Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 91, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWJ2_LEIDO

TriTrypDb:

LdBPK_210830.1 , LdCL_210013200 , LDHU3_21.0930

Length:

722

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWJ2

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	546	550	PF00656	0.556
CLV_NRD_NRD_1	152	154	PF00675	0.660
CLV_NRD_NRD_1	412	414	PF00675	0.786
CLV_NRD_NRD_1	513	515	PF00675	0.455
CLV_NRD_NRD_1	620	622	PF00675	0.688
CLV_PCSK_KEX2_1	412	414	PF00082	0.792
CLV_PCSK_KEX2_1	513	515	PF00082	0.459
CLV_PCSK_KEX2_1	620	622	PF00082	0.652
CLV_PCSK_PC7_1	616	622	PF00082	0.650
CLV_PCSK_SKI1_1	160	164	PF00082	0.470
CLV_PCSK_SKI1_1	206	210	PF00082	0.609
CLV_PCSK_SKI1_1	227	231	PF00082	0.295
CLV_PCSK_SKI1_1	278	282	PF00082	0.462
CLV_PCSK_SKI1_1	284	288	PF00082	0.441
CLV_PCSK_SKI1_1	31	35	PF00082	0.421
CLV_PCSK_SKI1_1	476	480	PF00082	0.465
CLV_PCSK_SKI1_1	489	493	PF00082	0.415
CLV_PCSK_SKI1_1	513	517	PF00082	0.417
CLV_PCSK_SKI1_1	530	534	PF00082	0.446
CLV_Separin_Metazoa	593	597	PF03568	0.592
DEG_APCC_KENBOX_2	309	313	PF00400	0.477
DEG_Nend_UBRbox_3	1	3	PF02207	0.546
DEG_SPOP_SBC_1	131	135	PF00917	0.548
DEG_SPOP_SBC_1	148	152	PF00917	0.431
DEG_SPOP_SBC_1	353	357	PF00917	0.423
DOC_CYCLIN_RxL_1	510	522	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	333	339	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	503	509	PF00134	0.495
DOC_MAPK_gen_1	308	315	PF00069	0.534
DOC_MAPK_gen_1	510	518	PF00069	0.455
DOC_MAPK_MEF2A_6	596	605	PF00069	0.616
DOC_PP1_RVXF_1	9	15	PF00149	0.476
DOC_PP2B_LxvP_1	163	166	PF13499	0.434
DOC_PP2B_LxvP_1	333	336	PF13499	0.496
DOC_PP2B_LxvP_1	503	506	PF13499	0.493
DOC_PP4_FxxP_1	146	149	PF00568	0.507
DOC_PP4_FxxP_1	162	165	PF00568	0.441
DOC_PP4_FxxP_1	76	79	PF00568	0.382
DOC_SPAK_OSR1_1	145	149	PF12202	0.506
DOC_SPAK_OSR1_1	3	7	PF12202	0.471
DOC_SPAK_OSR1_1	59	63	PF12202	0.446
DOC_USP7_MATH_1	125	129	PF00917	0.429
DOC_USP7_MATH_1	13	17	PF00917	0.587
DOC_USP7_MATH_1	131	135	PF00917	0.438
DOC_USP7_MATH_1	149	153	PF00917	0.624
DOC_USP7_MATH_1	213	217	PF00917	0.509
DOC_USP7_MATH_1	229	233	PF00917	0.386
DOC_USP7_MATH_1	48	52	PF00917	0.436
DOC_USP7_MATH_1	587	591	PF00917	0.513
DOC_USP7_UBL2_3	31	35	PF12436	0.484
DOC_USP7_UBL2_3	669	673	PF12436	0.522
DOC_WW_Pin1_4	132	137	PF00397	0.481
DOC_WW_Pin1_4	439	444	PF00397	0.555
DOC_WW_Pin1_4	540	545	PF00397	0.537
DOC_WW_Pin1_4	704	709	PF00397	0.668
LIG_14-3-3_CanoR_1	278	283	PF00244	0.420
LIG_14-3-3_CanoR_1	454	458	PF00244	0.589
LIG_14-3-3_CanoR_1	517	524	PF00244	0.480
LIG_14-3-3_CanoR_1	596	605	PF00244	0.603
LIG_14-3-3_CanoR_1	655	661	PF00244	0.584
LIG_Actin_WH2_2	282	297	PF00022	0.381
LIG_Actin_WH2_2	368	383	PF00022	0.421
LIG_AP2alpha_2	711	713	PF02296	0.388
LIG_APCC_ABBA_1	237	242	PF00400	0.475
LIG_APCC_ABBAyCdc20_2	236	242	PF00400	0.481
LIG_BRCT_BRCA1_1	400	404	PF00533	0.517
LIG_BRCT_BRCA1_1	56	60	PF00533	0.416
LIG_Clathr_ClatBox_1	200	204	PF01394	0.416
LIG_deltaCOP1_diTrp_1	158	162	PF00928	0.511
LIG_deltaCOP1_diTrp_1	91	97	PF00928	0.365
LIG_EH_1	401	405	PF12763	0.550
LIG_FHA_1	266	272	PF00498	0.591
LIG_FHA_1	277	283	PF00498	0.318
LIG_FHA_1	457	463	PF00498	0.480
LIG_FHA_1	473	479	PF00498	0.469
LIG_FHA_1	483	489	PF00498	0.455
LIG_FHA_1	498	504	PF00498	0.454
LIG_FHA_1	550	556	PF00498	0.468
LIG_FHA_1	90	96	PF00498	0.382
LIG_FHA_2	169	175	PF00498	0.393
LIG_FHA_2	265	271	PF00498	0.502
LIG_FHA_2	413	419	PF00498	0.625
LIG_FHA_2	551	557	PF00498	0.529
LIG_GBD_Chelix_1	372	380	PF00786	0.436
LIG_HCF-1_HBM_1	245	248	PF13415	0.391
LIG_LIR_Apic_2	144	149	PF02991	0.497
LIG_LIR_Gen_1	245	254	PF02991	0.358
LIG_LIR_Nem_3	158	162	PF02991	0.654
LIG_LIR_Nem_3	216	221	PF02991	0.464
LIG_LIR_Nem_3	245	251	PF02991	0.358
LIG_LIR_Nem_3	334	340	PF02991	0.456
LIG_LIR_Nem_3	348	354	PF02991	0.519
LIG_LIR_Nem_3	401	407	PF02991	0.538
LIG_LIR_Nem_3	636	642	PF02991	0.603
LIG_LIR_Nem_3	699	704	PF02991	0.529
LIG_MAD2	540	548	PF02301	0.380
LIG_NRBOX	523	529	PF00104	0.509
LIG_PCNA_yPIPBox_3	514	528	PF02747	0.478
LIG_PCNA_yPIPBox_3	611	625	PF02747	0.645
LIG_Pex14_1	14	18	PF04695	0.506
LIG_Pex14_2	296	300	PF04695	0.474
LIG_Pex14_2	713	717	PF04695	0.379
LIG_RPA_C_Fungi	583	595	PF08784	0.496
LIG_SH2_CRK	248	252	PF00017	0.363
LIG_SH2_CRK	337	341	PF00017	0.323
LIG_SH2_NCK_1	248	252	PF00017	0.398
LIG_SH2_NCK_1	337	341	PF00017	0.446
LIG_SH2_NCK_1	448	452	PF00017	0.400
LIG_SH2_SRC	337	340	PF00017	0.494
LIG_SH2_STAP1	248	252	PF00017	0.363
LIG_SH2_STAP1	597	601	PF00017	0.614
LIG_SH2_STAP1	656	660	PF00017	0.574
LIG_SH2_STAT3	219	222	PF00017	0.424
LIG_SH2_STAT3	263	266	PF00017	0.393
LIG_SH2_STAT5	219	222	PF00017	0.424
LIG_SH2_STAT5	263	266	PF00017	0.421
LIG_SH2_STAT5	656	659	PF00017	0.577
LIG_SH3_3	326	332	PF00018	0.466
LIG_SH3_3	333	339	PF00018	0.446
LIG_SH3_3	503	509	PF00018	0.534
LIG_SH3_3	538	544	PF00018	0.532
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.404
LIG_SUMO_SIM_par_1	188	193	PF11976	0.416
LIG_TRAF2_1	347	350	PF00917	0.482
LIG_TRAF2_1	356	359	PF00917	0.376
LIG_TRAF2_1	415	418	PF00917	0.660
LIG_TRAF2_1	421	424	PF00917	0.566
LIG_TYR_ITIM	335	340	PF00017	0.409
LIG_UBA3_1	189	195	PF00899	0.392
LIG_WRC_WIRS_1	49	54	PF05994	0.432
LIG_WW_3	164	168	PF00397	0.435
MOD_CDK_SPxxK_3	132	139	PF00069	0.461
MOD_CK1_1	129	135	PF00069	0.645
MOD_CK1_1	168	174	PF00069	0.420
MOD_CK1_1	232	238	PF00069	0.436
MOD_CK1_1	345	351	PF00069	0.616
MOD_CK1_1	364	370	PF00069	0.333
MOD_CK1_1	383	389	PF00069	0.548
MOD_CK1_1	456	462	PF00069	0.518
MOD_CK1_1	543	549	PF00069	0.520
MOD_CK1_1	690	696	PF00069	0.615
MOD_CK2_1	168	174	PF00069	0.402
MOD_CK2_1	250	256	PF00069	0.504
MOD_CK2_1	264	270	PF00069	0.493
MOD_CK2_1	344	350	PF00069	0.481
MOD_CK2_1	353	359	PF00069	0.465
MOD_CK2_1	412	418	PF00069	0.629
MOD_CK2_1	517	523	PF00069	0.551
MOD_CK2_1	587	593	PF00069	0.598
MOD_CK2_1	596	602	PF00069	0.581
MOD_DYRK1A_RPxSP_1	540	544	PF00069	0.484
MOD_GlcNHglycan	129	132	PF01048	0.657
MOD_GlcNHglycan	181	184	PF01048	0.377
MOD_GlcNHglycan	213	216	PF01048	0.481
MOD_GlcNHglycan	416	421	PF01048	0.710
MOD_GlcNHglycan	436	439	PF01048	0.515
MOD_GlcNHglycan	55	59	PF01048	0.540
MOD_GlcNHglycan	622	625	PF01048	0.702
MOD_GlcNHglycan	66	69	PF01048	0.513
MOD_GlcNHglycan	677	680	PF01048	0.500
MOD_GSK3_1	123	130	PF00069	0.504
MOD_GSK3_1	13	20	PF00069	0.595
MOD_GSK3_1	190	197	PF00069	0.466
MOD_GSK3_1	213	220	PF00069	0.547
MOD_GSK3_1	265	272	PF00069	0.603
MOD_GSK3_1	338	345	PF00069	0.417
MOD_GSK3_1	371	378	PF00069	0.506
MOD_GSK3_1	381	388	PF00069	0.560
MOD_GSK3_1	408	415	PF00069	0.612
MOD_GSK3_1	449	456	PF00069	0.544
MOD_GSK3_1	483	490	PF00069	0.528
MOD_GSK3_1	493	500	PF00069	0.503
MOD_GSK3_1	531	538	PF00069	0.399
MOD_GSK3_1	651	658	PF00069	0.603
MOD_LATS_1	653	659	PF00433	0.641
MOD_N-GLC_1	482	487	PF02516	0.459
MOD_NEK2_1	141	146	PF00069	0.484
MOD_NEK2_1	190	195	PF00069	0.342
MOD_NEK2_1	264	269	PF00069	0.509
MOD_NEK2_1	296	301	PF00069	0.413
MOD_NEK2_1	302	307	PF00069	0.382
MOD_NEK2_1	375	380	PF00069	0.516
MOD_NEK2_1	453	458	PF00069	0.521
MOD_NEK2_1	472	477	PF00069	0.453
MOD_NEK2_1	568	573	PF00069	0.648
MOD_NEK2_1	604	609	PF00069	0.547
MOD_NEK2_1	83	88	PF00069	0.401
MOD_NEK2_2	13	18	PF00069	0.501
MOD_NEK2_2	229	234	PF00069	0.308
MOD_NEK2_2	339	344	PF00069	0.388
MOD_NEK2_2	449	454	PF00069	0.418
MOD_PIKK_1	108	114	PF00454	0.399
MOD_PIKK_1	354	360	PF00454	0.521
MOD_PIKK_1	385	391	PF00454	0.462
MOD_PIKK_1	457	463	PF00454	0.439
MOD_PIKK_1	517	523	PF00454	0.430
MOD_PIKK_1	629	635	PF00454	0.575
MOD_PKA_1	412	418	PF00069	0.629
MOD_PKA_1	620	626	PF00069	0.692
MOD_PKA_2	412	418	PF00069	0.629
MOD_PKA_2	453	459	PF00069	0.594
MOD_PKA_2	587	593	PF00069	0.464
MOD_PKA_2	620	626	PF00069	0.689
MOD_PKA_2	654	660	PF00069	0.588
MOD_Plk_1	106	112	PF00069	0.397
MOD_Plk_1	522	528	PF00069	0.512
MOD_Plk_1	648	654	PF00069	0.625
MOD_Plk_1	690	696	PF00069	0.647
MOD_Plk_4	185	191	PF00069	0.433
MOD_Plk_4	278	284	PF00069	0.599
MOD_Plk_4	339	345	PF00069	0.389
MOD_Plk_4	371	377	PF00069	0.469
MOD_Plk_4	523	529	PF00069	0.450
MOD_Plk_4	78	84	PF00069	0.420
MOD_ProDKin_1	132	138	PF00069	0.467
MOD_ProDKin_1	439	445	PF00069	0.550
MOD_ProDKin_1	540	546	PF00069	0.536
MOD_ProDKin_1	704	710	PF00069	0.674
MOD_SUMO_for_1	572	575	PF00179	0.510
MOD_SUMO_rev_2	364	373	PF00179	0.434
MOD_SUMO_rev_2	7	13	PF00179	0.476
TRG_DiLeu_BaEn_1	425	430	PF01217	0.615
TRG_DiLeu_BaEn_1	523	528	PF01217	0.454
TRG_DiLeu_BaEn_2	157	163	PF01217	0.511
TRG_DiLeu_BaEn_2	310	316	PF01217	0.438
TRG_DiLeu_BaEn_2	467	473	PF01217	0.403
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.573
TRG_DiLeu_BaLyEn_6	678	683	PF01217	0.565
TRG_ENDOCYTIC_2	248	251	PF00928	0.338
TRG_ENDOCYTIC_2	337	340	PF00928	0.494
TRG_ER_diArg_1	233	236	PF00400	0.581
TRG_ER_diArg_1	512	514	PF00400	0.464
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD9	Leptomonas seymouri	55%	100%
A0A1X0NXN3	Trypanosomatidae	27%	88%
A0A3S5IR71	Trypanosoma rangeli	27%	88%
A4HBS2	Leishmania braziliensis	84%	100%
A4HZ76	Leishmania infantum	99%	100%
D0A1G1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	87%
E9AV43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QCD8	Leishmania major	93%	100%
V5AYE8	Trypanosoma cruzi	29%	88%