Cytochrome_b5-like_Heme/Steroid_binding_domain_co ntaining_protein_putative/Pfam:PF00173

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWT8_LEIDO

TriTrypDb:

LdBPK_211680.1 , LdCL_210022600 , LDHU3_21.1990

Length:

221

Annotations

Annotations by Jardim et al.

Mitochondrial protein, cytochrome b5-like Heme/Steroid binding domain

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWT8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.602
CLV_NRD_NRD_1	125	127	PF00675	0.526
CLV_PCSK_FUR_1	123	127	PF00082	0.600
CLV_PCSK_KEX2_1	125	127	PF00082	0.587
CLV_Separin_Metazoa	150	154	PF03568	0.540
DOC_USP7_MATH_1	119	123	PF00917	0.598
DOC_USP7_MATH_1	19	23	PF00917	0.475
DOC_USP7_UBL2_3	38	42	PF12436	0.538
DOC_WW_Pin1_4	28	33	PF00397	0.477
LIG_14-3-3_CanoR_1	128	134	PF00244	0.504
LIG_14-3-3_CanoR_1	164	169	PF00244	0.623
LIG_14-3-3_CanoR_1	3	10	PF00244	0.562
LIG_BIR_II_1	1	5	PF00653	0.569
LIG_FHA_1	122	128	PF00498	0.475
LIG_FHA_1	137	143	PF00498	0.460
LIG_FHA_1	29	35	PF00498	0.458
LIG_FHA_1	45	51	PF00498	0.547
LIG_FHA_2	132	138	PF00498	0.538
LIG_FHA_2	145	151	PF00498	0.407
LIG_FHA_2	181	187	PF00498	0.490
LIG_FHA_2	4	10	PF00498	0.445
LIG_LIR_Apic_2	102	108	PF02991	0.464
LIG_LIR_Apic_2	204	208	PF02991	0.454
LIG_LIR_Apic_2	81	85	PF02991	0.504
LIG_LIR_Gen_1	154	163	PF02991	0.551
LIG_LIR_Gen_1	165	175	PF02991	0.518
LIG_LIR_Gen_1	17	28	PF02991	0.512
LIG_LIR_Gen_1	194	203	PF02991	0.465
LIG_LIR_Nem_3	154	159	PF02991	0.496
LIG_LIR_Nem_3	165	171	PF02991	0.487
LIG_LIR_Nem_3	17	23	PF02991	0.513
LIG_LIR_Nem_3	194	199	PF02991	0.469
LIG_NRBOX	147	153	PF00104	0.602
LIG_PDZ_Class_1	216	221	PF00595	0.489
LIG_SH2_CRK	82	86	PF00017	0.520
LIG_SH2_GRB2like	213	216	PF00017	0.539
LIG_SH2_PTP2	20	23	PF00017	0.551
LIG_SH2_SRC	115	118	PF00017	0.476
LIG_SH2_SRC	206	209	PF00017	0.447
LIG_SH2_STAT5	115	118	PF00017	0.508
LIG_SH2_STAT5	156	159	PF00017	0.473
LIG_SH2_STAT5	166	169	PF00017	0.499
LIG_SH2_STAT5	20	23	PF00017	0.516
LIG_SH2_STAT5	206	209	PF00017	0.447
LIG_SH2_STAT5	5	8	PF00017	0.506
LIG_SH3_3	87	93	PF00018	0.561
LIG_SH3_4	48	55	PF00018	0.604
LIG_SUMO_SIM_par_1	26	31	PF11976	0.470
LIG_TRAF2_1	147	150	PF00917	0.536
MOD_CK2_1	131	137	PF00069	0.527
MOD_CK2_1	144	150	PF00069	0.453
MOD_CK2_1	3	9	PF00069	0.451
MOD_GlcNHglycan	76	79	PF01048	0.602
MOD_GSK3_1	131	138	PF00069	0.567
MOD_GSK3_1	74	81	PF00069	0.476
MOD_LATS_1	162	168	PF00433	0.618
MOD_NEK2_1	178	183	PF00069	0.592
MOD_PK_1	155	161	PF00069	0.555
MOD_PKB_1	153	161	PF00069	0.542
MOD_Plk_1	135	141	PF00069	0.486
MOD_Plk_1	144	150	PF00069	0.495
MOD_Plk_1	56	62	PF00069	0.490
MOD_Plk_2-3	136	142	PF00069	0.531
MOD_Plk_2-3	192	198	PF00069	0.597
MOD_Plk_4	164	170	PF00069	0.548
MOD_Plk_4	91	97	PF00069	0.508
MOD_ProDKin_1	28	34	PF00069	0.480
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.479
TRG_ENDOCYTIC_2	156	159	PF00928	0.516
TRG_ENDOCYTIC_2	166	169	PF00928	0.542
TRG_ENDOCYTIC_2	20	23	PF00928	0.551
TRG_ENDOCYTIC_2	37	40	PF00928	0.557
TRG_ER_diArg_1	123	126	PF00400	0.570
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3G7	Leptomonas seymouri	84%	100%
A0A0S4IWY2	Bodo saltans	60%	100%
A0A1X0NJA6	Trypanosomatidae	66%	99%
A0A3R7MUY6	Trypanosoma rangeli	64%	100%
A4HC15	Leishmania braziliensis	94%	100%
A4HZE1	Leishmania infantum	100%	100%
D0A144	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AVC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q0IHR1	Xenopus tropicalis	47%	100%
Q4QC51	Leishmania major	98%	100%
Q567I9	Danio rerio	47%	100%
Q5NCY3	Mus musculus	46%	97%
Q5PPR6	Xenopus laevis	48%	100%
Q5R4Q5	Pongo abelii	45%	97%
Q6P9G0	Homo sapiens	45%	97%