U4/U6_small_nuclear_ribonuclear_protein_putative/ GeneDB:LmjF.21.1120

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U4/U6 small nuclear ribonuclear protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWM8_LEIDO

TriTrypDb:

LdBPK_211360.1 , LdCL_210019100 , LDHU3_21.1610

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0110165	cellular anatomical entity	1	6
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	5
GO:0005840	ribosome	5	4
GO:0043228	non-membrane-bounded organelle	3	4
GO:0043232	intracellular non-membrane-bounded organelle	4	4

Expansion

Sequence features

A0A3S7WWM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWM8

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016740	transferase activity	2	5
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0017069	snRNA binding	5	1
GO:0017070	U6 snRNA binding	6	1
GO:0030621	U4 snRNA binding	6	1
GO:0030627	pre-mRNA 5'-splice site binding	6	1
GO:0036002	pre-mRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.486
CLV_C14_Caspase3-7	208	212	PF00656	0.490
CLV_C14_Caspase3-7	235	239	PF00656	0.657
CLV_C14_Caspase3-7	324	328	PF00656	0.452
CLV_C14_Caspase3-7	552	556	PF00656	0.769
CLV_NRD_NRD_1	383	385	PF00675	0.558
CLV_NRD_NRD_1	568	570	PF00675	0.618
CLV_NRD_NRD_1	606	608	PF00675	0.674
CLV_PCSK_KEX2_1	52	54	PF00082	0.587
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.629
CLV_PCSK_SKI1_1	132	136	PF00082	0.500
CLV_PCSK_SKI1_1	275	279	PF00082	0.557
CLV_PCSK_SKI1_1	355	359	PF00082	0.303
CLV_PCSK_SKI1_1	428	432	PF00082	0.196
CLV_PCSK_SKI1_1	78	82	PF00082	0.512
CLV_PCSK_SKI1_1	84	88	PF00082	0.532
CLV_Separin_Metazoa	604	608	PF03568	0.604
DEG_APCC_DBOX_1	427	435	PF00400	0.414
DEG_APCC_DBOX_1	472	480	PF00400	0.595
DEG_SCF_TRCP1_1	122	128	PF00400	0.565
DEG_SPOP_SBC_1	229	233	PF00917	0.623
DEG_SPOP_SBC_1	237	241	PF00917	0.660
DOC_MAPK_gen_1	198	207	PF00069	0.564
DOC_MAPK_gen_1	78	88	PF00069	0.552
DOC_PP1_RVXF_1	329	336	PF00149	0.388
DOC_PP2B_LxvP_1	102	105	PF13499	0.557
DOC_SPAK_OSR1_1	536	540	PF12202	0.561
DOC_USP7_MATH_1	105	109	PF00917	0.513
DOC_USP7_MATH_1	117	121	PF00917	0.572
DOC_USP7_MATH_1	152	156	PF00917	0.438
DOC_USP7_MATH_1	23	27	PF00917	0.696
DOC_USP7_MATH_1	318	322	PF00917	0.425
DOC_USP7_MATH_1	412	416	PF00917	0.539
DOC_USP7_MATH_1	422	426	PF00917	0.549
DOC_USP7_MATH_1	478	482	PF00917	0.722
DOC_USP7_MATH_1	512	516	PF00917	0.702
DOC_USP7_MATH_1	528	532	PF00917	0.699
DOC_USP7_MATH_1	572	576	PF00917	0.530
DOC_USP7_MATH_1	582	586	PF00917	0.620
DOC_USP7_MATH_1	91	95	PF00917	0.575
DOC_WW_Pin1_4	11	16	PF00397	0.711
DOC_WW_Pin1_4	148	153	PF00397	0.571
DOC_WW_Pin1_4	19	24	PF00397	0.629
DOC_WW_Pin1_4	285	290	PF00397	0.657
DOC_WW_Pin1_4	291	296	PF00397	0.599
DOC_WW_Pin1_4	360	365	PF00397	0.448
LIG_14-3-3_CanoR_1	154	160	PF00244	0.427
LIG_14-3-3_CanoR_1	204	208	PF00244	0.469
LIG_14-3-3_CanoR_1	428	437	PF00244	0.414
LIG_14-3-3_CanoR_1	482	492	PF00244	0.515
LIG_14-3-3_CanoR_1	536	540	PF00244	0.609
LIG_14-3-3_CterR_2	607	610	PF00244	0.528
LIG_APCC_ABBA_1	391	396	PF00400	0.622
LIG_BIR_II_1	1	5	PF00653	0.549
LIG_BIR_III_4	327	331	PF00653	0.486
LIG_BIR_III_4	396	400	PF00653	0.515
LIG_BRCT_BRCA1_1	13	17	PF00533	0.724
LIG_BRCT_BRCA1_1	187	191	PF00533	0.471
LIG_BRCT_BRCA1_1	414	418	PF00533	0.437
LIG_BRCT_BRCA1_1	479	483	PF00533	0.650
LIG_CSL_BTD_1	361	364	PF09270	0.480
LIG_FHA_1	254	260	PF00498	0.405
LIG_FHA_1	264	270	PF00498	0.363
LIG_FHA_1	291	297	PF00498	0.572
LIG_FHA_1	309	315	PF00498	0.276
LIG_FHA_1	439	445	PF00498	0.463
LIG_FHA_2	141	147	PF00498	0.428
LIG_FHA_2	156	162	PF00498	0.507
LIG_FHA_2	230	236	PF00498	0.677
LIG_FHA_2	322	328	PF00498	0.469
LIG_FHA_2	440	446	PF00498	0.437
LIG_FHA_2	503	509	PF00498	0.557
LIG_FHA_2	516	522	PF00498	0.670
LIG_LIR_Apic_2	417	422	PF02991	0.523
LIG_LIR_Gen_1	194	202	PF02991	0.514
LIG_LIR_Gen_1	534	544	PF02991	0.554
LIG_LIR_Gen_1	6	15	PF02991	0.670
LIG_LIR_Nem_3	162	168	PF02991	0.525
LIG_LIR_Nem_3	194	199	PF02991	0.523
LIG_LIR_Nem_3	495	501	PF02991	0.393
LIG_LIR_Nem_3	534	540	PF02991	0.554
LIG_LIR_Nem_3	6	11	PF02991	0.669
LIG_MYND_1	474	478	PF01753	0.600
LIG_PCNA_yPIPBox_3	30	43	PF02747	0.561
LIG_Rb_pABgroove_1	375	383	PF01858	0.539
LIG_SH2_CRK	419	423	PF00017	0.474
LIG_SH2_CRK	55	59	PF00017	0.552
LIG_SH2_GRB2like	419	422	PF00017	0.504
LIG_SH2_NCK_1	305	309	PF00017	0.582
LIG_SH2_PTP2	8	11	PF00017	0.719
LIG_SH2_SRC	159	162	PF00017	0.504
LIG_SH2_SRC	419	422	PF00017	0.504
LIG_SH2_STAP1	543	547	PF00017	0.487
LIG_SH2_STAT5	8	11	PF00017	0.700
LIG_SH3_3	110	116	PF00018	0.526
LIG_SH3_3	169	175	PF00018	0.429
LIG_SH3_3	471	477	PF00018	0.498
LIG_SUMO_SIM_anti_2	485	493	PF11976	0.454
LIG_SUMO_SIM_par_1	139	146	PF11976	0.446
LIG_UBA3_1	141	148	PF00899	0.319
LIG_UBA3_1	565	571	PF00899	0.615
MOD_CDK_SPK_2	11	16	PF00069	0.717
MOD_CDK_SPxK_1	148	154	PF00069	0.432
MOD_CDK_SPxxK_3	11	18	PF00069	0.709
MOD_CK1_1	120	126	PF00069	0.639
MOD_CK1_1	127	133	PF00069	0.628
MOD_CK1_1	155	161	PF00069	0.455
MOD_CK1_1	182	188	PF00069	0.529
MOD_CK1_1	230	236	PF00069	0.668
MOD_CK1_1	294	300	PF00069	0.668
MOD_CK1_1	3	9	PF00069	0.630
MOD_CK1_1	321	327	PF00069	0.428
MOD_CK1_1	515	521	PF00069	0.656
MOD_CK1_1	538	544	PF00069	0.605
MOD_CK1_1	545	551	PF00069	0.649
MOD_CK1_1	556	562	PF00069	0.614
MOD_CK2_1	229	235	PF00069	0.660
MOD_CK2_1	502	508	PF00069	0.596
MOD_CK2_1	515	521	PF00069	0.673
MOD_GlcNHglycan	119	122	PF01048	0.677
MOD_GlcNHglycan	129	132	PF01048	0.634
MOD_GlcNHglycan	136	139	PF01048	0.556
MOD_GlcNHglycan	181	184	PF01048	0.664
MOD_GlcNHglycan	218	221	PF01048	0.635
MOD_GlcNHglycan	232	235	PF01048	0.604
MOD_GlcNHglycan	240	243	PF01048	0.733
MOD_GlcNHglycan	283	286	PF01048	0.719
MOD_GlcNHglycan	338	341	PF01048	0.434
MOD_GlcNHglycan	370	373	PF01048	0.289
MOD_GlcNHglycan	424	427	PF01048	0.331
MOD_GlcNHglycan	514	517	PF01048	0.688
MOD_GlcNHglycan	526	529	PF01048	0.571
MOD_GlcNHglycan	530	533	PF01048	0.520
MOD_GlcNHglycan	555	558	PF01048	0.675
MOD_GlcNHglycan	580	583	PF01048	0.722
MOD_GlcNHglycan	584	587	PF01048	0.614
MOD_GSK3_1	120	127	PF00069	0.676
MOD_GSK3_1	148	155	PF00069	0.528
MOD_GSK3_1	185	192	PF00069	0.488
MOD_GSK3_1	19	26	PF00069	0.669
MOD_GSK3_1	205	212	PF00069	0.336
MOD_GSK3_1	224	231	PF00069	0.528
MOD_GSK3_1	233	240	PF00069	0.638
MOD_GSK3_1	281	288	PF00069	0.670
MOD_GSK3_1	290	297	PF00069	0.598
MOD_GSK3_1	304	311	PF00069	0.456
MOD_GSK3_1	318	325	PF00069	0.424
MOD_GSK3_1	440	447	PF00069	0.448
MOD_GSK3_1	478	485	PF00069	0.556
MOD_GSK3_1	524	531	PF00069	0.745
MOD_GSK3_1	535	542	PF00069	0.502
MOD_GSK3_1	551	558	PF00069	0.606
MOD_GSK3_1	578	585	PF00069	0.627
MOD_NEK2_1	17	22	PF00069	0.684
MOD_NEK2_1	189	194	PF00069	0.348
MOD_NEK2_1	260	265	PF00069	0.408
MOD_NEK2_1	278	283	PF00069	0.584
MOD_NEK2_1	439	444	PF00069	0.457
MOD_NEK2_1	483	488	PF00069	0.588
MOD_NEK2_1	535	540	PF00069	0.669
MOD_NEK2_1	578	583	PF00069	0.710
MOD_NEK2_1	70	75	PF00069	0.589
MOD_OFUCOSY	103	109	PF10250	0.463
MOD_PIKK_1	152	158	PF00454	0.535
MOD_PIKK_1	17	23	PF00454	0.666
MOD_PIKK_1	38	44	PF00454	0.632
MOD_PIKK_1	429	435	PF00454	0.457
MOD_PIKK_1	572	578	PF00454	0.516
MOD_PK_1	167	173	PF00069	0.473
MOD_PKA_1	384	390	PF00069	0.592
MOD_PKA_2	203	209	PF00069	0.458
MOD_PKA_2	535	541	PF00069	0.602
MOD_PKA_2	545	551	PF00069	0.541
MOD_Plk_1	444	450	PF00069	0.539
MOD_Plk_2-3	595	601	PF00069	0.756
MOD_Plk_4	140	146	PF00069	0.378
MOD_Plk_4	167	173	PF00069	0.491
MOD_Plk_4	191	197	PF00069	0.408
MOD_Plk_4	318	324	PF00069	0.360
MOD_Plk_4	4	10	PF00069	0.711
MOD_Plk_4	414	420	PF00069	0.525
MOD_ProDKin_1	11	17	PF00069	0.704
MOD_ProDKin_1	148	154	PF00069	0.572
MOD_ProDKin_1	19	25	PF00069	0.626
MOD_ProDKin_1	285	291	PF00069	0.650
MOD_ProDKin_1	360	366	PF00069	0.448
TRG_ENDOCYTIC_2	8	11	PF00928	0.719
TRG_ER_diArg_1	76	79	PF00400	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A5	Leptomonas seymouri	59%	94%
A0A0S4JGF5	Bodo saltans	30%	100%
A0A1X0NYH8	Trypanosomatidae	35%	94%
A0A422NAK4	Trypanosoma rangeli	40%	100%
A4HBX0	Leishmania braziliensis	83%	100%
D0A183	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AGY0	Leishmania infantum	100%	100%
E9AV96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QC84	Leishmania major	93%	100%
V5B548	Trypanosoma cruzi	40%	100%