Histone deacetylase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone deacetylase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWW4_LEIDO

TriTrypDb:

LdBPK_081300.1 , LdCL_210028300 , LDHU3_21.2660

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000118	histone deacetylase complex	3	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3S7WWW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWW4

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006476	protein deacetylation	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0016570	histone modification	5	1
GO:0016575	histone deacetylation	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0035601	protein deacylation	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0098732	macromolecule deacylation	5	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004407	histone deacetylase activity	4	1
GO:0016787	hydrolase activity	2	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	1
GO:0019213	deacetylase activity	3	1
GO:0033558	protein lysine deacetylase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	390	394	PF00656	0.595
CLV_NRD_NRD_1	153	155	PF00675	0.298
CLV_NRD_NRD_1	310	312	PF00675	0.252
CLV_NRD_NRD_1	373	375	PF00675	0.582
CLV_PCSK_KEX2_1	153	155	PF00082	0.273
CLV_PCSK_KEX2_1	3	5	PF00082	0.648
CLV_PCSK_KEX2_1	373	375	PF00082	0.576
CLV_PCSK_KEX2_1	614	616	PF00082	0.415
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.648
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.452
CLV_PCSK_SKI1_1	145	149	PF00082	0.304
CLV_PCSK_SKI1_1	207	211	PF00082	0.386
CLV_PCSK_SKI1_1	583	587	PF00082	0.273
DEG_APCC_DBOX_1	518	526	PF00400	0.585
DEG_SCF_FBW7_1	48	55	PF00400	0.698
DEG_SCF_FBW7_2	324	330	PF00400	0.589
DEG_SPOP_SBC_1	406	410	PF00917	0.657
DEG_SPOP_SBC_1	417	421	PF00917	0.666
DEG_SPOP_SBC_1	425	429	PF00917	0.607
DOC_ANK_TNKS_1	176	183	PF00023	0.491
DOC_CDC14_PxL_1	50	58	PF14671	0.698
DOC_CKS1_1	324	329	PF01111	0.440
DOC_CKS1_1	49	54	PF01111	0.698
DOC_CYCLIN_RxL_1	267	277	PF00134	0.513
DOC_CYCLIN_RxL_1	580	589	PF00134	0.448
DOC_CYCLIN_yCln2_LP_2	46	49	PF00134	0.623
DOC_MAPK_gen_1	516	525	PF00069	0.491
DOC_MAPK_MEF2A_6	10	19	PF00069	0.529
DOC_MAPK_MEF2A_6	516	524	PF00069	0.450
DOC_PIKK_1	330	337	PF02985	0.583
DOC_PP2B_LxvP_1	46	49	PF13499	0.732
DOC_PP2B_LxvP_1	56	59	PF13499	0.710
DOC_PP2B_PxIxI_1	268	274	PF00149	0.504
DOC_USP7_MATH_1	354	358	PF00917	0.793
DOC_USP7_MATH_1	366	370	PF00917	0.506
DOC_USP7_MATH_1	407	411	PF00917	0.663
DOC_USP7_MATH_1	417	421	PF00917	0.673
DOC_USP7_MATH_1	57	61	PF00917	0.737
DOC_USP7_MATH_1	575	579	PF00917	0.453
DOC_USP7_MATH_1	69	73	PF00917	0.698
DOC_WW_Pin1_4	108	113	PF00397	0.527
DOC_WW_Pin1_4	323	328	PF00397	0.536
DOC_WW_Pin1_4	449	454	PF00397	0.783
DOC_WW_Pin1_4	478	483	PF00397	0.431
DOC_WW_Pin1_4	48	53	PF00397	0.693
DOC_WW_Pin1_4	540	545	PF00397	0.475
DOC_WW_Pin1_4	622	627	PF00397	0.339
DOC_WW_Pin1_4	64	69	PF00397	0.637
DOC_WW_Pin1_4	84	89	PF00397	0.687
LIG_14-3-3_CanoR_1	122	128	PF00244	0.446
LIG_14-3-3_CanoR_1	311	321	PF00244	0.491
LIG_BIR_III_2	479	483	PF00653	0.518
LIG_BRCT_BRCA1_1	525	529	PF00533	0.448
LIG_Clathr_ClatBox_1	399	403	PF01394	0.611
LIG_EH1_1	547	555	PF00400	0.539
LIG_eIF4E_1	548	554	PF01652	0.539
LIG_FHA_1	282	288	PF00498	0.437
LIG_FHA_1	433	439	PF00498	0.624
LIG_FHA_1	442	448	PF00498	0.530
LIG_FHA_1	468	474	PF00498	0.463
LIG_FHA_1	96	102	PF00498	0.389
LIG_FHA_2	331	337	PF00498	0.591
LIG_FHA_2	456	462	PF00498	0.645
LIG_FHA_2	74	80	PF00498	0.748
LIG_IRF3_LxIS_1	292	298	PF10401	0.539
LIG_LIR_Apic_2	116	120	PF02991	0.293
LIG_LIR_Apic_2	85	89	PF02991	0.565
LIG_LIR_Gen_1	215	224	PF02991	0.479
LIG_LIR_Gen_1	380	388	PF02991	0.537
LIG_LIR_Gen_1	500	511	PF02991	0.448
LIG_LIR_Nem_3	168	173	PF02991	0.501
LIG_LIR_Nem_3	215	221	PF02991	0.498
LIG_LIR_Nem_3	23	28	PF02991	0.536
LIG_LIR_Nem_3	380	384	PF02991	0.535
LIG_LIR_Nem_3	500	506	PF02991	0.448
LIG_MYND_1	40	44	PF01753	0.622
LIG_MYND_1	48	52	PF01753	0.468
LIG_NRBOX	336	342	PF00104	0.715
LIG_SH2_CRK	239	243	PF00017	0.539
LIG_SH2_CRK	381	385	PF00017	0.619
LIG_SH2_NCK_1	117	121	PF00017	0.277
LIG_SH2_NCK_1	239	243	PF00017	0.539
LIG_SH2_NCK_1	289	293	PF00017	0.437
LIG_SH2_SRC	289	292	PF00017	0.448
LIG_SH2_STAP1	102	106	PF00017	0.362
LIG_SH2_STAT5	236	239	PF00017	0.474
LIG_SH2_STAT5	28	31	PF00017	0.484
LIG_SH2_STAT5	503	506	PF00017	0.453
LIG_SH2_STAT5	548	551	PF00017	0.463
LIG_SH3_3	218	224	PF00018	0.475
LIG_SH3_3	34	40	PF00018	0.622
LIG_SH3_3	348	354	PF00018	0.705
LIG_SH3_3	46	52	PF00018	0.634
LIG_SH3_3	507	513	PF00018	0.463
LIG_SUMO_SIM_anti_2	293	298	PF11976	0.448
LIG_SUMO_SIM_anti_2	521	526	PF11976	0.491
LIG_SUMO_SIM_par_1	270	275	PF11976	0.480
LIG_SUMO_SIM_par_1	293	298	PF11976	0.448
LIG_SUMO_SIM_par_1	521	526	PF11976	0.491
LIG_SUMO_SIM_par_1	561	566	PF11976	0.449
LIG_TRAF2_1	328	331	PF00917	0.379
LIG_TRAF2_1	460	463	PF00917	0.652
LIG_TYR_ITIM	379	384	PF00017	0.553
LIG_TYR_ITIM	501	506	PF00017	0.448
MOD_CDK_SPK_2	449	454	PF00069	0.511
MOD_CDK_SPxK_1	323	329	PF00069	0.440
MOD_CDK_SPxxK_3	449	456	PF00069	0.598
MOD_CK1_1	18	24	PF00069	0.610
MOD_CK1_1	188	194	PF00069	0.486
MOD_CK1_1	325	331	PF00069	0.574
MOD_CK1_1	408	414	PF00069	0.587
MOD_CK1_1	415	421	PF00069	0.574
MOD_CK1_1	424	430	PF00069	0.488
MOD_CK1_1	622	628	PF00069	0.489
MOD_CK1_1	72	78	PF00069	0.610
MOD_CK2_1	325	331	PF00069	0.545
MOD_CK2_1	349	355	PF00069	0.699
MOD_CK2_1	445	451	PF00069	0.557
MOD_CK2_1	455	461	PF00069	0.563
MOD_Cter_Amidation	371	374	PF01082	0.736
MOD_GlcNHglycan	20	23	PF01048	0.596
MOD_GlcNHglycan	210	213	PF01048	0.356
MOD_GlcNHglycan	314	317	PF01048	0.366
MOD_GlcNHglycan	341	344	PF01048	0.756
MOD_GlcNHglycan	351	354	PF01048	0.641
MOD_GlcNHglycan	415	418	PF01048	0.643
MOD_GlcNHglycan	423	426	PF01048	0.650
MOD_GlcNHglycan	530	533	PF01048	0.271
MOD_GlcNHglycan	544	547	PF01048	0.261
MOD_GlcNHglycan	587	591	PF01048	0.424
MOD_GlcNHglycan	61	64	PF01048	0.631
MOD_GlcNHglycan	71	74	PF01048	0.591
MOD_GlcNHglycan	89	92	PF01048	0.591
MOD_GSK3_1	185	192	PF00069	0.499
MOD_GSK3_1	208	215	PF00069	0.556
MOD_GSK3_1	405	412	PF00069	0.569
MOD_GSK3_1	413	420	PF00069	0.558
MOD_GSK3_1	421	428	PF00069	0.568
MOD_GSK3_1	441	448	PF00069	0.593
MOD_GSK3_1	48	55	PF00069	0.692
MOD_GSK3_1	536	543	PF00069	0.460
MOD_GSK3_1	69	76	PF00069	0.643
MOD_N-GLC_1	412	417	PF02516	0.728
MOD_N-GLC_1	432	437	PF02516	0.689
MOD_NEK2_1	295	300	PF00069	0.541
MOD_NEK2_1	536	541	PF00069	0.458
MOD_NEK2_1	585	590	PF00069	0.382
MOD_NEK2_2	619	624	PF00069	0.445
MOD_PKA_1	311	317	PF00069	0.491
MOD_PKA_2	176	182	PF00069	0.423
MOD_PKA_2	42	48	PF00069	0.691
MOD_PKA_2	455	461	PF00069	0.719
MOD_Plk_1	102	108	PF00069	0.462
MOD_Plk_1	78	84	PF00069	0.735
MOD_Plk_4	102	108	PF00069	0.453
MOD_Plk_4	176	182	PF00069	0.537
MOD_Plk_4	290	296	PF00069	0.463
MOD_Plk_4	42	48	PF00069	0.624
MOD_Plk_4	605	611	PF00069	0.389
MOD_ProDKin_1	108	114	PF00069	0.537
MOD_ProDKin_1	323	329	PF00069	0.536
MOD_ProDKin_1	449	455	PF00069	0.647
MOD_ProDKin_1	478	484	PF00069	0.431
MOD_ProDKin_1	48	54	PF00069	0.695
MOD_ProDKin_1	540	546	PF00069	0.475
MOD_ProDKin_1	622	628	PF00069	0.356
MOD_ProDKin_1	64	70	PF00069	0.638
MOD_ProDKin_1	84	90	PF00069	0.684
MOD_SUMO_rev_2	607	616	PF00179	0.489
MOD_SUMO_rev_2	7	12	PF00179	0.624
TRG_DiLeu_BaEn_1	502	507	PF01217	0.491
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.614
TRG_ENDOCYTIC_2	239	242	PF00928	0.539
TRG_ENDOCYTIC_2	381	384	PF00928	0.540
TRG_ENDOCYTIC_2	503	506	PF00928	0.471
TRG_ENDOCYTIC_2	547	550	PF00928	0.465
TRG_ER_diArg_1	152	154	PF00400	0.476
TRG_ER_diArg_1	373	376	PF00400	0.625
TRG_ER_diArg_1	453	456	PF00400	0.519
TRG_NLS_MonoExtC_3	2	8	PF00514	0.666
TRG_NLS_MonoExtN_4	2	7	PF00514	0.676
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	270	275	PF00026	0.228
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.248
TRG_Pf-PMV_PEXEL_1	600	605	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R2	Leptomonas seymouri	60%	93%
A0A0S4JEE2	Bodo saltans	34%	100%
A0A1X0NJV3	Trypanosomatidae	47%	96%
A0A422N700	Trypanosoma rangeli	48%	99%
A4HLD0	Leishmania braziliensis	81%	100%
A4HTR2	Leishmania infantum	99%	100%
C9ZIZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	92%
E9AVI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBZ5	Leishmania major	93%	100%
V5BFA4	Trypanosoma cruzi	46%	100%