RNA_polymerase_III_transcription_factor_(TF)IIIC_ subunit_putative/Pfam:PF09734

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA polymerase III transcription factor (TF)IIIC subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWK4_LEIDO

TriTrypDb:

LdBPK_211340.1 , LdCL_210018900 , LDHU3_21.1590

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000127	transcription factor TFIIIC complex	4	10
GO:0005667	transcription regulator complex	2	10
GO:0032991	protein-containing complex	1	10
GO:0090576	RNA polymerase III transcription regulator complex	3	10

Expansion

Sequence features

A0A3S7WWK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWK4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006352	DNA-templated transcription initiation	6	10
GO:0006384	transcription initiation at RNA polymerase III promoter	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0032774	RNA biosynthetic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.796
CLV_C14_Caspase3-7	260	264	PF00656	0.585
CLV_C14_Caspase3-7	417	421	PF00656	0.411
CLV_C14_Caspase3-7	447	451	PF00656	0.296
CLV_C14_Caspase3-7	85	89	PF00656	0.684
CLV_NRD_NRD_1	215	217	PF00675	0.636
CLV_NRD_NRD_1	243	245	PF00675	0.578
CLV_NRD_NRD_1	247	249	PF00675	0.542
CLV_NRD_NRD_1	509	511	PF00675	0.456
CLV_NRD_NRD_1	540	542	PF00675	0.508
CLV_NRD_NRD_1	552	554	PF00675	0.497
CLV_NRD_NRD_1	565	567	PF00675	0.535
CLV_NRD_NRD_1	59	61	PF00675	0.643
CLV_NRD_NRD_1	602	604	PF00675	0.549
CLV_NRD_NRD_1	606	608	PF00675	0.543
CLV_NRD_NRD_1	638	640	PF00675	0.557
CLV_PCSK_FUR_1	213	217	PF00082	0.685
CLV_PCSK_FUR_1	241	245	PF00082	0.546
CLV_PCSK_FUR_1	538	542	PF00082	0.492
CLV_PCSK_KEX2_1	132	134	PF00082	0.743
CLV_PCSK_KEX2_1	212	214	PF00082	0.602
CLV_PCSK_KEX2_1	215	217	PF00082	0.592
CLV_PCSK_KEX2_1	243	245	PF00082	0.547
CLV_PCSK_KEX2_1	247	249	PF00082	0.506
CLV_PCSK_KEX2_1	509	511	PF00082	0.456
CLV_PCSK_KEX2_1	540	542	PF00082	0.433
CLV_PCSK_KEX2_1	552	554	PF00082	0.462
CLV_PCSK_KEX2_1	565	567	PF00082	0.538
CLV_PCSK_KEX2_1	59	61	PF00082	0.615
CLV_PCSK_KEX2_1	602	604	PF00082	0.490
CLV_PCSK_KEX2_1	606	608	PF00082	0.496
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.718
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.629
CLV_PCSK_PC7_1	239	245	PF00082	0.597
CLV_PCSK_PC7_1	536	542	PF00082	0.522
CLV_PCSK_PC7_1	602	608	PF00082	0.528
CLV_PCSK_SKI1_1	146	150	PF00082	0.626
CLV_PCSK_SKI1_1	216	220	PF00082	0.673
CLV_PCSK_SKI1_1	531	535	PF00082	0.492
DEG_APCC_DBOX_1	145	153	PF00400	0.684
DEG_APCC_DBOX_1	552	560	PF00400	0.487
DEG_SCF_FBW7_1	33	38	PF00400	0.662
DEG_SPOP_SBC_1	109	113	PF00917	0.665
DEG_SPOP_SBC_1	37	41	PF00917	0.676
DEG_SPOP_SBC_1	658	662	PF00917	0.698
DOC_CDC14_PxL_1	318	326	PF14671	0.638
DOC_CKS1_1	312	317	PF01111	0.634
DOC_CYCLIN_RxL_1	525	537	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	302	308	PF00134	0.561
DOC_CYCLIN_yCln2_LP_2	569	575	PF00134	0.482
DOC_MAPK_gen_1	143	151	PF00069	0.561
DOC_MAPK_gen_1	154	164	PF00069	0.518
DOC_MAPK_gen_1	506	515	PF00069	0.531
DOC_MAPK_gen_1	562	571	PF00069	0.459
DOC_MAPK_MEF2A_6	22	31	PF00069	0.531
DOC_MAPK_MEF2A_6	233	240	PF00069	0.521
DOC_MAPK_MEF2A_6	509	517	PF00069	0.529
DOC_MAPK_MEF2A_6	565	573	PF00069	0.451
DOC_MAPK_NFAT4_5	233	241	PF00069	0.585
DOC_PP2B_LxvP_1	569	572	PF13499	0.501
DOC_PP2B_PxIxI_1	388	394	PF00149	0.393
DOC_PP4_FxxP_1	70	73	PF00568	0.528
DOC_USP7_MATH_1	10	14	PF00917	0.747
DOC_USP7_MATH_1	110	114	PF00917	0.669
DOC_USP7_MATH_1	20	24	PF00917	0.651
DOC_USP7_MATH_1	283	287	PF00917	0.749
DOC_USP7_MATH_1	320	324	PF00917	0.577
DOC_USP7_MATH_1	357	361	PF00917	0.429
DOC_USP7_MATH_1	395	399	PF00917	0.393
DOC_USP7_MATH_1	407	411	PF00917	0.215
DOC_USP7_MATH_1	491	495	PF00917	0.307
DOC_USP7_MATH_1	50	54	PF00917	0.733
DOC_USP7_MATH_1	657	661	PF00917	0.651
DOC_USP7_MATH_1	92	96	PF00917	0.614
DOC_WW_Pin1_4	31	36	PF00397	0.631
DOC_WW_Pin1_4	311	316	PF00397	0.600
DOC_WW_Pin1_4	4	9	PF00397	0.741
DOC_WW_Pin1_4	520	525	PF00397	0.509
DOC_WW_Pin1_4	76	81	PF00397	0.621
LIG_14-3-3_CanoR_1	143	152	PF00244	0.551
LIG_14-3-3_CanoR_1	157	163	PF00244	0.484
LIG_14-3-3_CanoR_1	22	28	PF00244	0.561
LIG_14-3-3_CanoR_1	284	292	PF00244	0.530
LIG_14-3-3_CanoR_1	502	506	PF00244	0.326
LIG_14-3-3_CanoR_1	509	517	PF00244	0.389
LIG_14-3-3_CanoR_1	552	557	PF00244	0.467
LIG_14-3-3_CanoR_1	607	615	PF00244	0.450
LIG_Actin_WH2_2	496	511	PF00022	0.393
LIG_BIR_III_4	278	282	PF00653	0.623
LIG_BIR_III_4	373	377	PF00653	0.337
LIG_BRCT_BRCA1_1	122	126	PF00533	0.698
LIG_BRCT_BRCA1_1	678	682	PF00533	0.652
LIG_CtBP_PxDLS_1	597	601	PF00389	0.533
LIG_eIF4E_1	231	237	PF01652	0.523
LIG_EVH1_2	331	335	PF00568	0.321
LIG_FHA_1	159	165	PF00498	0.570
LIG_FHA_1	252	258	PF00498	0.562
LIG_FHA_1	283	289	PF00498	0.677
LIG_FHA_1	307	313	PF00498	0.739
LIG_FHA_1	32	38	PF00498	0.662
LIG_FHA_1	388	394	PF00498	0.379
LIG_FHA_1	470	476	PF00498	0.306
LIG_FHA_1	502	508	PF00498	0.370
LIG_FHA_2	553	559	PF00498	0.417
LIG_FHA_2	650	656	PF00498	0.755
LIG_GBD_Chelix_1	444	452	PF00786	0.411
LIG_Integrin_RGD_1	86	88	PF01839	0.685
LIG_LIR_Apic_2	69	73	PF02991	0.537
LIG_LIR_Gen_1	23	32	PF02991	0.656
LIG_LIR_Gen_1	307	318	PF02991	0.638
LIG_LIR_Gen_1	384	393	PF02991	0.399
LIG_LIR_Gen_1	497	508	PF02991	0.437
LIG_LIR_Nem_3	23	27	PF02991	0.611
LIG_LIR_Nem_3	307	313	PF02991	0.537
LIG_LIR_Nem_3	384	388	PF02991	0.333
LIG_LIR_Nem_3	497	503	PF02991	0.437
LIG_LIR_Nem_3	543	547	PF02991	0.428
LIG_NRBOX	529	535	PF00104	0.487
LIG_NRBOX	625	631	PF00104	0.492
LIG_PCNA_PIPBox_1	225	234	PF02747	0.537
LIG_PCNA_yPIPBox_3	225	239	PF02747	0.517
LIG_PTB_Apo_2	226	233	PF02174	0.651
LIG_PTB_Apo_2	474	481	PF02174	0.321
LIG_PTB_Phospho_1	226	232	PF10480	0.655
LIG_SH2_CRK	159	163	PF00017	0.639
LIG_SH2_CRK	544	548	PF00017	0.519
LIG_SH2_NCK_1	492	496	PF00017	0.375
LIG_SH2_NCK_1	500	504	PF00017	0.331
LIG_SH2_PTP2	24	27	PF00017	0.630
LIG_SH2_SRC	346	349	PF00017	0.411
LIG_SH2_STAP1	615	619	PF00017	0.457
LIG_SH2_STAP1	622	626	PF00017	0.410
LIG_SH2_STAT5	159	162	PF00017	0.540
LIG_SH2_STAT5	24	27	PF00017	0.630
LIG_SH2_STAT5	473	476	PF00017	0.296
LIG_SH2_STAT5	570	573	PF00017	0.435
LIG_SH3_3	13	19	PF00018	0.698
LIG_SH3_3	24	30	PF00018	0.569
LIG_SH3_3	326	332	PF00018	0.393
LIG_SUMO_SIM_par_1	389	394	PF11976	0.393
LIG_TRAF2_1	177	180	PF00917	0.745
LIG_TRAF2_1	264	267	PF00917	0.624
LIG_TRAF2_1	394	397	PF00917	0.481
LIG_TRAF2_1	95	98	PF00917	0.687
LIG_TRAF2_2	572	577	PF00917	0.465
LIG_TYR_ITIM	498	503	PF00017	0.337
LIG_TYR_ITIM	542	547	PF00017	0.456
MOD_CK1_1	111	117	PF00069	0.751
MOD_CK1_1	118	124	PF00069	0.764
MOD_CK1_1	23	29	PF00069	0.618
MOD_CK1_1	286	292	PF00069	0.672
MOD_CK1_1	414	420	PF00069	0.393
MOD_CK1_1	494	500	PF00069	0.411
MOD_CK1_1	660	666	PF00069	0.688
MOD_CK2_1	174	180	PF00069	0.678
MOD_CK2_1	261	267	PF00069	0.681
MOD_CK2_1	391	397	PF00069	0.475
MOD_CK2_1	552	558	PF00069	0.439
MOD_CK2_1	662	668	PF00069	0.708
MOD_CK2_1	92	98	PF00069	0.729
MOD_GlcNHglycan	113	116	PF01048	0.697
MOD_GlcNHglycan	119	123	PF01048	0.690
MOD_GlcNHglycan	165	168	PF01048	0.565
MOD_GlcNHglycan	174	177	PF01048	0.601
MOD_GlcNHglycan	186	189	PF01048	0.765
MOD_GlcNHglycan	263	266	PF01048	0.729
MOD_GlcNHglycan	271	274	PF01048	0.822
MOD_GlcNHglycan	287	291	PF01048	0.602
MOD_GlcNHglycan	336	339	PF01048	0.359
MOD_GlcNHglycan	359	362	PF01048	0.392
MOD_GlcNHglycan	377	380	PF01048	0.402
MOD_GlcNHglycan	393	396	PF01048	0.449
MOD_GlcNHglycan	397	400	PF01048	0.345
MOD_GlcNHglycan	40	43	PF01048	0.705
MOD_GlcNHglycan	454	457	PF01048	0.334
MOD_GlcNHglycan	493	496	PF01048	0.411
MOD_GlcNHglycan	52	55	PF01048	0.649
MOD_GlcNHglycan	675	681	PF01048	0.670
MOD_GlcNHglycan	684	687	PF01048	0.614
MOD_GlcNHglycan	94	97	PF01048	0.726
MOD_GSK3_1	111	118	PF00069	0.782
MOD_GSK3_1	131	138	PF00069	0.669
MOD_GSK3_1	163	170	PF00069	0.617
MOD_GSK3_1	279	286	PF00069	0.748
MOD_GSK3_1	31	38	PF00069	0.582
MOD_GSK3_1	351	358	PF00069	0.395
MOD_GSK3_1	387	394	PF00069	0.412
MOD_GSK3_1	407	414	PF00069	0.413
MOD_GSK3_1	657	664	PF00069	0.607
MOD_GSK3_1	676	683	PF00069	0.706
MOD_GSK3_1	76	83	PF00069	0.625
MOD_LATS_1	550	556	PF00433	0.482
MOD_N-GLC_1	649	654	PF02516	0.757
MOD_NEK2_1	411	416	PF00069	0.393
MOD_NEK2_1	452	457	PF00069	0.411
MOD_NEK2_1	682	687	PF00069	0.650
MOD_PKA_1	552	558	PF00069	0.431
MOD_PKA_2	168	174	PF00069	0.713
MOD_PKA_2	184	190	PF00069	0.741
MOD_PKA_2	279	285	PF00069	0.798
MOD_PKA_2	439	445	PF00069	0.401
MOD_PKA_2	501	507	PF00069	0.355
MOD_PKA_2	508	514	PF00069	0.419
MOD_PKA_2	552	558	PF00069	0.413
MOD_PKB_1	516	524	PF00069	0.516
MOD_Plk_1	306	312	PF00069	0.657
MOD_Plk_1	395	401	PF00069	0.433
MOD_Plk_1	676	682	PF00069	0.703
MOD_Plk_4	407	413	PF00069	0.285
MOD_Plk_4	439	445	PF00069	0.438
MOD_Plk_4	494	500	PF00069	0.337
MOD_Plk_4	525	531	PF00069	0.447
MOD_Plk_4	552	558	PF00069	0.389
MOD_Plk_4	66	72	PF00069	0.509
MOD_ProDKin_1	31	37	PF00069	0.636
MOD_ProDKin_1	311	317	PF00069	0.598
MOD_ProDKin_1	4	10	PF00069	0.741
MOD_ProDKin_1	520	526	PF00069	0.502
MOD_ProDKin_1	76	82	PF00069	0.625
MOD_SUMO_rev_2	537	547	PF00179	0.461
TRG_DiLeu_BaEn_1	223	228	PF01217	0.673
TRG_DiLeu_BaEn_2	60	66	PF01217	0.645
TRG_DiLeu_BaEn_4	396	402	PF01217	0.411
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.662
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.411
TRG_DiLeu_BaLyEn_6	503	508	PF01217	0.393
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.477
TRG_ENDOCYTIC_2	159	162	PF00928	0.637
TRG_ENDOCYTIC_2	24	27	PF00928	0.550
TRG_ENDOCYTIC_2	500	503	PF00928	0.421
TRG_ENDOCYTIC_2	544	547	PF00928	0.508
TRG_ENDOCYTIC_2	570	573	PF00928	0.404
TRG_ER_diArg_1	213	216	PF00400	0.631
TRG_ER_diArg_1	238	241	PF00400	0.541
TRG_ER_diArg_1	246	248	PF00400	0.519
TRG_ER_diArg_1	482	485	PF00400	0.298
TRG_ER_diArg_1	508	510	PF00400	0.579
TRG_ER_diArg_1	515	518	PF00400	0.518
TRG_ER_diArg_1	538	541	PF00400	0.504
TRG_ER_diArg_1	564	566	PF00400	0.545
TRG_ER_diArg_1	636	639	PF00400	0.527
TRG_NLS_MonoCore_2	211	216	PF00514	0.676
TRG_NLS_MonoExtC_3	211	216	PF00514	0.676
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	639	644	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I9	Leptomonas seymouri	52%	94%
A0A1X0NZE8	Trypanosomatidae	33%	100%
A0A422NAG1	Trypanosoma rangeli	34%	100%
A4HIW4	Leishmania braziliensis	83%	99%
D0A185	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AGX8	Leishmania infantum	100%	100%
E9AV94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
Q4QC86	Leishmania major	93%	100%