N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWP5_LEIDO

TriTrypDb:

LdBPK_211740.1 , LdCL_210023200 , LDHU3_21.2050

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWP5

PDB structure(s): 7aih_Ah , 7am2_Ah , 7ane_Ah

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.372
CLV_C14_Caspase3-7	335	339	PF00656	0.527
CLV_C14_Caspase3-7	349	353	PF00656	0.527
CLV_NRD_NRD_1	187	189	PF00675	0.343
CLV_NRD_NRD_1	400	402	PF00675	0.403
CLV_NRD_NRD_1	445	447	PF00675	0.397
CLV_NRD_NRD_1	471	473	PF00675	0.576
CLV_NRD_NRD_1	499	501	PF00675	0.553
CLV_NRD_NRD_1	514	516	PF00675	0.580
CLV_PCSK_KEX2_1	187	189	PF00082	0.342
CLV_PCSK_KEX2_1	39	41	PF00082	0.466
CLV_PCSK_KEX2_1	400	402	PF00082	0.403
CLV_PCSK_KEX2_1	444	446	PF00082	0.393
CLV_PCSK_KEX2_1	471	473	PF00082	0.557
CLV_PCSK_KEX2_1	499	501	PF00082	0.559
CLV_PCSK_KEX2_1	5	7	PF00082	0.517
CLV_PCSK_KEX2_1	514	516	PF00082	0.587
CLV_PCSK_KEX2_1	524	526	PF00082	0.516
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.507
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.393
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.699
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.589
CLV_PCSK_PC7_1	495	501	PF00082	0.521
CLV_PCSK_SKI1_1	176	180	PF00082	0.335
CLV_PCSK_SKI1_1	289	293	PF00082	0.386
CLV_PCSK_SKI1_1	312	316	PF00082	0.318
CLV_PCSK_SKI1_1	33	37	PF00082	0.596
CLV_PCSK_SKI1_1	368	372	PF00082	0.420
CLV_PCSK_SKI1_1	386	390	PF00082	0.315
CLV_PCSK_SKI1_1	414	418	PF00082	0.455
CLV_PCSK_SKI1_1	427	431	PF00082	0.414
CLV_PCSK_SKI1_1	499	503	PF00082	0.573
CLV_PCSK_SKI1_1	525	529	PF00082	0.490
CLV_PCSK_SKI1_1	6	10	PF00082	0.519
DEG_APCC_DBOX_1	175	183	PF00400	0.318
DEG_Nend_Nbox_1	1	3	PF02207	0.490
DEG_ODPH_VHL_1	306	317	PF01847	0.422
DOC_ANK_TNKS_1	200	207	PF00023	0.374
DOC_CKS1_1	381	386	PF01111	0.384
DOC_CKS1_1	99	104	PF01111	0.326
DOC_CYCLIN_RxL_1	184	194	PF00134	0.413
DOC_MAPK_gen_1	134	144	PF00069	0.339
DOC_MAPK_gen_1	184	193	PF00069	0.349
DOC_MAPK_gen_1	5	11	PF00069	0.623
DOC_MIT_MIM_1	81	90	PF04212	0.431
DOC_PP1_RVXF_1	91	97	PF00149	0.327
DOC_PP4_FxxP_1	14	17	PF00568	0.413
DOC_PP4_FxxP_1	253	256	PF00568	0.357
DOC_PP4_FxxP_1	265	268	PF00568	0.418
DOC_PP4_FxxP_1	99	102	PF00568	0.316
DOC_USP7_MATH_1	280	284	PF00917	0.435
DOC_USP7_MATH_1	298	302	PF00917	0.317
DOC_USP7_MATH_1	42	46	PF00917	0.522
DOC_USP7_MATH_1	453	457	PF00917	0.517
DOC_USP7_MATH_2	17	23	PF00917	0.482
DOC_USP7_UBL2_3	519	523	PF12436	0.617
DOC_USP7_UBL2_3	93	97	PF12436	0.395
DOC_WW_Pin1_4	264	269	PF00397	0.493
DOC_WW_Pin1_4	294	299	PF00397	0.447
DOC_WW_Pin1_4	380	385	PF00397	0.357
DOC_WW_Pin1_4	98	103	PF00397	0.322
LIG_14-3-3_CanoR_1	151	155	PF00244	0.434
LIG_14-3-3_CanoR_1	361	367	PF00244	0.368
LIG_14-3-3_CanoR_1	400	408	PF00244	0.396
LIG_14-3-3_CanoR_1	82	86	PF00244	0.490
LIG_Actin_WH2_2	280	296	PF00022	0.386
LIG_Actin_WH2_2	385	402	PF00022	0.392
LIG_APCC_ABBA_1	107	112	PF00400	0.327
LIG_APCC_ABBA_1	285	290	PF00400	0.402
LIG_BRCT_BRCA1_1	83	87	PF00533	0.377
LIG_Clathr_ClatBox_1	179	183	PF01394	0.316
LIG_deltaCOP1_diTrp_1	200	207	PF00928	0.340
LIG_FHA_1	387	393	PF00498	0.333
LIG_FHA_1	479	485	PF00498	0.642
LIG_FHA_1	90	96	PF00498	0.308
LIG_FHA_1	99	105	PF00498	0.308
LIG_FHA_2	231	237	PF00498	0.376
LIG_FHA_2	273	279	PF00498	0.422
LIG_FHA_2	415	421	PF00498	0.392
LIG_FHA_2	480	486	PF00498	0.569
LIG_IBAR_NPY_1	222	224	PF08397	0.394
LIG_LIR_Apic_2	252	256	PF02991	0.390
LIG_LIR_Apic_2	262	268	PF02991	0.394
LIG_LIR_Gen_1	258	268	PF02991	0.503
LIG_LIR_Gen_1	27	35	PF02991	0.425
LIG_LIR_Gen_1	332	340	PF02991	0.381
LIG_LIR_Gen_1	526	536	PF02991	0.495
LIG_LIR_Nem_3	136	142	PF02991	0.435
LIG_LIR_Nem_3	200	205	PF02991	0.362
LIG_LIR_Nem_3	248	253	PF02991	0.374
LIG_LIR_Nem_3	258	264	PF02991	0.386
LIG_LIR_Nem_3	27	31	PF02991	0.438
LIG_LIR_Nem_3	332	336	PF02991	0.363
LIG_LIR_Nem_3	428	433	PF02991	0.341
LIG_LIR_Nem_3	526	531	PF02991	0.484
LIG_LIR_Nem_3	84	90	PF02991	0.348
LIG_NRBOX	461	467	PF00104	0.488
LIG_Pex14_1	448	452	PF04695	0.411
LIG_Pex14_1	65	69	PF04695	0.428
LIG_Pex14_2	261	265	PF04695	0.397
LIG_PTB_Apo_2	535	542	PF02174	0.519
LIG_PTB_Phospho_1	535	541	PF10480	0.515
LIG_REV1ctd_RIR_1	368	378	PF16727	0.481
LIG_SH2_CRK	28	32	PF00017	0.438
LIG_SH2_PTP2	224	227	PF00017	0.423
LIG_SH2_SRC	224	227	PF00017	0.404
LIG_SH2_STAT3	69	72	PF00017	0.529
LIG_SH2_STAT5	132	135	PF00017	0.480
LIG_SH2_STAT5	197	200	PF00017	0.319
LIG_SH2_STAT5	215	218	PF00017	0.361
LIG_SH2_STAT5	224	227	PF00017	0.370
LIG_SH2_STAT5	316	319	PF00017	0.302
LIG_SH2_STAT5	382	385	PF00017	0.378
LIG_SH2_STAT5	395	398	PF00017	0.245
LIG_SH2_STAT5	46	49	PF00017	0.554
LIG_SH2_STAT5	464	467	PF00017	0.505
LIG_SUMO_SIM_anti_2	233	239	PF11976	0.529
LIG_TRAF2_1	260	263	PF00917	0.474
LIG_TRAF2_1	332	335	PF00917	0.403
LIG_TRAF2_1	456	459	PF00917	0.460
LIG_TRFH_1	28	32	PF08558	0.517
LIG_TYR_ITIM	431	436	PF00017	0.355
LIG_WRPW_2	66	69	PF00400	0.467
MOD_CDK_SPxK_1	380	386	PF00069	0.381
MOD_CK1_1	269	275	PF00069	0.480
MOD_CK1_1	55	61	PF00069	0.504
MOD_CK2_1	329	335	PF00069	0.424
MOD_CK2_1	414	420	PF00069	0.399
MOD_CK2_1	453	459	PF00069	0.529
MOD_CK2_1	479	485	PF00069	0.581
MOD_CMANNOS	199	202	PF00535	0.341
MOD_Cter_Amidation	37	40	PF01082	0.484
MOD_Cter_Amidation	469	472	PF01082	0.515
MOD_GlcNHglycan	2	5	PF01048	0.645
MOD_GlcNHglycan	317	320	PF01048	0.329
MOD_GlcNHglycan	362	365	PF01048	0.357
MOD_GSK3_1	165	172	PF00069	0.398
MOD_GSK3_1	294	301	PF00069	0.334
MOD_GSK3_1	403	410	PF00069	0.444
MOD_GSK3_1	453	460	PF00069	0.527
MOD_GSK3_1	519	526	PF00069	0.547
MOD_N-GLC_1	49	54	PF02516	0.507
MOD_NEK2_1	169	174	PF00069	0.363
MOD_NEK2_1	315	320	PF00069	0.383
MOD_NEK2_1	357	362	PF00069	0.353
MOD_PIKK_1	169	175	PF00454	0.356
MOD_PK_1	523	529	PF00069	0.565
MOD_PKA_1	33	39	PF00069	0.469
MOD_PKA_1	523	529	PF00069	0.570
MOD_PKA_2	133	139	PF00069	0.423
MOD_PKA_2	150	156	PF00069	0.556
MOD_PKA_2	360	366	PF00069	0.341
MOD_PKA_2	513	519	PF00069	0.630
MOD_PKA_2	81	87	PF00069	0.490
MOD_Plk_1	110	116	PF00069	0.342
MOD_Plk_1	149	155	PF00069	0.364
MOD_Plk_1	457	463	PF00069	0.476
MOD_Plk_1	55	61	PF00069	0.493
MOD_Plk_2-3	458	464	PF00069	0.478
MOD_Plk_4	165	171	PF00069	0.382
MOD_Plk_4	280	286	PF00069	0.400
MOD_ProDKin_1	264	270	PF00069	0.489
MOD_ProDKin_1	294	300	PF00069	0.458
MOD_ProDKin_1	380	386	PF00069	0.355
MOD_ProDKin_1	98	104	PF00069	0.322
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.471
TRG_ENDOCYTIC_2	250	253	PF00928	0.367
TRG_ENDOCYTIC_2	28	31	PF00928	0.459
TRG_ENDOCYTIC_2	288	291	PF00928	0.373
TRG_ENDOCYTIC_2	433	436	PF00928	0.354
TRG_ER_diArg_1	186	188	PF00400	0.325
TRG_ER_diArg_1	399	401	PF00400	0.401
TRG_ER_diArg_1	445	447	PF00400	0.399
TRG_ER_diArg_1	499	501	PF00400	0.530
TRG_ER_diArg_1	513	515	PF00400	0.563
TRG_NLS_MonoExtN_4	443	448	PF00514	0.482
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	500	505	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W4	Leptomonas seymouri	84%	100%
A0A0S4JTY1	Bodo saltans	57%	99%
A0A1X0NHH6	Trypanosomatidae	64%	98%
A0A3R7KIX4	Trypanosoma rangeli	71%	100%
A4HBZ8	Leishmania braziliensis	94%	100%
A4HZE7	Leishmania infantum	100%	100%
D0A135	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AVD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QC45	Leishmania major	96%	100%
V5B1V1	Trypanosoma cruzi	72%	100%