Phosphoinositide phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoinositide phosphatase

Species:

Leishmania donovani

UniProt:

A0A3S7WWX6_LEIDO

TriTrypDb:

LdBPK_220120.1 , LdCL_220007300 , LDHU3_22.0390

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWX6

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016311	dephosphorylation	5	9
GO:0044237	cellular metabolic process	2	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004721	phosphoprotein phosphatase activity	3	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016791	phosphatase activity	5	9
GO:0042578	phosphoric ester hydrolase activity	4	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:0042577	lipid phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.358
CLV_PCSK_KEX2_1	113	115	PF00082	0.348
CLV_PCSK_KEX2_1	223	225	PF00082	0.283
CLV_PCSK_KEX2_1	5	7	PF00082	0.455
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.283
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.455
CLV_PCSK_SKI1_1	128	132	PF00082	0.282
CLV_PCSK_SKI1_1	136	140	PF00082	0.276
CLV_PCSK_SKI1_1	50	54	PF00082	0.348
DEG_SPOP_SBC_1	253	257	PF00917	0.439
DOC_CYCLIN_RxL_1	231	241	PF00134	0.282
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.170
DOC_MAPK_gen_1	136	145	PF00069	0.283
DOC_MAPK_gen_1	56	65	PF00069	0.257
DOC_MAPK_MEF2A_6	200	207	PF00069	0.348
DOC_PP2B_LxvP_1	165	168	PF13499	0.289
DOC_PP4_FxxP_1	84	87	PF00568	0.331
DOC_USP7_MATH_1	253	257	PF00917	0.416
DOC_USP7_UBL2_3	124	128	PF12436	0.385
DOC_USP7_UBL2_3	28	32	PF12436	0.295
DOC_USP7_UBL2_3	56	60	PF12436	0.348
DOC_WW_Pin1_4	43	48	PF00397	0.348
DOC_WW_Pin1_4	71	76	PF00397	0.305
LIG_14-3-3_CanoR_1	113	123	PF00244	0.311
LIG_AP2alpha_1	130	134	PF02296	0.269
LIG_BRCT_BRCA1_1	115	119	PF00533	0.326
LIG_FHA_1	115	121	PF00498	0.335
LIG_FHA_1	188	194	PF00498	0.333
LIG_FHA_1	88	94	PF00498	0.363
LIG_FHA_2	161	167	PF00498	0.239
LIG_LIR_Apic_2	248	253	PF02991	0.257
LIG_LIR_Apic_2	82	87	PF02991	0.372
LIG_LIR_Nem_3	122	126	PF02991	0.275
LIG_LIR_Nem_3	215	221	PF02991	0.328
LIG_LIR_Nem_3	82	86	PF02991	0.390
LIG_Pex14_2	119	123	PF04695	0.317
LIG_Pex14_2	130	134	PF04695	0.227
LIG_SH2_CRK	225	229	PF00017	0.283
LIG_SH2_NCK_1	225	229	PF00017	0.133
LIG_SH2_PTP2	250	253	PF00017	0.330
LIG_SH2_STAT5	250	253	PF00017	0.420
LIG_SH2_STAT5	61	64	PF00017	0.348
LIG_SH2_STAT5	83	86	PF00017	0.304
LIG_Sin3_3	157	164	PF02671	0.348
LIG_SUMO_SIM_par_1	6	11	PF11976	0.292
LIG_TYR_ITIM	31	36	PF00017	0.348
LIG_TYR_ITIM	81	86	PF00017	0.334
LIG_UBA3_1	53	60	PF00899	0.348
MOD_CDK_SPxxK_3	43	50	PF00069	0.348
MOD_CK1_1	187	193	PF00069	0.352
MOD_Cter_Amidation	48	51	PF01082	0.348
MOD_GlcNHglycan	106	109	PF01048	0.283
MOD_GSK3_1	251	258	PF00069	0.434
MOD_GSK3_1	87	94	PF00069	0.326
MOD_N-GLC_2	180	182	PF02516	0.348
MOD_NEK2_1	145	150	PF00069	0.247
MOD_NEK2_1	160	165	PF00069	0.231
MOD_NEK2_1	176	181	PF00069	0.246
MOD_NEK2_2	87	92	PF00069	0.383
MOD_OFUCOSY	182	188	PF10250	0.348
MOD_PK_1	224	230	PF00069	0.283
MOD_PKA_1	113	119	PF00069	0.358
MOD_PKA_2	113	119	PF00069	0.411
MOD_PKA_2	251	257	PF00069	0.417
MOD_Plk_4	115	121	PF00069	0.293
MOD_Plk_4	79	85	PF00069	0.417
MOD_ProDKin_1	43	49	PF00069	0.348
MOD_ProDKin_1	71	77	PF00069	0.305
MOD_SUMO_rev_2	116	126	PF00179	0.195
MOD_SUMO_rev_2	44	52	PF00179	0.338
MOD_SUMO_rev_2	64	72	PF00179	0.283
TRG_ENDOCYTIC_2	127	130	PF00928	0.278
TRG_ENDOCYTIC_2	225	228	PF00928	0.254
TRG_ENDOCYTIC_2	33	36	PF00928	0.348
TRG_ENDOCYTIC_2	83	86	PF00928	0.348
TRG_ER_diArg_1	112	114	PF00400	0.356
TRG_NES_CRM1_1	109	125	PF08389	0.348
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V5	Leptomonas seymouri	62%	100%
A0A0N1HYX0	Leptomonas seymouri	31%	100%
A0A0N1PC37	Leptomonas seymouri	33%	100%
A0A0N1PFC3	Leptomonas seymouri	35%	100%
A0A3S7X743	Leishmania donovani	27%	100%
A4HZQ2	Leishmania infantum	99%	100%
A4I9C5	Leishmania infantum	27%	100%
E9AVK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B4C5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
P40289	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	29%	95%
Q4Q3Q1	Leishmania major	29%	100%
Q4QBX1	Leishmania major	93%	100%