Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWM3_LEIDO

TriTrypDb:

LdBPK_211570.1 , LdCL_210021200 , LDHU3_21.1860

Length:

161

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWM3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.604
CLV_NRD_NRD_1	93	95	PF00675	0.685
CLV_PCSK_KEX2_1	10	12	PF00082	0.604
CLV_PCSK_KEX2_1	92	94	PF00082	0.713
CLV_PCSK_SKI1_1	102	106	PF00082	0.702
CLV_PCSK_SKI1_1	117	121	PF00082	0.602
DEG_APCC_DBOX_1	131	139	PF00400	0.389
DEG_Nend_UBRbox_1	1	4	PF02207	0.814
LIG_14-3-3_CanoR_1	21	30	PF00244	0.666
LIG_14-3-3_CanoR_1	5	9	PF00244	0.812
LIG_14-3-3_CanoR_1	58	64	PF00244	0.392
LIG_APCC_ABBA_1	118	123	PF00400	0.476
LIG_APCC_ABBAyCdc20_2	117	123	PF00400	0.421
LIG_BRCT_BRCA1_1	150	154	PF00533	0.435
LIG_FHA_2	138	144	PF00498	0.505
LIG_FHA_2	94	100	PF00498	0.429
LIG_GBD_Chelix_1	34	42	PF00786	0.409
LIG_LIR_Gen_1	151	158	PF02991	0.449
LIG_LIR_Gen_1	45	52	PF02991	0.387
LIG_LIR_Nem_3	143	149	PF02991	0.447
LIG_LIR_Nem_3	151	157	PF02991	0.458
LIG_LIR_Nem_3	45	50	PF02991	0.387
LIG_WRC_WIRS_1	105	110	PF05994	0.415
MOD_CK1_1	133	139	PF00069	0.513
MOD_CK2_1	104	110	PF00069	0.483
MOD_CK2_1	137	143	PF00069	0.477
MOD_Cter_Amidation	114	117	PF01082	0.641
MOD_GlcNHglycan	134	138	PF01048	0.692
MOD_GlcNHglycan	150	153	PF01048	0.674
MOD_GlcNHglycan	87	90	PF01048	0.728
MOD_GSK3_1	121	128	PF00069	0.467
MOD_GSK3_1	133	140	PF00069	0.463
MOD_GSK3_1	21	28	PF00069	0.753
MOD_NEK2_1	42	47	PF00069	0.455
MOD_NEK2_2	142	147	PF00069	0.429
MOD_OFUCOSY	18	25	PF10250	0.463
MOD_PK_1	125	131	PF00069	0.469
MOD_PKA_1	10	16	PF00069	0.665
MOD_PKA_1	93	99	PF00069	0.456
MOD_PKA_2	4	10	PF00069	0.786
MOD_PKA_2	93	99	PF00069	0.414
MOD_PKB_1	19	27	PF00069	0.699
MOD_Plk_1	142	148	PF00069	0.436
MOD_Plk_4	104	110	PF00069	0.485
MOD_Plk_4	125	131	PF00069	0.493
MOD_Plk_4	4	10	PF00069	0.804
MOD_Plk_4	42	48	PF00069	0.334
MOD_Plk_4	59	65	PF00069	0.404
MOD_SUMO_rev_2	110	118	PF00179	0.484
TRG_DiLeu_BaEn_1	114	119	PF01217	0.436
TRG_ER_diArg_1	19	22	PF00400	0.791
TRG_ER_diArg_1	9	11	PF00400	0.802
TRG_ER_diArg_1	91	94	PF00400	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSR8	Leptomonas seymouri	61%	100%
A0A0S4JJA7	Bodo saltans	46%	100%
A0A1X0NXY8	Trypanosomatidae	39%	100%
A0A3R7KIY1	Trypanosoma rangeli	44%	100%
A4HBY8	Leishmania braziliensis	67%	100%
A4HZD0	Leishmania infantum	100%	100%
D0A154	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AVB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QC63	Leishmania major	91%	100%