Dynein_arm_light_chain_putative/GeneDB:LmjF.21.10 20

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein arm light chain, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWL7_LEIDO

TriTrypDb:

LdBPK_211260.1 , LdCL_210017700 , LDHU3_21.1490

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWL7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.425
CLV_C14_Caspase3-7	264	268	PF00656	0.271
CLV_NRD_NRD_1	107	109	PF00675	0.386
CLV_NRD_NRD_1	149	151	PF00675	0.366
CLV_NRD_NRD_1	198	200	PF00675	0.424
CLV_NRD_NRD_1	244	246	PF00675	0.432
CLV_NRD_NRD_1	252	254	PF00675	0.372
CLV_NRD_NRD_1	38	40	PF00675	0.561
CLV_NRD_NRD_1	7	9	PF00675	0.556
CLV_NRD_NRD_1	79	81	PF00675	0.440
CLV_PCSK_KEX2_1	107	109	PF00082	0.380
CLV_PCSK_KEX2_1	149	151	PF00082	0.372
CLV_PCSK_KEX2_1	198	200	PF00082	0.319
CLV_PCSK_KEX2_1	244	246	PF00082	0.432
CLV_PCSK_KEX2_1	252	254	PF00082	0.372
CLV_PCSK_KEX2_1	273	275	PF00082	0.299
CLV_PCSK_KEX2_1	279	281	PF00082	0.246
CLV_PCSK_KEX2_1	38	40	PF00082	0.618
CLV_PCSK_KEX2_1	7	9	PF00082	0.762
CLV_PCSK_KEX2_1	74	76	PF00082	0.369
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.330
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.271
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.369
CLV_PCSK_SKI1_1	157	161	PF00082	0.306
CLV_PCSK_SKI1_1	170	174	PF00082	0.293
CLV_PCSK_SKI1_1	179	183	PF00082	0.222
CLV_PCSK_SKI1_1	198	202	PF00082	0.157
CLV_PCSK_SKI1_1	210	214	PF00082	0.226
CLV_PCSK_SKI1_1	75	79	PF00082	0.406
CLV_Separin_Metazoa	167	171	PF03568	0.386
DEG_Nend_UBRbox_1	1	4	PF02207	0.546
DEG_SPOP_SBC_1	110	114	PF00917	0.174
DOC_CKS1_1	103	108	PF01111	0.337
DOC_CYCLIN_RxL_1	154	163	PF00134	0.309
DOC_CYCLIN_RxL_1	195	203	PF00134	0.255
DOC_CYCLIN_RxL_1	72	82	PF00134	0.455
DOC_CYCLIN_yCln2_LP_2	287	293	PF00134	0.604
DOC_MAPK_gen_1	252	260	PF00069	0.186
DOC_MAPK_gen_1	74	85	PF00069	0.420
DOC_MAPK_MEF2A_6	179	186	PF00069	0.258
DOC_MAPK_MEF2A_6	90	98	PF00069	0.460
DOC_MAPK_NFAT4_5	179	187	PF00069	0.278
DOC_MAPK_RevD_3	23	39	PF00069	0.483
DOC_MAPK_RevD_3	94	108	PF00069	0.386
DOC_PP2B_LxvP_1	287	290	PF13499	0.517
DOC_PP4_FxxP_1	103	106	PF00568	0.278
DOC_USP7_MATH_1	124	128	PF00917	0.393
DOC_USP7_MATH_1	155	159	PF00917	0.268
DOC_USP7_MATH_1	73	77	PF00917	0.419
DOC_USP7_UBL2_3	217	221	PF12436	0.375
DOC_USP7_UBL2_3	74	78	PF12436	0.414
DOC_WW_Pin1_4	102	107	PF00397	0.317
DOC_WW_Pin1_4	120	125	PF00397	0.218
DOC_WW_Pin1_4	151	156	PF00397	0.337
LIG_14-3-3_CanoR_1	170	177	PF00244	0.258
LIG_14-3-3_CanoR_1	80	84	PF00244	0.466
LIG_APCC_ABBA_1	184	189	PF00400	0.278
LIG_FHA_1	112	118	PF00498	0.390
LIG_FHA_1	151	157	PF00498	0.386
LIG_LIR_Apic_2	101	106	PF02991	0.258
LIG_PCNA_TLS_4	97	104	PF02747	0.258
LIG_PCNA_yPIPBox_3	29	39	PF02747	0.519
LIG_SH2_CRK	64	68	PF00017	0.373
LIG_SH2_NCK_1	64	68	PF00017	0.373
LIG_SH2_PTP2	48	51	PF00017	0.406
LIG_SH2_SRC	48	51	PF00017	0.504
LIG_SH2_SRC	64	67	PF00017	0.339
LIG_SH2_SRC	68	71	PF00017	0.230
LIG_SH2_STAT5	48	51	PF00017	0.406
LIG_SH3_1	64	70	PF00018	0.377
LIG_SH3_2	70	75	PF14604	0.401
LIG_SH3_3	48	54	PF00018	0.403
LIG_SH3_3	64	70	PF00018	0.357
LIG_SH3_3	88	94	PF00018	0.451
LIG_TRAF2_1	40	43	PF00917	0.651
LIG_WRC_WIRS_1	100	105	PF05994	0.258
MOD_CDC14_SPxK_1	154	157	PF00782	0.337
MOD_CDK_SPK_2	102	107	PF00069	0.333
MOD_CDK_SPxK_1	102	108	PF00069	0.386
MOD_CDK_SPxK_1	151	157	PF00069	0.337
MOD_CK1_1	102	108	PF00069	0.372
MOD_CK2_1	245	251	PF00069	0.379
MOD_GlcNHglycan	21	24	PF01048	0.419
MOD_GlcNHglycan	50	54	PF01048	0.530
MOD_GSK3_1	120	127	PF00069	0.255
MOD_GSK3_1	151	158	PF00069	0.362
MOD_GSK3_1	17	24	PF00069	0.654
MOD_N-GLC_1	57	62	PF02516	0.545
MOD_NEK2_1	200	205	PF00069	0.272
MOD_NEK2_1	79	84	PF00069	0.516
MOD_NEK2_2	73	78	PF00069	0.416
MOD_PIKK_1	132	138	PF00454	0.386
MOD_PKA_1	38	44	PF00069	0.565
MOD_PKA_2	148	154	PF00069	0.309
MOD_PKA_2	38	44	PF00069	0.712
MOD_PKA_2	79	85	PF00069	0.463
MOD_Plk_1	57	63	PF00069	0.393
MOD_Plk_4	57	63	PF00069	0.383
MOD_Plk_4	99	105	PF00069	0.252
MOD_ProDKin_1	102	108	PF00069	0.317
MOD_ProDKin_1	120	126	PF00069	0.218
MOD_ProDKin_1	151	157	PF00069	0.337
MOD_SUMO_for_1	16	19	PF00179	0.492
MOD_SUMO_for_1	213	216	PF00179	0.258
MOD_SUMO_for_1	220	223	PF00179	0.258
MOD_SUMO_for_1	272	275	PF00179	0.258
TRG_DiLeu_BaEn_1	178	183	PF01217	0.258
TRG_DiLeu_BaEn_1	255	260	PF01217	0.258
TRG_ENDOCYTIC_2	48	51	PF00928	0.387
TRG_ER_diArg_1	106	108	PF00400	0.386
TRG_ER_diArg_1	198	200	PF00400	0.436
TRG_ER_diArg_1	243	245	PF00400	0.407
TRG_ER_diArg_1	37	39	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.258
TRG_Pf-PMV_PEXEL_1	244	249	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q9	Leptomonas seymouri	81%	99%
A0A0S4J6T9	Bodo saltans	33%	100%
A0A0S4J9S1	Bodo saltans	34%	100%
A0A0S4KGN7	Bodo saltans	58%	100%
A0A1X0NVG2	Trypanosomatidae	35%	100%
A0A1X0NXR5	Trypanosomatidae	62%	95%
A0A3Q8IC16	Leishmania donovani	34%	100%
A0A3R7KMX9	Trypanosoma rangeli	35%	100%
A0A422NWB3	Trypanosoma rangeli	58%	100%
A4HBW2	Leishmania braziliensis	89%	100%
A4I0S3	Leishmania infantum	34%	100%
D0A1A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AGX0	Leishmania infantum	99%	100%
E9AIH0	Leishmania braziliensis	33%	100%
E9AV86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AWS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
O14645	Homo sapiens	35%	100%
Q4FZV3	Rattus norvegicus	35%	100%
Q4QAP9	Leishmania major	34%	100%
Q4QC94	Leishmania major	96%	100%
Q4R3K5	Macaca fascicularis	35%	100%
Q8BVN8	Mus musculus	35%	100%
Q9VGG6	Drosophila melanogaster	31%	100%
V5B9Q0	Trypanosoma cruzi	35%	81%
V5BR59	Trypanosoma cruzi	33%	100%