SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWN7_LEIDO

TriTrypDb:

LdBPK_211210.1 , LdCL_210017200 , LDHU3_21.1440

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.720
CLV_C14_Caspase3-7	295	299	PF00656	0.715
CLV_C14_Caspase3-7	358	362	PF00656	0.607
CLV_C14_Caspase3-7	391	395	PF00656	0.697
CLV_C14_Caspase3-7	486	490	PF00656	0.584
CLV_C14_Caspase3-7	543	547	PF00656	0.736
CLV_C14_Caspase3-7	705	709	PF00656	0.768
CLV_NRD_NRD_1	171	173	PF00675	0.509
CLV_NRD_NRD_1	22	24	PF00675	0.582
CLV_NRD_NRD_1	314	316	PF00675	0.796
CLV_NRD_NRD_1	35	37	PF00675	0.637
CLV_NRD_NRD_1	41	43	PF00675	0.595
CLV_NRD_NRD_1	51	53	PF00675	0.524
CLV_NRD_NRD_1	521	523	PF00675	0.578
CLV_NRD_NRD_1	526	528	PF00675	0.627
CLV_NRD_NRD_1	584	586	PF00675	0.672
CLV_NRD_NRD_1	597	599	PF00675	0.496
CLV_NRD_NRD_1	612	614	PF00675	0.445
CLV_NRD_NRD_1	652	654	PF00675	0.455
CLV_PCSK_FUR_1	524	528	PF00082	0.662
CLV_PCSK_KEX2_1	171	173	PF00082	0.509
CLV_PCSK_KEX2_1	22	24	PF00082	0.582
CLV_PCSK_KEX2_1	35	37	PF00082	0.637
CLV_PCSK_KEX2_1	41	43	PF00082	0.595
CLV_PCSK_KEX2_1	51	53	PF00082	0.524
CLV_PCSK_KEX2_1	523	525	PF00082	0.617
CLV_PCSK_KEX2_1	526	528	PF00082	0.634
CLV_PCSK_KEX2_1	599	601	PF00082	0.525
CLV_PCSK_KEX2_1	612	614	PF00082	0.383
CLV_PCSK_KEX2_1	652	654	PF00082	0.474
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.652
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.634
CLV_PCSK_PC7_1	522	528	PF00082	0.686
CLV_PCSK_SKI1_1	105	109	PF00082	0.589
CLV_PCSK_SKI1_1	171	175	PF00082	0.484
CLV_PCSK_SKI1_1	177	181	PF00082	0.516
CLV_PCSK_SKI1_1	222	226	PF00082	0.682
CLV_PCSK_SKI1_1	232	236	PF00082	0.585
CLV_PCSK_SKI1_1	385	389	PF00082	0.668
CLV_PCSK_SKI1_1	401	405	PF00082	0.629
CLV_PCSK_SKI1_1	478	482	PF00082	0.671
CLV_PCSK_SKI1_1	537	541	PF00082	0.708
CLV_PCSK_SKI1_1	589	593	PF00082	0.517
CLV_PCSK_SKI1_1	599	603	PF00082	0.461
CLV_PCSK_SKI1_1	652	656	PF00082	0.524
CLV_PCSK_SKI1_1	660	664	PF00082	0.568
CLV_PCSK_SKI1_1	99	103	PF00082	0.612
DEG_APCC_DBOX_1	652	660	PF00400	0.462
DEG_SPOP_SBC_1	123	127	PF00917	0.698
DEG_SPOP_SBC_1	142	146	PF00917	0.581
DEG_SPOP_SBC_1	233	237	PF00917	0.732
DEG_SPOP_SBC_1	568	572	PF00917	0.797
DEG_SPOP_SBC_1	68	72	PF00917	0.743
DOC_CKS1_1	344	349	PF01111	0.573
DOC_CYCLIN_RxL_1	472	482	PF00134	0.672
DOC_CYCLIN_RxL_1	649	658	PF00134	0.462
DOC_MAPK_DCC_7	508	516	PF00069	0.641
DOC_MAPK_gen_1	105	115	PF00069	0.576
DOC_MAPK_gen_1	380	388	PF00069	0.577
DOC_MAPK_gen_1	41	49	PF00069	0.604
DOC_MAPK_gen_1	436	445	PF00069	0.586
DOC_MAPK_MEF2A_6	436	445	PF00069	0.567
DOC_MAPK_MEF2A_6	478	487	PF00069	0.644
DOC_MAPK_MEF2A_6	508	517	PF00069	0.602
DOC_PP1_RVXF_1	476	482	PF00149	0.649
DOC_PP2B_LxvP_1	196	199	PF13499	0.561
DOC_PP2B_LxvP_1	339	342	PF13499	0.810
DOC_USP7_MATH_1	132	136	PF00917	0.810
DOC_USP7_MATH_1	142	146	PF00917	0.756
DOC_USP7_MATH_1	148	152	PF00917	0.743
DOC_USP7_MATH_1	164	168	PF00917	0.473
DOC_USP7_MATH_1	233	237	PF00917	0.734
DOC_USP7_MATH_1	245	249	PF00917	0.724
DOC_USP7_MATH_1	395	399	PF00917	0.483
DOC_USP7_MATH_1	568	572	PF00917	0.782
DOC_USP7_MATH_1	69	73	PF00917	0.711
DOC_USP7_MATH_1	699	703	PF00917	0.701
DOC_USP7_UBL2_3	105	109	PF12436	0.675
DOC_WW_Pin1_4	236	241	PF00397	0.744
DOC_WW_Pin1_4	282	287	PF00397	0.670
DOC_WW_Pin1_4	316	321	PF00397	0.740
DOC_WW_Pin1_4	337	342	PF00397	0.783
DOC_WW_Pin1_4	343	348	PF00397	0.700
DOC_WW_Pin1_4	62	67	PF00397	0.761
DOC_WW_Pin1_4	9	14	PF00397	0.718
LIG_14-3-3_CanoR_1	143	150	PF00244	0.576
LIG_14-3-3_CanoR_1	165	171	PF00244	0.521
LIG_14-3-3_CanoR_1	177	186	PF00244	0.475
LIG_14-3-3_CanoR_1	246	253	PF00244	0.677
LIG_14-3-3_CanoR_1	478	484	PF00244	0.528
LIG_14-3-3_CanoR_1	51	55	PF00244	0.688
LIG_14-3-3_CanoR_1	550	560	PF00244	0.819
LIG_14-3-3_CanoR_1	598	607	PF00244	0.525
LIG_14-3-3_CanoR_1	612	620	PF00244	0.421
LIG_BIR_III_4	628	632	PF00653	0.555
LIG_CtBP_PxDLS_1	341	345	PF00389	0.582
LIG_deltaCOP1_diTrp_1	473	481	PF00928	0.670
LIG_EVH1_1	365	369	PF00568	0.602
LIG_FHA_1	102	108	PF00498	0.568
LIG_FHA_1	144	150	PF00498	0.709
LIG_FHA_1	440	446	PF00498	0.610
LIG_FHA_1	447	453	PF00498	0.559
LIG_FHA_1	474	480	PF00498	0.631
LIG_FHA_1	575	581	PF00498	0.714
LIG_FHA_2	187	193	PF00498	0.478
LIG_FHA_2	247	253	PF00498	0.625
LIG_FHA_2	322	328	PF00498	0.633
LIG_FHA_2	424	430	PF00498	0.499
LIG_FHA_2	703	709	PF00498	0.755
LIG_IRF3_LxIS_1	481	488	PF10401	0.467
LIG_LIR_Gen_1	182	192	PF02991	0.692
LIG_LIR_Gen_1	429	439	PF02991	0.617
LIG_LIR_Gen_1	617	626	PF02991	0.305
LIG_LIR_Nem_3	182	188	PF02991	0.572
LIG_LIR_Nem_3	191	197	PF02991	0.575
LIG_LIR_Nem_3	429	435	PF02991	0.622
LIG_LIR_Nem_3	510	515	PF02991	0.601
LIG_LIR_Nem_3	617	623	PF02991	0.307
LIG_MYND_2	347	351	PF01753	0.574
LIG_NRBOX	479	485	PF00104	0.642
LIG_NRBOX	620	626	PF00104	0.558
LIG_PDZ_Class_2	714	719	PF00595	0.581
LIG_PTB_Apo_2	156	163	PF02174	0.659
LIG_PTB_Apo_2	372	379	PF02174	0.647
LIG_PTB_Phospho_1	372	378	PF10480	0.650
LIG_Rb_pABgroove_1	496	504	PF01858	0.640
LIG_SH2_CRK	593	597	PF00017	0.568
LIG_SH2_NCK_1	425	429	PF00017	0.595
LIG_SH2_NCK_1	593	597	PF00017	0.514
LIG_SH2_SRC	185	188	PF00017	0.610
LIG_SH2_STAT5	185	188	PF00017	0.546
LIG_SH2_STAT5	195	198	PF00017	0.548
LIG_SH2_STAT5	223	226	PF00017	0.617
LIG_SH2_STAT5	425	428	PF00017	0.424
LIG_SH3_1	63	69	PF00018	0.574
LIG_SH3_3	136	142	PF00018	0.633
LIG_SH3_3	201	207	PF00018	0.718
LIG_SH3_3	303	309	PF00018	0.773
LIG_SH3_3	360	366	PF00018	0.714
LIG_SH3_3	63	69	PF00018	0.574
LIG_SH3_4	105	112	PF00018	0.644
LIG_SUMO_SIM_anti_2	12	18	PF11976	0.648
LIG_SUMO_SIM_anti_2	622	628	PF11976	0.285
LIG_SUMO_SIM_par_1	482	489	PF11976	0.652
LIG_SUMO_SIM_par_1	622	628	PF11976	0.285
LIG_TRAF2_1	275	278	PF00917	0.595
LIG_TRAF2_1	420	423	PF00917	0.577
LIG_TRAF2_1	462	465	PF00917	0.704
LIG_TRFH_1	337	341	PF08558	0.813
LIG_TYR_ITIM	591	596	PF00017	0.551
LIG_UBA3_1	431	438	PF00899	0.575
MOD_CDK_SPxxK_3	236	243	PF00069	0.706
MOD_CK1_1	144	150	PF00069	0.736
MOD_CK1_1	236	242	PF00069	0.699
MOD_CK1_1	248	254	PF00069	0.585
MOD_CK1_1	28	34	PF00069	0.566
MOD_CK1_1	314	320	PF00069	0.760
MOD_CK1_1	53	59	PF00069	0.712
MOD_CK1_1	541	547	PF00069	0.714
MOD_CK1_1	567	573	PF00069	0.798
MOD_CK1_1	62	68	PF00069	0.780
MOD_CK1_1	70	76	PF00069	0.656
MOD_CK1_1	702	708	PF00069	0.708
MOD_CK1_1	9	15	PF00069	0.520
MOD_CK2_1	131	137	PF00069	0.683
MOD_CK2_1	246	252	PF00069	0.657
MOD_CK2_1	321	327	PF00069	0.753
MOD_CK2_1	337	343	PF00069	0.574
MOD_CK2_1	417	423	PF00069	0.572
MOD_CK2_1	485	491	PF00069	0.630
MOD_CK2_1	611	617	PF00069	0.542
MOD_GlcNHglycan	120	123	PF01048	0.703
MOD_GlcNHglycan	133	137	PF01048	0.619
MOD_GlcNHglycan	146	149	PF01048	0.785
MOD_GlcNHglycan	182	185	PF01048	0.593
MOD_GlcNHglycan	200	203	PF01048	0.508
MOD_GlcNHglycan	27	30	PF01048	0.614
MOD_GlcNHglycan	327	331	PF01048	0.684
MOD_GlcNHglycan	334	337	PF01048	0.721
MOD_GlcNHglycan	542	546	PF01048	0.748
MOD_GlcNHglycan	566	569	PF01048	0.800
MOD_GlcNHglycan	664	667	PF01048	0.719
MOD_GlcNHglycan	682	685	PF01048	0.740
MOD_GlcNHglycan	701	704	PF01048	0.581
MOD_GlcNHglycan	8	11	PF01048	0.554
MOD_GSK3_1	118	125	PF00069	0.663
MOD_GSK3_1	128	135	PF00069	0.720
MOD_GSK3_1	144	151	PF00069	0.777
MOD_GSK3_1	232	239	PF00069	0.677
MOD_GSK3_1	278	285	PF00069	0.675
MOD_GSK3_1	314	321	PF00069	0.671
MOD_GSK3_1	446	453	PF00069	0.591
MOD_GSK3_1	479	486	PF00069	0.553
MOD_GSK3_1	564	571	PF00069	0.712
MOD_GSK3_1	662	669	PF00069	0.626
MOD_GSK3_1	67	74	PF00069	0.758
MOD_GSK3_1	698	705	PF00069	0.798
MOD_N-GLC_1	439	444	PF02516	0.710
MOD_NEK2_1	179	184	PF00069	0.649
MOD_NEK2_1	388	393	PF00069	0.691
MOD_NEK2_1	404	409	PF00069	0.489
MOD_NEK2_1	479	484	PF00069	0.526
MOD_NEK2_1	59	64	PF00069	0.764
MOD_NEK2_1	592	597	PF00069	0.598
MOD_NEK2_1	655	660	PF00069	0.552
MOD_NEK2_1	662	667	PF00069	0.611
MOD_NEK2_1	75	80	PF00069	0.623
MOD_PIKK_1	148	154	PF00454	0.763
MOD_PIKK_1	552	558	PF00454	0.722
MOD_PIKK_1	580	586	PF00454	0.719
MOD_PKA_1	599	605	PF00069	0.520
MOD_PKA_2	142	148	PF00069	0.578
MOD_PKA_2	164	170	PF00069	0.596
MOD_PKA_2	245	251	PF00069	0.717
MOD_PKA_2	314	320	PF00069	0.734
MOD_PKA_2	50	56	PF00069	0.629
MOD_PKA_2	599	605	PF00069	0.573
MOD_PKA_2	611	617	PF00069	0.396
MOD_Plk_1	439	445	PF00069	0.640
MOD_Plk_2-3	264	270	PF00069	0.620
MOD_Plk_4	12	18	PF00069	0.621
MOD_Plk_4	28	34	PF00069	0.523
MOD_Plk_4	450	456	PF00069	0.571
MOD_Plk_4	619	625	PF00069	0.290
MOD_Plk_4	71	77	PF00069	0.797
MOD_ProDKin_1	236	242	PF00069	0.742
MOD_ProDKin_1	282	288	PF00069	0.674
MOD_ProDKin_1	316	322	PF00069	0.738
MOD_ProDKin_1	337	343	PF00069	0.781
MOD_ProDKin_1	62	68	PF00069	0.756
MOD_ProDKin_1	9	15	PF00069	0.714
MOD_SUMO_for_1	539	542	PF00179	0.712
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.745
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.519
TRG_DiLeu_LyEn_5	510	515	PF01217	0.640
TRG_ENDOCYTIC_2	185	188	PF00928	0.580
TRG_ENDOCYTIC_2	593	596	PF00928	0.563
TRG_ER_diArg_1	170	172	PF00400	0.509
TRG_ER_diArg_1	22	24	PF00400	0.578
TRG_ER_diArg_1	34	36	PF00400	0.569
TRG_ER_diArg_1	383	386	PF00400	0.607
TRG_ER_diArg_1	522	525	PF00400	0.679
TRG_ER_diArg_1	611	613	PF00400	0.467
TRG_ER_diArg_1	651	653	PF00400	0.470
TRG_NLS_Bipartite_1	585	602	PF00514	0.479
TRG_NLS_MonoCore_2	522	527	PF00514	0.710
TRG_NLS_MonoExtC_3	521	526	PF00514	0.620
TRG_NLS_MonoExtC_3	597	603	PF00514	0.600
TRG_NLS_MonoExtN_4	522	527	PF00514	0.630
TRG_Pf-PMV_PEXEL_1	35	40	PF00026	0.674
TRG_Pf-PMV_PEXEL_1	496	500	PF00026	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0P8	Leptomonas seymouri	47%	100%
A0A1X0NXZ3	Trypanosomatidae	36%	100%
A0A3S5IS33	Trypanosoma rangeli	36%	100%
A4HBV7	Leishmania braziliensis	72%	98%
D0A197	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AGW5	Leishmania infantum	100%	100%
E9AV81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QC99	Leishmania major	90%	99%
V5BFI7	Trypanosoma cruzi	38%	100%