GPI transamidase component GAA1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase component GAA1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWY8_LEIDO

TriTrypDb:

LdBPK_212180.1 , LdCL_210027500 , LDHU3_21.2590

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0008303	caspase complex	5	11
GO:0032991	protein-containing complex	1	11
GO:0042765	GPI-anchor transamidase complex	3	11
GO:0098796	membrane protein complex	2	11
GO:0140534	endoplasmic reticulum protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1905368	peptidase complex	3	11
GO:1905369	endopeptidase complex	4	11

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Expansion

Sequence features

A0A3S7WWY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWY8

Function

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Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016255	attachment of GPI anchor to protein	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.535
CLV_NRD_NRD_1	188	190	PF00675	0.544
CLV_NRD_NRD_1	3	5	PF00675	0.344
CLV_NRD_NRD_1	37	39	PF00675	0.596
CLV_NRD_NRD_1	77	79	PF00675	0.612
CLV_PCSK_FUR_1	75	79	PF00082	0.579
CLV_PCSK_KEX2_1	108	110	PF00082	0.530
CLV_PCSK_KEX2_1	188	190	PF00082	0.544
CLV_PCSK_KEX2_1	3	5	PF00082	0.369
CLV_PCSK_KEX2_1	77	79	PF00082	0.610

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2W7	Leptomonas seymouri	66%	100%
A0A1X0NIY4	Trypanosomatidae	39%	100%
A0A3R7N823	Trypanosoma rangeli	39%	99%
A4HLC3	Leishmania braziliensis	83%	100%
A4HZI7	Leishmania infantum	100%	100%
D0A0Y9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AVH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QC02	Leishmania major	95%	100%
V5DID2	Trypanosoma cruzi	37%	96%

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