Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WWV6_LEIDO

TriTrypDb:

LdBPK_220003.1 , LdCL_220005200 , LDHU3_22.0060

Length:

144

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.521
CLV_NRD_NRD_1	133	135	PF00675	0.524
CLV_NRD_NRD_1	82	84	PF00675	0.617
CLV_NRD_NRD_1	86	88	PF00675	0.528
CLV_PCSK_KEX2_1	133	135	PF00082	0.524
CLV_PCSK_KEX2_1	88	90	PF00082	0.640
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.640
CLV_PCSK_SKI1_1	134	138	PF00082	0.524
DOC_CYCLIN_yCln2_LP_2	109	112	PF00134	0.640
DOC_MAPK_gen_1	83	93	PF00069	0.599
DOC_MAPK_MEF2A_6	18	26	PF00069	0.533
DOC_PP2B_LxvP_1	109	112	PF13499	0.566
DOC_PP4_FxxP_1	108	111	PF00568	0.763
DOC_PP4_FxxP_1	127	130	PF00568	0.560
DOC_USP7_MATH_1	30	34	PF00917	0.607
DOC_USP7_UBL2_3	84	88	PF12436	0.569
DOC_WW_Pin1_4	25	30	PF00397	0.634
DOC_WW_Pin1_4	94	99	PF00397	0.649
LIG_14-3-3_CanoR_1	40	46	PF00244	0.596
LIG_APCC_ABBAyCdc20_2	123	129	PF00400	0.437
LIG_BIR_II_1	1	5	PF00653	0.663
LIG_BRCT_BRCA1_1	104	108	PF00533	0.559
LIG_FHA_1	130	136	PF00498	0.584
LIG_FHA_1	21	27	PF00498	0.519
LIG_FHA_2	111	117	PF00498	0.581
LIG_LIR_Apic_2	105	111	PF02991	0.583
LIG_LIR_Nem_3	33	38	PF02991	0.535
LIG_LIR_Nem_3	75	81	PF02991	0.525
LIG_LYPXL_SIV_4	37	45	PF13949	0.554
LIG_SH2_CRK	38	42	PF00017	0.481
LIG_SH2_STAP1	78	82	PF00017	0.572
LIG_SH2_STAT3	49	52	PF00017	0.558
LIG_SH2_STAT5	49	52	PF00017	0.617
LIG_SH2_STAT5	81	84	PF00017	0.540
LIG_SH3_2	7	12	PF14604	0.490
LIG_SH3_3	4	10	PF00018	0.600
LIG_SH3_3	79	85	PF00018	0.597
LIG_SH3_4	84	91	PF00018	0.633
LIG_SUMO_SIM_par_1	22	28	PF11976	0.558
LIG_TYR_ITIM	36	41	PF00017	0.489
MOD_CK1_1	28	34	PF00069	0.685
MOD_CK2_1	94	100	PF00069	0.610
MOD_GSK3_1	125	132	PF00069	0.626
MOD_GSK3_1	40	47	PF00069	0.592
MOD_GSK3_1	68	75	PF00069	0.585
MOD_PIKK_1	110	116	PF00454	0.586
MOD_PIKK_1	60	66	PF00454	0.532
MOD_PKA_1	83	89	PF00069	0.618
MOD_PKA_2	68	74	PF00069	0.591
MOD_Plk_4	73	79	PF00069	0.522
MOD_ProDKin_1	25	31	PF00069	0.633
MOD_ProDKin_1	94	100	PF00069	0.649
TRG_ENDOCYTIC_2	38	41	PF00928	0.488
TRG_ER_diArg_1	133	135	PF00400	0.524
TRG_NLS_MonoExtN_4	84	91	PF00514	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS75	Leptomonas seymouri	80%	99%
A0A1X0NT17	Trypanosomatidae	56%	100%
A0A422MUD0	Trypanosoma rangeli	47%	100%
A4HC53	Leishmania braziliensis	83%	100%
E9AGY2	Leishmania infantum	100%	100%
E9AVI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QBZ2	Leishmania major	88%	100%