EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WWY3_LEIDO

TriTrypDb:

LdBPK_220250.1 , LdCL_220008600 , LDHU3_22.0520

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWY3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.603
CLV_C14_Caspase3-7	256	260	PF00656	0.500
CLV_C14_Caspase3-7	6	10	PF00656	0.366
CLV_PCSK_KEX2_1	71	73	PF00082	0.506
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.506
CLV_PCSK_SKI1_1	188	192	PF00082	0.556
CLV_PCSK_SKI1_1	40	44	PF00082	0.486
CLV_PCSK_SKI1_1	71	75	PF00082	0.423
DEG_APCC_DBOX_1	39	47	PF00400	0.486
DEG_Nend_UBRbox_1	1	4	PF02207	0.581
DEG_SPOP_SBC_1	154	158	PF00917	0.555
DOC_CKS1_1	160	165	PF01111	0.636
DOC_CYCLIN_RxL_1	37	45	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.458
DOC_PP1_RVXF_1	186	192	PF00149	0.474
DOC_PP1_RVXF_1	225	231	PF00149	0.423
DOC_PP2B_LxvP_1	81	84	PF13499	0.510
DOC_PP4_FxxP_1	47	50	PF00568	0.502
DOC_USP7_MATH_1	154	158	PF00917	0.632
DOC_USP7_MATH_1	167	171	PF00917	0.604
DOC_USP7_MATH_1	48	52	PF00917	0.594
DOC_USP7_MATH_1	73	77	PF00917	0.489
DOC_USP7_MATH_1	95	99	PF00917	0.621
DOC_WW_Pin1_4	159	164	PF00397	0.671
DOC_WW_Pin1_4	206	211	PF00397	0.545
DOC_WW_Pin1_4	46	51	PF00397	0.480
LIG_14-3-3_CanoR_1	153	163	PF00244	0.633
LIG_14-3-3_CanoR_1	64	74	PF00244	0.371
LIG_BIR_III_4	166	170	PF00653	0.587
LIG_CSL_BTD_1	81	84	PF09270	0.517
LIG_CtBP_PxDLS_1	85	89	PF00389	0.530
LIG_FHA_1	143	149	PF00498	0.627
LIG_FHA_1	156	162	PF00498	0.645
LIG_FHA_1	163	169	PF00498	0.562
LIG_FHA_1	215	221	PF00498	0.503
LIG_FHA_1	76	82	PF00498	0.469
LIG_FHA_2	108	114	PF00498	0.489
LIG_FHA_2	124	130	PF00498	0.580
LIG_FHA_2	254	260	PF00498	0.576
LIG_Integrin_isoDGR_2	31	33	PF01839	0.437
LIG_LIR_Apic_2	103	109	PF02991	0.610
LIG_LIR_Apic_2	45	50	PF02991	0.501
LIG_LIR_Gen_1	265	273	PF02991	0.391
LIG_LIR_Nem_3	197	203	PF02991	0.393
LIG_LIR_Nem_3	265	270	PF02991	0.417
LIG_NBox_RRM_1	7	17	PF00076	0.377
LIG_NRBOX	244	250	PF00104	0.414
LIG_NRBOX	7	13	PF00104	0.487
LIG_RPA_C_Fungi	166	178	PF08784	0.554
LIG_SH2_STAT5	106	109	PF00017	0.544
LIG_SH3_3	157	163	PF00018	0.635
LIG_SH3_3	207	213	PF00018	0.512
LIG_SH3_3	80	86	PF00018	0.553
LIG_TRAF2_1	195	198	PF00917	0.438
MOD_CK1_1	155	161	PF00069	0.670
MOD_CK1_1	49	55	PF00069	0.636
MOD_CK1_1	87	93	PF00069	0.587
MOD_CK2_1	107	113	PF00069	0.515
MOD_CK2_1	123	129	PF00069	0.634
MOD_CK2_1	192	198	PF00069	0.419
MOD_CK2_1	206	212	PF00069	0.466
MOD_GlcNHglycan	65	68	PF01048	0.599
MOD_GlcNHglycan	93	96	PF01048	0.686
MOD_GlcNHglycan	97	100	PF01048	0.515
MOD_GSK3_1	129	136	PF00069	0.597
MOD_GSK3_1	155	162	PF00069	0.628
MOD_GSK3_1	42	49	PF00069	0.557
MOD_GSK3_1	87	94	PF00069	0.601
MOD_NEK2_1	42	47	PF00069	0.487
MOD_NEK2_1	65	70	PF00069	0.546
MOD_PIKK_1	123	129	PF00454	0.608
MOD_PIKK_1	51	57	PF00454	0.621
MOD_PIKK_1	65	71	PF00454	0.459
MOD_PKA_2	152	158	PF00069	0.692
MOD_PKA_2	63	69	PF00069	0.388
MOD_PKB_1	151	159	PF00069	0.647
MOD_Plk_1	141	147	PF00069	0.727
MOD_Plk_1	2	8	PF00069	0.470
MOD_Plk_2-3	3	9	PF00069	0.477
MOD_Plk_4	142	148	PF00069	0.648
MOD_Plk_4	3	9	PF00069	0.559
MOD_Plk_4	84	90	PF00069	0.589
MOD_ProDKin_1	159	165	PF00069	0.669
MOD_ProDKin_1	206	212	PF00069	0.549
MOD_ProDKin_1	46	52	PF00069	0.487
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.481
TRG_ENDOCYTIC_2	193	196	PF00928	0.420
TRG_ENDOCYTIC_2	200	203	PF00928	0.363
TRG_ER_diArg_1	151	154	PF00400	0.763
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB35	Leptomonas seymouri	39%	99%
A4HC86	Leishmania braziliensis	62%	100%
A4HZR5	Leishmania infantum	99%	100%
E9AVM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QBV8	Leishmania major	87%	100%