Histone deacetylase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone deacetylase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWW4_LEIDO

TriTrypDb:

LdBPK_081300.1 , LdCL_210028300 , LDHU3_21.2660

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000118	histone deacetylase complex	3	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

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Expansion

Sequence features

A0A3S7WWW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWW4

Function

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Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006476	protein deacetylation	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004407	histone deacetylase activity	4	1
GO:0016787	hydrolase activity	2	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	1
GO:0019213	deacetylase activity	3	1
GO:0033558	protein lysine deacetylase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	390	394	PF00656	0.595
CLV_NRD_NRD_1	153	155	PF00675	0.298
CLV_NRD_NRD_1	310	312	PF00675	0.252
CLV_NRD_NRD_1	373	375	PF00675	0.582
CLV_PCSK_KEX2_1	153	155	PF00082	0.273
CLV_PCSK_KEX2_1	3	5	PF00082	0.648
CLV_PCSK_KEX2_1	373	375	PF00082	0.576
CLV_PCSK_KEX2_1	614	616	PF00082	0.415
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.648
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.452

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R2	Leptomonas seymouri	60%	93%
A0A0S4JEE2	Bodo saltans	34%	100%
A0A1X0NJV3	Trypanosomatidae	47%	96%
A0A422N700	Trypanosoma rangeli	48%	99%
A4HLD0	Leishmania braziliensis	81%	100%
A4HTR2	Leishmania infantum	99%	100%
C9ZIZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	92%
E9AVI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBZ5	Leishmania major	93%	100%
V5BFA4	Trypanosoma cruzi	46%	100%

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