Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWL4_LEIDO

TriTrypDb:

LdBPK_211440.1 , LdCL_210019900 , LDHU3_21.1720

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.724
CLV_C14_Caspase3-7	236	240	PF00656	0.616
CLV_NRD_NRD_1	147	149	PF00675	0.805
CLV_NRD_NRD_1	165	167	PF00675	0.357
CLV_NRD_NRD_1	226	228	PF00675	0.651
CLV_PCSK_FUR_1	145	149	PF00082	0.713
CLV_PCSK_KEX2_1	147	149	PF00082	0.729
CLV_PCSK_KEX2_1	165	167	PF00082	0.363
CLV_PCSK_KEX2_1	226	228	PF00082	0.651
CLV_PCSK_KEX2_1	63	65	PF00082	0.819
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.819
CLV_PCSK_SKI1_1	16	20	PF00082	0.566
CLV_PCSK_SKI1_1	166	170	PF00082	0.576
CLV_PCSK_SKI1_1	226	230	PF00082	0.499
DEG_APCC_DBOX_1	15	23	PF00400	0.699
DEG_SPOP_SBC_1	107	111	PF00917	0.582
DEG_SPOP_SBC_1	93	97	PF00917	0.731
DOC_CYCLIN_RxL_1	163	171	PF00134	0.649
DOC_MAPK_DCC_7	11	20	PF00069	0.566
DOC_MAPK_gen_1	226	233	PF00069	0.660
DOC_MAPK_MEF2A_6	226	233	PF00069	0.660
DOC_USP7_MATH_1	106	110	PF00917	0.669
DOC_USP7_MATH_1	146	150	PF00917	0.799
DOC_USP7_MATH_1	283	287	PF00917	0.664
DOC_USP7_MATH_1	47	51	PF00917	0.681
DOC_USP7_MATH_1	94	98	PF00917	0.810
DOC_WW_Pin1_4	132	137	PF00397	0.681
LIG_14-3-3_CanoR_1	11	19	PF00244	0.606
LIG_14-3-3_CanoR_1	145	151	PF00244	0.742
LIG_14-3-3_CanoR_1	46	52	PF00244	0.680
LIG_BIR_II_1	1	5	PF00653	0.712
LIG_FHA_1	228	234	PF00498	0.659
LIG_FHA_1	257	263	PF00498	0.753
LIG_FHA_1	32	38	PF00498	0.683
LIG_FHA_1	52	58	PF00498	0.545
LIG_FHA_2	232	238	PF00498	0.656
LIG_FHA_2	94	100	PF00498	0.586
LIG_LIR_Gen_1	34	40	PF02991	0.548
LIG_LIR_Nem_3	179	185	PF02991	0.569
LIG_LIR_Nem_3	286	291	PF02991	0.553
LIG_LIR_Nem_3	34	38	PF02991	0.551
LIG_NRBOX	224	230	PF00104	0.656
LIG_SH2_CRK	182	186	PF00017	0.567
LIG_SH2_STAT3	250	253	PF00017	0.675
LIG_SH2_STAT5	209	212	PF00017	0.646
LIG_SH2_STAT5	250	253	PF00017	0.675
LIG_SH3_3	128	134	PF00018	0.730
LIG_SH3_3	264	270	PF00018	0.757
LIG_TRAF2_1	234	237	PF00917	0.663
MOD_CK1_1	109	115	PF00069	0.829
MOD_CK1_1	27	33	PF00069	0.668
MOD_CK1_1	50	56	PF00069	0.789
MOD_CK1_1	66	72	PF00069	0.542
MOD_CK2_1	231	237	PF00069	0.661
MOD_CK2_1	93	99	PF00069	0.711
MOD_GlcNHglycan	153	156	PF01048	0.654
MOD_GlcNHglycan	182	185	PF01048	0.466
MOD_GlcNHglycan	26	29	PF01048	0.663
MOD_GlcNHglycan	77	80	PF01048	0.713
MOD_GSK3_1	106	113	PF00069	0.820
MOD_GSK3_1	146	153	PF00069	0.776
MOD_GSK3_1	203	210	PF00069	0.648
MOD_GSK3_1	227	234	PF00069	0.659
MOD_GSK3_1	27	34	PF00069	0.669
MOD_GSK3_1	47	54	PF00069	0.505
MOD_GSK3_1	71	78	PF00069	0.753
MOD_N-GLC_2	21	23	PF02516	0.656
MOD_NEK2_1	168	173	PF00069	0.654
MOD_NEK2_1	202	207	PF00069	0.647
MOD_NEK2_1	57	62	PF00069	0.671
MOD_NEK2_1	83	88	PF00069	0.713
MOD_PK_1	85	91	PF00069	0.672
MOD_PKA_1	63	69	PF00069	0.825
MOD_PKA_2	10	16	PF00069	0.606
MOD_PKA_2	146	152	PF00069	0.755
MOD_PKA_2	207	213	PF00069	0.651
MOD_PKA_2	63	69	PF00069	0.825
MOD_Plk_1	178	184	PF00069	0.538
MOD_ProDKin_1	132	138	PF00069	0.686
MOD_SUMO_for_1	176	179	PF00179	0.645
TRG_DiLeu_BaEn_1	224	229	PF01217	0.653
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.632
TRG_DiLeu_LyEn_5	224	229	PF01217	0.653
TRG_ENDOCYTIC_2	182	185	PF00928	0.626
TRG_ENDOCYTIC_2	186	189	PF00928	0.599
TRG_ENDOCYTIC_2	209	212	PF00928	0.485
TRG_ER_diArg_1	145	148	PF00400	0.808
TRG_ER_diArg_1	164	166	PF00400	0.347
TRG_ER_diArg_1	225	227	PF00400	0.657
TRG_NLS_MonoCore_2	60	65	PF00514	0.736
TRG_NLS_MonoExtN_4	61	66	PF00514	0.733
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HBX6	Leishmania braziliensis	78%	100%
A4HZ96	Leishmania infantum	99%	100%
E9AVA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QC76	Leishmania major	93%	100%