Peroxisomal membrane protein PEX14

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxin 14

Species:

Leishmania donovani

UniProt:

A0A3S7WWU5_LEIDO

TriTrypDb:

LdBPK_212210.1 , LdCL_210027800 , LDHU3_21.2620

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	9
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	9
GO:0031903	microbody membrane	5	9
GO:0042579	microbody	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0098588	bounding membrane of organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0032991	protein-containing complex	1	1
GO:1990351	transporter complex	2	1
GO:1990429	peroxisomal importomer complex	3	1

Expansion

Sequence features

A0A3S7WWU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWU5

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	9
GO:0009987	cellular process	1	9
GO:0016560	protein import into peroxisome matrix, docking	5	9
GO:0033036	macromolecule localization	2	9
GO:0051179	localization	1	9
GO:0051641	cellular localization	2	9
GO:0070727	cellular macromolecule localization	3	9

Molecular functions
Term	Name	Level	Count
GO:0005102	signaling receptor binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.697
CLV_C14_Caspase3-7	26	30	PF00656	0.586
CLV_NRD_NRD_1	182	184	PF00675	0.559
CLV_NRD_NRD_1	268	270	PF00675	0.532
CLV_NRD_NRD_1	47	49	PF00675	0.356
CLV_PCSK_FUR_1	45	49	PF00082	0.340
CLV_PCSK_KEX2_1	182	184	PF00082	0.598
CLV_PCSK_KEX2_1	252	254	PF00082	0.458
CLV_PCSK_KEX2_1	47	49	PF00082	0.356
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.458
CLV_PCSK_SKI1_1	262	266	PF00082	0.518
CLV_PCSK_SKI1_1	56	60	PF00082	0.376
CLV_PCSK_SKI1_1	69	73	PF00082	0.347
CLV_PCSK_SKI1_1	77	81	PF00082	0.464
DOC_ANK_TNKS_1	152	159	PF00023	0.436
DOC_MAPK_gen_1	269	277	PF00069	0.433
DOC_PP1_RVXF_1	146	153	PF00149	0.498
DOC_PP2B_LxvP_1	13	16	PF13499	0.630
DOC_PP2B_LxvP_1	225	228	PF13499	0.569
DOC_USP7_MATH_1	23	27	PF00917	0.593
DOC_USP7_MATH_1	235	239	PF00917	0.584
DOC_USP7_MATH_1	50	54	PF00917	0.325
DOC_USP7_UBL2_3	184	188	PF12436	0.630
DOC_WW_Pin1_4	103	108	PF00397	0.778
DOC_WW_Pin1_4	121	126	PF00397	0.637
DOC_WW_Pin1_4	134	139	PF00397	0.557
DOC_WW_Pin1_4	174	179	PF00397	0.463
DOC_WW_Pin1_4	213	218	PF00397	0.753
DOC_WW_Pin1_4	240	245	PF00397	0.595
DOC_WW_Pin1_4	351	356	PF00397	0.660
DOC_WW_Pin1_4	376	381	PF00397	0.691
DOC_WW_Pin1_4	422	427	PF00397	0.666
DOC_WW_Pin1_4	456	461	PF00397	0.780
DOC_WW_Pin1_4	46	51	PF00397	0.291
LIG_14-3-3_CanoR_1	145	151	PF00244	0.751
LIG_14-3-3_CanoR_1	182	191	PF00244	0.637
LIG_14-3-3_CanoR_1	295	303	PF00244	0.539
LIG_14-3-3_CanoR_1	77	84	PF00244	0.502
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_BRCT_BRCA1_1	337	341	PF00533	0.668
LIG_EABR_CEP55_1	332	341	PF12180	0.529
LIG_EVH1_1	225	229	PF00568	0.623
LIG_FHA_1	103	109	PF00498	0.617
LIG_FHA_1	128	134	PF00498	0.683
LIG_FHA_1	145	151	PF00498	0.585
LIG_FHA_1	246	252	PF00498	0.566
LIG_FHA_1	295	301	PF00498	0.541
LIG_FHA_1	395	401	PF00498	0.730
LIG_FHA_2	254	260	PF00498	0.512
LIG_FHA_2	322	328	PF00498	0.579
LIG_FHA_2	344	350	PF00498	0.777
LIG_FHA_2	434	440	PF00498	0.603
LIG_LIR_Nem_3	149	155	PF02991	0.512
LIG_LIR_Nem_3	165	170	PF02991	0.433
LIG_LIR_Nem_3	338	344	PF02991	0.678
LIG_MLH1_MIPbox_1	337	341	PF16413	0.668
LIG_MYND_1	223	227	PF01753	0.554
LIG_MYND_1	414	418	PF01753	0.503
LIG_SH2_NCK_1	427	431	PF00017	0.523
LIG_SH2_SRC	427	430	PF00017	0.582
LIG_SH2_STAP1	129	133	PF00017	0.667
LIG_SH2_STAP1	427	431	PF00017	0.523
LIG_SH2_STAT5	129	132	PF00017	0.670
LIG_SH2_STAT5	340	343	PF00017	0.685
LIG_SH3_3	132	138	PF00018	0.682
LIG_SH3_3	17	23	PF00018	0.654
LIG_SH3_3	220	226	PF00018	0.625
LIG_SH3_3	3	9	PF00018	0.693
LIG_SH3_3	331	337	PF00018	0.753
LIG_SH3_3	369	375	PF00018	0.766
LIG_SH3_3	377	383	PF00018	0.714
LIG_SH3_3	387	393	PF00018	0.768
LIG_SH3_3	411	417	PF00018	0.631
LIG_SH3_3	437	443	PF00018	0.754
LIG_SH3_3	84	90	PF00018	0.581
LIG_WW_2	223	226	PF00397	0.559
MOD_CDK_SPxK_1	213	219	PF00069	0.631
MOD_CK1_1	165	171	PF00069	0.354
MOD_CK1_1	206	212	PF00069	0.675
MOD_CK1_1	240	246	PF00069	0.543
MOD_CK1_1	343	349	PF00069	0.686
MOD_CK1_1	359	365	PF00069	0.680
MOD_CK2_1	174	180	PF00069	0.469
MOD_CK2_1	204	210	PF00069	0.637
MOD_CK2_1	21	27	PF00069	0.673
MOD_CK2_1	321	327	PF00069	0.610
MOD_CK2_1	343	349	PF00069	0.778
MOD_CK2_1	433	439	PF00069	0.650
MOD_CK2_1	46	52	PF00069	0.358
MOD_GlcNHglycan	108	111	PF01048	0.600
MOD_GlcNHglycan	164	167	PF01048	0.484
MOD_GlcNHglycan	200	203	PF01048	0.673
MOD_GlcNHglycan	206	209	PF01048	0.740
MOD_GlcNHglycan	239	242	PF01048	0.577
MOD_GlcNHglycan	277	280	PF01048	0.509
MOD_GlcNHglycan	315	318	PF01048	0.580
MOD_GlcNHglycan	35	38	PF01048	0.348
MOD_GlcNHglycan	361	364	PF01048	0.717
MOD_GlcNHglycan	405	408	PF01048	0.602
MOD_GSK3_1	182	189	PF00069	0.635
MOD_GSK3_1	194	201	PF00069	0.705
MOD_GSK3_1	204	211	PF00069	0.664
MOD_GSK3_1	29	36	PF00069	0.301
MOD_GSK3_1	336	343	PF00069	0.638
MOD_GSK3_1	351	358	PF00069	0.594
MOD_GSK3_1	361	368	PF00069	0.665
MOD_GSK3_1	46	53	PF00069	0.308
MOD_GSK3_1	99	106	PF00069	0.652
MOD_NEK2_1	275	280	PF00069	0.415
MOD_NEK2_1	41	46	PF00069	0.340
MOD_NEK2_2	129	134	PF00069	0.637
MOD_PIKK_1	127	133	PF00454	0.653
MOD_PIKK_1	294	300	PF00454	0.468
MOD_PIKK_1	319	325	PF00454	0.632
MOD_PIKK_1	50	56	PF00454	0.400
MOD_PK_1	83	89	PF00069	0.541
MOD_PKA_1	182	188	PF00069	0.625
MOD_PKA_2	144	150	PF00069	0.760
MOD_PKA_2	182	188	PF00069	0.633
MOD_PKA_2	192	198	PF00069	0.680
MOD_PKA_2	294	300	PF00069	0.543
MOD_Plk_1	30	36	PF00069	0.343
MOD_Plk_1	355	361	PF00069	0.636
MOD_Plk_4	129	135	PF00069	0.584
MOD_Plk_4	336	342	PF00069	0.664
MOD_ProDKin_1	103	109	PF00069	0.777
MOD_ProDKin_1	121	127	PF00069	0.635
MOD_ProDKin_1	134	140	PF00069	0.555
MOD_ProDKin_1	174	180	PF00069	0.469
MOD_ProDKin_1	213	219	PF00069	0.757
MOD_ProDKin_1	240	246	PF00069	0.589
MOD_ProDKin_1	351	357	PF00069	0.659
MOD_ProDKin_1	376	382	PF00069	0.691
MOD_ProDKin_1	422	428	PF00069	0.667
MOD_ProDKin_1	456	462	PF00069	0.780
MOD_ProDKin_1	46	52	PF00069	0.291
MOD_SUMO_rev_2	180	189	PF00179	0.565
MOD_SUMO_rev_2	249	254	PF00179	0.517
MOD_SUMO_rev_2	257	264	PF00179	0.430
TRG_DiLeu_BaEn_4	249	255	PF01217	0.518
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.631
TRG_ENDOCYTIC_2	170	173	PF00928	0.517
TRG_ER_diArg_1	181	183	PF00400	0.545
TRG_ER_diArg_1	45	48	PF00400	0.297
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA53	Leptomonas seymouri	57%	95%
A0A1X0NHT0	Trypanosomatidae	34%	100%
A4HLC6	Leishmania braziliensis	71%	100%
A4HZJ0	Leishmania infantum	100%	100%
D0A0Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AVI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QBZ9	Leishmania major	92%	100%