Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWT7_LEIDO

TriTrypDb:

LdBPK_211660.1 , LdCL_210022300 , LDHU3_21.1970

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7WWT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWT7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	237	241	PF00656	0.635
CLV_NRD_NRD_1	229	231	PF00675	0.533
CLV_NRD_NRD_1	254	256	PF00675	0.640
CLV_NRD_NRD_1	52	54	PF00675	0.629
CLV_NRD_NRD_1	82	84	PF00675	0.574
CLV_PCSK_FUR_1	252	256	PF00082	0.624
CLV_PCSK_KEX2_1	228	230	PF00082	0.508
CLV_PCSK_KEX2_1	254	256	PF00082	0.640
CLV_PCSK_KEX2_1	52	54	PF00082	0.629
CLV_PCSK_KEX2_1	82	84	PF00082	0.574
CLV_PCSK_PC7_1	224	230	PF00082	0.592
CLV_PCSK_SKI1_1	143	147	PF00082	0.679
CLV_PCSK_SKI1_1	18	22	PF00082	0.640
CLV_PCSK_SKI1_1	199	203	PF00082	0.525
CLV_PCSK_SKI1_1	35	39	PF00082	0.515
CLV_PCSK_SKI1_1	82	86	PF00082	0.595
DEG_SPOP_SBC_1	89	93	PF00917	0.661
DOC_AGCK_PIF_1	42	47	PF00069	0.596
DOC_CYCLIN_RxL_1	15	24	PF00134	0.588
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.508
DOC_PP1_RVXF_1	65	71	PF00149	0.613
DOC_PP1_RVXF_1	80	87	PF00149	0.562
DOC_PP2B_LxvP_1	108	111	PF13499	0.673
DOC_USP7_MATH_1	157	161	PF00917	0.678
DOC_USP7_MATH_1	90	94	PF00917	0.686
DOC_USP7_MATH_1	97	101	PF00917	0.682
LIG_14-3-3_CanoR_1	155	164	PF00244	0.743
LIG_14-3-3_CanoR_1	172	181	PF00244	0.524
LIG_14-3-3_CanoR_1	259	266	PF00244	0.697
LIG_14-3-3_CanoR_1	40	45	PF00244	0.584
LIG_14-3-3_CanoR_1	96	106	PF00244	0.681
LIG_APCC_ABBA_1	193	198	PF00400	0.635
LIG_APCC_ABBAyCdc20_2	192	198	PF00400	0.626
LIG_CaM_IQ_9	27	42	PF13499	0.582
LIG_Clathr_ClatBox_1	116	120	PF01394	0.555
LIG_Clathr_ClatBox_1	20	24	PF01394	0.517
LIG_deltaCOP1_diTrp_1	253	258	PF00928	0.623
LIG_FHA_1	200	206	PF00498	0.459
LIG_FHA_2	142	148	PF00498	0.663
LIG_LIR_Gen_1	184	195	PF02991	0.536
LIG_LIR_Gen_1	39	50	PF02991	0.555
LIG_LIR_Gen_1	7	17	PF02991	0.606
LIG_LIR_Nem_3	204	209	PF02991	0.486
LIG_LIR_Nem_3	39	45	PF02991	0.572
LIG_LIR_Nem_3	46	50	PF02991	0.543
LIG_LIR_Nem_3	7	12	PF02991	0.566
LIG_Pex14_1	221	225	PF04695	0.597
LIG_Pex14_2	44	48	PF04695	0.624
LIG_PTB_Apo_2	216	223	PF02174	0.549
LIG_REV1ctd_RIR_1	83	89	PF16727	0.656
LIG_SH2_CRK	210	214	PF00017	0.484
LIG_SH2_CRK	9	13	PF00017	0.550
LIG_SH2_STAT5	187	190	PF00017	0.653
LIG_SH2_STAT5	210	213	PF00017	0.513
LIG_SH2_STAT5	225	228	PF00017	0.411
LIG_SH2_STAT5	36	39	PF00017	0.598
LIG_SH2_STAT5	69	72	PF00017	0.707
LIG_SUMO_SIM_anti_2	113	120	PF11976	0.552
LIG_SUMO_SIM_par_1	113	120	PF11976	0.548
LIG_WRC_WIRS_1	44	49	PF05994	0.578
MOD_CK1_1	128	134	PF00069	0.608
MOD_CK1_1	160	166	PF00069	0.653
MOD_CK1_1	167	173	PF00069	0.627
MOD_CK1_1	262	268	PF00069	0.664
MOD_CK1_1	43	49	PF00069	0.550
MOD_CK1_1	72	78	PF00069	0.525
MOD_CK1_1	92	98	PF00069	0.408
MOD_CK2_1	141	147	PF00069	0.697
MOD_CK2_1	172	178	PF00069	0.624
MOD_GlcNHglycan	159	162	PF01048	0.686
MOD_GlcNHglycan	174	177	PF01048	0.560
MOD_GlcNHglycan	92	95	PF01048	0.703
MOD_GlcNHglycan	99	102	PF01048	0.704
MOD_GSK3_1	121	128	PF00069	0.518
MOD_GSK3_1	156	163	PF00069	0.663
MOD_GSK3_1	164	171	PF00069	0.483
MOD_GSK3_1	172	179	PF00069	0.613
MOD_GSK3_1	181	188	PF00069	0.582
MOD_GSK3_1	229	236	PF00069	0.571
MOD_GSK3_1	88	95	PF00069	0.704
MOD_N-GLC_1	185	190	PF02516	0.645
MOD_N-GLC_1	40	45	PF02516	0.575
MOD_NEK2_1	146	151	PF00069	0.607
MOD_NEK2_1	181	186	PF00069	0.566
MOD_NEK2_1	201	206	PF00069	0.548
MOD_NEK2_1	4	9	PF00069	0.628
MOD_PIKK_1	121	127	PF00454	0.616
MOD_PKA_1	229	235	PF00069	0.575
MOD_PKA_2	229	235	PF00069	0.575
MOD_PKA_2	4	10	PF00069	0.656
MOD_PKA_2	95	101	PF00069	0.669
MOD_Plk_1	141	147	PF00069	0.697
MOD_Plk_1	185	191	PF00069	0.648
MOD_Plk_1	40	46	PF00069	0.556
MOD_Plk_2-3	141	147	PF00069	0.689
MOD_Plk_4	125	131	PF00069	0.560
MOD_Plk_4	229	235	PF00069	0.492
TRG_DiLeu_BaEn_2	177	183	PF01217	0.600
TRG_ENDOCYTIC_2	187	190	PF00928	0.552
TRG_ENDOCYTIC_2	210	213	PF00928	0.474
TRG_ENDOCYTIC_2	9	12	PF00928	0.541
TRG_ER_diArg_1	228	230	PF00400	0.497
TRG_ER_diArg_1	254	256	PF00400	0.604
TRG_ER_diArg_1	33	36	PF00400	0.632
TRG_ER_diArg_1	65	68	PF00400	0.700
TRG_ER_diArg_1	81	83	PF00400	0.421
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.722
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V9	Leptomonas seymouri	61%	98%
A0A0S4IH77	Bodo saltans	31%	100%
A0A1X0NHE8	Trypanosomatidae	41%	100%
A4HBY9	Leishmania braziliensis	80%	100%
A4HZD9	Leishmania infantum	100%	100%
D0A146	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AVC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QC53	Leishmania major	93%	100%
V5B1U8	Trypanosoma cruzi	40%	100%