Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WWW7_LEIDO

TriTrypDb:

LdBPK_211950.1 , LdCL_210025200 , LDHU3_21.2340

Length:

241

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	92	96	PF00656	0.487
CLV_NRD_NRD_1	129	131	PF00675	0.513
CLV_NRD_NRD_1	220	222	PF00675	0.629
CLV_PCSK_KEX2_1	168	170	PF00082	0.496
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.496
CLV_PCSK_SKI1_1	122	126	PF00082	0.615
CLV_PCSK_SKI1_1	43	47	PF00082	0.526
DEG_Nend_UBRbox_1	1	4	PF02207	0.647
DOC_CKS1_1	231	236	PF01111	0.562
DOC_CYCLIN_RxL_1	130	143	PF00134	0.429
DOC_CYCLIN_yCln2_LP_2	228	234	PF00134	0.487
DOC_MAPK_gen_1	130	140	PF00069	0.494
DOC_MAPK_gen_1	17	25	PF00069	0.597
DOC_SPAK_OSR1_1	193	197	PF12202	0.425
DOC_USP7_MATH_1	30	34	PF00917	0.479
DOC_USP7_MATH_1	85	89	PF00917	0.401
DOC_USP7_UBL2_3	147	151	PF12436	0.497
DOC_USP7_UBL2_3	36	40	PF12436	0.515
DOC_USP7_UBL2_3	43	47	PF12436	0.386
DOC_WW_Pin1_4	230	235	PF00397	0.555
DOC_WW_Pin1_4	24	29	PF00397	0.589
LIG_14-3-3_CanoR_1	211	220	PF00244	0.532
LIG_Actin_WH2_2	110	127	PF00022	0.511
LIG_AP2alpha_1	183	187	PF02296	0.466
LIG_APCC_ABBA_1	196	201	PF00400	0.429
LIG_BRCT_BRCA1_1	110	114	PF00533	0.495
LIG_BRCT_BRCA1_1	65	69	PF00533	0.412
LIG_FHA_1	135	141	PF00498	0.480
LIG_FHA_1	55	61	PF00498	0.492
LIG_LIR_Gen_1	184	194	PF02991	0.468
LIG_LIR_Nem_3	111	117	PF02991	0.507
LIG_LIR_Nem_3	184	190	PF02991	0.470
LIG_LIR_Nem_3	191	197	PF02991	0.402
LIG_PCNA_PIPBox_1	202	211	PF02747	0.368
LIG_Pex14_2	183	187	PF04695	0.466
LIG_Pex14_2	190	194	PF04695	0.389
LIG_SH2_STAT5	162	165	PF00017	0.559
LIG_SH3_3	228	234	PF00018	0.541
LIG_SUMO_SIM_anti_2	137	143	PF11976	0.443
LIG_SUMO_SIM_par_1	76	83	PF11976	0.491
MOD_CDK_SPK_2	230	235	PF00069	0.506
MOD_CK1_1	109	115	PF00069	0.563
MOD_CK1_1	214	220	PF00069	0.481
MOD_CK2_1	129	135	PF00069	0.504
MOD_CK2_1	85	91	PF00069	0.424
MOD_GlcNHglycan	213	216	PF01048	0.519
MOD_GlcNHglycan	82	85	PF01048	0.477
MOD_GlcNHglycan	87	90	PF01048	0.414
MOD_GSK3_1	24	31	PF00069	0.554
MOD_GSK3_1	50	57	PF00069	0.473
MOD_GSK3_1	9	16	PF00069	0.673
MOD_NEK2_1	106	111	PF00069	0.432
MOD_NEK2_1	13	18	PF00069	0.633
MOD_NEK2_1	140	145	PF00069	0.420
MOD_NEK2_1	161	166	PF00069	0.496
MOD_NEK2_1	79	84	PF00069	0.420
MOD_PIKK_1	140	146	PF00454	0.483
MOD_PIKK_1	163	169	PF00454	0.504
MOD_PKA_2	129	135	PF00069	0.504
MOD_PKA_2	54	60	PF00069	0.431
MOD_Plk_1	106	112	PF00069	0.479
MOD_Plk_1	134	140	PF00069	0.493
MOD_Plk_1	174	180	PF00069	0.493
MOD_Plk_1	28	34	PF00069	0.575
MOD_Plk_4	134	140	PF00069	0.372
MOD_ProDKin_1	230	236	PF00069	0.556
MOD_ProDKin_1	24	30	PF00069	0.584
MOD_SUMO_rev_2	119	127	PF00179	0.517
MOD_SUMO_rev_2	153	158	PF00179	0.533
MOD_SUMO_rev_2	200	205	PF00179	0.460
TRG_ENDOCYTIC_2	199	202	PF00928	0.479
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HC21	Leishmania braziliensis	74%	100%
A4HZG4	Leishmania infantum	99%	100%
E9AVF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QC25	Leishmania major	94%	100%