Zinc finger C-x8-C-x5-C-x3-H type (And similar), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWZ1_LEIDO

TriTrypDb:

LdBPK_220040.1 , LdCL_220006500 , LDHU3_22.0250

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWZ1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.555
CLV_C14_Caspase3-7	344	348	PF00656	0.584
CLV_NRD_NRD_1	254	256	PF00675	0.317
DEG_Kelch_Keap1_1	191	196	PF01344	0.607
DOC_CKS1_1	139	144	PF01111	0.424
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.383
DOC_MAPK_MEF2A_6	215	222	PF00069	0.426
DOC_PP2B_LxvP_1	243	246	PF13499	0.480
DOC_PP2B_LxvP_1	84	87	PF13499	0.352
DOC_PP4_FxxP_1	139	142	PF00568	0.436
DOC_PP4_FxxP_1	303	306	PF00568	0.578
DOC_USP7_MATH_1	126	130	PF00917	0.511
DOC_USP7_MATH_1	188	192	PF00917	0.715
DOC_USP7_MATH_1	21	25	PF00917	0.582
DOC_USP7_MATH_1	275	279	PF00917	0.510
DOC_USP7_MATH_1	312	316	PF00917	0.635
DOC_USP7_MATH_1	365	369	PF00917	0.646
DOC_USP7_MATH_1	393	397	PF00917	0.698
DOC_USP7_MATH_1	403	407	PF00917	0.672
DOC_USP7_MATH_1	47	51	PF00917	0.636
DOC_USP7_MATH_1	69	73	PF00917	0.507
DOC_USP7_MATH_2	168	174	PF00917	0.505
DOC_WW_Pin1_4	1	6	PF00397	0.501
DOC_WW_Pin1_4	138	143	PF00397	0.405
DOC_WW_Pin1_4	286	291	PF00397	0.586
DOC_WW_Pin1_4	53	58	PF00397	0.549
LIG_14-3-3_CanoR_1	292	300	PF00244	0.597
LIG_14-3-3_CanoR_1	394	402	PF00244	0.676
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BRCT_BRCA1_1	3	7	PF00533	0.475
LIG_FHA_1	13	19	PF00498	0.562
LIG_FHA_1	226	232	PF00498	0.325
LIG_FHA_2	200	206	PF00498	0.616
LIG_FHA_2	364	370	PF00498	0.685
LIG_IBAR_NPY_1	400	402	PF08397	0.515
LIG_LIR_Apic_2	137	142	PF02991	0.501
LIG_LIR_Apic_2	302	306	PF02991	0.582
LIG_LIR_Gen_1	264	275	PF02991	0.276
LIG_LIR_Nem_3	264	270	PF02991	0.283
LIG_MYND_1	376	380	PF01753	0.572
LIG_SH2_NCK_1	402	406	PF00017	0.597
LIG_SH2_SRC	402	405	PF00017	0.645
LIG_SH2_STAT5	67	70	PF00017	0.535
LIG_UBA3_1	241	249	PF00899	0.399
LIG_WW_3	166	170	PF00397	0.535
MOD_CDK_SPxK_1	286	292	PF00069	0.553
MOD_CK1_1	208	214	PF00069	0.523
MOD_CK1_1	308	314	PF00069	0.704
MOD_CK1_1	353	359	PF00069	0.568
MOD_CK1_1	38	44	PF00069	0.587
MOD_CK1_1	387	393	PF00069	0.746
MOD_CK1_1	72	78	PF00069	0.552
MOD_CK1_1	9	15	PF00069	0.614
MOD_CK2_1	126	132	PF00069	0.387
MOD_CK2_1	190	196	PF00069	0.619
MOD_CK2_1	230	236	PF00069	0.410
MOD_CK2_1	275	281	PF00069	0.523
MOD_CK2_1	363	369	PF00069	0.728
MOD_GlcNHglycan	172	175	PF01048	0.678
MOD_GlcNHglycan	186	189	PF01048	0.606
MOD_GlcNHglycan	19	22	PF01048	0.562
MOD_GlcNHglycan	207	210	PF01048	0.564
MOD_GlcNHglycan	277	280	PF01048	0.488
MOD_GlcNHglycan	293	296	PF01048	0.541
MOD_GlcNHglycan	312	315	PF01048	0.640
MOD_GlcNHglycan	40	43	PF01048	0.624
MOD_GlcNHglycan	74	77	PF01048	0.409
MOD_GSK3_1	17	24	PF00069	0.493
MOD_GSK3_1	184	191	PF00069	0.630
MOD_GSK3_1	282	289	PF00069	0.668
MOD_GSK3_1	301	308	PF00069	0.559
MOD_GSK3_1	319	326	PF00069	0.639
MOD_GSK3_1	333	340	PF00069	0.690
MOD_GSK3_1	346	353	PF00069	0.608
MOD_GSK3_1	359	366	PF00069	0.712
MOD_GSK3_1	47	54	PF00069	0.609
MOD_GSK3_1	72	79	PF00069	0.413
MOD_GSK3_1	8	15	PF00069	0.582
MOD_N-GLC_1	184	189	PF02516	0.709
MOD_N-GLC_1	341	346	PF02516	0.577
MOD_N-GLC_2	224	226	PF02516	0.439
MOD_N-GLC_2	263	265	PF02516	0.341
MOD_NEK2_1	199	204	PF00069	0.513
MOD_NEK2_1	230	235	PF00069	0.477
MOD_NEK2_1	284	289	PF00069	0.753
MOD_NEK2_1	291	296	PF00069	0.710
MOD_NEK2_1	333	338	PF00069	0.666
MOD_NEK2_1	346	351	PF00069	0.720
MOD_NEK2_1	58	63	PF00069	0.524
MOD_PIKK_1	319	325	PF00454	0.628
MOD_PIKK_1	337	343	PF00454	0.609
MOD_PIKK_1	350	356	PF00454	0.540
MOD_PIKK_1	58	64	PF00454	0.478
MOD_PKA_2	291	297	PF00069	0.625
MOD_PKA_2	393	399	PF00069	0.680
MOD_PKA_2	47	53	PF00069	0.615
MOD_Plk_1	263	269	PF00069	0.424
MOD_Plk_1	403	409	PF00069	0.604
MOD_Plk_4	126	132	PF00069	0.483
MOD_Plk_4	263	269	PF00069	0.393
MOD_Plk_4	334	340	PF00069	0.713
MOD_Plk_4	341	347	PF00069	0.712
MOD_Plk_4	40	46	PF00069	0.633
MOD_ProDKin_1	1	7	PF00069	0.502
MOD_ProDKin_1	138	144	PF00069	0.397
MOD_ProDKin_1	286	292	PF00069	0.587
MOD_ProDKin_1	53	59	PF00069	0.546
TRG_DiLeu_BaEn_1	40	45	PF01217	0.555
TRG_DiLeu_BaEn_1	98	103	PF01217	0.525
TRG_DiLeu_BaEn_3	236	242	PF01217	0.502
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.575
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.508
TRG_ER_diArg_1	45	48	PF00400	0.622
TRG_ER_FFAT_2	304	315	PF00635	0.474
TRG_NES_CRM1_1	100	112	PF08389	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY30	Leptomonas seymouri	59%	99%
A0A1X0NUJ7	Trypanosomatidae	36%	100%
A0A3R7MUT8	Trypanosoma rangeli	36%	100%
A4HC69	Leishmania braziliensis	73%	100%
A4HZP4	Leishmania infantum	100%	100%
E9AVK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QBX9	Leishmania major	94%	100%
V5DBU7	Trypanosoma cruzi	37%	100%