Ring finger domain/RING-H2 zinc finger/Zinc finger, C3HC4 type (RING finger) containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWM2_LEIDO

TriTrypDb:

LdBPK_211540.1 , LdCL_210020900 , LDHU3_21.1820

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0005634	nucleus	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3S7WWM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWM2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0005488	binding	1	2
GO:0005515	protein binding	2	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0097602	cullin family protein binding	3	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.659
CLV_PCSK_KEX2_1	128	130	PF00082	0.622
CLV_PCSK_SKI1_1	190	194	PF00082	0.620
CLV_PCSK_SKI1_1	236	240	PF00082	0.424
CLV_PCSK_SKI1_1	257	261	PF00082	0.404
DOC_CDC14_PxL_1	69	77	PF14671	0.607
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.611
DOC_USP7_MATH_1	10	14	PF00917	0.634
DOC_USP7_MATH_1	122	126	PF00917	0.780
DOC_USP7_MATH_1	192	196	PF00917	0.643
DOC_USP7_MATH_1	199	203	PF00917	0.613
DOC_USP7_MATH_1	216	220	PF00917	0.530
DOC_USP7_MATH_1	57	61	PF00917	0.638
DOC_USP7_MATH_2	102	108	PF00917	0.635
DOC_WW_Pin1_4	115	120	PF00397	0.491
DOC_WW_Pin1_4	136	141	PF00397	0.664
DOC_WW_Pin1_4	194	199	PF00397	0.717
DOC_WW_Pin1_4	204	209	PF00397	0.542
DOC_WW_Pin1_4	268	273	PF00397	0.381
DOC_WW_Pin1_4	80	85	PF00397	0.643
DOC_WW_Pin1_4	98	103	PF00397	0.480
LIG_14-3-3_CanoR_1	159	163	PF00244	0.541
LIG_14-3-3_CanoR_1	257	262	PF00244	0.489
LIG_FHA_1	106	112	PF00498	0.585
LIG_FHA_1	158	164	PF00498	0.626
LIG_FHA_1	221	227	PF00498	0.675
LIG_FHA_1	27	33	PF00498	0.620
LIG_FHA_2	238	244	PF00498	0.369
LIG_LIR_Gen_1	107	116	PF02991	0.583
LIG_LIR_Nem_3	107	112	PF02991	0.584
LIG_LIR_Nem_3	50	55	PF02991	0.714
LIG_NRBOX	74	80	PF00104	0.577
LIG_Pex14_2	2	6	PF04695	0.545
LIG_SH2_CRK	264	268	PF00017	0.284
LIG_SH2_STAT5	245	248	PF00017	0.304
LIG_SH3_3	108	114	PF00018	0.545
LIG_SH3_3	137	143	PF00018	0.746
LIG_SH3_3	202	208	PF00018	0.599
LIG_SH3_3	96	102	PF00018	0.677
LIG_SUMO_SIM_par_1	74	83	PF11976	0.626
LIG_TRAF2_1	101	104	PF00917	0.636
LIG_WRC_WIRS_1	106	111	PF05994	0.584
MOD_CK1_1	118	124	PF00069	0.661
MOD_CK1_1	169	175	PF00069	0.656
MOD_CK1_1	181	187	PF00069	0.594
MOD_CK1_1	207	213	PF00069	0.591
MOD_CK1_1	220	226	PF00069	0.655
MOD_CK1_1	80	86	PF00069	0.641
MOD_CK2_1	124	130	PF00069	0.774
MOD_CK2_1	162	168	PF00069	0.577
MOD_CK2_1	237	243	PF00069	0.369
MOD_CK2_1	98	104	PF00069	0.583
MOD_GlcNHglycan	12	15	PF01048	0.578
MOD_GlcNHglycan	164	167	PF01048	0.581
MOD_GlcNHglycan	168	171	PF01048	0.596
MOD_GlcNHglycan	175	178	PF01048	0.754
MOD_GlcNHglycan	3	6	PF01048	0.663
MOD_GlcNHglycan	52	55	PF01048	0.573
MOD_GlcNHglycan	59	62	PF01048	0.577
MOD_GlcNHglycan	8	11	PF01048	0.606
MOD_GSK3_1	1	8	PF00069	0.745
MOD_GSK3_1	10	17	PF00069	0.578
MOD_GSK3_1	114	121	PF00069	0.584
MOD_GSK3_1	124	131	PF00069	0.604
MOD_GSK3_1	158	165	PF00069	0.683
MOD_GSK3_1	169	176	PF00069	0.667
MOD_GSK3_1	178	185	PF00069	0.650
MOD_GSK3_1	190	197	PF00069	0.528
MOD_GSK3_1	199	206	PF00069	0.647
MOD_GSK3_1	216	223	PF00069	0.512
MOD_GSK3_1	57	64	PF00069	0.656
MOD_GSK3_1	79	86	PF00069	0.596
MOD_N-GLC_1	14	19	PF02516	0.572
MOD_NEK2_1	157	162	PF00069	0.580
MOD_NEK2_1	250	255	PF00069	0.303
MOD_NEK2_1	79	84	PF00069	0.553
MOD_PIKK_1	192	198	PF00454	0.717
MOD_PIKK_1	199	205	PF00454	0.648
MOD_PKA_1	128	134	PF00069	0.544
MOD_PKA_2	128	134	PF00069	0.658
MOD_PKA_2	158	164	PF00069	0.558
MOD_Plk_2-3	237	243	PF00069	0.369
MOD_Plk_4	158	164	PF00069	0.676
MOD_Plk_4	26	32	PF00069	0.613
MOD_ProDKin_1	115	121	PF00069	0.493
MOD_ProDKin_1	136	142	PF00069	0.661
MOD_ProDKin_1	194	200	PF00069	0.718
MOD_ProDKin_1	204	210	PF00069	0.545
MOD_ProDKin_1	268	274	PF00069	0.385
MOD_ProDKin_1	80	86	PF00069	0.643
MOD_ProDKin_1	98	104	PF00069	0.479
MOD_SUMO_rev_2	233	241	PF00179	0.369
TRG_Pf-PMV_PEXEL_1	224	229	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K6	Leptomonas seymouri	37%	95%
A4HBY6	Leishmania braziliensis	72%	100%
A4HZC7	Leishmania infantum	99%	100%
E9AVB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QC66	Leishmania major	89%	99%