Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWV7_LEIDO

TriTrypDb:

LdBPK_211850.1 , LdCL_210024200 , LDHU3_21.2200

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWV7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.601
CLV_NRD_NRD_1	222	224	PF00675	0.632
CLV_PCSK_KEX2_1	185	187	PF00082	0.662
CLV_PCSK_KEX2_1	222	224	PF00082	0.632
CLV_PCSK_KEX2_1	277	279	PF00082	0.623
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.623
CLV_PCSK_SKI1_1	2	6	PF00082	0.653
CLV_PCSK_SKI1_1	244	248	PF00082	0.427
DEG_Nend_UBRbox_1	1	4	PF02207	0.659
DEG_SCF_FBW7_2	4	11	PF00400	0.634
DEG_SPOP_SBC_1	16	20	PF00917	0.651
DEG_SPOP_SBC_1	214	218	PF00917	0.644
DEG_SPOP_SBC_1	24	28	PF00917	0.597
DOC_ANK_TNKS_1	178	185	PF00023	0.621
DOC_CKS1_1	198	203	PF01111	0.586
DOC_CYCLIN_RxL_1	244	255	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.447
DOC_MAPK_gen_1	244	253	PF00069	0.429
DOC_MAPK_MEF2A_6	244	253	PF00069	0.429
DOC_PP4_FxxP_1	306	309	PF00568	0.676
DOC_SPAK_OSR1_1	321	325	PF12202	0.535
DOC_USP7_MATH_1	174	178	PF00917	0.564
DOC_USP7_MATH_1	192	196	PF00917	0.727
DOC_USP7_MATH_1	23	27	PF00917	0.760
DOC_USP7_MATH_1	287	291	PF00917	0.627
DOC_USP7_MATH_1	297	301	PF00917	0.613
DOC_USP7_MATH_1	317	321	PF00917	0.601
DOC_USP7_MATH_1	387	391	PF00917	0.647
DOC_USP7_MATH_1	41	45	PF00917	0.507
DOC_USP7_MATH_1	62	66	PF00917	0.625
DOC_USP7_UBL2_3	2	6	PF12436	0.653
DOC_WW_Pin1_4	170	175	PF00397	0.588
DOC_WW_Pin1_4	197	202	PF00397	0.575
DOC_WW_Pin1_4	208	213	PF00397	0.626
DOC_WW_Pin1_4	215	220	PF00397	0.628
DOC_WW_Pin1_4	272	277	PF00397	0.596
DOC_WW_Pin1_4	283	288	PF00397	0.620
DOC_WW_Pin1_4	311	316	PF00397	0.588
DOC_WW_Pin1_4	350	355	PF00397	0.664
DOC_WW_Pin1_4	4	9	PF00397	0.645
DOC_WW_Pin1_4	408	413	PF00397	0.603
DOC_WW_Pin1_4	89	94	PF00397	0.647
LIG_14-3-3_CanoR_1	278	287	PF00244	0.685
LIG_14-3-3_CanoR_1	321	330	PF00244	0.494
LIG_14-3-3_CanoR_1	405	413	PF00244	0.671
LIG_14-3-3_CanoR_1	416	420	PF00244	0.529
LIG_14-3-3_CanoR_1	46	50	PF00244	0.612
LIG_Actin_WH2_2	68	85	PF00022	0.609
LIG_APCC_ABBA_1	74	79	PF00400	0.617
LIG_BIR_III_2	273	277	PF00653	0.623
LIG_BRCT_BRCA1_1	302	306	PF00533	0.667
LIG_CSL_BTD_1	198	201	PF09270	0.576
LIG_FHA_1	127	133	PF00498	0.404
LIG_FHA_1	152	158	PF00498	0.450
LIG_FHA_2	323	329	PF00498	0.459
LIG_FHA_2	338	344	PF00498	0.626
LIG_HCF-1_HBM_1	123	126	PF13415	0.452
LIG_LIR_Apic_2	303	309	PF02991	0.657
LIG_LIR_Gen_1	103	114	PF02991	0.488
LIG_LIR_Gen_1	255	264	PF02991	0.434
LIG_LIR_Nem_3	103	109	PF02991	0.602
LIG_LIR_Nem_3	255	261	PF02991	0.410
LIG_NRBOX	144	150	PF00104	0.423
LIG_NRBOX	423	429	PF00104	0.520
LIG_SH2_CRK	106	110	PF00017	0.463
LIG_SH2_STAT3	131	134	PF00017	0.465
LIG_SH2_STAT3	426	429	PF00017	0.521
LIG_SH2_STAT5	106	109	PF00017	0.466
LIG_SH2_STAT5	131	134	PF00017	0.451
LIG_SH2_STAT5	426	429	PF00017	0.521
LIG_SH3_3	177	183	PF00018	0.643
LIG_SH3_3	195	201	PF00018	0.580
LIG_SH3_3	265	271	PF00018	0.531
LIG_SH3_3	302	308	PF00018	0.601
LIG_SH3_3	91	97	PF00018	0.627
LIG_TRFH_1	72	76	PF08558	0.621
MOD_CDC14_SPxK_1	275	278	PF00782	0.613
MOD_CDK_SPK_2	272	277	PF00069	0.596
MOD_CDK_SPK_2	4	9	PF00069	0.645
MOD_CDK_SPxK_1	272	278	PF00069	0.599
MOD_CDK_SPxxK_3	215	222	PF00069	0.695
MOD_CK1_1	28	34	PF00069	0.632
MOD_CK1_1	280	286	PF00069	0.644
MOD_CK1_1	300	306	PF00069	0.515
MOD_CK1_1	320	326	PF00069	0.562
MOD_CK1_1	368	374	PF00069	0.677
MOD_CK1_1	380	386	PF00069	0.570
MOD_CK1_1	44	50	PF00069	0.546
MOD_CK1_1	63	69	PF00069	0.476
MOD_CK1_1	92	98	PF00069	0.716
MOD_CK1_1	99	105	PF00069	0.593
MOD_CK2_1	320	326	PF00069	0.523
MOD_Cter_Amidation	183	186	PF01082	0.661
MOD_GlcNHglycan	174	177	PF01048	0.627
MOD_GlcNHglycan	194	197	PF01048	0.565
MOD_GlcNHglycan	206	209	PF01048	0.633
MOD_GlcNHglycan	282	285	PF01048	0.752
MOD_GlcNHglycan	289	292	PF01048	0.636
MOD_GlcNHglycan	299	302	PF01048	0.536
MOD_GlcNHglycan	374	377	PF01048	0.643
MOD_GlcNHglycan	379	382	PF01048	0.601
MOD_GlcNHglycan	401	404	PF01048	0.679
MOD_GlcNHglycan	406	409	PF01048	0.720
MOD_GlcNHglycan	62	65	PF01048	0.638
MOD_GlcNHglycan	89	92	PF01048	0.614
MOD_GSK3_1	11	18	PF00069	0.658
MOD_GSK3_1	140	147	PF00069	0.432
MOD_GSK3_1	170	177	PF00069	0.534
MOD_GSK3_1	204	211	PF00069	0.619
MOD_GSK3_1	213	220	PF00069	0.623
MOD_GSK3_1	24	31	PF00069	0.576
MOD_GSK3_1	283	290	PF00069	0.642
MOD_GSK3_1	368	375	PF00069	0.662
MOD_GSK3_1	399	406	PF00069	0.800
MOD_GSK3_1	41	48	PF00069	0.775
MOD_GSK3_1	58	65	PF00069	0.503
MOD_GSK3_1	85	92	PF00069	0.616
MOD_GSK3_1	96	103	PF00069	0.473
MOD_N-GLC_1	126	131	PF02516	0.426
MOD_N-GLC_1	192	197	PF02516	0.645
MOD_N-GLC_1	214	219	PF02516	0.633
MOD_N-GLC_1	24	29	PF02516	0.638
MOD_N-GLC_1	251	256	PF02516	0.508
MOD_NEK2_1	204	209	PF00069	0.622
MOD_NEK2_1	251	256	PF00069	0.508
MOD_NEK2_1	372	377	PF00069	0.651
MOD_NEK2_1	427	432	PF00069	0.521
MOD_NEK2_2	126	131	PF00069	0.426
MOD_PIKK_1	300	306	PF00454	0.670
MOD_PIKK_1	387	393	PF00454	0.700
MOD_PIKK_1	41	47	PF00454	0.590
MOD_PIKK_1	92	98	PF00454	0.599
MOD_PKA_1	185	191	PF00069	0.661
MOD_PKA_1	277	283	PF00069	0.690
MOD_PKA_2	185	191	PF00069	0.633
MOD_PKA_2	204	210	PF00069	0.500
MOD_PKA_2	277	283	PF00069	0.742
MOD_PKA_2	320	326	PF00069	0.523
MOD_PKA_2	372	378	PF00069	0.635
MOD_PKA_2	404	410	PF00069	0.674
MOD_PKA_2	415	421	PF00069	0.529
MOD_PKA_2	45	51	PF00069	0.645
MOD_Plk_1	126	132	PF00069	0.427
MOD_Plk_1	387	393	PF00069	0.647
MOD_Plk_1	53	59	PF00069	0.579
MOD_Plk_2-3	420	426	PF00069	0.528
MOD_Plk_4	104	110	PF00069	0.472
MOD_Plk_4	11	17	PF00069	0.600
MOD_Plk_4	140	146	PF00069	0.433
MOD_Plk_4	152	158	PF00069	0.568
MOD_Plk_4	308	314	PF00069	0.672
MOD_ProDKin_1	170	176	PF00069	0.593
MOD_ProDKin_1	197	203	PF00069	0.580
MOD_ProDKin_1	208	214	PF00069	0.627
MOD_ProDKin_1	215	221	PF00069	0.629
MOD_ProDKin_1	272	278	PF00069	0.599
MOD_ProDKin_1	283	289	PF00069	0.620
MOD_ProDKin_1	311	317	PF00069	0.587
MOD_ProDKin_1	350	356	PF00069	0.658
MOD_ProDKin_1	4	10	PF00069	0.645
MOD_ProDKin_1	408	414	PF00069	0.602
MOD_ProDKin_1	89	95	PF00069	0.645
MOD_SUMO_for_1	8	11	PF00179	0.554
TRG_DiLeu_BaEn_1	11	16	PF01217	0.607
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.596
TRG_ENDOCYTIC_2	106	109	PF00928	0.466
TRG_ENDOCYTIC_2	258	261	PF00928	0.392
TRG_ER_diArg_1	160	163	PF00400	0.453
TRG_ER_diArg_1	222	225	PF00400	0.633
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K6	Leptomonas seymouri	57%	100%
A4HC07	Leishmania braziliensis	83%	100%
A4HZG3	Leishmania infantum	100%	100%
E9AVE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	97%
Q4QC35	Leishmania major	95%	100%