Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWY1_LEIDO

TriTrypDb:

LdBPK_220006.1 , LdCL_220005500 , LDHU3_22.0100

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWY1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.597
CLV_C14_Caspase3-7	407	411	PF00656	0.655
CLV_NRD_NRD_1	261	263	PF00675	0.603
CLV_NRD_NRD_1	271	273	PF00675	0.538
CLV_NRD_NRD_1	311	313	PF00675	0.432
CLV_NRD_NRD_1	336	338	PF00675	0.581
CLV_NRD_NRD_1	420	422	PF00675	0.593
CLV_PCSK_FUR_1	418	422	PF00082	0.591
CLV_PCSK_KEX2_1	205	207	PF00082	0.441
CLV_PCSK_KEX2_1	231	233	PF00082	0.581
CLV_PCSK_KEX2_1	261	263	PF00082	0.563
CLV_PCSK_KEX2_1	311	313	PF00082	0.432
CLV_PCSK_KEX2_1	336	338	PF00082	0.581
CLV_PCSK_KEX2_1	354	356	PF00082	0.610
CLV_PCSK_KEX2_1	420	422	PF00082	0.684
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.502
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.611
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.569
CLV_PCSK_SKI1_1	420	424	PF00082	0.748
CLV_PCSK_SKI1_1	434	438	PF00082	0.562
CLV_PCSK_SKI1_1	456	460	PF00082	0.598
CLV_Separin_Metazoa	165	169	PF03568	0.436
CLV_Separin_Metazoa	253	257	PF03568	0.494
DEG_APCC_DBOX_1	121	129	PF00400	0.500
DEG_APCC_DBOX_1	402	410	PF00400	0.696
DEG_COP1_1	17	26	PF00400	0.560
DEG_SPOP_SBC_1	5	9	PF00917	0.704
DOC_MAPK_gen_1	278	285	PF00069	0.531
DOC_PP4_FxxP_1	459	462	PF00568	0.525
DOC_PP4_MxPP_1	1	4	PF00568	0.653
DOC_USP7_MATH_1	37	41	PF00917	0.568
DOC_USP7_MATH_1	428	432	PF00917	0.572
DOC_USP7_MATH_1	43	47	PF00917	0.588
DOC_WW_Pin1_4	15	20	PF00397	0.680
DOC_WW_Pin1_4	426	431	PF00397	0.577
LIG_14-3-3_CanoR_1	122	130	PF00244	0.606
LIG_14-3-3_CanoR_1	171	175	PF00244	0.531
LIG_14-3-3_CanoR_1	29	34	PF00244	0.624
LIG_14-3-3_CanoR_1	420	427	PF00244	0.594
LIG_14-3-3_CanoR_1	456	462	PF00244	0.627
LIG_14-3-3_CanoR_1	73	78	PF00244	0.514
LIG_14-3-3_CanoR_1	94	100	PF00244	0.443
LIG_Actin_WH2_2	222	239	PF00022	0.530
LIG_Actin_WH2_2	331	348	PF00022	0.574
LIG_Actin_WH2_2	79	96	PF00022	0.550
LIG_BRCT_BRCA1_1	158	162	PF00533	0.438
LIG_BRCT_BRCA1_1	367	371	PF00533	0.546
LIG_CaM_IQ_9	74	90	PF13499	0.424
LIG_Clathr_ClatBox_1	111	115	PF01394	0.429
LIG_deltaCOP1_diTrp_1	27	33	PF00928	0.612
LIG_DLG_GKlike_1	217	225	PF00625	0.461
LIG_EH1_1	105	113	PF00400	0.486
LIG_FHA_1	118	124	PF00498	0.455
LIG_FHA_1	151	157	PF00498	0.452
LIG_FHA_1	18	24	PF00498	0.755
LIG_FHA_1	30	36	PF00498	0.490
LIG_FHA_2	199	205	PF00498	0.502
LIG_FHA_2	302	308	PF00498	0.580
LIG_LIR_Apic_2	457	462	PF02991	0.520
LIG_LIR_Gen_1	250	257	PF02991	0.513
LIG_LIR_Gen_1	27	37	PF02991	0.551
LIG_LIR_Gen_1	279	289	PF02991	0.441
LIG_LIR_Nem_3	190	195	PF02991	0.465
LIG_LIR_Nem_3	250	254	PF02991	0.500
LIG_LIR_Nem_3	27	33	PF02991	0.533
LIG_LIR_Nem_3	279	285	PF02991	0.467
LIG_SH2_NCK_1	425	429	PF00017	0.589
LIG_SH2_SRC	68	71	PF00017	0.564
LIG_SH2_STAP1	203	207	PF00017	0.523
LIG_SH2_STAP1	251	255	PF00017	0.498
LIG_SUMO_SIM_par_1	109	115	PF11976	0.524
LIG_TRAF2_1	11	14	PF00917	0.640
LIG_TRAF2_1	239	242	PF00917	0.502
LIG_TRAF2_1	25	28	PF00917	0.457
LIG_TRAF2_1	300	303	PF00917	0.583
LIG_TRAF2_1	328	331	PF00917	0.464
LIG_TRAF2_1	67	70	PF00917	0.569
MOD_CK1_1	457	463	PF00069	0.622
MOD_CK2_1	187	193	PF00069	0.576
MOD_CK2_1	22	28	PF00069	0.563
MOD_CK2_1	236	242	PF00069	0.498
MOD_CK2_1	43	49	PF00069	0.598
MOD_CK2_1	457	463	PF00069	0.627
MOD_CK2_1	9	15	PF00069	0.642
MOD_GlcNHglycan	406	409	PF01048	0.702
MOD_GlcNHglycan	456	459	PF01048	0.657
MOD_GSK3_1	15	22	PF00069	0.597
MOD_GSK3_1	166	173	PF00069	0.482
MOD_GSK3_1	187	194	PF00069	0.473
MOD_GSK3_1	236	243	PF00069	0.501
MOD_GSK3_1	457	464	PF00069	0.639
MOD_GSK3_1	5	12	PF00069	0.692
MOD_NEK2_1	118	123	PF00069	0.509
MOD_NEK2_1	156	161	PF00069	0.511
MOD_NEK2_1	170	175	PF00069	0.393
MOD_NEK2_1	225	230	PF00069	0.487
MOD_NEK2_1	6	11	PF00069	0.742
MOD_PIKK_1	68	74	PF00454	0.560
MOD_PIKK_1	9	15	PF00454	0.529
MOD_PKA_1	420	426	PF00069	0.682
MOD_PKA_2	170	176	PF00069	0.477
MOD_PKA_2	28	34	PF00069	0.625
MOD_PKA_2	404	410	PF00069	0.699
MOD_PKA_2	420	426	PF00069	0.682
MOD_PKA_2	93	99	PF00069	0.545
MOD_PKB_1	299	307	PF00069	0.643
MOD_PKB_1	418	426	PF00069	0.592
MOD_PKB_1	447	455	PF00069	0.637
MOD_Plk_1	301	307	PF00069	0.608
MOD_Plk_4	301	307	PF00069	0.624
MOD_ProDKin_1	15	21	PF00069	0.684
MOD_ProDKin_1	426	432	PF00069	0.577
MOD_SUMO_for_1	230	233	PF00179	0.485
TRG_DiLeu_BaEn_1	250	255	PF01217	0.497
TRG_DiLeu_BaEn_4	137	143	PF01217	0.483
TRG_ENDOCYTIC_2	189	192	PF00928	0.428
TRG_ENDOCYTIC_2	251	254	PF00928	0.545
TRG_ER_diArg_1	298	301	PF00400	0.555
TRG_ER_diArg_1	336	338	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S5	Leptomonas seymouri	66%	91%
A0A1X0NTJ5	Trypanosomatidae	32%	78%
A0A422N4N0	Trypanosoma rangeli	36%	75%
A4HC57	Leishmania braziliensis	86%	100%
E9AGY5	Leishmania infantum	99%	100%
E9AVJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QBY9	Leishmania major	93%	100%
V5BK97	Trypanosoma cruzi	35%	100%