SET domain family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWX4_LEIDO

TriTrypDb:

LdBPK_220005.1 , LdCL_220005400 , LDHU3_22.0090

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.502
CLV_C14_Caspase3-7	136	140	PF00656	0.377
CLV_C14_Caspase3-7	178	182	PF00656	0.530
CLV_C14_Caspase3-7	37	41	PF00656	0.547
CLV_NRD_NRD_1	222	224	PF00675	0.334
CLV_PCSK_KEX2_1	222	224	PF00082	0.334
DEG_Nend_Nbox_1	1	3	PF02207	0.443
DOC_CDC14_PxL_1	44	52	PF14671	0.488
DOC_MAPK_FxFP_2	255	258	PF00069	0.586
DOC_MAPK_gen_1	222	229	PF00069	0.586
DOC_MAPK_MEF2A_6	155	162	PF00069	0.510
DOC_PP1_RVXF_1	270	276	PF00149	0.509
DOC_PP4_FxxP_1	186	189	PF00568	0.482
DOC_PP4_FxxP_1	255	258	PF00568	0.586
DOC_PP4_FxxP_1	281	284	PF00568	0.509
DOC_USP7_MATH_1	140	144	PF00917	0.530
DOC_USP7_MATH_1	171	175	PF00917	0.537
DOC_WW_Pin1_4	101	106	PF00397	0.562
DOC_WW_Pin1_4	51	56	PF00397	0.404
DOC_WW_Pin1_4	58	63	PF00397	0.400
LIG_14-3-3_CanoR_1	72	77	PF00244	0.557
LIG_14-3-3_CanoR_1	82	86	PF00244	0.586
LIG_APCC_ABBA_1	207	212	PF00400	0.539
LIG_CaM_NSCaTE_8	63	70	PF13499	0.546
LIG_FHA_1	212	218	PF00498	0.538
LIG_FHA_1	244	250	PF00498	0.529
LIG_FHA_1	71	77	PF00498	0.509
LIG_FHA_2	134	140	PF00498	0.460
LIG_FHA_2	35	41	PF00498	0.554
LIG_FHA_2	73	79	PF00498	0.539
LIG_LIR_Apic_2	183	189	PF02991	0.498
LIG_LIR_Apic_2	253	258	PF02991	0.586
LIG_LIR_Gen_1	18	24	PF02991	0.422
LIG_LIR_Gen_1	92	102	PF02991	0.496
LIG_LIR_LC3C_4	143	146	PF02991	0.530
LIG_LIR_Nem_3	18	22	PF02991	0.508
LIG_LIR_Nem_3	254	260	PF02991	0.480
LIG_LIR_Nem_3	277	282	PF02991	0.469
LIG_LIR_Nem_3	92	98	PF02991	0.502
LIG_LYPXL_yS_3	257	260	PF13949	0.530
LIG_MYND_1	189	193	PF01753	0.496
LIG_PCNA_TLS_4	103	110	PF02747	0.550
LIG_PDZ_Class_3	282	287	PF00595	0.541
LIG_Pex14_1	275	279	PF04695	0.379
LIG_SH2_CRK	19	23	PF00017	0.551
LIG_SH2_PTP2	259	262	PF00017	0.584
LIG_SH2_SRC	19	22	PF00017	0.543
LIG_SH2_SRC	259	262	PF00017	0.471
LIG_SH2_STAP1	269	273	PF00017	0.522
LIG_SH2_STAP1	85	89	PF00017	0.586
LIG_SH2_STAT3	109	112	PF00017	0.586
LIG_SH2_STAT5	109	112	PF00017	0.482
LIG_SH2_STAT5	21	24	PF00017	0.572
LIG_SH2_STAT5	259	262	PF00017	0.516
LIG_SH2_STAT5	49	52	PF00017	0.490
LIG_SH2_STAT5	74	77	PF00017	0.477
LIG_SH3_3	174	180	PF00018	0.496
LIG_SH3_3	9	15	PF00018	0.400
LIG_SH3_3	99	105	PF00018	0.550
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.476
LIG_TRAF2_1	75	78	PF00917	0.534
LIG_TYR_ITIM	17	22	PF00017	0.534
LIG_UBA3_1	229	235	PF00899	0.586
MOD_CK1_1	54	60	PF00069	0.424
MOD_CK2_1	101	107	PF00069	0.562
MOD_CK2_1	72	78	PF00069	0.493
MOD_GlcNHglycan	5	8	PF01048	0.500
MOD_GSK3_1	129	136	PF00069	0.460
MOD_GSK3_1	260	267	PF00069	0.456
MOD_GSK3_1	54	61	PF00069	0.336
MOD_GSK3_1	77	84	PF00069	0.439
MOD_GSK3_1	89	96	PF00069	0.490
MOD_N-GLC_1	205	210	PF02516	0.342
MOD_NEK2_1	211	216	PF00069	0.531
MOD_NEK2_1	268	273	PF00069	0.437
MOD_NEK2_2	205	210	PF00069	0.535
MOD_NEK2_2	34	39	PF00069	0.467
MOD_NEK2_2	90	95	PF00069	0.521
MOD_PKA_1	222	228	PF00069	0.567
MOD_PKA_2	222	228	PF00069	0.516
MOD_PKA_2	243	249	PF00069	0.534
MOD_PKA_2	81	87	PF00069	0.569
MOD_Plk_1	151	157	PF00069	0.535
MOD_Plk_1	205	211	PF00069	0.553
MOD_Plk_1	253	259	PF00069	0.562
MOD_Plk_1	77	83	PF00069	0.481
MOD_Plk_4	140	146	PF00069	0.516
MOD_Plk_4	187	193	PF00069	0.562
MOD_Plk_4	205	211	PF00069	0.461
MOD_Plk_4	264	270	PF00069	0.543
MOD_Plk_4	90	96	PF00069	0.468
MOD_ProDKin_1	101	107	PF00069	0.562
MOD_ProDKin_1	51	57	PF00069	0.407
MOD_ProDKin_1	58	64	PF00069	0.393
TRG_DiLeu_BaEn_1	42	47	PF01217	0.427
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.562
TRG_ENDOCYTIC_2	19	22	PF00928	0.505
TRG_ENDOCYTIC_2	257	260	PF00928	0.491
TRG_ER_diArg_1	221	223	PF00400	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZC8	Leptomonas seymouri	64%	82%
A0A1X0NT21	Trypanosomatidae	41%	100%
A0A3R7M657	Trypanosoma rangeli	39%	100%
A4HC56	Leishmania braziliensis	84%	100%
C9ZSB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AGY4	Leishmania infantum	100%	100%
E9AVI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QBZ0	Leishmania major	96%	100%
V5BB74	Trypanosoma cruzi	38%	99%