Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWR8_LEIDO

TriTrypDb:

LdBPK_211510.1 , LdCL_210020600 , LDHU3_21.1790

Length:

835

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	546	550	PF00656	0.468
CLV_C14_Caspase3-7	572	576	PF00656	0.484
CLV_NRD_NRD_1	31	33	PF00675	0.532
CLV_NRD_NRD_1	367	369	PF00675	0.611
CLV_NRD_NRD_1	383	385	PF00675	0.557
CLV_NRD_NRD_1	516	518	PF00675	0.783
CLV_NRD_NRD_1	617	619	PF00675	0.555
CLV_PCSK_KEX2_1	366	368	PF00082	0.617
CLV_PCSK_KEX2_1	516	518	PF00082	0.783
CLV_PCSK_KEX2_1	617	619	PF00082	0.555
CLV_PCSK_KEX2_1	684	686	PF00082	0.569
CLV_PCSK_KEX2_1	832	834	PF00082	0.765
CLV_PCSK_PC1ET2_1	684	686	PF00082	0.569
CLV_PCSK_PC1ET2_1	832	834	PF00082	0.765
CLV_PCSK_SKI1_1	165	169	PF00082	0.446
CLV_PCSK_SKI1_1	237	241	PF00082	0.494
CLV_PCSK_SKI1_1	617	621	PF00082	0.549
CLV_PCSK_SKI1_1	676	680	PF00082	0.641
DEG_APCC_DBOX_1	232	240	PF00400	0.573
DOC_ANK_TNKS_1	398	405	PF00023	0.521
DOC_CKS1_1	88	93	PF01111	0.621
DOC_MAPK_gen_1	217	225	PF00069	0.475
DOC_MAPK_gen_1	32	40	PF00069	0.611
DOC_MAPK_gen_1	607	616	PF00069	0.503
DOC_MAPK_MEF2A_6	217	225	PF00069	0.475
DOC_MAPK_MEF2A_6	428	435	PF00069	0.540
DOC_MAPK_MEF2A_6	651	659	PF00069	0.472
DOC_MAPK_NFAT4_5	428	436	PF00069	0.543
DOC_PP1_RVXF_1	307	313	PF00149	0.544
DOC_PP2B_LxvP_1	431	434	PF13499	0.551
DOC_USP7_MATH_1	105	109	PF00917	0.499
DOC_USP7_MATH_1	291	295	PF00917	0.505
DOC_USP7_MATH_1	325	329	PF00917	0.682
DOC_USP7_MATH_1	339	343	PF00917	0.836
DOC_USP7_MATH_1	350	354	PF00917	0.635
DOC_USP7_MATH_1	356	360	PF00917	0.548
DOC_USP7_MATH_1	386	390	PF00917	0.530
DOC_USP7_MATH_1	502	506	PF00917	0.847
DOC_USP7_MATH_1	528	532	PF00917	0.515
DOC_USP7_MATH_1	548	552	PF00917	0.252
DOC_USP7_MATH_1	747	751	PF00917	0.683
DOC_USP7_MATH_1	755	759	PF00917	0.685
DOC_USP7_MATH_1	792	796	PF00917	0.503
DOC_USP7_MATH_1	828	832	PF00917	0.599
DOC_USP7_MATH_2	718	724	PF00917	0.683
DOC_USP7_UBL2_3	676	680	PF12436	0.539
DOC_WW_Pin1_4	327	332	PF00397	0.751
DOC_WW_Pin1_4	335	340	PF00397	0.724
DOC_WW_Pin1_4	423	428	PF00397	0.518
DOC_WW_Pin1_4	586	591	PF00397	0.584
DOC_WW_Pin1_4	87	92	PF00397	0.620
LIG_14-3-3_CanoR_1	159	167	PF00244	0.466
LIG_14-3-3_CanoR_1	423	427	PF00244	0.618
LIG_14-3-3_CanoR_1	87	91	PF00244	0.511
LIG_APCC_ABBA_1	432	437	PF00400	0.586
LIG_BIR_II_1	1	5	PF00653	0.604
LIG_BIR_III_4	126	130	PF00653	0.470
LIG_BRCT_BRCA1_1	27	31	PF00533	0.597
LIG_BRCT_BRCA1_2	27	33	PF00533	0.614
LIG_CtBP_PxDLS_1	222	226	PF00389	0.580
LIG_CtBP_PxDLS_1	654	658	PF00389	0.470
LIG_deltaCOP1_diTrp_1	638	644	PF00928	0.574
LIG_EH1_1	411	419	PF00400	0.486
LIG_eIF4E_1	412	418	PF01652	0.481
LIG_eIF4E_1	784	790	PF01652	0.784
LIG_FHA_1	112	118	PF00498	0.509
LIG_FHA_1	183	189	PF00498	0.542
LIG_FHA_1	22	28	PF00498	0.483
LIG_FHA_1	293	299	PF00498	0.509
LIG_FHA_1	311	317	PF00498	0.556
LIG_FHA_1	35	41	PF00498	0.512
LIG_FHA_1	47	53	PF00498	0.504
LIG_FHA_1	533	539	PF00498	0.578
LIG_FHA_1	650	656	PF00498	0.479
LIG_FHA_1	83	89	PF00498	0.598
LIG_FHA_2	107	113	PF00498	0.556
LIG_FHA_2	179	185	PF00498	0.568
LIG_FHA_2	56	62	PF00498	0.323
LIG_LIR_Gen_1	152	157	PF02991	0.425
LIG_LIR_Gen_1	232	243	PF02991	0.488
LIG_LIR_Gen_1	246	256	PF02991	0.483
LIG_LIR_Gen_1	279	289	PF02991	0.465
LIG_LIR_Gen_1	306	315	PF02991	0.547
LIG_LIR_Gen_1	35	43	PF02991	0.435
LIG_LIR_Gen_1	638	648	PF02991	0.462
LIG_LIR_Gen_1	704	713	PF02991	0.529
LIG_LIR_Gen_1	798	809	PF02991	0.491
LIG_LIR_Nem_3	112	118	PF02991	0.485
LIG_LIR_Nem_3	125	131	PF02991	0.448
LIG_LIR_Nem_3	152	156	PF02991	0.433
LIG_LIR_Nem_3	232	238	PF02991	0.466
LIG_LIR_Nem_3	246	251	PF02991	0.481
LIG_LIR_Nem_3	306	310	PF02991	0.548
LIG_LIR_Nem_3	35	39	PF02991	0.438
LIG_LIR_Nem_3	543	547	PF02991	0.454
LIG_LIR_Nem_3	621	626	PF02991	0.435
LIG_LIR_Nem_3	637	643	PF02991	0.474
LIG_LIR_Nem_3	704	708	PF02991	0.527
LIG_LIR_Nem_3	798	804	PF02991	0.482
LIG_NRP_CendR_1	832	835	PF00754	0.783
LIG_PCNA_PIPBox_1	414	423	PF02747	0.490
LIG_Pex14_1	640	644	PF04695	0.565
LIG_Pex14_2	153	157	PF04695	0.474
LIG_Pex14_2	264	268	PF04695	0.457
LIG_REV1ctd_RIR_1	154	163	PF16727	0.371
LIG_SH2_CRK	102	106	PF00017	0.546
LIG_SH2_CRK	3	7	PF00017	0.625
LIG_SH2_CRK	307	311	PF00017	0.538
LIG_SH2_CRK	36	40	PF00017	0.591
LIG_SH2_CRK	705	709	PF00017	0.529
LIG_SH2_CRK	799	803	PF00017	0.479
LIG_SH2_NCK_1	287	291	PF00017	0.471
LIG_SH2_NCK_1	774	778	PF00017	0.689
LIG_SH2_PTP2	801	804	PF00017	0.475
LIG_SH2_SRC	624	627	PF00017	0.428
LIG_SH2_STAP1	281	285	PF00017	0.462
LIG_SH2_STAP1	36	40	PF00017	0.489
LIG_SH2_STAP1	624	628	PF00017	0.455
LIG_SH2_STAT3	215	218	PF00017	0.475
LIG_SH2_STAT3	373	376	PF00017	0.627
LIG_SH2_STAT3	560	563	PF00017	0.705
LIG_SH2_STAT5	118	121	PF00017	0.562
LIG_SH2_STAT5	163	166	PF00017	0.439
LIG_SH2_STAT5	192	195	PF00017	0.417
LIG_SH2_STAT5	215	218	PF00017	0.577
LIG_SH2_STAT5	235	238	PF00017	0.242
LIG_SH2_STAT5	36	39	PF00017	0.593
LIG_SH2_STAT5	373	376	PF00017	0.525
LIG_SH2_STAT5	412	415	PF00017	0.486
LIG_SH2_STAT5	421	424	PF00017	0.508
LIG_SH2_STAT5	430	433	PF00017	0.536
LIG_SH2_STAT5	526	529	PF00017	0.558
LIG_SH2_STAT5	536	539	PF00017	0.475
LIG_SH2_STAT5	603	606	PF00017	0.469
LIG_SH2_STAT5	643	646	PF00017	0.446
LIG_SH2_STAT5	774	777	PF00017	0.689
LIG_SH2_STAT5	801	804	PF00017	0.475
LIG_SH3_1	519	525	PF00018	0.682
LIG_SH3_3	328	334	PF00018	0.742
LIG_SH3_3	5	11	PF00018	0.558
LIG_SH3_3	519	525	PF00018	0.682
LIG_SH3_3	75	81	PF00018	0.457
LIG_SH3_CIN85_PxpxPR_1	518	523	PF14604	0.630
LIG_SUMO_SIM_anti_2	179	187	PF11976	0.522
LIG_SUMO_SIM_anti_2	68	73	PF11976	0.495
LIG_SUMO_SIM_par_1	176	181	PF11976	0.492
LIG_TRAF2_1	290	293	PF00917	0.523
LIG_TRAF2_1	478	481	PF00917	0.819
LIG_TRAF2_1	51	54	PF00917	0.473
LIG_TRAF2_1	530	533	PF00917	0.496
LIG_TRAF2_1	763	766	PF00917	0.702
LIG_TRAF2_1	824	827	PF00917	0.642
LIG_TYR_ITIM	599	604	PF00017	0.450
LIG_TYR_ITIM	797	802	PF00017	0.586
LIG_UBA3_1	390	395	PF00899	0.491
LIG_UBA3_1	537	542	PF00899	0.477
LIG_WW_3	334	338	PF00397	0.767
MOD_CDK_SPK_2	423	428	PF00069	0.518
MOD_CDK_SPxxK_3	87	94	PF00069	0.618
MOD_CK1_1	108	114	PF00069	0.523
MOD_CK1_1	186	192	PF00069	0.539
MOD_CK1_1	357	363	PF00069	0.691
MOD_CK1_1	543	549	PF00069	0.446
MOD_CK1_1	669	675	PF00069	0.631
MOD_CK1_1	772	778	PF00069	0.672
MOD_CK1_1	795	801	PF00069	0.454
MOD_CK2_1	300	306	PF00069	0.563
MOD_CK2_1	386	392	PF00069	0.522
MOD_CK2_1	451	457	PF00069	0.734
MOD_CK2_1	47	53	PF00069	0.565
MOD_CK2_1	527	533	PF00069	0.515
MOD_CK2_1	55	61	PF00069	0.484
MOD_Cter_Amidation	514	517	PF01082	0.782
MOD_DYRK1A_RPxSP_1	423	427	PF00069	0.618
MOD_GlcNHglycan	172	175	PF01048	0.564
MOD_GlcNHglycan	26	30	PF01048	0.524
MOD_GlcNHglycan	323	326	PF01048	0.714
MOD_GlcNHglycan	341	344	PF01048	0.772
MOD_GlcNHglycan	352	355	PF01048	0.633
MOD_GlcNHglycan	356	359	PF01048	0.587
MOD_GlcNHglycan	414	417	PF01048	0.475
MOD_GlcNHglycan	488	491	PF01048	0.751
MOD_GlcNHglycan	49	52	PF01048	0.511
MOD_GlcNHglycan	498	501	PF01048	0.698
MOD_GlcNHglycan	556	559	PF01048	0.542
MOD_GlcNHglycan	571	574	PF01048	0.454
MOD_GlcNHglycan	722	725	PF01048	0.723
MOD_GlcNHglycan	728	732	PF01048	0.775
MOD_GlcNHglycan	758	761	PF01048	0.801
MOD_GlcNHglycan	775	778	PF01048	0.724
MOD_GlcNHglycan	790	793	PF01048	0.487
MOD_GSK3_1	178	185	PF00069	0.560
MOD_GSK3_1	21	28	PF00069	0.558
MOD_GSK3_1	217	224	PF00069	0.487
MOD_GSK3_1	321	328	PF00069	0.706
MOD_GSK3_1	335	342	PF00069	0.799
MOD_GSK3_1	350	357	PF00069	0.714
MOD_GSK3_1	408	415	PF00069	0.506
MOD_GSK3_1	496	503	PF00069	0.704
MOD_GSK3_1	528	535	PF00069	0.603
MOD_GSK3_1	662	669	PF00069	0.553
MOD_GSK3_1	769	776	PF00069	0.708
MOD_GSK3_1	780	787	PF00069	0.655
MOD_GSK3_1	788	795	PF00069	0.432
MOD_GSK3_1	82	89	PF00069	0.550
MOD_N-GLC_1	100	105	PF02516	0.566
MOD_N-GLC_1	269	274	PF02516	0.518
MOD_N-GLC_1	320	325	PF02516	0.726
MOD_N-GLC_1	726	731	PF02516	0.722
MOD_N-GLC_1	747	752	PF02516	0.817
MOD_N-GLC_1	784	789	PF02516	0.700
MOD_NEK2_1	132	137	PF00069	0.501
MOD_NEK2_1	168	173	PF00069	0.488
MOD_NEK2_1	178	183	PF00069	0.391
MOD_NEK2_1	285	290	PF00069	0.507
MOD_NEK2_1	310	315	PF00069	0.550
MOD_NEK2_1	435	440	PF00069	0.554
MOD_NEK2_1	46	51	PF00069	0.602
MOD_NEK2_1	662	667	PF00069	0.544
MOD_NEK2_1	72	77	PF00069	0.528
MOD_NEK2_2	626	631	PF00069	0.580
MOD_NEK2_2	769	774	PF00069	0.675
MOD_PIKK_1	187	193	PF00454	0.597
MOD_PIKK_1	323	329	PF00454	0.740
MOD_PK_1	217	223	PF00069	0.479
MOD_PKA_1	684	690	PF00069	0.569
MOD_PKA_2	158	164	PF00069	0.478
MOD_PKA_2	21	27	PF00069	0.503
MOD_PKA_2	422	428	PF00069	0.513
MOD_PKA_2	684	690	PF00069	0.569
MOD_PKA_2	720	726	PF00069	0.712
MOD_PKA_2	792	798	PF00069	0.498
MOD_PKA_2	86	92	PF00069	0.516
MOD_Plk_1	100	106	PF00069	0.551
MOD_Plk_1	111	117	PF00069	0.433
MOD_Plk_1	178	184	PF00069	0.501
MOD_Plk_1	285	291	PF00069	0.480
MOD_Plk_1	292	298	PF00069	0.496
MOD_Plk_1	34	40	PF00069	0.495
MOD_Plk_1	369	375	PF00069	0.533
MOD_Plk_1	548	554	PF00069	0.467
MOD_Plk_1	669	675	PF00069	0.631
MOD_Plk_1	784	790	PF00069	0.668
MOD_Plk_4	178	184	PF00069	0.480
MOD_Plk_4	311	317	PF00069	0.658
MOD_Plk_4	34	40	PF00069	0.500
MOD_Plk_4	386	392	PF00069	0.522
MOD_Plk_4	408	414	PF00069	0.509
MOD_Plk_4	532	538	PF00069	0.475
MOD_Plk_4	548	554	PF00069	0.356
MOD_Plk_4	769	775	PF00069	0.678
MOD_Plk_4	792	798	PF00069	0.511
MOD_ProDKin_1	327	333	PF00069	0.750
MOD_ProDKin_1	335	341	PF00069	0.724
MOD_ProDKin_1	423	429	PF00069	0.525
MOD_ProDKin_1	586	592	PF00069	0.579
MOD_ProDKin_1	87	93	PF00069	0.615
MOD_SUMO_rev_2	379	386	PF00179	0.638
MOD_SUMO_rev_2	480	490	PF00179	0.706
MOD_SUMO_rev_2	806	814	PF00179	0.608
TRG_DiLeu_BaEn_3	532	538	PF01217	0.475
TRG_DiLeu_BaEn_4	493	499	PF01217	0.758
TRG_DiLeu_BaEn_4	64	70	PF01217	0.519
TRG_ENDOCYTIC_2	235	238	PF00928	0.470
TRG_ENDOCYTIC_2	281	284	PF00928	0.465
TRG_ENDOCYTIC_2	307	310	PF00928	0.541
TRG_ENDOCYTIC_2	36	39	PF00928	0.513
TRG_ENDOCYTIC_2	430	433	PF00928	0.560
TRG_ENDOCYTIC_2	601	604	PF00928	0.396
TRG_ENDOCYTIC_2	643	646	PF00928	0.546
TRG_ENDOCYTIC_2	705	708	PF00928	0.535
TRG_ENDOCYTIC_2	799	802	PF00928	0.484
TRG_ER_diArg_1	366	368	PF00400	0.617
TRG_ER_diArg_1	516	519	PF00400	0.825
TRG_ER_diArg_1	520	523	PF00400	0.711
TRG_ER_diArg_1	616	618	PF00400	0.556
TRG_NES_CRM1_1	170	184	PF08389	0.599
TRG_NES_CRM1_1	68	82	PF08389	0.525
TRG_Pf-PMV_PEXEL_1	297	302	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	707	712	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	805	810	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P586	Leptomonas seymouri	64%	99%
A4HBY2	Leishmania braziliensis	84%	100%
A4HZC4	Leishmania infantum	100%	100%
E9AVB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QC69	Leishmania major	95%	100%