RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWY0_LEIDO

TriTrypDb:

LdBPK_220070.1 , LdCL_220006800 , LDHU3_22.0290

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7WWY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWY0

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	16
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0005509	calcium ion binding	5	10
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.467
CLV_NRD_NRD_1	275	277	PF00675	0.371
CLV_NRD_NRD_1	334	336	PF00675	0.277
CLV_NRD_NRD_1	354	356	PF00675	0.604
CLV_NRD_NRD_1	385	387	PF00675	0.428
CLV_NRD_NRD_1	404	406	PF00675	0.348
CLV_PCSK_FUR_1	405	409	PF00082	0.342
CLV_PCSK_KEX2_1	275	277	PF00082	0.371
CLV_PCSK_KEX2_1	334	336	PF00082	0.311
CLV_PCSK_KEX2_1	353	355	PF00082	0.594
CLV_PCSK_KEX2_1	404	406	PF00082	0.348
CLV_PCSK_KEX2_1	407	409	PF00082	0.336
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.350
CLV_PCSK_SKI1_1	247	251	PF00082	0.543
CLV_PCSK_SKI1_1	255	259	PF00082	0.537
CLV_PCSK_SKI1_1	404	408	PF00082	0.357
CLV_PCSK_SKI1_1	63	67	PF00082	0.424
CLV_PCSK_SKI1_1	91	95	PF00082	0.407
DOC_ANK_TNKS_1	38	45	PF00023	0.353
DOC_CKS1_1	58	63	PF01111	0.464
DOC_CYCLIN_yCln2_LP_2	144	150	PF00134	0.566
DOC_MAPK_gen_1	404	412	PF00069	0.336
DOC_PP1_RVXF_1	230	237	PF00149	0.462
DOC_PP1_RVXF_1	406	413	PF00149	0.333
DOC_PP4_FxxP_1	412	415	PF00568	0.360
DOC_USP7_MATH_1	130	134	PF00917	0.649
DOC_USP7_MATH_1	139	143	PF00917	0.643
DOC_WW_Pin1_4	133	138	PF00397	0.738
DOC_WW_Pin1_4	152	157	PF00397	0.742
DOC_WW_Pin1_4	57	62	PF00397	0.455
LIG_14-3-3_CanoR_1	185	195	PF00244	0.531
LIG_14-3-3_CanoR_1	344	348	PF00244	0.383
LIG_BIR_II_1	1	5	PF00653	0.516
LIG_BRCT_BRCA1_1	260	264	PF00533	0.318
LIG_CaM_NSCaTE_8	184	191	PF13499	0.462
LIG_Clathr_ClatBox_1	298	302	PF01394	0.435
LIG_Clathr_ClatBox_1	306	310	PF01394	0.392
LIG_FHA_1	111	117	PF00498	0.430
LIG_FHA_1	23	29	PF00498	0.447
LIG_FHA_1	257	263	PF00498	0.401
LIG_FHA_1	377	383	PF00498	0.470
LIG_FHA_1	45	51	PF00498	0.428
LIG_FHA_2	109	115	PF00498	0.419
LIG_FHA_2	126	132	PF00498	0.533
LIG_FHA_2	189	195	PF00498	0.402
LIG_FHA_2	427	433	PF00498	0.378
LIG_FHA_2	82	88	PF00498	0.342
LIG_KLC1_Yacidic_2	120	124	PF13176	0.430
LIG_LIR_Gen_1	158	169	PF02991	0.532
LIG_LIR_Gen_1	261	272	PF02991	0.324
LIG_LIR_Gen_1	287	296	PF02991	0.476
LIG_LIR_Gen_1	326	336	PF02991	0.390
LIG_LIR_Gen_1	84	93	PF02991	0.439
LIG_LIR_Nem_3	158	164	PF02991	0.593
LIG_LIR_Nem_3	194	198	PF02991	0.479
LIG_LIR_Nem_3	199	205	PF02991	0.420
LIG_LIR_Nem_3	207	212	PF02991	0.452
LIG_LIR_Nem_3	261	267	PF02991	0.317
LIG_LIR_Nem_3	287	292	PF02991	0.381
LIG_LIR_Nem_3	326	332	PF02991	0.371
LIG_LIR_Nem_3	84	88	PF02991	0.334
LIG_Pex14_1	81	85	PF04695	0.345
LIG_Rb_LxCxE_1	90	107	PF01857	0.452
LIG_SH2_SRC	413	416	PF00017	0.342
LIG_SH2_STAP1	178	182	PF00017	0.359
LIG_SH2_STAP1	289	293	PF00017	0.397
LIG_SH2_STAT5	122	125	PF00017	0.451
LIG_SH2_STAT5	319	322	PF00017	0.409
LIG_SH2_STAT5	4	7	PF00017	0.372
LIG_SH2_STAT5	402	405	PF00017	0.541
LIG_SH3_3	211	217	PF00018	0.357
LIG_SH3_3	237	243	PF00018	0.328
LIG_SH3_3	442	448	PF00018	0.495
LIG_SUMO_SIM_par_1	25	32	PF11976	0.373
LIG_SUMO_SIM_par_1	297	302	PF11976	0.372
LIG_TRAF2_1	117	120	PF00917	0.336
LIG_TRAF2_1	429	432	PF00917	0.388
MOD_CDK_SPxK_1	57	63	PF00069	0.465
MOD_CK1_1	133	139	PF00069	0.709
MOD_CK1_1	168	174	PF00069	0.657
MOD_CK1_1	187	193	PF00069	0.514
MOD_CK1_1	338	344	PF00069	0.430
MOD_CK1_1	346	352	PF00069	0.623
MOD_CK1_1	416	422	PF00069	0.334
MOD_CK2_1	100	106	PF00069	0.637
MOD_CK2_1	108	114	PF00069	0.469
MOD_CK2_1	125	131	PF00069	0.521
MOD_CK2_1	152	158	PF00069	0.537
MOD_CK2_1	426	432	PF00069	0.497
MOD_GlcNHglycan	131	135	PF01048	0.700
MOD_GlcNHglycan	167	170	PF01048	0.650
MOD_GlcNHglycan	349	352	PF01048	0.626
MOD_GlcNHglycan	365	368	PF01048	0.328
MOD_GlcNHglycan	414	418	PF01048	0.326
MOD_GlcNHglycan	76	79	PF01048	0.359
MOD_GSK3_1	184	191	PF00069	0.406
MOD_GSK3_1	343	350	PF00069	0.410
MOD_GSK3_1	358	365	PF00069	0.404
MOD_GSK3_1	431	438	PF00069	0.433
MOD_GSK3_1	53	60	PF00069	0.423
MOD_N-GLC_1	165	170	PF02516	0.568
MOD_NEK2_1	123	128	PF00069	0.483
MOD_NEK2_1	188	193	PF00069	0.459
MOD_NEK2_1	258	263	PF00069	0.431
MOD_NEK2_1	347	352	PF00069	0.494
MOD_NEK2_1	358	363	PF00069	0.446
MOD_NEK2_1	421	426	PF00069	0.424
MOD_NEK2_1	435	440	PF00069	0.340
MOD_NEK2_1	69	74	PF00069	0.410
MOD_OFUCOSY	41	48	PF10250	0.355
MOD_PIKK_1	416	422	PF00454	0.334
MOD_PIKK_1	69	75	PF00454	0.346
MOD_PKA_2	184	190	PF00069	0.487
MOD_PKA_2	343	349	PF00069	0.386
MOD_Plk_1	358	364	PF00069	0.609
MOD_Plk_1	421	427	PF00069	0.452
MOD_Plk_1	431	437	PF00069	0.437
MOD_Plk_1	7	13	PF00069	0.458
MOD_Plk_4	139	145	PF00069	0.618
MOD_Plk_4	343	349	PF00069	0.403
MOD_Plk_4	358	364	PF00069	0.409
MOD_Plk_4	431	437	PF00069	0.389
MOD_ProDKin_1	133	139	PF00069	0.735
MOD_ProDKin_1	152	158	PF00069	0.746
MOD_ProDKin_1	57	63	PF00069	0.465
MOD_SUMO_rev_2	100	110	PF00179	0.524
MOD_SUMO_rev_2	241	249	PF00179	0.413
TRG_DiLeu_BaEn_1	201	206	PF01217	0.408
TRG_DiLeu_BaEn_1	431	436	PF01217	0.375
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.312
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.443
TRG_ENDOCYTIC_2	195	198	PF00928	0.474
TRG_ENDOCYTIC_2	202	205	PF00928	0.565
TRG_ENDOCYTIC_2	289	292	PF00928	0.412
TRG_ENDOCYTIC_2	85	88	PF00928	0.316
TRG_ER_diArg_1	334	337	PF00400	0.279
TRG_ER_diArg_1	353	355	PF00400	0.603
TRG_ER_diArg_1	403	405	PF00400	0.361
TRG_NES_CRM1_1	290	302	PF08389	0.356
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILD7	Leptomonas seymouri	61%	99%
A0A1X0NTS2	Trypanosomatidae	35%	100%
A0A3Q8IMS6	Leishmania donovani	25%	100%
A0A3S7WYG1	Leishmania donovani	24%	100%
A4HDK3	Leishmania braziliensis	24%	100%
A4HDK4	Leishmania braziliensis	24%	100%
A4HZP7	Leishmania infantum	100%	100%
A4I0X7	Leishmania infantum	25%	100%
A4I0X8	Leishmania infantum	25%	100%
E9AVK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AWY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AWY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	99%
Q4QAJ2	Leishmania major	27%	99%
Q4QAJ3	Leishmania major	24%	100%
Q4QBX6	Leishmania major	90%	100%