Pumillio protein 3, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding regulatory protein (pumilio family), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWX7_LEIDO

TriTrypDb:

LdBPK_212050.1 , LdCL_210026200 , LDHU3_21.2440

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWX7

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0005488	binding	1	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.748
CLV_NRD_NRD_1	116	118	PF00675	0.756
CLV_NRD_NRD_1	134	136	PF00675	0.595
CLV_NRD_NRD_1	514	516	PF00675	0.571
CLV_PCSK_KEX2_1	101	103	PF00082	0.748
CLV_PCSK_KEX2_1	136	138	PF00082	0.660
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.678
CLV_PCSK_SKI1_1	314	318	PF00082	0.375
CLV_PCSK_SKI1_1	373	377	PF00082	0.390
DEG_COP1_1	150	160	PF00400	0.535
DEG_SCF_FBW7_1	278	285	PF00400	0.336
DOC_CDC14_PxL_1	414	422	PF14671	0.397
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.774
DOC_MAPK_MEF2A_6	407	416	PF00069	0.372
DOC_PP2B_LxvP_1	88	91	PF13499	0.778
DOC_PP4_FxxP_1	48	51	PF00568	0.639
DOC_PP4_FxxP_1	522	525	PF00568	0.726
DOC_USP7_MATH_1	403	407	PF00917	0.482
DOC_USP7_MATH_1	80	84	PF00917	0.722
DOC_USP7_MATH_1	91	95	PF00917	0.596
DOC_USP7_UBL2_3	36	40	PF12436	0.776
DOC_USP7_UBL2_3	505	509	PF12436	0.423
DOC_WW_Pin1_4	128	133	PF00397	0.703
DOC_WW_Pin1_4	278	283	PF00397	0.336
DOC_WW_Pin1_4	366	371	PF00397	0.391
DOC_WW_Pin1_4	49	54	PF00397	0.621
DOC_WW_Pin1_4	537	542	PF00397	0.747
DOC_WW_Pin1_4	545	550	PF00397	0.725
DOC_WW_Pin1_4	58	63	PF00397	0.632
DOC_WW_Pin1_4	76	81	PF00397	0.475
DOC_WW_Pin1_4	94	99	PF00397	0.683
LIG_14-3-3_CanoR_1	137	144	PF00244	0.709
LIG_14-3-3_CanoR_1	342	351	PF00244	0.520
LIG_Actin_WH2_2	425	440	PF00022	0.336
LIG_AP2alpha_2	390	392	PF02296	0.336
LIG_BIR_II_1	1	5	PF00653	0.714
LIG_BIR_III_4	318	322	PF00653	0.352
LIG_BRCT_BRCA1_1	184	188	PF00533	0.533
LIG_BRCT_BRCA1_1	44	48	PF00533	0.632
LIG_EH1_1	285	293	PF00400	0.336
LIG_FHA_1	125	131	PF00498	0.742
LIG_FHA_1	223	229	PF00498	0.419
LIG_FHA_1	283	289	PF00498	0.323
LIG_FHA_1	344	350	PF00498	0.478
LIG_FHA_1	409	415	PF00498	0.388
LIG_FHA_1	66	72	PF00498	0.739
LIG_FHA_2	14	20	PF00498	0.504
LIG_FHA_2	2	8	PF00498	0.641
LIG_FHA_2	203	209	PF00498	0.382
LIG_FHA_2	219	225	PF00498	0.336
LIG_FHA_2	295	301	PF00498	0.391
LIG_FHA_2	53	59	PF00498	0.677
LIG_LIR_Apic_2	45	51	PF02991	0.641
LIG_LIR_Gen_1	12	22	PF02991	0.681
LIG_LIR_Gen_1	244	255	PF02991	0.336
LIG_LIR_Gen_1	83	92	PF02991	0.770
LIG_LIR_Nem_3	12	18	PF02991	0.670
LIG_LIR_Nem_3	244	250	PF02991	0.336
LIG_LIR_Nem_3	338	344	PF02991	0.312
LIG_LIR_Nem_3	390	395	PF02991	0.313
LIG_LIR_Nem_3	464	469	PF02991	0.323
LIG_LIR_Nem_3	83	88	PF02991	0.695
LIG_MAD2	435	443	PF02301	0.370
LIG_MLH1_MIPbox_1	184	188	PF16413	0.533
LIG_NRP_CendR_1	553	554	PF00754	0.572
LIG_PCNA_yPIPBox_3	317	329	PF02747	0.323
LIG_PTB_Apo_2	496	503	PF02174	0.421
LIG_PTB_Phospho_1	496	502	PF10480	0.427
LIG_Rb_pABgroove_1	250	258	PF01858	0.336
LIG_SH2_CRK	341	345	PF00017	0.362
LIG_SH2_GRB2like	15	18	PF00017	0.684
LIG_SH2_GRB2like	247	250	PF00017	0.336
LIG_SH2_NCK_1	92	96	PF00017	0.773
LIG_SH2_STAP1	247	251	PF00017	0.336
LIG_SH2_STAP1	502	506	PF00017	0.427
LIG_SH2_STAT3	395	398	PF00017	0.323
LIG_SH2_STAT3	469	472	PF00017	0.323
LIG_SH2_STAT5	15	18	PF00017	0.692
LIG_SH2_STAT5	187	190	PF00017	0.616
LIG_SH2_STAT5	214	217	PF00017	0.450
LIG_SH2_STAT5	24	27	PF00017	0.675
LIG_SH2_STAT5	339	342	PF00017	0.461
LIG_SH2_STAT5	395	398	PF00017	0.311
LIG_SH2_STAT5	399	402	PF00017	0.311
LIG_SH2_STAT5	41	44	PF00017	0.644
LIG_SH2_STAT5	469	472	PF00017	0.323
LIG_SH2_STAT5	92	95	PF00017	0.749
LIG_SH3_2	72	77	PF14604	0.495
LIG_SH3_3	126	132	PF00018	0.772
LIG_SH3_3	267	273	PF00018	0.371
LIG_SH3_3	29	35	PF00018	0.571
LIG_SH3_3	489	495	PF00018	0.415
LIG_SH3_3	69	75	PF00018	0.744
LIG_SH3_4	36	43	PF00018	0.700
LIG_SUMO_SIM_par_1	276	281	PF11976	0.409
LIG_TRAF2_1	297	300	PF00917	0.299
MOD_CDK_SPK_2	366	371	PF00069	0.439
MOD_CDK_SPxxK_3	128	135	PF00069	0.677
MOD_CDK_SPxxK_3	366	373	PF00069	0.418
MOD_CDK_SPxxK_3	537	544	PF00069	0.767
MOD_CDK_SPxxK_3	94	101	PF00069	0.749
MOD_CK1_1	52	58	PF00069	0.679
MOD_CK1_1	537	543	PF00069	0.756
MOD_CK1_1	84	90	PF00069	0.725
MOD_CK1_1	94	100	PF00069	0.692
MOD_CK2_1	1	7	PF00069	0.712
MOD_CK2_1	120	126	PF00069	0.706
MOD_CK2_1	13	19	PF00069	0.662
MOD_CK2_1	293	299	PF00069	0.324
MOD_CK2_1	52	58	PF00069	0.749
MOD_Cter_Amidation	551	554	PF01082	0.567
MOD_GlcNHglycan	111	114	PF01048	0.738
MOD_GlcNHglycan	122	125	PF01048	0.670
MOD_GlcNHglycan	179	183	PF01048	0.657
MOD_GlcNHglycan	93	96	PF01048	0.698
MOD_GSK3_1	120	127	PF00069	0.632
MOD_GSK3_1	147	154	PF00069	0.719
MOD_GSK3_1	178	185	PF00069	0.683
MOD_GSK3_1	218	225	PF00069	0.258
MOD_GSK3_1	278	285	PF00069	0.342
MOD_GSK3_1	343	350	PF00069	0.448
MOD_GSK3_1	35	42	PF00069	0.722
MOD_GSK3_1	533	540	PF00069	0.729
MOD_GSK3_1	76	83	PF00069	0.683
MOD_GSK3_1	9	16	PF00069	0.534
MOD_GSK3_1	90	97	PF00069	0.574
MOD_N-GLC_1	107	112	PF02516	0.706
MOD_N-GLC_1	408	413	PF02516	0.415
MOD_N-GLC_1	81	86	PF02516	0.731
MOD_NEK2_1	1	6	PF00069	0.697
MOD_NEK2_1	107	112	PF00069	0.745
MOD_NEK2_1	291	296	PF00069	0.336
MOD_NEK2_1	67	72	PF00069	0.707
MOD_PIKK_1	165	171	PF00454	0.599
MOD_PIKK_1	42	48	PF00454	0.634
MOD_PKB_1	135	143	PF00069	0.567
MOD_Plk_1	28	34	PF00069	0.748
MOD_Plk_1	408	414	PF00069	0.473
MOD_Plk_1	81	87	PF00069	0.723
MOD_ProDKin_1	128	134	PF00069	0.705
MOD_ProDKin_1	278	284	PF00069	0.336
MOD_ProDKin_1	366	372	PF00069	0.391
MOD_ProDKin_1	49	55	PF00069	0.619
MOD_ProDKin_1	537	543	PF00069	0.749
MOD_ProDKin_1	545	551	PF00069	0.725
MOD_ProDKin_1	58	64	PF00069	0.632
MOD_ProDKin_1	76	82	PF00069	0.475
MOD_ProDKin_1	94	100	PF00069	0.684
MOD_SUMO_rev_2	110	119	PF00179	0.761
MOD_SUMO_rev_2	296	304	PF00179	0.258
MOD_SUMO_rev_2	402	408	PF00179	0.416
TRG_DiLeu_BaLyEn_6	492	497	PF01217	0.529
TRG_ENDOCYTIC_2	15	18	PF00928	0.684
TRG_ENDOCYTIC_2	247	250	PF00928	0.336
TRG_ENDOCYTIC_2	341	344	PF00928	0.361
TRG_ER_diArg_1	198	201	PF00400	0.562
TRG_NLS_Bipartite_1	117	139	PF00514	0.690
TRG_NLS_MonoExtN_4	132	139	PF00514	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC50	Leptomonas seymouri	72%	96%
A0A0S4IY52	Bodo saltans	49%	78%
A0A0S4JMB8	Bodo saltans	32%	79%
A0A1X0NHM5	Trypanosomatidae	57%	98%
A0A422N8V0	Trypanosoma rangeli	56%	100%
A4HC32	Leishmania braziliensis	84%	100%
A4HZH4	Leishmania infantum	99%	100%
D0A0Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	95%
E9AVG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QC15	Leishmania major	93%	100%
V5B1W9	Trypanosoma cruzi	54%	99%