T-complex protein 1 subunit delta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

T-complex protein 1, delta subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWK8_LEIDO

TriTrypDb:

LdBPK_211330.1 , LdCL_210018400 , LDHU3_21.1570

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005832	chaperonin-containing T-complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0101031	protein folding chaperone complex	3	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

A0A3S7WWK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWK8

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0044183	protein folding chaperone	1	12
GO:0051082	unfolded protein binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:0140662	ATP-dependent protein folding chaperone	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.359
CLV_C14_Caspase3-7	23	27	PF00656	0.805
CLV_NRD_NRD_1	17	19	PF00675	0.832
CLV_NRD_NRD_1	191	193	PF00675	0.422
CLV_NRD_NRD_1	280	282	PF00675	0.360
CLV_NRD_NRD_1	506	508	PF00675	0.359
CLV_PCSK_KEX2_1	17	19	PF00082	0.854
CLV_PCSK_KEX2_1	428	430	PF00082	0.361
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.361
CLV_PCSK_SKI1_1	275	279	PF00082	0.359
CLV_PCSK_SKI1_1	282	286	PF00082	0.359
CLV_PCSK_SKI1_1	289	293	PF00082	0.359
CLV_PCSK_SKI1_1	303	307	PF00082	0.359
CLV_PCSK_SKI1_1	372	376	PF00082	0.436
DEG_APCC_DBOX_1	280	288	PF00400	0.359
DOC_ANK_TNKS_1	450	457	PF00023	0.453
DOC_CYCLIN_yCln2_LP_2	182	188	PF00134	0.359
DOC_MAPK_gen_1	192	203	PF00069	0.360
DOC_MAPK_gen_1	278	287	PF00069	0.359
DOC_MAPK_gen_1	289	298	PF00069	0.359
DOC_MAPK_HePTP_8	143	155	PF00069	0.444
DOC_MAPK_MEF2A_6	146	155	PF00069	0.375
DOC_MAPK_MEF2A_6	292	300	PF00069	0.359
DOC_PP1_RVXF_1	392	399	PF00149	0.375
DOC_PP2B_LxvP_1	182	185	PF13499	0.359
DOC_PP2B_LxvP_1	254	257	PF13499	0.359
DOC_USP7_MATH_1	167	171	PF00917	0.359
DOC_USP7_MATH_1	494	498	PF00917	0.394
DOC_USP7_UBL2_3	142	146	PF12436	0.382
DOC_USP7_UBL2_3	278	282	PF12436	0.375
DOC_WW_Pin1_4	252	257	PF00397	0.359
DOC_WW_Pin1_4	365	370	PF00397	0.359
LIG_14-3-3_CanoR_1	207	216	PF00244	0.359
LIG_14-3-3_CanoR_1	401	407	PF00244	0.419
LIG_14-3-3_CanoR_1	49	53	PF00244	0.359
LIG_14-3-3_CanoR_1	531	540	PF00244	0.453
LIG_14-3-3_CanoR_1	80	86	PF00244	0.501
LIG_Actin_WH2_2	105	120	PF00022	0.359
LIG_Actin_WH2_2	188	206	PF00022	0.328
LIG_Actin_WH2_2	292	309	PF00022	0.359
LIG_BIR_II_1	1	5	PF00653	0.755
LIG_BRCT_BRCA1_1	133	137	PF00533	0.348
LIG_BRCT_BRCA1_1	313	317	PF00533	0.359
LIG_FHA_1	104	110	PF00498	0.359
LIG_FHA_1	207	213	PF00498	0.480
LIG_FHA_1	217	223	PF00498	0.419
LIG_FHA_1	244	250	PF00498	0.359
LIG_FHA_1	262	268	PF00498	0.392
LIG_FHA_1	336	342	PF00498	0.375
LIG_FHA_1	510	516	PF00498	0.359
LIG_FHA_1	525	531	PF00498	0.359
LIG_FHA_2	213	219	PF00498	0.359
LIG_FHA_2	257	263	PF00498	0.359
LIG_FHA_2	264	270	PF00498	0.359
LIG_FHA_2	27	33	PF00498	0.595
LIG_FHA_2	325	331	PF00498	0.501
LIG_FHA_2	360	366	PF00498	0.569
LIG_FHA_2	473	479	PF00498	0.359
LIG_GBD_Chelix_1	44	52	PF00786	0.453
LIG_LIR_Gen_1	268	277	PF02991	0.392
LIG_LIR_Gen_1	467	477	PF02991	0.359
LIG_LIR_Nem_3	467	472	PF02991	0.359
LIG_PDZ_Class_1	546	551	PF00595	0.359
LIG_REV1ctd_RIR_1	396	405	PF16727	0.375
LIG_RPA_C_Fungi	3	15	PF08784	0.661
LIG_SH2_NCK_1	465	469	PF00017	0.390
LIG_SH2_NCK_1	474	478	PF00017	0.325
LIG_SH2_SRC	465	468	PF00017	0.453
LIG_SH2_STAP1	465	469	PF00017	0.453
LIG_SH2_STAT5	270	273	PF00017	0.441
LIG_SH2_STAT5	283	286	PF00017	0.326
LIG_SH2_STAT5	474	477	PF00017	0.359
LIG_SH3_3	376	382	PF00018	0.359
LIG_SH3_3	516	522	PF00018	0.359
LIG_SH3_3	80	86	PF00018	0.359
LIG_SUMO_SIM_anti_2	106	113	PF11976	0.359
LIG_SUMO_SIM_anti_2	246	251	PF11976	0.375
LIG_SUMO_SIM_par_1	262	269	PF11976	0.394
LIG_SUMO_SIM_par_1	483	490	PF11976	0.359
LIG_SUMO_SIM_par_1	521	528	PF11976	0.359
LIG_SUMO_SIM_par_1	90	95	PF11976	0.359
LIG_TRAF2_1	119	122	PF00917	0.394
LIG_TRFH_1	252	256	PF08558	0.359
LIG_UBA3_1	284	292	PF00899	0.359
LIG_UBA3_1	538	542	PF00899	0.359
LIG_UBA3_1	90	96	PF00899	0.375
LIG_WRC_WIRS_1	457	462	PF05994	0.453
MOD_CDC14_SPxK_1	255	258	PF00782	0.359
MOD_CDK_SPxK_1	252	258	PF00069	0.359
MOD_CDK_SPxxK_3	365	372	PF00069	0.359
MOD_CK1_1	170	176	PF00069	0.359
MOD_CK1_1	177	183	PF00069	0.359
MOD_CK1_1	263	269	PF00069	0.359
MOD_CK1_1	36	42	PF00069	0.443
MOD_CK1_1	486	492	PF00069	0.359
MOD_CK2_1	133	139	PF00069	0.497
MOD_CK2_1	256	262	PF00069	0.359
MOD_CK2_1	324	330	PF00069	0.501
MOD_CK2_1	359	365	PF00069	0.452
MOD_CK2_1	472	478	PF00069	0.359
MOD_GlcNHglycan	1	4	PF01048	0.774
MOD_GlcNHglycan	10	13	PF01048	0.764
MOD_GlcNHglycan	209	212	PF01048	0.419
MOD_GlcNHglycan	369	372	PF01048	0.394
MOD_GlcNHglycan	496	499	PF01048	0.394
MOD_GlcNHglycan	501	504	PF01048	0.394
MOD_GlcNHglycan	527	530	PF01048	0.394
MOD_GSK3_1	166	173	PF00069	0.359
MOD_GSK3_1	212	219	PF00069	0.362
MOD_GSK3_1	252	259	PF00069	0.359
MOD_GSK3_1	261	268	PF00069	0.359
MOD_N-GLC_1	20	25	PF02516	0.738
MOD_N-GLC_1	26	31	PF02516	0.632
MOD_N-GLC_1	350	355	PF02516	0.501
MOD_N-GLC_1	36	41	PF02516	0.357
MOD_N-GLC_2	138	140	PF02516	0.375
MOD_NEK2_1	261	266	PF00069	0.420
MOD_NEK2_1	392	397	PF00069	0.359
MOD_NEK2_1	400	405	PF00069	0.359
MOD_NEK2_1	415	420	PF00069	0.359
MOD_NEK2_1	523	528	PF00069	0.359
MOD_NEK2_1	81	86	PF00069	0.359
MOD_PIKK_1	128	134	PF00454	0.375
MOD_PIKK_1	174	180	PF00454	0.359
MOD_PIKK_1	26	32	PF00454	0.620
MOD_PIKK_1	268	274	PF00454	0.375
MOD_PKA_2	159	165	PF00069	0.359
MOD_PKA_2	206	212	PF00069	0.501
MOD_PKA_2	33	39	PF00069	0.460
MOD_PKA_2	400	406	PF00069	0.359
MOD_PKA_2	48	54	PF00069	0.359
MOD_Plk_1	149	155	PF00069	0.385
MOD_Plk_1	243	249	PF00069	0.359
MOD_Plk_1	261	267	PF00069	0.483
MOD_Plk_1	268	274	PF00069	0.388
MOD_Plk_4	159	165	PF00069	0.359
MOD_Plk_4	301	307	PF00069	0.371
MOD_Plk_4	359	365	PF00069	0.492
MOD_Plk_4	402	408	PF00069	0.419
MOD_Plk_4	65	71	PF00069	0.386
MOD_Plk_4	73	79	PF00069	0.331
MOD_ProDKin_1	252	258	PF00069	0.359
MOD_ProDKin_1	365	371	PF00069	0.359
MOD_SUMO_for_1	277	280	PF00179	0.359
MOD_SUMO_for_1	64	67	PF00179	0.453
MOD_SUMO_rev_2	274	284	PF00179	0.375
TRG_DiLeu_BaEn_1	280	285	PF01217	0.359
TRG_DiLeu_BaLyEn_6	519	524	PF01217	0.359
TRG_ENDOCYTIC_2	270	273	PF00928	0.392
TRG_ER_diArg_1	16	18	PF00400	0.722
TRG_NES_CRM1_1	316	330	PF08389	0.359
TRG_NES_CRM1_1	335	350	PF08389	0.359
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	413	417	PF00026	0.375
TRG_PTS1	548	551	PF00515	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U4	Leptomonas seymouri	94%	100%
A0A0N1HUM6	Leptomonas seymouri	32%	100%
A0A0N1HUW6	Leptomonas seymouri	31%	100%
A0A0N1HXN1	Leptomonas seymouri	26%	100%
A0A0N1I104	Leptomonas seymouri	30%	96%
A0A0N1I2L2	Leptomonas seymouri	33%	100%
A0A0N1II94	Leptomonas seymouri	31%	100%
A0A0N1IM41	Leptomonas seymouri	28%	100%
A0A0S4IWM5	Bodo saltans	32%	100%
A0A0S4J048	Bodo saltans	31%	97%
A0A0S4J2A3	Bodo saltans	31%	95%
A0A0S4JDP9	Bodo saltans	32%	100%
A0A0S4JFF0	Bodo saltans	79%	96%
A0A0S4KI45	Bodo saltans	28%	100%
A0A0S4KIR9	Bodo saltans	34%	100%
A0A0S4KJ28	Bodo saltans	31%	100%
A0A0S4KQ13	Bodo saltans	26%	100%
A0A1X0NJG5	Trypanosomatidae	26%	100%
A0A1X0NL95	Trypanosomatidae	29%	100%
A0A1X0NSG8	Trypanosomatidae	32%	100%
A0A1X0NUN9	Trypanosomatidae	33%	100%
A0A1X0NWR4	Trypanosomatidae	31%	99%
A0A1X0NXT3	Trypanosomatidae	85%	100%
A0A1X0P4G0	Trypanosomatidae	31%	100%
A0A1X0P560	Trypanosomatidae	30%	97%
A0A3Q8IFF2	Leishmania donovani	31%	100%
A0A3Q8II90	Leishmania donovani	28%	100%
A0A3Q8IJL9	Leishmania donovani	31%	100%
A0A3R7KZ57	Trypanosoma rangeli	31%	100%
A0A3R7N205	Trypanosoma rangeli	32%	100%
A0A3R7NPP8	Trypanosoma rangeli	29%	100%
A0A3R7NRL8	Trypanosoma rangeli	33%	100%
A0A3R7RBS2	Trypanosoma rangeli	30%	97%
A0A3R7RTF6	Trypanosoma rangeli	27%	100%
A0A3S5H7C3	Leishmania donovani	31%	100%
A0A3S7WSR3	Leishmania donovani	26%	100%
A0A3S7X0N9	Leishmania donovani	32%	100%
A0A3S7X5D6	Leishmania donovani	32%	100%
A0A422NW95	Trypanosoma rangeli	83%	100%
A0A422NY11	Trypanosoma rangeli	31%	99%
A0QLP6	Mycobacterium avium (strain 104)	22%	100%
A1AJ51	Escherichia coli O1:K1 / APEC	22%	100%
A1AST1	Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)	22%	99%
A1SMW1	Nocardioides sp. (strain ATCC BAA-499 / JS614)	22%	100%
A1W0K4	Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)	22%	100%
A1WZJ2	Halorhodospira halophila (strain DSM 244 / SL1)	23%	100%
A4H7F6	Leishmania braziliensis	28%	100%
A4HCZ3	Leishmania braziliensis	30%	100%
A4HFQ1	Leishmania braziliensis	32%	100%
A4HK82	Leishmania braziliensis	33%	100%
A4HKX2	Leishmania braziliensis	32%	100%
A4HN57	Leishmania braziliensis	30%	100%
A4HQL2	Leishmania braziliensis	28%	100%
A4I0H8	Leishmania infantum	31%	100%
A4I2S6	Leishmania infantum	32%	100%
A4I7R7	Leishmania infantum	32%	100%
A4I8F2	Leishmania infantum	31%	100%
A4IBS4	Leishmania infantum	31%	100%
A4ICD2	Leishmania infantum	28%	100%
A4IJV3	Geobacillus thermodenitrificans (strain NG80-2)	24%	100%
A4J8H4	Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1)	21%	100%
A4W5N8	Enterobacter sp. (strain 638)	22%	100%
A4XJ09	Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)	23%	100%
A5CTX3	Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382)	22%	100%
A5CZ03	Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)	23%	100%
A5FIV1	Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101)	22%	100%
A5G9I2	Geotalea uraniireducens (strain Rf4)	23%	100%
A5N5D7	Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)	21%	100%
A5WD52	Psychrobacter sp. (strain PRwf-1)	22%	100%
A6H125	Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86)	22%	100%
A6LQ87	Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)	22%	100%
A6NM43	Homo sapiens	23%	99%
A6TH53	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	21%	100%
A6TLJ1	Alkaliphilus metalliredigens (strain QYMF)	23%	100%
A6U7N0	Sinorhizobium medicae (strain WSM419)	22%	100%
A6U901	Sinorhizobium medicae (strain WSM419)	23%	100%
A6W5Y6	Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)	24%	100%
A7GKG0	Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)	23%	100%
A7H2F8	Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)	22%	100%
A7MX54	Vibrio campbellii (strain ATCC BAA-1116)	22%	100%
A7Z207	Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)	23%	100%
A7ZV12	Escherichia coli O139:H28 (strain E24377A / ETEC)	22%	100%
A8A7N9	Escherichia coli O9:H4 (strain HS)	22%	100%
A8AMQ6	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	21%	100%
A8FAG3	Bacillus pumilus (strain SAFR-032)	23%	100%
A8FMS6	Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)	22%	100%
A8M497	Salinispora arenicola (strain CNS-205)	22%	100%
A8MJJ7	Alkaliphilus oremlandii (strain OhILAs)	22%	100%
A8X6I9	Caenorhabditis briggsae	30%	100%
A9GBQ2	Sorangium cellulosum (strain So ce56)	23%	100%
B0RAY1	Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1)	22%	100%
B0S1R4	Finegoldia magna (strain ATCC 29328 / DSM 20472 / WAL 2508)	22%	100%
B0U418	Xylella fastidiosa (strain M12)	22%	100%
B1ITQ5	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	22%	100%
B1LQG4	Escherichia coli (strain SMS-3-5 / SECEC)	22%	100%
B1XDP7	Escherichia coli (strain K12 / DH10B)	22%	100%
B1YEP6	Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 / 255-15)	24%	100%
B2I7D4	Xylella fastidiosa (strain M23)	22%	100%
B2TY18	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	22%	100%
B2VL84	Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99)	21%	100%
B3E8G0	Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)	22%	100%
B4EXE2	Proteus mirabilis (strain HI4320)	21%	100%
B5E9Y2	Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem)	23%	100%
B5Y368	Klebsiella pneumoniae (strain 342)	21%	100%
B5Y894	Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / OCM 4 / BT)	22%	100%
B5Z2F2	Escherichia coli O157:H7 (strain EC4115 / EHEC)	22%	100%
B6I615	Escherichia coli (strain SE11)	22%	100%
B6IU98	Rhodospirillum centenum (strain ATCC 51521 / SW)	20%	100%
B6JPA7	Helicobacter pylori (strain P12)	23%	100%
B7LC02	Escherichia coli (strain 55989 / EAEC)	22%	100%
B7M8Q4	Escherichia coli O8 (strain IAI1)	22%	100%
B7MKU8	Escherichia coli O45:K1 (strain S88 / ExPEC)	22%	100%
B7MSV9	Escherichia coli O81 (strain ED1a)	22%	100%
B7NG81	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	22%	100%
B7NTK2	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	22%	100%
B7UPW3	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	22%	100%
B8FNT7	Desulfitobacterium hafniense (strain DSM 10664 / DCB-2)	24%	100%
B9DMM2	Staphylococcus carnosus (strain TM300)	22%	100%
B9DYY5	Clostridium kluyveri (strain NBRC 12016)	21%	100%
B9MLY9	Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320)	22%	100%
C4LCA2	Tolumonas auensis (strain DSM 9187 / TA4)	20%	100%
C5A1D5	Escherichia coli (strain K12 / MC4100 / BW2952)	22%	100%
C5BDK5	Edwardsiella ictaluri (strain 93-146)	21%	100%
C5BZB0	Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)	22%	100%
C6DKC7	Pectobacterium carotovorum subsp. carotovorum (strain PC1)	22%	100%
C6DY43	Geobacter sp. (strain M21)	23%	100%
C9ZVA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
C9ZYU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	97%
D0A1B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	84%	100%
D0A3R6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A5Y5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A6E2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A9X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0AAR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ADA4	Leishmania major	32%	100%
E9AFL0	Leishmania major	31%	100%
E9AGK2	Leishmania infantum	27%	100%
E9AGX7	Leishmania infantum	100%	100%
E9AIQ3	Leishmania braziliensis	97%	100%
E9APJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AUC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AV93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AWE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AZ29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B2M5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B3B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B6R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
O00782	Oxytricha granulifera	32%	99%
O04450	Arabidopsis thaliana	34%	100%
O15891	Tetrahymena pyriformis	32%	100%
O24730	Thermococcus sp. (strain JCM 11816 / KS-1)	37%	100%
O24731	Thermococcus sp. (strain KS-8)	35%	100%
O24732	Thermococcus sp. (strain KS-8)	36%	100%
O24734	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	36%	99%
O24735	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	36%	100%
O26320	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	35%	100%
O26885	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	35%	100%
O28045	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	36%	100%
O28821	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	36%	100%
O30560	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	34%	99%
O30561	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	35%	98%
O50305	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	24%	100%
O57762	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	36%	100%
O60008	Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01)	22%	93%
O66190	Enterobacter asburiae	22%	100%
O66192	Kluyvera intermedia	21%	100%
O66196	Lelliottia amnigena	22%	100%
O66198	Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56)	21%	100%
O66200	Enterobacter agglomerans	21%	100%
O66210	Klebsiella oxytoca	21%	100%
O66212	Raoultella planticola	21%	100%
O66214	Raoultella ornithinolytica	21%	100%
O66218	Pantoea ananas	21%	100%
O66220	Pectobacterium carotovorum subsp. carotovorum	22%	100%
O66222	Erwinia aphidicola	21%	100%
O69289	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	22%	100%
O74341	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
O77323	Plasmodium falciparum (isolate 3D7)	31%	100%
O77622	Oryctolagus cuniculus	29%	100%
O93624	Methanothermococcus thermolithotrophicus	35%	100%
O94501	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	99%
O94515	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P09239	Mycobacterium leprae (strain TN)	22%	100%
P0A6F5	Escherichia coli (strain K12)	22%	100%
P0A6F6	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	22%	100%
P0A6F7	Escherichia coli O157:H7	22%	100%
P0A6F8	Shigella flexneri	22%	100%
P0C0N6	Staphylococcus epidermidis	21%	100%
P0C0N7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	21%	100%
P11983	Mus musculus	31%	99%
P12612	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	99%
P12613	Drosophila melanogaster	30%	99%
P17987	Homo sapiens	32%	99%
P18279	Cricetulus griseus	32%	99%
P26209	Bacillus sp. (strain PS3)	24%	100%
P28480	Rattus norvegicus	32%	99%
P28488	Saccharolobus shibatae	35%	100%
P28598	Bacillus subtilis (strain 168)	24%	100%
P28769	Arabidopsis thaliana	31%	100%
P35470	Rhizobium meliloti (strain 1021)	23%	100%
P39076	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P39077	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P39078	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	100%
P39079	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P40227	Homo sapiens	28%	100%
P40412	Avena sativa	34%	100%
P40413	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	98%
P41988	Caenorhabditis elegans	32%	100%
P42384	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	22%	100%
P42932	Mus musculus	30%	100%
P42943	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P46219	Saccharolobus shibatae	38%	98%
P46550	Caenorhabditis elegans	28%	100%
P47079	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	97%
P47207	Caenorhabditis elegans	31%	100%
P47208	Caenorhabditis elegans	59%	100%
P47209	Caenorhabditis elegans	35%	100%
P47828	Candida albicans	28%	100%
P48212	Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372)	22%	100%
P48424	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	38%	100%
P48425	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	36%	100%
P48605	Drosophila melanogaster	31%	100%
P48643	Homo sapiens	36%	100%
P49368	Homo sapiens	31%	100%
P50016	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	37%	100%
P50142	Ajellomyces capsulatus	23%	93%
P50143	Xenopus laevis	31%	100%
P50990	Homo sapiens	31%	100%
P50991	Homo sapiens	56%	100%
P50999	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	56%	100%
P53451	Takifugu rubripes	55%	100%
P54408	Tetrahymena pyriformis	30%	99%
P54409	Tetrahymena pyriformis	32%	99%
P54411	Avena sativa	34%	100%
P61111	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	36%	100%
P61112	Thermococcus sp. (strain JCM 11816 / KS-1)	36%	100%
P61438	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)	22%	100%
P61439	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)	22%	100%
P78371	Homo sapiens	29%	100%
P78921	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
P80313	Mus musculus	33%	100%
P80314	Mus musculus	29%	100%
P80315	Mus musculus	54%	100%
P80316	Mus musculus	36%	100%
P80317	Mus musculus	28%	100%
P80318	Mus musculus	30%	100%
P87153	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	99%
Q00768	Streptomyces albus G	22%	100%
Q03SQ9	Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947)	22%	100%
Q07201	Geobacillus stearothermophilus	24%	100%
Q0ACQ9	Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)	24%	100%
Q0RRL9	Frankia alni (strain ACN14a)	22%	100%
Q0SET3	Rhodococcus jostii (strain RHA1)	22%	100%
Q0SXD6	Shigella flexneri serotype 5b (strain 8401)	22%	100%
Q0T9P8	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	22%	100%
Q10147	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q18CT5	Clostridioides difficile (strain 630)	23%	100%
Q1AXU6	Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1)	22%	100%
Q1GRD4	Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)	22%	100%
Q1H4F2	Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)	23%	100%
Q1QDC9	Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5)	21%	100%
Q1R3B6	Escherichia coli (strain UTI89 / UPEC)	22%	100%
Q24QE3	Desulfitobacterium hafniense (strain Y51)	24%	100%
Q2JKV7	Synechococcus sp. (strain JA-2-3B'a(2-13))	22%	100%
Q2JYW6	Rhizobium etli (strain CFN 42 / ATCC 51251)	22%	100%
Q2NKZ1	Bos taurus	33%	100%
Q2RGL8	Moorella thermoacetica (strain ATCC 39073 / JCM 9320)	23%	100%
Q2RL13	Moorella thermoacetica (strain ATCC 39073 / JCM 9320)	23%	100%
Q2T9X2	Bos taurus	56%	100%
Q31T78	Shigella boydii serotype 4 (strain Sb227)	22%	100%
Q328C4	Shigella dysenteriae serotype 1 (strain Sd197)	22%	100%
Q32L40	Bos taurus	32%	99%
Q37757	Cyanophora paradoxa	22%	100%
Q39ZP5	Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)	23%	100%
Q3A0V2	Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1)	22%	100%
Q3ADX3	Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)	22%	100%
Q3M1B1	Trichormus variabilis (strain ATCC 29413 / PCC 7937)	22%	100%
Q3MHL7	Bos taurus	28%	100%
Q3T084	Bos taurus	29%	100%
Q3T0K2	Bos taurus	31%	100%
Q3YUJ7	Shigella sonnei (strain Ss046)	22%	100%
Q3Z6L3	Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195)	23%	100%
Q3ZBH0	Bos taurus	29%	100%
Q3ZCI9	Bos taurus	31%	100%
Q487Q9	Colwellia psychrerythraea (strain 34H / ATCC BAA-681)	22%	100%
Q49YY5	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	21%	100%
Q4FU94	Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4)	21%	100%
Q4JTF2	Corynebacterium jeikeium (strain K411)	22%	100%
Q4L7R4	Staphylococcus haemolyticus (strain JCSC1435)	22%	100%
Q4Q063	Leishmania major	28%	100%
Q4Q4U5	Leishmania major	31%	100%
Q4Q5I2	Leishmania major	32%	100%
Q4QB32	Leishmania major	31%	100%
Q4QC87	Leishmania major	99%	100%
Q4QFY8	Leishmania major	27%	100%
Q4R5G2	Macaca fascicularis	32%	99%
Q4R5J0	Macaca fascicularis	31%	100%
Q4R6F8	Macaca fascicularis	29%	100%
Q4R6V2	Macaca fascicularis	36%	100%
Q4R963	Macaca fascicularis	30%	100%
Q52500	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	37%	100%
Q53546	Desulfurococcus sp. (strain SY)	38%	100%
Q54CL2	Dictyostelium discoideum	57%	100%
Q54ER7	Dictyostelium discoideum	33%	99%
Q54ES9	Dictyostelium discoideum	32%	100%
Q54TD3	Dictyostelium discoideum	33%	100%
Q54TH8	Dictyostelium discoideum	28%	100%
Q552J0	Dictyostelium discoideum	29%	100%
Q55BM4	Dictyostelium discoideum	29%	100%
Q58405	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	34%	100%
Q5B041	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	22%	94%
Q5HMZ1	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	21%	100%
Q5HTP2	Campylobacter jejuni (strain RM1221)	22%	100%
Q5NVF9	Pongo abelii	31%	100%
Q5R5C8	Pongo abelii	33%	100%
Q5R637	Pongo abelii	56%	100%
Q5RAP1	Pongo abelii	31%	100%
Q5RCD2	Pongo abelii	28%	100%
Q5RF02	Pongo abelii	36%	100%
Q5WJN4	Alkalihalobacillus clausii (strain KSM-K16)	23%	100%
Q5XIM9	Rattus norvegicus	29%	100%
Q5ZJ54	Gallus gallus	29%	100%
Q5ZJK8	Gallus gallus	34%	100%
Q61390	Mus musculus	28%	100%
Q65MZ8	Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)	24%	100%
Q68FQ0	Rattus norvegicus	35%	100%
Q6ADK2	Leifsonia xyli subsp. xyli (strain CTCB07)	22%	100%
Q6BXF6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	53%	100%
Q6C100	Yarrowia lipolytica (strain CLIB 122 / E 150)	51%	100%
Q6CL82	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	52%	100%
Q6EE31	Gallus gallus	30%	100%
Q6FQT2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	51%	100%
Q6GF43	Staphylococcus aureus (strain MRSA252)	21%	100%
Q6P502	Rattus norvegicus	30%	100%
Q75A36	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	51%	100%
Q76NU3	Dictyostelium discoideum	29%	100%
Q7M7I7	Vibrio vulnificus (strain YJ016)	22%	100%
Q7MAZ7	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	20%	100%
Q7MBB2	Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))	22%	100%
Q7TPB1	Rattus norvegicus	55%	100%
Q82DI5	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	23%	100%
Q82GG6	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	22%	100%
Q84WV1	Arabidopsis thaliana	31%	99%
Q87BC0	Xylella fastidiosa (strain Temecula1 / ATCC 700964)	22%	100%
Q8CXL3	Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)	24%	100%
Q8KIX3	Buchnera aphidicola subsp. Tetraneura caerulescens	22%	100%
Q8L7N0	Arabidopsis thaliana	24%	100%
Q8R5T7	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	21%	100%
Q8SQP2	Encephalitozoon cuniculi (strain GB-M1)	29%	100%
Q8SR53	Encephalitozoon cuniculi (strain GB-M1)	28%	100%
Q8SR76	Encephalitozoon cuniculi (strain GB-M1)	28%	100%
Q8SRP9	Encephalitozoon cuniculi (strain GB-M1)	31%	100%
Q8SS33	Encephalitozoon cuniculi (strain GB-M1)	23%	100%
Q8SSC9	Encephalitozoon cuniculi (strain GB-M1)	27%	100%
Q8SSH3	Encephalitozoon cuniculi (strain GB-M1)	37%	100%
Q8VV84	Parageobacillus thermoglucosidasius	24%	100%
Q92526	Homo sapiens	30%	100%
Q93GT6	Tetragenococcus halophilus	23%	100%
Q93GT8	Colwellia maris	22%	100%
Q93QI2	Rhodococcus hoagii	21%	100%
Q940P8	Arabidopsis thaliana	31%	100%
Q94757	Schistosoma mansoni	31%	100%
Q94K05	Arabidopsis thaliana	29%	100%
Q96SF2	Homo sapiens	23%	99%
Q99832	Homo sapiens	34%	100%
Q9AFA5	Tsukamurella paurometabola	21%	100%
Q9ALA9	Vibrio vulnificus (strain CMCP6)	22%	100%
Q9EZV1	Thermotoga neapolitana	22%	100%
Q9HH21	Saccharolobus shibatae	33%	100%
Q9HHA2	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	35%	100%
Q9HN70	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	36%	98%
Q9HNI0	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	32%	99%
Q9KKF0	Clostridioides difficile	23%	100%
Q9KXU5	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	21%	100%
Q9L7P5	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	22%	100%
Q9LKI7	Thalassiosira weissflogii	30%	99%
Q9LV21	Arabidopsis thaliana	56%	100%
Q9M888	Arabidopsis thaliana	24%	100%
Q9N358	Caenorhabditis elegans	28%	100%
Q9N4J8	Caenorhabditis elegans	29%	100%
Q9NB32	Ochlerotatus triseriatus	55%	100%
Q9PFP2	Xylella fastidiosa (strain 9a5c)	22%	100%
Q9SF16	Arabidopsis thaliana	31%	99%
Q9UTM4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
Q9V2Q7	Pyrococcus abyssi (strain GE5 / Orsay)	36%	100%
Q9V2S9	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	38%	99%
Q9V2T3	Desulfurococcus mucosus	34%	100%
Q9V2T4	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	35%	100%
Q9V2T5	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	36%	99%
Q9V2T7	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	34%	100%
Q9V2T8	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	35%	99%
Q9VPS5	Drosophila melanogaster	20%	85%
Q9W790	Paleosuchus palpebrosus	32%	99%
Q9XAU7	Pseudoalteromonas translucida (strain TAC 125)	21%	100%
Q9XT06	Monodelphis domestica	31%	99%
Q9YA66	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	36%	100%
Q9YDK6	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	36%	99%
V5AR01	Trypanosoma cruzi	83%	100%
V5B209	Trypanosoma cruzi	27%	100%
V5B5Q0	Trypanosoma cruzi	33%	100%
V5BD32	Trypanosoma cruzi	29%	100%
V5BL37	Trypanosoma cruzi	31%	100%
V5BNS0	Trypanosoma cruzi	31%	99%
V5C2S4	Trypanosoma cruzi	30%	97%
V5DHJ5	Trypanosoma cruzi	32%	100%