Protein kinase domain/Protein tyrosine kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein kinase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWM5_LEIDO

TriTrypDb:

LdBPK_210910.1 , LdCL_210014100 , LDHU3_21.1050

Length:

984

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005773	vacuole	5	1
GO:0005776	autophagosome	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWM5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0006914	autophagy	3	5
GO:0008152	metabolic process	1	6
GO:0009056	catabolic process	2	5
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044248	cellular catabolic process	3	5
GO:0061919	process utilizing autophagic mechanism	2	5
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0006996	organelle organization	4	1
GO:0007033	vacuole organization	5	1
GO:0016043	cellular component organization	3	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0046777	protein autophosphorylation	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1905037	autophagosome organization	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	604	608	PF00656	0.540
CLV_C14_Caspase3-7	826	830	PF00656	0.596
CLV_NRD_NRD_1	216	218	PF00675	0.309
CLV_NRD_NRD_1	881	883	PF00675	0.651
CLV_PCSK_KEX2_1	214	216	PF00082	0.309
CLV_PCSK_KEX2_1	881	883	PF00082	0.651
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.309
CLV_PCSK_PC7_1	877	883	PF00082	0.614
CLV_PCSK_SKI1_1	137	141	PF00082	0.307
CLV_PCSK_SKI1_1	200	204	PF00082	0.309
CLV_PCSK_SKI1_1	221	225	PF00082	0.309
CLV_PCSK_SKI1_1	303	307	PF00082	0.386
CLV_PCSK_SKI1_1	551	555	PF00082	0.714
CLV_PCSK_SKI1_1	610	614	PF00082	0.483
CLV_PCSK_SKI1_1	877	881	PF00082	0.547
CLV_PCSK_SKI1_1	882	886	PF00082	0.553
CLV_PCSK_SKI1_1	944	948	PF00082	0.654
CLV_Separin_Metazoa	324	328	PF03568	0.309
CLV_Separin_Metazoa	342	346	PF03568	0.309
DEG_APCC_DBOX_1	958	966	PF00400	0.551
DEG_Nend_UBRbox_2	1	3	PF02207	0.713
DEG_SCF_FBW7_2	60	67	PF00400	0.656
DEG_SPOP_SBC_1	157	161	PF00917	0.328
DEG_SPOP_SBC_1	489	493	PF00917	0.724
DEG_SPOP_SBC_1	561	565	PF00917	0.649
DEG_SPOP_SBC_1	738	742	PF00917	0.573
DEG_SPOP_SBC_1	884	888	PF00917	0.522
DEG_SPOP_SBC_1	94	98	PF00917	0.699
DEG_SPOP_SBC_1	979	983	PF00917	0.575
DOC_ANK_TNKS_1	900	907	PF00023	0.591
DOC_CKS1_1	293	298	PF01111	0.309
DOC_CKS1_1	61	66	PF01111	0.660
DOC_CYCLIN_RxL_1	607	616	PF00134	0.478
DOC_MAPK_DCC_7	392	402	PF00069	0.540
DOC_MAPK_gen_1	166	174	PF00069	0.318
DOC_MAPK_gen_1	221	230	PF00069	0.309
DOC_MAPK_JIP1_4	224	230	PF00069	0.309
DOC_MAPK_MEF2A_6	166	174	PF00069	0.309
DOC_MAPK_MEF2A_6	871	880	PF00069	0.552
DOC_PP1_RVXF_1	942	948	PF00149	0.608
DOC_PP2B_LxvP_1	139	142	PF13499	0.386
DOC_PP2B_LxvP_1	775	778	PF13499	0.681
DOC_PP4_FxxP_1	402	405	PF00568	0.483
DOC_PP4_FxxP_1	575	578	PF00568	0.652
DOC_PP4_FxxP_1	99	102	PF00568	0.708
DOC_USP7_MATH_1	262	266	PF00917	0.261
DOC_USP7_MATH_1	405	409	PF00917	0.609
DOC_USP7_MATH_1	485	489	PF00917	0.708
DOC_USP7_MATH_1	509	513	PF00917	0.655
DOC_USP7_MATH_1	521	525	PF00917	0.573
DOC_USP7_MATH_1	589	593	PF00917	0.583
DOC_USP7_MATH_1	645	649	PF00917	0.615
DOC_USP7_MATH_1	738	742	PF00917	0.709
DOC_USP7_MATH_1	750	754	PF00917	0.553
DOC_USP7_MATH_1	863	867	PF00917	0.674
DOC_USP7_MATH_1	88	92	PF00917	0.703
DOC_USP7_MATH_1	914	918	PF00917	0.742
DOC_USP7_MATH_1	94	98	PF00917	0.772
DOC_USP7_MATH_1	979	983	PF00917	0.607
DOC_WW_Pin1_4	104	109	PF00397	0.608
DOC_WW_Pin1_4	283	288	PF00397	0.386
DOC_WW_Pin1_4	292	297	PF00397	0.309
DOC_WW_Pin1_4	423	428	PF00397	0.667
DOC_WW_Pin1_4	557	562	PF00397	0.697
DOC_WW_Pin1_4	60	65	PF00397	0.590
DOC_WW_Pin1_4	817	822	PF00397	0.616
DOC_WW_Pin1_4	846	851	PF00397	0.632
DOC_WW_Pin1_4	905	910	PF00397	0.672
LIG_14-3-3_CanoR_1	200	205	PF00244	0.338
LIG_14-3-3_CanoR_1	368	374	PF00244	0.330
LIG_14-3-3_CanoR_1	377	381	PF00244	0.315
LIG_14-3-3_CanoR_1	385	389	PF00244	0.376
LIG_14-3-3_CanoR_1	610	615	PF00244	0.478
LIG_14-3-3_CanoR_1	788	793	PF00244	0.547
LIG_14-3-3_CanoR_1	845	850	PF00244	0.697
LIG_14-3-3_CanoR_1	882	892	PF00244	0.533
LIG_Actin_WH2_2	950	965	PF00022	0.561
LIG_APCC_ABBAyCdc20_2	216	222	PF00400	0.309
LIG_BRCT_BRCA1_1	167	171	PF00533	0.386
LIG_BRCT_BRCA1_1	285	289	PF00533	0.309
LIG_BRCT_BRCA1_1	95	99	PF00533	0.701
LIG_EVH1_2	398	402	PF00568	0.451
LIG_FHA_1	201	207	PF00498	0.316
LIG_FHA_1	237	243	PF00498	0.318
LIG_FHA_1	399	405	PF00498	0.540
LIG_FHA_1	561	567	PF00498	0.765
LIG_FHA_1	585	591	PF00498	0.515
LIG_FHA_1	681	687	PF00498	0.501
LIG_FHA_1	838	844	PF00498	0.596
LIG_FHA_1	885	891	PF00498	0.541
LIG_FHA_1	913	919	PF00498	0.613
LIG_FHA_2	229	235	PF00498	0.414
LIG_FHA_2	268	274	PF00498	0.388
LIG_FHA_2	368	374	PF00498	0.309
LIG_FHA_2	705	711	PF00498	0.614
LIG_FHA_2	738	744	PF00498	0.685
LIG_FHA_2	859	865	PF00498	0.715
LIG_FHA_2	884	890	PF00498	0.723
LIG_GBD_Chelix_1	614	622	PF00786	0.550
LIG_LIR_Apic_2	295	301	PF02991	0.309
LIG_LIR_Apic_2	401	405	PF02991	0.475
LIG_LIR_Apic_2	573	578	PF02991	0.651
LIG_LIR_Apic_2	917	923	PF02991	0.676
LIG_LIR_Apic_2	96	102	PF02991	0.703
LIG_LIR_Gen_1	133	142	PF02991	0.386
LIG_LIR_Gen_1	168	177	PF02991	0.309
LIG_LIR_Gen_1	524	533	PF02991	0.664
LIG_LIR_Gen_1	592	601	PF02991	0.647
LIG_LIR_Nem_3	133	138	PF02991	0.386
LIG_LIR_Nem_3	168	174	PF02991	0.309
LIG_LIR_Nem_3	283	288	PF02991	0.386
LIG_LIR_Nem_3	346	351	PF02991	0.386
LIG_LIR_Nem_3	524	529	PF02991	0.670
LIG_LIR_Nem_3	592	596	PF02991	0.643
LIG_MAD2	217	225	PF02301	0.309
LIG_MAD2	944	952	PF02301	0.604
LIG_MYND_1	395	399	PF01753	0.536
LIG_MYND_1	905	909	PF01753	0.580
LIG_MYND_1	925	929	PF01753	0.664
LIG_NRBOX	875	881	PF00104	0.548
LIG_Pex14_2	285	289	PF04695	0.386
LIG_PTB_Apo_2	540	547	PF02174	0.569
LIG_PTB_Phospho_1	540	546	PF10480	0.568
LIG_Rb_pABgroove_1	112	120	PF01858	0.386
LIG_SH2_CRK	39	43	PF00017	0.451
LIG_SH2_CRK	546	550	PF00017	0.608
LIG_SH2_CRK	920	924	PF00017	0.562
LIG_SH2_NCK_1	24	28	PF00017	0.416
LIG_SH2_PTP2	13	16	PF00017	0.534
LIG_SH2_SRC	598	601	PF00017	0.508
LIG_SH2_STAP1	118	122	PF00017	0.386
LIG_SH2_STAP1	626	630	PF00017	0.554
LIG_SH2_STAP1	682	686	PF00017	0.500
LIG_SH2_STAT3	600	603	PF00017	0.513
LIG_SH2_STAT5	13	16	PF00017	0.526
LIG_SH2_STAT5	177	180	PF00017	0.353
LIG_SH2_STAT5	546	549	PF00017	0.653
LIG_SH2_STAT5	598	601	PF00017	0.536
LIG_SH2_STAT5	617	620	PF00017	0.549
LIG_SH2_STAT5	629	632	PF00017	0.428
LIG_SH2_STAT5	635	638	PF00017	0.402
LIG_SH2_STAT5	682	685	PF00017	0.497
LIG_SH3_1	392	398	PF00018	0.545
LIG_SH3_1	546	552	PF00018	0.682
LIG_SH3_1	920	926	PF00018	0.588
LIG_SH3_2	464	469	PF14604	0.676
LIG_SH3_3	135	141	PF00018	0.436
LIG_SH3_3	390	396	PF00018	0.555
LIG_SH3_3	449	455	PF00018	0.814
LIG_SH3_3	461	467	PF00018	0.602
LIG_SH3_3	481	487	PF00018	0.750
LIG_SH3_3	505	511	PF00018	0.703
LIG_SH3_3	546	552	PF00018	0.609
LIG_SH3_3	58	64	PF00018	0.584
LIG_SH3_3	724	730	PF00018	0.692
LIG_SH3_3	775	781	PF00018	0.690
LIG_SH3_3	847	853	PF00018	0.629
LIG_SH3_3	919	925	PF00018	0.777
LIG_SH3_3	946	952	PF00018	0.535
LIG_SH3_3	99	105	PF00018	0.689
LIG_Sin3_3	226	233	PF02671	0.386
LIG_SUMO_SIM_anti_2	112	119	PF11976	0.309
LIG_SUMO_SIM_anti_2	592	598	PF11976	0.569
LIG_SUMO_SIM_par_1	319	324	PF11976	0.309
LIG_TRAF2_1	726	729	PF00917	0.615
LIG_TRFH_1	575	579	PF08558	0.653
LIG_TYR_ITIM	37	42	PF00017	0.459
LIG_TYR_ITIM	596	601	PF00017	0.579
LIG_UBA3_1	210	214	PF00899	0.386
LIG_WRC_WIRS_1	590	595	PF05994	0.574
LIG_WW_2	395	398	PF00397	0.528
LIG_WW_3	140	144	PF00397	0.386
MOD_CDC14_SPxK_1	300	303	PF00782	0.309
MOD_CDK_SPxK_1	297	303	PF00069	0.309
MOD_CK1_1	158	164	PF00069	0.327
MOD_CK1_1	165	171	PF00069	0.440
MOD_CK1_1	436	442	PF00069	0.731
MOD_CK1_1	488	494	PF00069	0.722
MOD_CK1_1	560	566	PF00069	0.628
MOD_CK1_1	568	574	PF00069	0.651
MOD_CK1_1	70	76	PF00069	0.654
MOD_CK1_1	705	711	PF00069	0.647
MOD_CK1_1	736	742	PF00069	0.657
MOD_CK1_1	753	759	PF00069	0.644
MOD_CK1_1	933	939	PF00069	0.561
MOD_CK1_1	95	101	PF00069	0.746
MOD_CK1_1	978	984	PF00069	0.610
MOD_CK2_1	158	164	PF00069	0.422
MOD_CK2_1	267	273	PF00069	0.390
MOD_CK2_1	480	486	PF00069	0.757
MOD_CK2_1	705	711	PF00069	0.679
MOD_CK2_1	723	729	PF00069	0.587
MOD_CK2_1	737	743	PF00069	0.639
MOD_CK2_1	883	889	PF00069	0.595
MOD_CK2_1	910	916	PF00069	0.636
MOD_GlcNHglycan	145	149	PF01048	0.386
MOD_GlcNHglycan	231	234	PF01048	0.453
MOD_GlcNHglycan	262	265	PF01048	0.339
MOD_GlcNHglycan	316	319	PF01048	0.309
MOD_GlcNHglycan	433	436	PF01048	0.827
MOD_GlcNHglycan	45	48	PF01048	0.503
MOD_GlcNHglycan	567	570	PF01048	0.631
MOD_GlcNHglycan	692	695	PF01048	0.587
MOD_GlcNHglycan	7	10	PF01048	0.761
MOD_GlcNHglycan	704	707	PF01048	0.531
MOD_GlcNHglycan	748	751	PF01048	0.574
MOD_GlcNHglycan	898	901	PF01048	0.709
MOD_GlcNHglycan	90	93	PF01048	0.763
MOD_GlcNHglycan	912	915	PF01048	0.639
MOD_GlcNHglycan	932	935	PF01048	0.715
MOD_GlcNHglycan	937	940	PF01048	0.504
MOD_GlcNHglycan	977	980	PF01048	0.587
MOD_GSK3_1	100	107	PF00069	0.577
MOD_GSK3_1	155	162	PF00069	0.277
MOD_GSK3_1	288	295	PF00069	0.309
MOD_GSK3_1	334	341	PF00069	0.386
MOD_GSK3_1	429	436	PF00069	0.705
MOD_GSK3_1	485	492	PF00069	0.663
MOD_GSK3_1	557	564	PF00069	0.625
MOD_GSK3_1	63	70	PF00069	0.631
MOD_GSK3_1	636	643	PF00069	0.552
MOD_GSK3_1	733	740	PF00069	0.624
MOD_GSK3_1	746	753	PF00069	0.649
MOD_GSK3_1	807	814	PF00069	0.624
MOD_GSK3_1	853	860	PF00069	0.646
MOD_GSK3_1	88	95	PF00069	0.782
MOD_GSK3_1	910	917	PF00069	0.675
MOD_GSK3_1	953	960	PF00069	0.598
MOD_GSK3_1	970	977	PF00069	0.415
MOD_N-GLC_1	845	850	PF02516	0.697
MOD_N-GLC_2	647	649	PF02516	0.623
MOD_NEK2_1	156	161	PF00069	0.289
MOD_NEK2_1	228	233	PF00069	0.346
MOD_NEK2_1	326	331	PF00069	0.309
MOD_NEK2_1	384	389	PF00069	0.333
MOD_NEK2_1	636	641	PF00069	0.603
MOD_NEK2_1	702	707	PF00069	0.556
MOD_NEK2_1	746	751	PF00069	0.687
MOD_NEK2_1	787	792	PF00069	0.623
MOD_NEK2_1	816	821	PF00069	0.646
MOD_NEK2_1	930	935	PF00069	0.572
MOD_NEK2_2	209	214	PF00069	0.309
MOD_PIKK_1	334	340	PF00454	0.309
MOD_PIKK_1	433	439	PF00454	0.710
MOD_PIKK_1	499	505	PF00454	0.654
MOD_PIKK_1	67	73	PF00454	0.706
MOD_PK_1	480	486	PF00069	0.717
MOD_PK_1	788	794	PF00069	0.611
MOD_PKA_2	165	171	PF00069	0.309
MOD_PKA_2	326	332	PF00069	0.328
MOD_PKA_2	367	373	PF00069	0.309
MOD_PKA_2	376	382	PF00069	0.309
MOD_PKA_2	384	390	PF00069	0.309
MOD_PKA_2	515	521	PF00069	0.708
MOD_PKA_2	640	646	PF00069	0.616
MOD_PKA_2	787	793	PF00069	0.618
MOD_Plk_1	837	843	PF00069	0.574
MOD_Plk_1	863	869	PF00069	0.679
MOD_Plk_2-3	961	967	PF00069	0.576
MOD_Plk_4	384	390	PF00069	0.386
MOD_Plk_4	45	51	PF00069	0.468
MOD_Plk_4	610	616	PF00069	0.571
MOD_Plk_4	811	817	PF00069	0.650
MOD_ProDKin_1	104	110	PF00069	0.593
MOD_ProDKin_1	283	289	PF00069	0.386
MOD_ProDKin_1	292	298	PF00069	0.309
MOD_ProDKin_1	423	429	PF00069	0.667
MOD_ProDKin_1	557	563	PF00069	0.695
MOD_ProDKin_1	60	66	PF00069	0.596
MOD_ProDKin_1	817	823	PF00069	0.614
MOD_ProDKin_1	846	852	PF00069	0.630
MOD_ProDKin_1	905	911	PF00069	0.673
MOD_SUMO_for_1	333	336	PF00179	0.386
MOD_SUMO_rev_2	77	84	PF00179	0.720
TRG_DiLeu_BaLyEn_6	770	775	PF01217	0.801
TRG_ENDOCYTIC_2	13	16	PF00928	0.534
TRG_ENDOCYTIC_2	39	42	PF00928	0.451
TRG_ENDOCYTIC_2	598	601	PF00928	0.652
TRG_ER_diArg_1	215	217	PF00400	0.309
TRG_ER_diArg_1	697	700	PF00400	0.541
TRG_ER_diArg_1	880	882	PF00400	0.657
TRG_NLS_MonoCore_2	213	218	PF00514	0.309
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGM5	Leptomonas seymouri	43%	92%
A4HZ84	Leishmania infantum	100%	100%
E9AV51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCD0	Leishmania major	92%	99%