Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Exocyst complex component EXO99

Species:

Leishmania donovani

UniProt:

A0A3S7WWR2_LEIDO

TriTrypDb:

LdBPK_211910.1 , LdCL_210024800 , LDHU3_21.2280

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0000145	exocyst	3	1
GO:0005634	nucleus	5	1
GO:0020016	ciliary pocket	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

A0A3S7WWR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWR2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006364	rRNA processing	8	6
GO:0006396	RNA processing	6	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0016072	rRNA metabolic process	7	6
GO:0034470	ncRNA processing	7	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034660	ncRNA metabolic process	6	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.500
CLV_NRD_NRD_1	19	21	PF00675	0.638
CLV_NRD_NRD_1	260	262	PF00675	0.543
CLV_NRD_NRD_1	406	408	PF00675	0.756
CLV_NRD_NRD_1	433	435	PF00675	0.514
CLV_NRD_NRD_1	447	449	PF00675	0.297
CLV_NRD_NRD_1	462	464	PF00675	0.370
CLV_NRD_NRD_1	613	615	PF00675	0.558
CLV_NRD_NRD_1	667	669	PF00675	0.518
CLV_NRD_NRD_1	762	764	PF00675	0.597
CLV_NRD_NRD_1	875	877	PF00675	0.437
CLV_NRD_NRD_1	922	924	PF00675	0.702
CLV_PCSK_KEX2_1	18	20	PF00082	0.693
CLV_PCSK_KEX2_1	260	262	PF00082	0.543
CLV_PCSK_KEX2_1	406	408	PF00082	0.698
CLV_PCSK_KEX2_1	447	449	PF00082	0.397
CLV_PCSK_KEX2_1	462	464	PF00082	0.370
CLV_PCSK_KEX2_1	667	669	PF00082	0.481
CLV_PCSK_SKI1_1	24	28	PF00082	0.612
CLV_PCSK_SKI1_1	447	451	PF00082	0.441
CLV_PCSK_SKI1_1	463	467	PF00082	0.517
CLV_PCSK_SKI1_1	584	588	PF00082	0.563
CLV_PCSK_SKI1_1	610	614	PF00082	0.434
CLV_PCSK_SKI1_1	727	731	PF00082	0.393
CLV_PCSK_SKI1_1	923	927	PF00082	0.612
DEG_APCC_DBOX_1	19	27	PF00400	0.682
DEG_APCC_DBOX_1	296	304	PF00400	0.550
DEG_APCC_DBOX_1	583	591	PF00400	0.561
DEG_Nend_UBRbox_2	1	3	PF02207	0.620
DEG_SCF_FBW7_1	420	426	PF00400	0.521
DEG_SPOP_SBC_1	164	168	PF00917	0.620
DOC_CDC14_PxL_1	391	399	PF14671	0.561
DOC_CKS1_1	420	425	PF01111	0.594
DOC_CYCLIN_RxL_1	18	28	PF00134	0.642
DOC_CYCLIN_RxL_1	459	470	PF00134	0.538
DOC_MAPK_gen_1	763	770	PF00069	0.479
DOC_MAPK_JIP1_4	727	733	PF00069	0.399
DOC_MAPK_MEF2A_6	584	591	PF00069	0.560
DOC_MAPK_NFAT4_5	584	592	PF00069	0.568
DOC_MAPK_RevD_3	600	615	PF00069	0.526
DOC_PP1_RVXF_1	313	319	PF00149	0.479
DOC_PP1_RVXF_1	519	525	PF00149	0.475
DOC_PP1_RVXF_1	620	627	PF00149	0.519
DOC_PP4_FxxP_1	796	799	PF00568	0.507
DOC_SPAK_OSR1_1	795	799	PF12202	0.620
DOC_USP7_MATH_1	128	132	PF00917	0.510
DOC_USP7_MATH_1	13	17	PF00917	0.629
DOC_USP7_MATH_1	164	168	PF00917	0.587
DOC_USP7_MATH_1	249	253	PF00917	0.558
DOC_USP7_MATH_1	550	554	PF00917	0.594
DOC_USP7_MATH_1	647	651	PF00917	0.522
DOC_USP7_MATH_1	82	86	PF00917	0.511
DOC_WW_Pin1_4	137	142	PF00397	0.555
DOC_WW_Pin1_4	214	219	PF00397	0.555
DOC_WW_Pin1_4	416	421	PF00397	0.778
DOC_WW_Pin1_4	63	68	PF00397	0.545
LIG_14-3-3_CanoR_1	148	154	PF00244	0.530
LIG_14-3-3_CanoR_1	156	160	PF00244	0.592
LIG_14-3-3_CanoR_1	414	423	PF00244	0.585
LIG_14-3-3_CanoR_1	646	655	PF00244	0.540
LIG_14-3-3_CanoR_1	775	783	PF00244	0.426
LIG_14-3-3_CanoR_1	884	893	PF00244	0.475
LIG_BIR_III_4	439	443	PF00653	0.534
LIG_BRCT_BRCA1_1	253	257	PF00533	0.488
LIG_Clathr_ClatBox_1	76	80	PF01394	0.421
LIG_deltaCOP1_diTrp_1	107	114	PF00928	0.488
LIG_FHA_1	101	107	PF00498	0.428
LIG_FHA_1	180	186	PF00498	0.493
LIG_FHA_1	288	294	PF00498	0.392
LIG_FHA_1	33	39	PF00498	0.545
LIG_FHA_1	420	426	PF00498	0.521
LIG_FHA_1	517	523	PF00498	0.477
LIG_FHA_1	536	542	PF00498	0.477
LIG_FHA_1	69	75	PF00498	0.561
LIG_FHA_1	782	788	PF00498	0.584
LIG_FHA_1	814	820	PF00498	0.484
LIG_FHA_2	363	369	PF00498	0.547
LIG_FHA_2	424	430	PF00498	0.676
LIG_FHA_2	583	589	PF00498	0.592
LIG_FHA_2	808	814	PF00498	0.514
LIG_FHA_2	883	889	PF00498	0.568
LIG_LIR_Apic_2	793	799	PF02991	0.524
LIG_LIR_Gen_1	451	460	PF02991	0.405
LIG_LIR_Gen_1	516	524	PF02991	0.440
LIG_LIR_Gen_1	621	631	PF02991	0.536
LIG_LIR_Gen_1	739	750	PF02991	0.395
LIG_LIR_Gen_1	754	762	PF02991	0.437
LIG_LIR_Gen_1	811	821	PF02991	0.404
LIG_LIR_Gen_1	914	925	PF02991	0.510
LIG_LIR_Nem_3	273	277	PF02991	0.364
LIG_LIR_Nem_3	451	456	PF02991	0.400
LIG_LIR_Nem_3	488	492	PF02991	0.544
LIG_LIR_Nem_3	516	520	PF02991	0.448
LIG_LIR_Nem_3	621	626	PF02991	0.523
LIG_LIR_Nem_3	696	701	PF02991	0.443
LIG_LIR_Nem_3	739	745	PF02991	0.409
LIG_LIR_Nem_3	754	759	PF02991	0.445
LIG_LIR_Nem_3	811	817	PF02991	0.405
LIG_LIR_Nem_3	857	862	PF02991	0.446
LIG_LIR_Nem_3	914	920	PF02991	0.464
LIG_NRBOX	22	28	PF00104	0.569
LIG_PCNA_yPIPBox_3	562	571	PF02747	0.449
LIG_PDZ_Class_3	926	931	PF00595	0.711
LIG_Pex14_2	669	673	PF04695	0.554
LIG_PTAP_UEV_1	160	165	PF05743	0.682
LIG_SH2_CRK	353	357	PF00017	0.409
LIG_SH2_CRK	453	457	PF00017	0.457
LIG_SH2_CRK	642	646	PF00017	0.511
LIG_SH2_NCK_1	11	15	PF00017	0.606
LIG_SH2_SRC	752	755	PF00017	0.515
LIG_SH2_STAP1	237	241	PF00017	0.549
LIG_SH2_STAP1	294	298	PF00017	0.496
LIG_SH2_STAT3	298	301	PF00017	0.531
LIG_SH2_STAT5	11	14	PF00017	0.532
LIG_SH2_STAT5	193	196	PF00017	0.478
LIG_SH2_STAT5	445	448	PF00017	0.457
LIG_SH2_STAT5	742	745	PF00017	0.508
LIG_SH2_STAT5	752	755	PF00017	0.528
LIG_SH2_STAT5	878	881	PF00017	0.506
LIG_SH3_3	154	160	PF00018	0.636
LIG_SH3_3	273	279	PF00018	0.424
LIG_SH3_3	417	423	PF00018	0.758
LIG_SH3_3	479	485	PF00018	0.526
LIG_SH3_5	485	489	PF00018	0.447
LIG_SUMO_SIM_anti_2	238	246	PF11976	0.536
LIG_SUMO_SIM_anti_2	477	483	PF11976	0.444
LIG_SUMO_SIM_anti_2	585	591	PF11976	0.562
LIG_SUMO_SIM_anti_2	700	706	PF11976	0.515
LIG_SUMO_SIM_anti_2	813	819	PF11976	0.421
LIG_SUMO_SIM_par_1	280	285	PF11976	0.408
LIG_SUMO_SIM_par_1	287	295	PF11976	0.364
LIG_SUMO_SIM_par_1	536	542	PF11976	0.502
LIG_SUMO_SIM_par_1	579	585	PF11976	0.596
LIG_SUMO_SIM_par_1	597	604	PF11976	0.358
LIG_SUMO_SIM_par_1	908	915	PF11976	0.521
LIG_TRAF2_1	427	430	PF00917	0.631
LIG_TRAF2_1	651	654	PF00917	0.530
LIG_TRAF2_1	707	710	PF00917	0.476
LIG_TYR_ITIM	640	645	PF00017	0.535
LIG_WRC_WIRS_1	742	747	PF05994	0.389
LIG_WRC_WIRS_1	883	888	PF05994	0.561
MOD_CK1_1	155	161	PF00069	0.643
MOD_CK1_1	180	186	PF00069	0.537
MOD_CK1_1	287	293	PF00069	0.404
MOD_CK1_1	331	337	PF00069	0.490
MOD_CK1_1	413	419	PF00069	0.757
MOD_CK1_1	516	522	PF00069	0.558
MOD_CK1_1	533	539	PF00069	0.375
MOD_CK1_1	582	588	PF00069	0.509
MOD_CK2_1	101	107	PF00069	0.421
MOD_CK2_1	128	134	PF00069	0.413
MOD_CK2_1	423	429	PF00069	0.659
MOD_CK2_1	807	813	PF00069	0.499
MOD_CK2_1	847	853	PF00069	0.500
MOD_CK2_1	882	888	PF00069	0.503
MOD_GlcNHglycan	134	138	PF01048	0.458
MOD_GlcNHglycan	161	164	PF01048	0.705
MOD_GlcNHglycan	227	230	PF01048	0.471
MOD_GlcNHglycan	233	236	PF01048	0.411
MOD_GlcNHglycan	247	250	PF01048	0.306
MOD_GlcNHglycan	408	411	PF01048	0.729
MOD_GlcNHglycan	48	51	PF01048	0.528
MOD_GlcNHglycan	497	500	PF01048	0.389
MOD_GlcNHglycan	649	652	PF01048	0.550
MOD_GlcNHglycan	71	74	PF01048	0.432
MOD_GlcNHglycan	777	780	PF01048	0.434
MOD_GlcNHglycan	849	852	PF01048	0.459
MOD_GlcNHglycan	895	899	PF01048	0.642
MOD_GSK3_1	128	135	PF00069	0.435
MOD_GSK3_1	155	162	PF00069	0.603
MOD_GSK3_1	165	172	PF00069	0.447
MOD_GSK3_1	227	234	PF00069	0.391
MOD_GSK3_1	245	252	PF00069	0.468
MOD_GSK3_1	324	331	PF00069	0.498
MOD_GSK3_1	360	367	PF00069	0.512
MOD_GSK3_1	406	413	PF00069	0.785
MOD_GSK3_1	419	426	PF00069	0.553
MOD_GSK3_1	529	536	PF00069	0.531
MOD_GSK3_1	550	557	PF00069	0.516
MOD_GSK3_1	737	744	PF00069	0.416
MOD_GSK3_1	790	797	PF00069	0.503
MOD_GSK3_1	804	811	PF00069	0.388
MOD_GSK3_1	9	16	PF00069	0.596
MOD_N-GLC_2	176	178	PF02516	0.451
MOD_NEK2_1	1	6	PF00069	0.572
MOD_NEK2_1	114	119	PF00069	0.391
MOD_NEK2_1	169	174	PF00069	0.432
MOD_NEK2_1	243	248	PF00069	0.509
MOD_NEK2_1	325	330	PF00069	0.452
MOD_NEK2_1	33	38	PF00069	0.570
MOD_NEK2_1	360	365	PF00069	0.418
MOD_NEK2_1	380	385	PF00069	0.241
MOD_NEK2_1	46	51	PF00069	0.342
MOD_NEK2_1	524	529	PF00069	0.445
MOD_NEK2_1	535	540	PF00069	0.378
MOD_NEK2_1	61	66	PF00069	0.358
MOD_NEK2_1	626	631	PF00069	0.501
MOD_NEK2_1	68	73	PF00069	0.457
MOD_NEK2_1	746	751	PF00069	0.456
MOD_NEK2_1	790	795	PF00069	0.597
MOD_NEK2_1	894	899	PF00069	0.463
MOD_NEK2_2	128	133	PF00069	0.550
MOD_NEK2_2	879	884	PF00069	0.521
MOD_OFUCOSY	125	132	PF10250	0.507
MOD_PIKK_1	626	632	PF00454	0.577
MOD_PIKK_1	683	689	PF00454	0.494
MOD_PKA_1	406	412	PF00069	0.727
MOD_PKA_2	132	138	PF00069	0.552
MOD_PKA_2	147	153	PF00069	0.532
MOD_PKA_2	155	161	PF00069	0.718
MOD_PKA_2	406	412	PF00069	0.738
MOD_PKA_2	413	419	PF00069	0.775
MOD_PKA_2	794	800	PF00069	0.590
MOD_PKB_1	543	551	PF00069	0.565
MOD_Plk_1	1	7	PF00069	0.530
MOD_Plk_1	188	194	PF00069	0.471
MOD_Plk_1	237	243	PF00069	0.543
MOD_Plk_1	378	384	PF00069	0.390
MOD_Plk_1	524	530	PF00069	0.510
MOD_Plk_1	791	797	PF00069	0.590
MOD_Plk_1	804	810	PF00069	0.462
MOD_Plk_2-3	554	560	PF00069	0.541
MOD_Plk_2-3	601	607	PF00069	0.386
MOD_Plk_4	1	7	PF00069	0.596
MOD_Plk_4	165	171	PF00069	0.452
MOD_Plk_4	180	186	PF00069	0.389
MOD_Plk_4	188	194	PF00069	0.383
MOD_Plk_4	227	233	PF00069	0.394
MOD_Plk_4	237	243	PF00069	0.399
MOD_Plk_4	277	283	PF00069	0.357
MOD_Plk_4	524	530	PF00069	0.490
MOD_Plk_4	741	747	PF00069	0.392
MOD_Plk_4	813	819	PF00069	0.483
MOD_ProDKin_1	137	143	PF00069	0.555
MOD_ProDKin_1	214	220	PF00069	0.541
MOD_ProDKin_1	416	422	PF00069	0.772
MOD_ProDKin_1	63	69	PF00069	0.557
MOD_SUMO_for_1	898	901	PF00179	0.571
TRG_DiLeu_BaEn_1	134	139	PF01217	0.438
TRG_DiLeu_BaEn_2	109	115	PF01217	0.488
TRG_DiLeu_BaEn_2	618	624	PF01217	0.404
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.476
TRG_DiLeu_BaLyEn_6	607	612	PF01217	0.546
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.459
TRG_ENDOCYTIC_2	453	456	PF00928	0.416
TRG_ENDOCYTIC_2	489	492	PF00928	0.462
TRG_ENDOCYTIC_2	517	520	PF00928	0.525
TRG_ENDOCYTIC_2	642	645	PF00928	0.532
TRG_ENDOCYTIC_2	674	677	PF00928	0.502
TRG_ENDOCYTIC_2	698	701	PF00928	0.433
TRG_ENDOCYTIC_2	742	745	PF00928	0.396
TRG_ER_diArg_1	119	122	PF00400	0.396
TRG_ER_diArg_1	17	20	PF00400	0.678
TRG_ER_diArg_1	314	317	PF00400	0.501
TRG_ER_diArg_1	446	448	PF00400	0.404
TRG_ER_diArg_1	462	464	PF00400	0.352
TRG_ER_diArg_1	667	669	PF00400	0.580
TRG_ER_diArg_1	91	94	PF00400	0.499
TRG_NES_CRM1_1	474	488	PF08389	0.523
TRG_NES_CRM1_1	813	826	PF08389	0.443
TRG_NLS_MonoExtN_4	922	927	PF00514	0.602
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	569	574	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBU1	Leptomonas seymouri	72%	100%
A0A1X0NJ82	Trypanosomatidae	43%	100%
A0A422N8B4	Trypanosoma rangeli	42%	100%
A4HC13	Leishmania braziliensis	85%	100%
A4HZF4	Leishmania infantum	100%	100%
D0A113	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AVF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QC29	Leishmania major	96%	100%
V5B1W3	Trypanosoma cruzi	43%	100%