Microtubule-binding protein MIP-T3, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Microtubule-binding protein MIP-T3, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWV8_LEIDO

TriTrypDb:

LdBPK_211880.1 , LdCL_210024500 , LDHU3_21.2250

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0030992	intraciliary transport particle B	2	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWV8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0065007	biological regulation	1	1
GO:0070507	regulation of microtubule cytoskeleton organization	5	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005515	protein binding	2	6
GO:0008017	microtubule binding	5	6
GO:0008092	cytoskeletal protein binding	3	6
GO:0015631	tubulin binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.636
CLV_C14_Caspase3-7	55	59	PF00656	0.636
CLV_NRD_NRD_1	125	127	PF00675	0.544
CLV_NRD_NRD_1	167	169	PF00675	0.629
CLV_NRD_NRD_1	174	176	PF00675	0.568
CLV_NRD_NRD_1	223	225	PF00675	0.786
CLV_NRD_NRD_1	239	241	PF00675	0.850
CLV_NRD_NRD_1	333	335	PF00675	0.345
CLV_NRD_NRD_1	428	430	PF00675	0.435
CLV_PCSK_FUR_1	164	168	PF00082	0.741
CLV_PCSK_FUR_1	172	176	PF00082	0.654
CLV_PCSK_KEX2_1	166	168	PF00082	0.631
CLV_PCSK_KEX2_1	172	174	PF00082	0.569
CLV_PCSK_KEX2_1	180	182	PF00082	0.534
CLV_PCSK_KEX2_1	225	227	PF00082	0.725
CLV_PCSK_KEX2_1	273	275	PF00082	0.863
CLV_PCSK_KEX2_1	325	327	PF00082	0.321
CLV_PCSK_KEX2_1	333	335	PF00082	0.321
CLV_PCSK_KEX2_1	428	430	PF00082	0.435
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.767
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.514
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.729
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.863
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.435
CLV_PCSK_PC7_1	168	174	PF00082	0.759
CLV_PCSK_PC7_1	221	227	PF00082	0.869
CLV_PCSK_SKI1_1	314	318	PF00082	0.435
CLV_PCSK_SKI1_1	65	69	PF00082	0.435
DEG_APCC_DBOX_1	378	386	PF00400	0.636
DEG_Nend_UBRbox_2	1	3	PF02207	0.691
DOC_MAPK_gen_1	65	71	PF00069	0.636
DOC_MAPK_RevD_3	311	326	PF00069	0.636
DOC_PP1_RVXF_1	66	72	PF00149	0.636
DOC_USP7_MATH_1	115	119	PF00917	0.523
DOC_USP7_MATH_1	142	146	PF00917	0.865
DOC_USP7_MATH_1	235	239	PF00917	0.699
DOC_USP7_MATH_1	89	93	PF00917	0.538
DOC_USP7_UBL2_3	61	65	PF12436	0.636
DOC_WW_Pin1_4	260	265	PF00397	0.626
DOC_WW_Pin1_4	82	87	PF00397	0.592
LIG_14-3-3_CanoR_1	20	26	PF00244	0.483
LIG_14-3-3_CanoR_1	428	435	PF00244	0.636
LIG_Actin_WH2_2	446	462	PF00022	0.636
LIG_BIR_III_2	261	265	PF00653	0.839
LIG_FHA_1	101	107	PF00498	0.608
LIG_FHA_1	20	26	PF00498	0.636
LIG_FHA_1	227	233	PF00498	0.693
LIG_FHA_1	247	253	PF00498	0.852
LIG_FHA_1	261	267	PF00498	0.577
LIG_FHA_1	302	308	PF00498	0.833
LIG_FHA_1	405	411	PF00498	0.636
LIG_FHA_1	454	460	PF00498	0.636
LIG_FHA_2	158	164	PF00498	0.734
LIG_FHA_2	196	202	PF00498	0.799
LIG_FHA_2	277	283	PF00498	0.765
LIG_FHA_2	6	12	PF00498	0.636
LIG_LIR_Gen_1	105	115	PF02991	0.636
LIG_LIR_Gen_1	287	296	PF02991	0.797
LIG_LIR_Nem_3	105	110	PF02991	0.636
LIG_LIR_Nem_3	287	292	PF02991	0.796
LIG_PCNA_yPIPBox_3	7	16	PF02747	0.636
LIG_SH2_STAT5	33	36	PF00017	0.528
LIG_SH3_1	240	246	PF00018	0.841
LIG_SH3_3	240	246	PF00018	0.724
LIG_TRAF2_1	156	159	PF00917	0.745
LIG_TRAF2_1	160	163	PF00917	0.685
LIG_TRAF2_1	198	201	PF00917	0.870
LIG_TRAF2_1	434	437	PF00917	0.636
LIG_TRAF2_1	96	99	PF00917	0.636
LIG_WRC_WIRS_1	38	43	PF05994	0.580
LIG_WW_3	242	246	PF00397	0.839
MOD_CK1_1	150	156	PF00069	0.752
MOD_CK1_1	212	218	PF00069	0.749
MOD_CK1_1	357	363	PF00069	0.549
MOD_CK2_1	143	149	PF00069	0.869
MOD_CK2_1	157	163	PF00069	0.593
MOD_CK2_1	195	201	PF00069	0.835
MOD_CK2_1	276	282	PF00069	0.773
MOD_CK2_1	431	437	PF00069	0.636
MOD_CK2_1	5	11	PF00069	0.636
MOD_Cter_Amidation	271	274	PF01082	0.857
MOD_GlcNHglycan	117	120	PF01048	0.687
MOD_GlcNHglycan	128	131	PF01048	0.760
MOD_GlcNHglycan	149	152	PF01048	0.761
MOD_GlcNHglycan	211	214	PF01048	0.796
MOD_GlcNHglycan	237	240	PF01048	0.733
MOD_GlcNHglycan	58	61	PF01048	0.380
MOD_GSK3_1	143	150	PF00069	0.703
MOD_GSK3_1	195	202	PF00069	0.836
MOD_GSK3_1	231	238	PF00069	0.756
MOD_GSK3_1	353	360	PF00069	0.615
MOD_GSK3_1	85	92	PF00069	0.592
MOD_NEK2_1	42	47	PF00069	0.634
MOD_NEK2_1	459	464	PF00069	0.619
MOD_NEK2_1	473	478	PF00069	0.453
MOD_PIKK_1	5	11	PF00454	0.582
MOD_PKA_1	126	132	PF00069	0.661
MOD_PKA_1	147	153	PF00069	0.758
MOD_PKA_1	225	231	PF00069	0.827
MOD_PKA_1	428	434	PF00069	0.636
MOD_PKA_2	19	25	PF00069	0.483
MOD_PKA_2	225	231	PF00069	0.772
MOD_PKA_2	428	434	PF00069	0.636
MOD_PKA_2	459	465	PF00069	0.636
MOD_PKA_2	89	95	PF00069	0.538
MOD_PKB_1	224	232	PF00069	0.750
MOD_Plk_1	431	437	PF00069	0.636
MOD_Plk_2-3	278	284	PF00069	0.840
MOD_Plk_4	37	43	PF00069	0.552
MOD_Plk_4	459	465	PF00069	0.636
MOD_Plk_4	473	479	PF00069	0.470
MOD_ProDKin_1	260	266	PF00069	0.628
MOD_ProDKin_1	82	88	PF00069	0.592
MOD_SUMO_rev_2	146	156	PF00179	0.753
MOD_SUMO_rev_2	294	301	PF00179	0.755
MOD_SUMO_rev_2	309	316	PF00179	0.458
MOD_SUMO_rev_2	58	67	PF00179	0.636
TRG_DiLeu_BaEn_1	380	385	PF01217	0.608
TRG_ER_diArg_1	172	175	PF00400	0.601
TRG_NES_CRM1_1	401	416	PF08389	0.636
TRG_NLS_MonoExtC_3	272	278	PF00514	0.861
TRG_NLS_MonoExtN_4	270	277	PF00514	0.858
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HC10	Leishmania braziliensis	79%	99%
A4HZM1	Leishmania infantum	100%	100%
E9AVE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QC32	Leishmania major	95%	100%