Vitamin B6 photo-protection and homoeostasis, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vitamin B6 photo-protection and homoeostasis, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWW0_LEIDO

TriTrypDb:

LdBPK_211770.1 , LdCL_210023500 , LDHU3_21.2080

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7WWW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.698
CLV_C14_Caspase3-7	583	587	PF00656	0.700
CLV_C14_Caspase3-7	627	631	PF00656	0.764
CLV_NRD_NRD_1	309	311	PF00675	0.502
CLV_NRD_NRD_1	360	362	PF00675	0.418
CLV_NRD_NRD_1	391	393	PF00675	0.431
CLV_NRD_NRD_1	465	467	PF00675	0.556
CLV_NRD_NRD_1	495	497	PF00675	0.512
CLV_NRD_NRD_1	542	544	PF00675	0.529
CLV_NRD_NRD_1	566	568	PF00675	0.442
CLV_NRD_NRD_1	614	616	PF00675	0.521
CLV_NRD_NRD_1	62	64	PF00675	0.283
CLV_NRD_NRD_1	622	624	PF00675	0.492
CLV_PCSK_FUR_1	540	544	PF00082	0.522
CLV_PCSK_KEX2_1	360	362	PF00082	0.418
CLV_PCSK_KEX2_1	391	393	PF00082	0.447
CLV_PCSK_KEX2_1	441	443	PF00082	0.456
CLV_PCSK_KEX2_1	495	497	PF00082	0.525
CLV_PCSK_KEX2_1	542	544	PF00082	0.577
CLV_PCSK_KEX2_1	566	568	PF00082	0.442
CLV_PCSK_KEX2_1	61	63	PF00082	0.282
CLV_PCSK_KEX2_1	614	616	PF00082	0.549
CLV_PCSK_KEX2_1	622	624	PF00082	0.508
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.456
CLV_PCSK_PC7_1	58	64	PF00082	0.356
CLV_PCSK_SKI1_1	108	112	PF00082	0.249
CLV_PCSK_SKI1_1	188	192	PF00082	0.356
CLV_PCSK_SKI1_1	228	232	PF00082	0.282
CLV_PCSK_SKI1_1	511	515	PF00082	0.468
CLV_PCSK_SKI1_1	551	555	PF00082	0.516
CLV_PCSK_SKI1_1	63	67	PF00082	0.349
CLV_PCSK_SKI1_1	70	74	PF00082	0.287
CLV_PCSK_SKI1_1	99	103	PF00082	0.320
DEG_APCC_DBOX_1	107	115	PF00400	0.483
DEG_COP1_1	426	436	PF00400	0.594
DEG_Nend_Nbox_1	1	3	PF02207	0.647
DEG_SCF_TRCP1_1	205	211	PF00400	0.453
DEG_SCF_TRCP1_1	312	317	PF00400	0.711
DOC_CDC14_PxL_1	335	343	PF14671	0.595
DOC_CKS1_1	45	50	PF01111	0.767
DOC_CYCLIN_RxL_1	331	340	PF00134	0.657
DOC_CYCLIN_RxL_1	67	75	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.483
DOC_MAPK_gen_1	310	318	PF00069	0.710
DOC_MAPK_gen_1	506	514	PF00069	0.667
DOC_MAPK_MEF2A_6	108	116	PF00069	0.483
DOC_MAPK_RevD_3	428	442	PF00069	0.699
DOC_PP1_RVXF_1	288	294	PF00149	0.483
DOC_PP1_RVXF_1	369	375	PF00149	0.600
DOC_PP1_RVXF_1	509	515	PF00149	0.668
DOC_PP2B_LxvP_1	175	178	PF13499	0.472
DOC_PP2B_LxvP_1	286	289	PF13499	0.483
DOC_PP2B_LxvP_1	336	339	PF13499	0.600
DOC_USP7_MATH_1	230	234	PF00917	0.532
DOC_USP7_MATH_1	252	256	PF00917	0.356
DOC_USP7_MATH_1	264	268	PF00917	0.278
DOC_USP7_MATH_1	347	351	PF00917	0.626
DOC_USP7_MATH_1	403	407	PF00917	0.711
DOC_USP7_MATH_1	582	586	PF00917	0.776
DOC_USP7_MATH_1	633	637	PF00917	0.754
DOC_WW_Pin1_4	322	327	PF00397	0.671
DOC_WW_Pin1_4	41	46	PF00397	0.711
DOC_WW_Pin1_4	47	52	PF00397	0.710
DOC_WW_Pin1_4	472	477	PF00397	0.753
DOC_WW_Pin1_4	590	595	PF00397	0.725
DOC_WW_Pin1_4	599	604	PF00397	0.623
LIG_14-3-3_CanoR_1	155	160	PF00244	0.483
LIG_14-3-3_CanoR_1	209	218	PF00244	0.483
LIG_14-3-3_CanoR_1	232	236	PF00244	0.526
LIG_14-3-3_CanoR_1	62	72	PF00244	0.556
LIG_BRCT_BRCA1_1	140	144	PF00533	0.483
LIG_BRCT_BRCA1_1	347	351	PF00533	0.681
LIG_CSL_BTD_1	178	181	PF09270	0.556
LIG_CSL_BTD_1	436	439	PF09270	0.599
LIG_FHA_1	100	106	PF00498	0.380
LIG_FHA_1	134	140	PF00498	0.472
LIG_FHA_1	156	162	PF00498	0.556
LIG_FHA_1	164	170	PF00498	0.485
LIG_FHA_1	23	29	PF00498	0.744
LIG_FHA_1	365	371	PF00498	0.620
LIG_FHA_1	417	423	PF00498	0.671
LIG_FHA_1	605	611	PF00498	0.738
LIG_FHA_1	667	673	PF00498	0.644
LIG_FHA_1	80	86	PF00498	0.483
LIG_FHA_2	447	453	PF00498	0.693
LIG_FHA_2	64	70	PF00498	0.556
LIG_FHA_2	652	658	PF00498	0.752
LIG_GBD_Chelix_1	64	72	PF00786	0.326
LIG_LIR_Gen_1	141	152	PF02991	0.458
LIG_LIR_Gen_1	158	165	PF02991	0.555
LIG_LIR_Gen_1	296	306	PF02991	0.618
LIG_LIR_Gen_1	350	359	PF02991	0.663
LIG_LIR_Gen_1	419	428	PF02991	0.617
LIG_LIR_Gen_1	666	675	PF02991	0.637
LIG_LIR_Nem_3	141	147	PF02991	0.483
LIG_LIR_Nem_3	158	162	PF02991	0.483
LIG_LIR_Nem_3	185	190	PF02991	0.475
LIG_LIR_Nem_3	237	241	PF02991	0.385
LIG_LIR_Nem_3	267	272	PF02991	0.298
LIG_LIR_Nem_3	296	301	PF02991	0.580
LIG_LIR_Nem_3	350	355	PF02991	0.605
LIG_LIR_Nem_3	377	382	PF02991	0.616
LIG_LIR_Nem_3	417	423	PF02991	0.598
LIG_LIR_Nem_3	426	430	PF02991	0.623
LIG_LIR_Nem_3	666	671	PF02991	0.634
LIG_MAD2	70	78	PF02301	0.526
LIG_NRBOX	657	663	PF00104	0.660
LIG_Pex14_1	527	531	PF04695	0.615
LIG_Pex14_2	212	216	PF04695	0.483
LIG_Pex14_2	374	378	PF04695	0.583
LIG_PTB_Apo_2	662	669	PF02174	0.651
LIG_PTB_Phospho_1	662	668	PF10480	0.657
LIG_REV1ctd_RIR_1	376	384	PF16727	0.587
LIG_RPA_C_Fungi	56	68	PF08784	0.282
LIG_SH2_CRK	249	253	PF00017	0.282
LIG_SH2_CRK	275	279	PF00017	0.324
LIG_SH2_CRK	352	356	PF00017	0.570
LIG_SH2_CRK	362	366	PF00017	0.495
LIG_SH2_CRK	536	540	PF00017	0.626
LIG_SH2_CRK	668	672	PF00017	0.518
LIG_SH2_NCK_1	249	253	PF00017	0.282
LIG_SH2_NCK_1	352	356	PF00017	0.467
LIG_SH2_PTP2	421	424	PF00017	0.576
LIG_SH2_STAP1	352	356	PF00017	0.467
LIG_SH2_STAP1	668	672	PF00017	0.518
LIG_SH2_STAT5	362	365	PF00017	0.517
LIG_SH2_STAT5	421	424	PF00017	0.512
LIG_SH2_STAT5	427	430	PF00017	0.491
LIG_SH2_STAT5	5	8	PF00017	0.647
LIG_SH2_STAT5	529	532	PF00017	0.608
LIG_SH2_STAT5	668	671	PF00017	0.519
LIG_SH3_3	175	181	PF00018	0.324
LIG_SH3_3	341	347	PF00018	0.530
LIG_SH3_3	39	45	PF00018	0.731
LIG_SH3_3	419	425	PF00018	0.483
LIG_SH3_3	48	54	PF00018	0.622
LIG_SH3_3	509	515	PF00018	0.584
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.496
LIG_SUMO_SIM_anti_2	333	340	PF11976	0.477
LIG_SUMO_SIM_par_1	24	30	PF11976	0.496
LIG_SUMO_SIM_par_1	320	325	PF11976	0.519
LIG_SUMO_SIM_par_1	333	340	PF11976	0.468
LIG_TYR_ITIM	521	526	PF00017	0.509
LIG_WRC_WIRS_1	235	240	PF05994	0.385
MOD_CDK_SPK_2	322	327	PF00069	0.588
MOD_CK1_1	126	132	PF00069	0.281
MOD_CK1_1	234	240	PF00069	0.365
MOD_CK1_1	325	331	PF00069	0.548
MOD_CK1_1	44	50	PF00069	0.703
MOD_CK1_1	585	591	PF00069	0.729
MOD_CK1_1	602	608	PF00069	0.567
MOD_CK1_1	79	85	PF00069	0.426
MOD_CK2_1	446	452	PF00069	0.637
MOD_CK2_1	63	69	PF00069	0.426
MOD_CK2_1	651	657	PF00069	0.649
MOD_CK2_1	77	83	PF00069	0.253
MOD_Cter_Amidation	493	496	PF01082	0.659
MOD_GlcNHglycan	194	197	PF01048	0.318
MOD_GlcNHglycan	205	208	PF01048	0.220
MOD_GlcNHglycan	266	269	PF01048	0.323
MOD_GlcNHglycan	312	315	PF01048	0.643
MOD_GlcNHglycan	327	330	PF01048	0.352
MOD_GlcNHglycan	347	350	PF01048	0.377
MOD_GlcNHglycan	401	404	PF01048	0.559
MOD_GlcNHglycan	457	460	PF01048	0.560
MOD_GlcNHglycan	476	479	PF01048	0.583
MOD_GlcNHglycan	55	58	PF01048	0.683
MOD_GSK3_1	122	129	PF00069	0.324
MOD_GSK3_1	230	237	PF00069	0.303
MOD_GSK3_1	247	254	PF00069	0.259
MOD_GSK3_1	306	313	PF00069	0.616
MOD_GSK3_1	347	354	PF00069	0.607
MOD_GSK3_1	399	406	PF00069	0.676
MOD_GSK3_1	40	47	PF00069	0.643
MOD_GSK3_1	470	477	PF00069	0.773
MOD_GSK3_1	49	56	PF00069	0.619
MOD_GSK3_1	598	605	PF00069	0.574
MOD_GSK3_1	629	636	PF00069	0.762
MOD_GSK3_1	99	106	PF00069	0.338
MOD_N-GLC_1	559	564	PF02516	0.695
MOD_N-GLC_1	99	104	PF02516	0.426
MOD_NEK2_1	123	128	PF00069	0.294
MOD_NEK2_1	138	143	PF00069	0.394
MOD_NEK2_1	306	311	PF00069	0.635
MOD_NEK2_1	351	356	PF00069	0.627
MOD_NEK2_1	374	379	PF00069	0.486
MOD_NEK2_1	547	552	PF00069	0.538
MOD_NEK2_1	651	656	PF00069	0.685
MOD_NEK2_2	182	187	PF00069	0.311
MOD_NEK2_2	347	352	PF00069	0.618
MOD_NEK2_2	366	371	PF00069	0.388
MOD_PIKK_1	210	216	PF00454	0.282
MOD_PKA_1	310	316	PF00069	0.638
MOD_PKA_2	208	214	PF00069	0.309
MOD_PKA_2	231	237	PF00069	0.385
MOD_PKA_2	455	461	PF00069	0.680
MOD_PKA_2	651	657	PF00069	0.649
MOD_PKB_1	61	69	PF00069	0.385
MOD_Plk_1	416	422	PF00069	0.508
MOD_Plk_1	559	565	PF00069	0.693
MOD_Plk_2-3	426	432	PF00069	0.510
MOD_Plk_4	126	132	PF00069	0.324
MOD_Plk_4	138	144	PF00069	0.324
MOD_Plk_4	182	188	PF00069	0.355
MOD_Plk_4	234	240	PF00069	0.309
MOD_Plk_4	296	302	PF00069	0.533
MOD_Plk_4	314	320	PF00069	0.466
MOD_Plk_4	347	353	PF00069	0.663
MOD_Plk_4	374	380	PF00069	0.496
MOD_Plk_4	416	422	PF00069	0.661
MOD_Plk_4	667	673	PF00069	0.525
MOD_ProDKin_1	322	328	PF00069	0.582
MOD_ProDKin_1	41	47	PF00069	0.645
MOD_ProDKin_1	472	478	PF00069	0.703
MOD_ProDKin_1	590	596	PF00069	0.660
MOD_ProDKin_1	599	605	PF00069	0.514
TRG_DiLeu_BaEn_1	37	42	PF01217	0.715
TRG_DiLeu_BaEn_1	657	662	PF01217	0.583
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.452
TRG_ENDOCYTIC_2	275	278	PF00928	0.324
TRG_ENDOCYTIC_2	298	301	PF00928	0.568
TRG_ENDOCYTIC_2	352	355	PF00928	0.494
TRG_ENDOCYTIC_2	356	359	PF00928	0.455
TRG_ENDOCYTIC_2	420	423	PF00928	0.476
TRG_ENDOCYTIC_2	427	430	PF00928	0.516
TRG_ENDOCYTIC_2	523	526	PF00928	0.505
TRG_ENDOCYTIC_2	531	534	PF00928	0.506
TRG_ENDOCYTIC_2	536	539	PF00928	0.521
TRG_ENDOCYTIC_2	668	671	PF00928	0.519
TRG_ER_diArg_1	359	361	PF00400	0.496
TRG_ER_diArg_1	539	542	PF00400	0.577
TRG_ER_diArg_1	566	568	PF00400	0.547
TRG_ER_diArg_1	61	63	PF00400	0.329
TRG_ER_diArg_1	614	616	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	380	385	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W6	Leptomonas seymouri	53%	98%
A4HZF0	Leishmania infantum	100%	100%
E9AVD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QC42	Leishmania major	88%	100%