Coiled-coil domain-containing protein 66, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWJ6_LEIDO

TriTrypDb:

LdBPK_211270.1 , LdCL_210017800 , LDHU3_21.1500

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	679	683	PF00656	0.779
CLV_C14_Caspase3-7	739	743	PF00656	0.585
CLV_C14_Caspase3-7	806	810	PF00656	0.677
CLV_NRD_NRD_1	329	331	PF00675	0.516
CLV_NRD_NRD_1	358	360	PF00675	0.550
CLV_NRD_NRD_1	395	397	PF00675	0.588
CLV_NRD_NRD_1	403	405	PF00675	0.655
CLV_NRD_NRD_1	47	49	PF00675	0.594
CLV_NRD_NRD_1	533	535	PF00675	0.523
CLV_NRD_NRD_1	547	549	PF00675	0.670
CLV_NRD_NRD_1	7	9	PF00675	0.557
CLV_NRD_NRD_1	817	819	PF00675	0.646
CLV_PCSK_FUR_1	366	370	PF00082	0.651
CLV_PCSK_KEX2_1	358	360	PF00082	0.550
CLV_PCSK_KEX2_1	368	370	PF00082	0.655
CLV_PCSK_KEX2_1	395	397	PF00082	0.551
CLV_PCSK_KEX2_1	403	405	PF00082	0.580
CLV_PCSK_KEX2_1	47	49	PF00082	0.594
CLV_PCSK_KEX2_1	533	535	PF00082	0.523
CLV_PCSK_KEX2_1	547	549	PF00082	0.670
CLV_PCSK_KEX2_1	6	8	PF00082	0.565
CLV_PCSK_KEX2_1	817	819	PF00082	0.653
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.655
CLV_PCSK_PC7_1	3	9	PF00082	0.558
CLV_PCSK_PC7_1	529	535	PF00082	0.649
CLV_PCSK_SKI1_1	322	326	PF00082	0.523
CLV_PCSK_SKI1_1	371	375	PF00082	0.566
CLV_PCSK_SKI1_1	435	439	PF00082	0.705
CLV_PCSK_SKI1_1	533	537	PF00082	0.521
DEG_APCC_DBOX_1	528	536	PF00400	0.650
DEG_COP1_1	417	427	PF00400	0.520
DEG_Nend_Nbox_1	1	3	PF02207	0.607
DEG_SPOP_SBC_1	451	455	PF00917	0.713
DEG_SPOP_SBC_1	630	634	PF00917	0.701
DOC_CKS1_1	410	415	PF01111	0.608
DOC_CKS1_1	502	507	PF01111	0.590
DOC_CKS1_1	747	752	PF01111	0.718
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	474	480	PF00134	0.739
DOC_CYCLIN_yCln2_LP_2	502	508	PF00134	0.678
DOC_MAPK_gen_1	184	191	PF00069	0.612
DOC_MAPK_gen_1	547	555	PF00069	0.624
DOC_MAPK_MEF2A_6	184	191	PF00069	0.612
DOC_PP2B_LxvP_1	175	178	PF13499	0.760
DOC_PP2B_LxvP_1	443	446	PF13499	0.583
DOC_PP2B_LxvP_1	468	471	PF13499	0.769
DOC_PP2B_LxvP_1	474	477	PF13499	0.660
DOC_PP2B_LxvP_1	618	621	PF13499	0.637
DOC_PP2B_LxvP_1	666	669	PF13499	0.677
DOC_PP4_FxxP_1	694	697	PF00568	0.622
DOC_PP4_FxxP_1	698	701	PF00568	0.631
DOC_PP4_FxxP_1	775	778	PF00568	0.740
DOC_USP7_MATH_1	150	154	PF00917	0.661
DOC_USP7_MATH_1	213	217	PF00917	0.812
DOC_USP7_MATH_1	256	260	PF00917	0.681
DOC_USP7_MATH_1	275	279	PF00917	0.769
DOC_USP7_MATH_1	437	441	PF00917	0.703
DOC_USP7_MATH_1	452	456	PF00917	0.560
DOC_USP7_MATH_1	469	473	PF00917	0.702
DOC_USP7_MATH_1	549	553	PF00917	0.688
DOC_USP7_MATH_1	563	567	PF00917	0.600
DOC_USP7_MATH_1	569	573	PF00917	0.535
DOC_USP7_MATH_1	586	590	PF00917	0.783
DOC_USP7_MATH_1	608	612	PF00917	0.730
DOC_USP7_MATH_1	629	633	PF00917	0.640
DOC_USP7_MATH_1	654	658	PF00917	0.633
DOC_USP7_MATH_1	661	665	PF00917	0.651
DOC_USP7_MATH_1	669	673	PF00917	0.705
DOC_USP7_MATH_1	756	760	PF00917	0.671
DOC_USP7_MATH_1	763	767	PF00917	0.674
DOC_USP7_UBL2_3	327	331	PF12436	0.572
DOC_USP7_UBL2_3	435	439	PF12436	0.768
DOC_WW_Pin1_4	119	124	PF00397	0.728
DOC_WW_Pin1_4	132	137	PF00397	0.647
DOC_WW_Pin1_4	160	165	PF00397	0.626
DOC_WW_Pin1_4	204	209	PF00397	0.803
DOC_WW_Pin1_4	224	229	PF00397	0.791
DOC_WW_Pin1_4	235	240	PF00397	0.699
DOC_WW_Pin1_4	247	252	PF00397	0.577
DOC_WW_Pin1_4	271	276	PF00397	0.839
DOC_WW_Pin1_4	409	414	PF00397	0.604
DOC_WW_Pin1_4	495	500	PF00397	0.635
DOC_WW_Pin1_4	501	506	PF00397	0.659
DOC_WW_Pin1_4	565	570	PF00397	0.642
DOC_WW_Pin1_4	584	589	PF00397	0.648
DOC_WW_Pin1_4	648	653	PF00397	0.667
DOC_WW_Pin1_4	704	709	PF00397	0.681
DOC_WW_Pin1_4	746	751	PF00397	0.760
DOC_WW_Pin1_4	759	764	PF00397	0.575
DOC_WW_Pin1_4	779	784	PF00397	0.668
DOC_WW_Pin1_4	796	801	PF00397	0.730
DOC_WW_Pin1_4	819	824	PF00397	0.810
LIG_14-3-3_CanoR_1	246	251	PF00244	0.672
LIG_14-3-3_CanoR_1	276	284	PF00244	0.765
LIG_14-3-3_CanoR_1	603	609	PF00244	0.751
LIG_14-3-3_CanoR_1	610	619	PF00244	0.612
LIG_14-3-3_CanoR_1	699	709	PF00244	0.688
LIG_14-3-3_CanoR_1	735	741	PF00244	0.592
LIG_14-3-3_CanoR_1	774	778	PF00244	0.646
LIG_14-3-3_CanoR_1	817	824	PF00244	0.652
LIG_Actin_WH2_2	480	498	PF00022	0.675
LIG_CtBP_PxDLS_1	203	207	PF00389	0.679
LIG_EH_1	27	31	PF12763	0.634
LIG_EVH1_1	618	622	PF00568	0.633
LIG_EVH1_2	187	191	PF00568	0.614
LIG_FHA_1	161	167	PF00498	0.612
LIG_FHA_1	523	529	PF00498	0.640
LIG_FHA_1	534	540	PF00498	0.458
LIG_FHA_1	675	681	PF00498	0.731
LIG_FHA_1	724	730	PF00498	0.721
LIG_FHA_2	679	685	PF00498	0.772
LIG_FHA_2	737	743	PF00498	0.588
LIG_FHA_2	806	812	PF00498	0.807
LIG_LIR_Apic_2	504	510	PF02991	0.563
LIG_LIR_Apic_2	692	697	PF02991	0.628
LIG_LIR_Nem_3	160	165	PF02991	0.606
LIG_LIR_Nem_3	645	649	PF02991	0.565
LIG_Pex14_2	694	698	PF04695	0.742
LIG_SH2_CRK	133	137	PF00017	0.649
LIG_SH2_GRB2like	80	83	PF00017	0.585
LIG_SH2_NCK_1	112	116	PF00017	0.630
LIG_SH2_NCK_1	128	132	PF00017	0.751
LIG_SH2_NCK_1	133	137	PF00017	0.679
LIG_SH2_STAT5	21	24	PF00017	0.559
LIG_SH2_STAT5	236	239	PF00017	0.742
LIG_SH2_STAT5	485	488	PF00017	0.633
LIG_SH2_STAT5	580	583	PF00017	0.651
LIG_SH3_1	89	95	PF00018	0.714
LIG_SH3_3	161	167	PF00018	0.617
LIG_SH3_3	179	185	PF00018	0.660
LIG_SH3_3	207	213	PF00018	0.734
LIG_SH3_3	215	221	PF00018	0.690
LIG_SH3_3	250	256	PF00018	0.668
LIG_SH3_3	407	413	PF00018	0.720
LIG_SH3_3	416	422	PF00018	0.821
LIG_SH3_3	425	431	PF00018	0.655
LIG_SH3_3	470	476	PF00018	0.667
LIG_SH3_3	478	484	PF00018	0.585
LIG_SH3_3	61	67	PF00018	0.642
LIG_SH3_3	616	622	PF00018	0.641
LIG_SH3_3	625	631	PF00018	0.678
LIG_SH3_3	702	708	PF00018	0.684
LIG_SH3_3	725	731	PF00018	0.588
LIG_SH3_3	735	741	PF00018	0.593
LIG_SH3_3	744	750	PF00018	0.597
LIG_SH3_3	89	95	PF00018	0.672
LIG_SUMO_SIM_par_1	202	207	PF11976	0.674
LIG_TRAF2_1	298	301	PF00917	0.609
LIG_TRAF2_1	31	34	PF00917	0.608
LIG_WRC_WIRS_1	159	164	PF05994	0.549
LIG_WRC_WIRS_1	609	614	PF05994	0.596
MOD_CDC14_SPxK_1	782	785	PF00782	0.648
MOD_CDK_SPK_2	119	124	PF00069	0.662
MOD_CDK_SPK_2	224	229	PF00069	0.748
MOD_CDK_SPK_2	271	276	PF00069	0.777
MOD_CDK_SPxK_1	779	785	PF00069	0.651
MOD_CDK_SPxxK_3	119	126	PF00069	0.644
MOD_CDK_SPxxK_3	235	242	PF00069	0.699
MOD_CK1_1	160	166	PF00069	0.655
MOD_CK1_1	455	461	PF00069	0.709
MOD_CK1_1	527	533	PF00069	0.594
MOD_CK1_1	611	617	PF00069	0.675
MOD_CK1_1	678	684	PF00069	0.781
MOD_CK1_1	723	729	PF00069	0.692
MOD_CK1_1	759	765	PF00069	0.672
MOD_CK2_1	110	116	PF00069	0.701
MOD_CK2_1	194	200	PF00069	0.760
MOD_CK2_1	235	241	PF00069	0.668
MOD_CK2_1	28	34	PF00069	0.598
MOD_CK2_1	294	300	PF00069	0.572
MOD_CK2_1	678	684	PF00069	0.714
MOD_CK2_1	773	779	PF00069	0.643
MOD_Cter_Amidation	124	127	PF01082	0.580
MOD_GlcNHglycan	112	115	PF01048	0.644
MOD_GlcNHglycan	192	195	PF01048	0.818
MOD_GlcNHglycan	196	199	PF01048	0.762
MOD_GlcNHglycan	264	267	PF01048	0.646
MOD_GlcNHglycan	279	282	PF01048	0.641
MOD_GlcNHglycan	296	299	PF01048	0.570
MOD_GlcNHglycan	447	450	PF01048	0.644
MOD_GlcNHglycan	492	495	PF01048	0.678
MOD_GlcNHglycan	565	568	PF01048	0.663
MOD_GlcNHglycan	604	607	PF01048	0.789
MOD_GlcNHglycan	633	636	PF01048	0.640
MOD_GlcNHglycan	656	659	PF01048	0.678
MOD_GlcNHglycan	765	768	PF01048	0.698
MOD_GlcNHglycan	96	99	PF01048	0.717
MOD_GSK3_1	190	197	PF00069	0.812
MOD_GSK3_1	220	227	PF00069	0.618
MOD_GSK3_1	245	252	PF00069	0.660
MOD_GSK3_1	271	278	PF00069	0.781
MOD_GSK3_1	451	458	PF00069	0.744
MOD_GSK3_1	565	572	PF00069	0.688
MOD_GSK3_1	576	583	PF00069	0.652
MOD_GSK3_1	610	617	PF00069	0.703
MOD_GSK3_1	674	681	PF00069	0.728
MOD_GSK3_1	685	692	PF00069	0.600
MOD_GSK3_1	700	707	PF00069	0.739
MOD_GSK3_1	751	758	PF00069	0.698
MOD_GSK3_1	759	766	PF00069	0.614
MOD_GSK3_1	779	786	PF00069	0.703
MOD_GSK3_1	796	803	PF00069	0.708
MOD_N-GLC_1	262	267	PF02516	0.695
MOD_N-GLC_1	78	83	PF02516	0.663
MOD_N-GLC_2	512	514	PF02516	0.718
MOD_NEK2_1	438	443	PF00069	0.762
MOD_NEK2_1	676	681	PF00069	0.785
MOD_PIKK_1	150	156	PF00454	0.697
MOD_PIKK_1	213	219	PF00454	0.670
MOD_PIKK_1	389	395	PF00454	0.701
MOD_PIKK_1	455	461	PF00454	0.591
MOD_PIKK_1	522	528	PF00454	0.682
MOD_PKA_1	533	539	PF00069	0.520
MOD_PKA_1	817	823	PF00069	0.694
MOD_PKA_2	245	251	PF00069	0.712
MOD_PKA_2	275	281	PF00069	0.767
MOD_PKA_2	389	395	PF00069	0.660
MOD_PKA_2	533	539	PF00069	0.528
MOD_PKA_2	602	608	PF00069	0.767
MOD_PKA_2	773	779	PF00069	0.674
MOD_PKA_2	817	823	PF00069	0.657
MOD_PKA_2	85	91	PF00069	0.597
MOD_Plk_4	249	255	PF00069	0.774
MOD_Plk_4	469	475	PF00069	0.759
MOD_Plk_4	576	582	PF00069	0.656
MOD_Plk_4	661	667	PF00069	0.766
MOD_Plk_4	714	720	PF00069	0.684
MOD_ProDKin_1	119	125	PF00069	0.725
MOD_ProDKin_1	132	138	PF00069	0.648
MOD_ProDKin_1	160	166	PF00069	0.627
MOD_ProDKin_1	204	210	PF00069	0.798
MOD_ProDKin_1	224	230	PF00069	0.791
MOD_ProDKin_1	235	241	PF00069	0.697
MOD_ProDKin_1	247	253	PF00069	0.579
MOD_ProDKin_1	271	277	PF00069	0.839
MOD_ProDKin_1	409	415	PF00069	0.607
MOD_ProDKin_1	495	501	PF00069	0.635
MOD_ProDKin_1	565	571	PF00069	0.640
MOD_ProDKin_1	584	590	PF00069	0.649
MOD_ProDKin_1	648	654	PF00069	0.667
MOD_ProDKin_1	704	710	PF00069	0.680
MOD_ProDKin_1	746	752	PF00069	0.758
MOD_ProDKin_1	759	765	PF00069	0.573
MOD_ProDKin_1	779	785	PF00069	0.671
MOD_ProDKin_1	796	802	PF00069	0.782
MOD_ProDKin_1	819	825	PF00069	0.813
MOD_SUMO_rev_2	367	376	PF00179	0.549
TRG_DiLeu_BaEn_2	689	695	PF01217	0.639
TRG_ENDOCYTIC_2	609	612	PF00928	0.650
TRG_ER_diArg_1	36	39	PF00400	0.648
TRG_ER_diArg_1	403	406	PF00400	0.710
TRG_ER_diArg_1	46	48	PF00400	0.615
TRG_ER_diArg_1	532	534	PF00400	0.529
TRG_ER_diArg_1	6	8	PF00400	0.558
TRG_ER_diArg_1	817	819	PF00400	0.658
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	671	675	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1W4	Leptomonas seymouri	43%	93%
A4HBW3	Leishmania braziliensis	69%	100%
E9AGX1	Leishmania infantum	96%	100%
E9AV87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4QC93	Leishmania major	90%	99%