Uncharacterized conserved protein (DUF2036), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterized conserved protein (DUF2036), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWY5_LEIDO

TriTrypDb:

LdBPK_220030.1 , LdCL_220006400 , LDHU3_22.0220

Length:

475

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031390	Ctf18 RFC-like complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0000775	chromosome, centromeric region	3	1
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098687	chromosomal region	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWY5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	11
GO:0007062	sister chromatid cohesion	3	11
GO:0007064	mitotic sister chromatid cohesion	4	11
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	11
GO:0022402	cell cycle process	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0051276	chromosome organization	5	11
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1903047	mitotic cell cycle process	3	12
GO:0034086	maintenance of sister chromatid cohesion	3	1
GO:0034088	maintenance of mitotic sister chromatid cohesion	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.468
CLV_NRD_NRD_1	101	103	PF00675	0.330
CLV_NRD_NRD_1	289	291	PF00675	0.393
CLV_NRD_NRD_1	88	90	PF00675	0.329
CLV_PCSK_FUR_1	45	49	PF00082	0.437
CLV_PCSK_KEX2_1	101	103	PF00082	0.305
CLV_PCSK_KEX2_1	289	291	PF00082	0.358
CLV_PCSK_KEX2_1	47	49	PF00082	0.453
CLV_PCSK_KEX2_1	88	90	PF00082	0.338
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.453
CLV_PCSK_SKI1_1	27	31	PF00082	0.372
CLV_PCSK_SKI1_1	422	426	PF00082	0.376
DEG_MDM2_SWIB_1	350	358	PF02201	0.328
DEG_Nend_UBRbox_2	1	3	PF02207	0.662
DOC_CYCLIN_RxL_1	419	426	PF00134	0.366
DOC_CYCLIN_yCln2_LP_2	444	447	PF00134	0.572
DOC_MAPK_gen_1	383	390	PF00069	0.398
DOC_MAPK_MEF2A_6	410	417	PF00069	0.398
DOC_PP2B_LxvP_1	311	314	PF13499	0.409
DOC_PP2B_LxvP_1	444	447	PF13499	0.545
DOC_USP7_MATH_1	106	110	PF00917	0.400
DOC_USP7_MATH_1	194	198	PF00917	0.435
DOC_USP7_MATH_1	241	245	PF00917	0.398
DOC_USP7_MATH_1	35	39	PF00917	0.445
DOC_USP7_MATH_1	357	361	PF00917	0.428
DOC_USP7_MATH_1	409	413	PF00917	0.491
DOC_USP7_MATH_1	43	47	PF00917	0.448
DOC_USP7_MATH_1	447	451	PF00917	0.579
DOC_USP7_MATH_2	409	415	PF00917	0.475
DOC_WW_Pin1_4	130	135	PF00397	0.491
DOC_WW_Pin1_4	210	215	PF00397	0.439
DOC_WW_Pin1_4	33	38	PF00397	0.432
DOC_WW_Pin1_4	50	55	PF00397	0.370
LIG_14-3-3_CanoR_1	17	22	PF00244	0.482
LIG_14-3-3_CanoR_1	199	204	PF00244	0.387
LIG_14-3-3_CanoR_1	208	214	PF00244	0.338
LIG_14-3-3_CanoR_1	48	54	PF00244	0.453
LIG_BIR_III_2	356	360	PF00653	0.475
LIG_BRCT_BRCA1_1	152	156	PF00533	0.413
LIG_BRCT_BRCA1_1	359	363	PF00533	0.396
LIG_BRCT_BRCA1_1	393	397	PF00533	0.398
LIG_BRCT_BRCA1_1	413	417	PF00533	0.475
LIG_Clathr_ClatBox_1	18	22	PF01394	0.363
LIG_CSL_BTD_1	406	409	PF09270	0.449
LIG_eIF4E_1	92	98	PF01652	0.363
LIG_FHA_1	125	131	PF00498	0.484
LIG_FHA_1	142	148	PF00498	0.281
LIG_FHA_1	336	342	PF00498	0.413
LIG_FHA_1	82	88	PF00498	0.363
LIG_FHA_1	93	99	PF00498	0.328
LIG_FHA_2	175	181	PF00498	0.315
LIG_FHA_2	377	383	PF00498	0.489
LIG_LIR_Apic_2	31	37	PF02991	0.359
LIG_LIR_Apic_2	403	409	PF02991	0.461
LIG_LIR_Apic_2	459	465	PF02991	0.461
LIG_LIR_Gen_1	173	181	PF02991	0.409
LIG_LIR_Gen_1	202	210	PF02991	0.397
LIG_LIR_Gen_1	448	456	PF02991	0.473
LIG_LIR_Nem_3	15	19	PF02991	0.355
LIG_LIR_Nem_3	173	178	PF02991	0.391
LIG_LIR_Nem_3	202	206	PF02991	0.330
LIG_LIR_Nem_3	272	277	PF02991	0.384
LIG_LIR_Nem_3	448	454	PF02991	0.486
LIG_LYPXL_L_2	273	282	PF13949	0.413
LIG_LYPXL_S_1	273	277	PF13949	0.363
LIG_LYPXL_yS_3	274	277	PF13949	0.363
LIG_NRBOX	216	222	PF00104	0.449
LIG_NRBOX	231	237	PF00104	0.475
LIG_PCNA_yPIPBox_3	428	441	PF02747	0.433
LIG_Pex14_2	350	354	PF04695	0.328
LIG_Rb_pABgroove_1	150	158	PF01858	0.449
LIG_SH2_CRK	16	20	PF00017	0.363
LIG_SH2_CRK	462	466	PF00017	0.498
LIG_SH2_CRK	471	475	PF00017	0.430
LIG_SH2_GRB2like	143	146	PF00017	0.475
LIG_SH2_GRB2like	92	95	PF00017	0.344
LIG_SH2_PTP2	387	390	PF00017	0.475
LIG_SH2_STAP1	143	147	PF00017	0.475
LIG_SH2_STAP1	92	96	PF00017	0.344
LIG_SH2_STAT5	143	146	PF00017	0.423
LIG_SH2_STAT5	175	178	PF00017	0.407
LIG_SH2_STAT5	201	204	PF00017	0.344
LIG_SH2_STAT5	387	390	PF00017	0.475
LIG_SH2_STAT5	440	443	PF00017	0.434
LIG_SH3_1	462	468	PF00018	0.549
LIG_SH3_3	190	196	PF00018	0.449
LIG_SH3_3	302	308	PF00018	0.475
LIG_SH3_3	386	392	PF00018	0.390
LIG_SH3_3	462	468	PF00018	0.480
LIG_SUMO_SIM_anti_2	300	306	PF11976	0.394
LIG_SUMO_SIM_anti_2	63	68	PF11976	0.435
LIG_SUMO_SIM_par_1	17	23	PF11976	0.328
LIG_TRAF2_1	177	180	PF00917	0.378
LIG_TRFH_1	425	429	PF08558	0.413
LIG_TYR_ITIM	469	474	PF00017	0.425
LIG_WRC_WIRS_1	347	352	PF05994	0.413
MOD_CK1_1	174	180	PF00069	0.370
MOD_CK1_1	188	194	PF00069	0.301
MOD_CK1_1	46	52	PF00069	0.385
MOD_CK1_1	53	59	PF00069	0.455
MOD_CK1_1	83	89	PF00069	0.449
MOD_CK2_1	174	180	PF00069	0.317
MOD_CK2_1	210	216	PF00069	0.346
MOD_CK2_1	376	382	PF00069	0.437
MOD_DYRK1A_RPxSP_1	50	54	PF00069	0.475
MOD_GlcNHglycan	108	111	PF01048	0.459
MOD_GlcNHglycan	167	170	PF01048	0.485
MOD_GlcNHglycan	188	191	PF01048	0.391
MOD_GlcNHglycan	196	199	PF01048	0.341
MOD_GlcNHglycan	37	40	PF01048	0.409
MOD_GlcNHglycan	393	396	PF01048	0.440
MOD_GlcNHglycan	55	58	PF01048	0.457
MOD_GlcNHglycan	60	63	PF01048	0.434
MOD_GSK3_1	124	131	PF00069	0.421
MOD_GSK3_1	181	188	PF00069	0.404
MOD_GSK3_1	397	404	PF00069	0.427
MOD_GSK3_1	46	53	PF00069	0.449
MOD_N-GLC_1	165	170	PF02516	0.398
MOD_N-GLC_1	298	303	PF02516	0.461
MOD_NEK2_1	155	160	PF00069	0.415
MOD_NEK2_1	171	176	PF00069	0.449
MOD_NEK2_1	209	214	PF00069	0.370
MOD_NEK2_1	220	225	PF00069	0.383
MOD_NEK2_1	397	402	PF00069	0.469
MOD_NEK2_1	97	102	PF00069	0.399
MOD_PK_1	17	23	PF00069	0.413
MOD_PKA_2	116	122	PF00069	0.398
MOD_PKA_2	456	462	PF00069	0.575
MOD_PKA_2	49	55	PF00069	0.475
MOD_PKB_1	139	147	PF00069	0.398
MOD_Plk_1	165	171	PF00069	0.398
MOD_Plk_1	258	264	PF00069	0.407
MOD_Plk_1	298	304	PF00069	0.475
MOD_Plk_1	447	453	PF00069	0.564
MOD_Plk_2-3	411	417	PF00069	0.398
MOD_Plk_4	171	177	PF00069	0.449
MOD_Plk_4	269	275	PF00069	0.358
MOD_Plk_4	298	304	PF00069	0.359
MOD_Plk_4	358	364	PF00069	0.314
MOD_Plk_4	376	382	PF00069	0.389
MOD_Plk_4	401	407	PF00069	0.364
MOD_Plk_4	440	446	PF00069	0.474
MOD_Plk_4	92	98	PF00069	0.361
MOD_ProDKin_1	130	136	PF00069	0.491
MOD_ProDKin_1	210	216	PF00069	0.439
MOD_ProDKin_1	33	39	PF00069	0.432
MOD_ProDKin_1	50	56	PF00069	0.370
TRG_DiLeu_BaEn_1	216	221	PF01217	0.449
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.328
TRG_ENDOCYTIC_2	16	19	PF00928	0.417
TRG_ENDOCYTIC_2	175	178	PF00928	0.409
TRG_ENDOCYTIC_2	274	277	PF00928	0.344
TRG_ENDOCYTIC_2	387	390	PF00928	0.417
TRG_ENDOCYTIC_2	471	474	PF00928	0.425
TRG_ER_diArg_1	101	103	PF00400	0.317
TRG_ER_diArg_1	87	89	PF00400	0.345
TRG_NES_CRM1_1	426	439	PF08389	0.474
TRG_NLS_MonoExtN_4	45	51	PF00514	0.448
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC72	Leptomonas seymouri	56%	98%
A0A0S4JIP1	Bodo saltans	23%	100%
A0A1X0NTK3	Trypanosomatidae	34%	97%
A0A422NSK5	Trypanosoma rangeli	35%	100%
A4HC68	Leishmania braziliensis	79%	100%
A4HZP3	Leishmania infantum	100%	100%
C9ZSD4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AVJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QBY0	Leishmania major	94%	100%
V5BFR5	Trypanosoma cruzi	34%	100%