2-oxoisovalerate dehydrogenase subunit alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2-oxoisovalerate dehydrogenase alpha subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWV0_LEIDO

TriTrypDb:

LdBPK_211670.1 , LdCL_210022500 , LDHU3_21.1980

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex	4	1
GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045239	tricarboxylic acid cycle enzyme complex	3	1
GO:0045240	dihydrolipoyl dehydrogenase complex	4	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1990204	oxidoreductase complex	3	1

Expansion

Sequence features

A0A3S7WWV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWV0

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	11
GO:0006520	amino acid metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009063	amino acid catabolic process	4	11
GO:0009081	branched-chain amino acid metabolic process	4	11
GO:0009083	branched-chain amino acid catabolic process	5	11
GO:0009987	cellular process	1	11
GO:0016054	organic acid catabolic process	4	11
GO:0019752	carboxylic acid metabolic process	5	11
GO:0043436	oxoacid metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044282	small molecule catabolic process	3	11
GO:0046395	carboxylic acid catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901565	organonitrogen compound catabolic process	4	11
GO:1901575	organic substance catabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003863	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	5	11
GO:0016491	oxidoreductase activity	2	11
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	4	11
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.586
CLV_C14_Caspase3-7	335	339	PF00656	0.515
CLV_C14_Caspase3-7	37	41	PF00656	0.564
CLV_C14_Caspase3-7	74	78	PF00656	0.647
CLV_NRD_NRD_1	251	253	PF00675	0.307
CLV_NRD_NRD_1	346	348	PF00675	0.284
CLV_NRD_NRD_1	423	425	PF00675	0.307
CLV_NRD_NRD_1	431	433	PF00675	0.272
CLV_PCSK_FUR_1	421	425	PF00082	0.210
CLV_PCSK_KEX2_1	217	219	PF00082	0.293
CLV_PCSK_KEX2_1	251	253	PF00082	0.314
CLV_PCSK_KEX2_1	423	425	PF00082	0.302
CLV_PCSK_KEX2_1	431	433	PF00082	0.281
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.293
CLV_PCSK_SKI1_1	136	140	PF00082	0.353
CLV_PCSK_SKI1_1	358	362	PF00082	0.311
CLV_PCSK_SKI1_1	424	428	PF00082	0.327
DEG_APCC_DBOX_1	423	431	PF00400	0.410
DEG_Nend_Nbox_1	1	3	PF02207	0.657
DEG_SCF_FBW7_1	307	313	PF00400	0.473
DEG_SCF_FBW7_2	452	457	PF00400	0.555
DEG_SPOP_SBC_1	42	46	PF00917	0.647
DOC_CKS1_1	307	312	PF01111	0.459
DOC_CKS1_1	409	414	PF01111	0.511
DOC_MAPK_gen_1	347	354	PF00069	0.511
DOC_PP1_RVXF_1	144	150	PF00149	0.459
DOC_USP7_MATH_1	310	314	PF00917	0.489
DOC_USP7_MATH_1	380	384	PF00917	0.539
DOC_USP7_MATH_1	412	416	PF00917	0.511
DOC_USP7_MATH_1	469	473	PF00917	0.580
DOC_USP7_MATH_1	83	87	PF00917	0.753
DOC_WW_Pin1_4	223	228	PF00397	0.490
DOC_WW_Pin1_4	306	311	PF00397	0.451
DOC_WW_Pin1_4	392	397	PF00397	0.471
DOC_WW_Pin1_4	408	413	PF00397	0.442
DOC_WW_Pin1_4	450	455	PF00397	0.427
DOC_WW_Pin1_4	81	86	PF00397	0.682
LIG_14-3-3_CanoR_1	146	150	PF00244	0.459
LIG_14-3-3_CanoR_1	20	30	PF00244	0.591
LIG_14-3-3_CanoR_1	266	272	PF00244	0.534
LIG_APCC_ABBA_1	151	156	PF00400	0.539
LIG_APCC_Cbox_1	401	407	PF00515	0.438
LIG_CSL_BTD_1	409	412	PF09270	0.490
LIG_FHA_1	111	117	PF00498	0.610
LIG_FHA_1	253	259	PF00498	0.410
LIG_FHA_1	364	370	PF00498	0.521
LIG_FHA_1	414	420	PF00498	0.430
LIG_FHA_1	43	49	PF00498	0.516
LIG_FHA_1	451	457	PF00498	0.488
LIG_FHA_2	187	193	PF00498	0.484
LIG_FHA_2	259	265	PF00498	0.563
LIG_FHA_2	372	378	PF00498	0.498
LIG_FHA_2	420	426	PF00498	0.501
LIG_FHA_2	441	447	PF00498	0.491
LIG_FHA_2	47	53	PF00498	0.545
LIG_FHA_2	85	91	PF00498	0.669
LIG_GBD_Chelix_1	361	369	PF00786	0.363
LIG_LIR_Apic_2	406	412	PF02991	0.508
LIG_LIR_Gen_1	148	158	PF02991	0.514
LIG_LIR_Gen_1	398	405	PF02991	0.512
LIG_LIR_Gen_1	446	456	PF02991	0.486
LIG_LIR_Nem_3	171	177	PF02991	0.459
LIG_LIR_Nem_3	184	188	PF02991	0.459
LIG_LIR_Nem_3	392	397	PF02991	0.468
LIG_LIR_Nem_3	398	403	PF02991	0.470
LIG_LIR_Nem_3	446	452	PF02991	0.513
LIG_PDZ_Class_3	474	479	PF00595	0.615
LIG_Pex14_1	34	38	PF04695	0.498
LIG_Pex14_2	390	394	PF04695	0.473
LIG_PTB_Apo_2	299	306	PF02174	0.474
LIG_PTB_Apo_2	32	39	PF02174	0.517
LIG_PTB_Phospho_1	299	305	PF10480	0.474
LIG_REV1ctd_RIR_1	296	305	PF16727	0.539
LIG_SH2_CRK	327	331	PF00017	0.473
LIG_SH2_CRK	343	347	PF00017	0.473
LIG_SH2_NCK_1	188	192	PF00017	0.533
LIG_SH2_SRC	305	308	PF00017	0.490
LIG_SH2_STAP1	240	244	PF00017	0.473
LIG_SH2_STAT5	188	191	PF00017	0.473
LIG_SH3_3	221	227	PF00018	0.498
LIG_SH3_3	434	440	PF00018	0.422
LIG_SH3_3	53	59	PF00018	0.530
LIG_SUMO_SIM_par_1	358	363	PF11976	0.459
MOD_CDK_SPxxK_3	392	399	PF00069	0.475
MOD_CK1_1	114	120	PF00069	0.581
MOD_CK1_1	308	314	PF00069	0.450
MOD_CK1_1	370	376	PF00069	0.462
MOD_CK1_1	46	52	PF00069	0.544
MOD_CK2_1	166	172	PF00069	0.539
MOD_CK2_1	186	192	PF00069	0.327
MOD_CK2_1	258	264	PF00069	0.563
MOD_CK2_1	380	386	PF00069	0.490
MOD_CK2_1	392	398	PF00069	0.490
MOD_CK2_1	419	425	PF00069	0.501
MOD_CK2_1	84	90	PF00069	0.677
MOD_GlcNHglycan	125	128	PF01048	0.419
MOD_GlcNHglycan	77	80	PF01048	0.690
MOD_GlcNHglycan	97	100	PF01048	0.671
MOD_GSK3_1	110	117	PF00069	0.474
MOD_GSK3_1	123	130	PF00069	0.350
MOD_GSK3_1	145	152	PF00069	0.450
MOD_GSK3_1	223	230	PF00069	0.459
MOD_GSK3_1	254	261	PF00069	0.553
MOD_GSK3_1	287	294	PF00069	0.473
MOD_GSK3_1	306	313	PF00069	0.355
MOD_GSK3_1	363	370	PF00069	0.472
MOD_GSK3_1	371	378	PF00069	0.442
MOD_GSK3_1	408	415	PF00069	0.459
MOD_GSK3_1	42	49	PF00069	0.507
MOD_GSK3_1	91	98	PF00069	0.677
MOD_LATS_1	108	114	PF00433	0.473
MOD_NEK2_1	149	154	PF00069	0.457
MOD_NEK2_1	2	7	PF00069	0.635
MOD_NEK2_1	258	263	PF00069	0.560
MOD_NEK2_1	288	293	PF00069	0.487
MOD_NEK2_1	390	395	PF00069	0.539
MOD_NEK2_2	145	150	PF00069	0.459
MOD_NEK2_2	293	298	PF00069	0.473
MOD_NEK2_2	469	474	PF00069	0.503
MOD_PIKK_1	227	233	PF00454	0.469
MOD_PIKK_1	310	316	PF00454	0.489
MOD_PKA_2	145	151	PF00069	0.459
MOD_PKA_2	19	25	PF00069	0.602
MOD_PKA_2	367	373	PF00069	0.479
MOD_Plk_1	110	116	PF00069	0.563
MOD_Plk_1	376	382	PF00069	0.475
MOD_Plk_4	111	117	PF00069	0.537
MOD_Plk_4	149	155	PF00069	0.533
MOD_Plk_4	254	260	PF00069	0.542
MOD_Plk_4	267	273	PF00069	0.493
MOD_Plk_4	293	299	PF00069	0.459
MOD_ProDKin_1	223	229	PF00069	0.490
MOD_ProDKin_1	306	312	PF00069	0.451
MOD_ProDKin_1	392	398	PF00069	0.471
MOD_ProDKin_1	408	414	PF00069	0.442
MOD_ProDKin_1	450	456	PF00069	0.420
MOD_ProDKin_1	81	87	PF00069	0.683
MOD_SUMO_for_1	109	112	PF00179	0.552
TRG_AP2beta_CARGO_1	398	407	PF09066	0.507
TRG_ENDOCYTIC_2	150	153	PF00928	0.539
TRG_ENDOCYTIC_2	343	346	PF00928	0.511
TRG_ER_diArg_1	251	253	PF00400	0.507
TRG_ER_diArg_1	381	384	PF00400	0.490
TRG_ER_diArg_1	421	424	PF00400	0.504
TRG_ER_diArg_1	430	432	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY9	Leptomonas seymouri	26%	100%
A0A0N1P9U6	Leptomonas seymouri	76%	100%
A0A1X0NHX6	Trypanosomatidae	53%	100%
A0A3Q8IB83	Leishmania donovani	26%	100%
A0A3R7KFA1	Trypanosoma rangeli	26%	100%
A0A422NSQ8	Trypanosoma rangeli	52%	100%
A4H9P1	Leishmania braziliensis	28%	100%
A4HC14	Leishmania braziliensis	85%	100%
A4HY08	Leishmania infantum	26%	100%
A4HZE0	Leishmania infantum	100%	100%
A5A6H9	Pan troglodytes	43%	100%
A7MB35	Bos taurus	26%	100%
D0A145	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ARS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AVC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O24457	Arabidopsis thaliana	23%	100%
O31404	Bacillus subtilis (strain 168)	28%	100%
O45924	Caenorhabditis elegans	47%	100%
P09060	Pseudomonas putida	31%	100%
P11178	Bos taurus	43%	100%
P11960	Rattus norvegicus	44%	100%
P12694	Homo sapiens	44%	100%
P21873	Geobacillus stearothermophilus	29%	100%
P21881	Bacillus subtilis (strain 168)	31%	100%
P26267	Ascaris suum	25%	100%
P26268	Ascaris suum	25%	100%
P26284	Rattus norvegicus	25%	100%
P29804	Sus scrofa	26%	100%
P35485	Acholeplasma laidlawii	28%	100%
P47516	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	28%	100%
P50136	Mus musculus	43%	100%
P51267	Porphyra purpurea	28%	100%
P52900	Sminthopsis macroura	24%	100%
P60089	Staphylococcus aureus (strain Mu50 / ATCC 700699)	29%	100%
P60090	Staphylococcus aureus (strain MW2)	29%	100%
P75390	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	28%	100%
P9WIS2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	35%	100%
P9WIS3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	35%	100%
Q06437	Rattus norvegicus	23%	100%
Q4MTG0	Bacillus cereus	30%	100%
Q4QC52	Leishmania major	94%	100%
Q4QDQ1	Leishmania major	26%	100%
Q54M22	Dictyostelium discoideum	45%	100%
Q5HGZ1	Staphylococcus aureus (strain COL)	29%	100%
Q5HQ76	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	30%	100%
Q5SLR4	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	35%	100%
Q654V6	Oryza sativa subsp. japonica	25%	100%
Q6GAC1	Staphylococcus aureus (strain MSSA476)	29%	100%
Q6GHZ2	Staphylococcus aureus (strain MRSA252)	29%	100%
Q72GU1	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	35%	100%
Q7XTJ3	Oryza sativa subsp. japonica	26%	100%
Q820A6	Staphylococcus aureus (strain N315)	29%	100%
Q84JL2	Arabidopsis thaliana	43%	100%
Q8CPN3	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	30%	100%
Q8HXY4	Macaca fascicularis	43%	100%
Q9I1M2	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	35%	100%
Q9LPL5	Arabidopsis thaliana	45%	100%
V5AZ52	Trypanosoma cruzi	26%	100%
V5DIA0	Trypanosoma cruzi	52%	100%