Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWT3_LEIDO

TriTrypDb:

LdBPK_212100.1 , LdCL_210026700 , LDHU3_21.2500

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWT3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.552
CLV_NRD_NRD_1	11	13	PF00675	0.569
CLV_NRD_NRD_1	130	132	PF00675	0.525
CLV_NRD_NRD_1	25	27	PF00675	0.466
CLV_NRD_NRD_1	66	68	PF00675	0.446
CLV_PCSK_KEX2_1	121	123	PF00082	0.590
CLV_PCSK_KEX2_1	130	132	PF00082	0.463
CLV_PCSK_KEX2_1	27	29	PF00082	0.577
CLV_PCSK_KEX2_1	55	57	PF00082	0.567
CLV_PCSK_KEX2_1	68	70	PF00082	0.410
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.590
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.572
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.567
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.392
CLV_PCSK_SKI1_1	121	125	PF00082	0.592
CLV_PCSK_SKI1_1	151	155	PF00082	0.623
CLV_PCSK_SKI1_1	31	35	PF00082	0.591
DEG_APCC_DBOX_1	40	48	PF00400	0.365
DOC_MAPK_gen_1	31	39	PF00069	0.453
DOC_PP1_RVXF_1	29	36	PF00149	0.587
DOC_PP2B_LxvP_1	123	126	PF13499	0.611
DOC_PP4_FxxP_1	59	62	PF00568	0.440
DOC_USP7_MATH_1	8	12	PF00917	0.615
DOC_USP7_MATH_1	99	103	PF00917	0.750
DOC_USP7_UBL2_3	13	17	PF12436	0.651
DOC_USP7_UBL2_3	132	136	PF12436	0.701
DOC_USP7_UBL2_3	27	31	PF12436	0.494
DOC_WW_Pin1_4	87	92	PF00397	0.670
DOC_WW_Pin1_4	93	98	PF00397	0.746
LIG_Actin_WH2_2	40	57	PF00022	0.541
LIG_BRCT_BRCA1_1	10	14	PF00533	0.669
LIG_FHA_1	34	40	PF00498	0.583
LIG_FHA_1	88	94	PF00498	0.728
LIG_FHA_2	1	7	PF00498	0.743
LIG_REV1ctd_RIR_1	107	116	PF16727	0.605
LIG_SH3_4	132	139	PF00018	0.614
LIG_TRAF2_1	86	89	PF00917	0.676
LIG_WRC_WIRS_1	163	168	PF05994	0.607
MOD_GSK3_1	162	169	PF00069	0.611
MOD_GSK3_1	33	40	PF00069	0.584
MOD_NEK2_1	166	171	PF00069	0.653
MOD_NEK2_1	33	38	PF00069	0.544
MOD_PKA_2	37	43	PF00069	0.571
MOD_Plk_2-3	101	107	PF00069	0.695
MOD_Plk_2-3	162	168	PF00069	0.516
MOD_Plk_4	111	117	PF00069	0.583
MOD_Plk_4	162	168	PF00069	0.611
MOD_ProDKin_1	87	93	PF00069	0.670
MOD_SUMO_for_1	47	50	PF00179	0.353
MOD_SUMO_rev_2	118	123	PF00179	0.640
MOD_SUMO_rev_2	77	86	PF00179	0.630
TRG_DiLeu_BaEn_1	66	71	PF01217	0.438
TRG_ER_diArg_1	129	131	PF00400	0.484
TRG_ER_diArg_1	56	59	PF00400	0.566
TRG_ER_diArg_1	67	70	PF00400	0.419
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NH88	Trypanosomatidae	35%	97%
A0A422N8U7	Trypanosoma rangeli	35%	98%
A4HC37	Leishmania braziliensis	74%	99%
A4HZH9	Leishmania infantum	99%	100%
D0A0Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	82%
E9AVG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QC10	Leishmania major	88%	100%