein amino acid modification	5	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043543	protein acylation	5	10
GO:0044238	primary metabolic process	2	10
GO:0051604	protein maturation	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004596	peptide alpha-N-acetyltransferase activity	8	10
GO:0008080	N-acetyltransferase activity	6	10
GO:0016407	acetyltransferase activity	5	10
GO:0016410	N-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0034212	peptide N-acetyltransferase activity	7	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.262
CLV_C14_Caspase3-7	258	262	PF00656	0.316
CLV_NRD_NRD_1	180	182	PF00675	0.253
CLV_PCSK_KEX2_1	8	10	PF00082	0.675
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.704
CLV_PCSK_SKI1_1	68	72	PF00082	0.425
CLV_Separin_Metazoa	216	220	PF03568	0.326
DOC_CKS1_1	228	233	PF01111	0.249
DOC_MAPK_gen_1	178	188	PF00069	0.371
DOC_MAPK_gen_1	219	228	PF00069	0.249
DOC_MAPK_MEF2A_6	209	217	PF00069	0.243
DOC_MAPK_MEF2A_6	236	244	PF00069	0.249
DOC_PP4_FxxP_1	145	148	PF00568	0.298
DOC_USP7_MATH_1	134	138	PF00917	0.334
DOC_USP7_MATH_1	163	167	PF00917	0.246
DOC_USP7_MATH_1	174	178	PF00917	0.257
DOC_USP7_UBL2_3	266	270	PF12436	0.395
DOC_USP7_UBL2_3	38	42	PF12436	0.480
DOC_USP7_UBL2_3	4	8	PF12436	0.572
DOC_WW_Pin1_4	159	164	PF00397	0.326
DOC_WW_Pin1_4	227	232	PF00397	0.249
LIG_14-3-3_CanoR_1	209	214	PF00244	0.321
LIG_BIR_III_2	271	275	PF00653	0.572
LIG_FHA_1	126	132	PF00498	0.349
LIG_FHA_1	212	218	PF00498	0.257
LIG_FHA_1	230	236	PF00498	0.294
LIG_FHA_1	247	253	PF00498	0.344
LIG_FHA_1	281	287	PF00498	0.544
LIG_FHA_2	159	165	PF00498	0.294
LIG_FHA_2	91	97	PF00498	0.383
LIG_KLC1_Yacidic_2	224	229	PF13176	0.249
LIG_LIR_Gen_1	132	143	PF02991	0.316
LIG_LIR_Gen_1	82	92	PF02991	0.445
LIG_LIR_Gen_1	96	107	PF02991	0.314
LIG_LIR_Nem_3	132	138	PF02991	0.336
LIG_LIR_Nem_3	139	145	PF02991	0.291
LIG_LIR_Nem_3	82	88	PF02991	0.479
LIG_LIR_Nem_3	96	102	PF02991	0.316
LIG_PDZ_Class_3	284	289	PF00595	0.637
LIG_Pex14_2	143	147	PF04695	0.288
LIG_PTB_Apo_2	240	247	PF02174	0.294
LIG_SH2_GRB2like	241	244	PF00017	0.294
LIG_SH2_GRB2like	85	88	PF00017	0.461
LIG_SH2_PTP2	85	88	PF00017	0.486
LIG_SH2_SRC	256	259	PF00017	0.375
LIG_SH2_SRC	85	88	PF00017	0.461
LIG_SH2_STAT5	107	110	PF00017	0.306
LIG_SH2_STAT5	142	145	PF00017	0.291
LIG_SH2_STAT5	191	194	PF00017	0.249
LIG_SH2_STAT5	227	230	PF00017	0.249
LIG_SH2_STAT5	241	244	PF00017	0.249
LIG_SH2_STAT5	251	254	PF00017	0.330
LIG_SH2_STAT5	256	259	PF00017	0.249
LIG_SH2_STAT5	61	64	PF00017	0.575
LIG_SH2_STAT5	85	88	PF00017	0.462
LIG_SH3_3	83	89	PF00018	0.481
LIG_SUMO_SIM_anti_2	214	220	PF11976	0.269
LIG_SUMO_SIM_par_1	208	214	PF11976	0.244
LIG_TRAF2_1	79	82	PF00917	0.625
LIG_TRAF2_1	93	96	PF00917	0.277
LIG_WRC_WIRS_1	135	140	PF05994	0.314
MOD_CK1_1	136	142	PF00069	0.306
MOD_CK1_1	159	165	PF00069	0.313
MOD_CK1_1	177	183	PF00069	0.251
MOD_CK2_1	113	119	PF00069	0.463
MOD_CK2_1	273	279	PF00069	0.507
MOD_CK2_1	90	96	PF00069	0.383
MOD_GSK3_1	125	132	PF00069	0.337
MOD_GSK3_1	158	165	PF00069	0.233
MOD_GSK3_1	205	212	PF00069	0.331
MOD_GSK3_1	273	280	PF00069	0.648
MOD_NEK2_1	150	155	PF00069	0.392
MOD_NEK2_1	246	251	PF00069	0.322
MOD_PIKK_1	40	46	PF00454	0.568
MOD_PKA_1	37	43	PF00069	0.511
MOD_PKA_2	177	183	PF00069	0.269
MOD_Plk_1	163	169	PF00069	0.351
MOD_Plk_1	21	27	PF00069	0.493
MOD_Plk_1	49	55	PF00069	0.582
MOD_Plk_2-3	21	27	PF00069	0.454
MOD_Plk_4	163	169	PF00069	0.407
MOD_ProDKin_1	159	165	PF00069	0.326
MOD_ProDKin_1	227	233	PF00069	0.249
MOD_SUMO_rev_2	43	53	PF00179	0.529
TRG_ENDOCYTIC_2	110	113	PF00928	0.315
TRG_ENDOCYTIC_2	135	138	PF00928	0.326
TRG_ENDOCYTIC_2	140	143	PF00928	0.286
TRG_ENDOCYTIC_2	191	194	PF00928	0.249
TRG_ENDOCYTIC_2	241	244	PF00928	0.249
TRG_ENDOCYTIC_2	85	88	PF00928	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R0	Leptomonas seymouri	77%	100%
A0A1X0NT56	Trypanosomatidae	62%	99%
A0A422MXL6	Trypanosoma rangeli	60%	97%
A4HZS3	Leishmania infantum	100%	100%
C9ZRK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	94%
E9AVM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QBV1	Leishmania major	97%	100%
V5CKM9	Trypanosoma cruzi	60%	96%