Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWI8_LEIDO

TriTrypDb:

LdBPK_211140.1 , LdCL_210016400 , LDHU3_21.1340

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.481
CLV_C14_Caspase3-7	406	410	PF00656	0.658
CLV_NRD_NRD_1	133	135	PF00675	0.593
CLV_NRD_NRD_1	200	202	PF00675	0.682
CLV_NRD_NRD_1	251	253	PF00675	0.514
CLV_NRD_NRD_1	275	277	PF00675	0.588
CLV_NRD_NRD_1	340	342	PF00675	0.588
CLV_NRD_NRD_1	344	346	PF00675	0.578
CLV_NRD_NRD_1	368	370	PF00675	0.497
CLV_PCSK_KEX2_1	133	135	PF00082	0.593
CLV_PCSK_KEX2_1	199	201	PF00082	0.695
CLV_PCSK_KEX2_1	251	253	PF00082	0.514
CLV_PCSK_KEX2_1	275	277	PF00082	0.586
CLV_PCSK_KEX2_1	340	342	PF00082	0.588
CLV_PCSK_SKI1_1	11	15	PF00082	0.573
CLV_PCSK_SKI1_1	306	310	PF00082	0.545
DEG_SCF_FBW7_1	100	105	PF00400	0.599
DEG_SPOP_SBC_1	102	106	PF00917	0.588
DEG_SPOP_SBC_1	318	322	PF00917	0.641
DOC_ANK_TNKS_1	199	206	PF00023	0.543
DOC_MAPK_gen_1	251	257	PF00069	0.446
DOC_MAPK_gen_1	275	282	PF00069	0.546
DOC_MAPK_MEF2A_6	110	118	PF00069	0.471
DOC_MAPK_MEF2A_6	275	284	PF00069	0.542
DOC_PP1_RVXF_1	9	16	PF00149	0.499
DOC_PP2B_LxvP_1	36	39	PF13499	0.583
DOC_USP7_MATH_1	103	107	PF00917	0.600
DOC_USP7_MATH_1	167	171	PF00917	0.628
DOC_USP7_MATH_1	274	278	PF00917	0.497
DOC_USP7_MATH_1	317	321	PF00917	0.724
DOC_USP7_MATH_1	325	329	PF00917	0.684
DOC_WW_Pin1_4	98	103	PF00397	0.605
LIG_14-3-3_CanoR_1	11	16	PF00244	0.588
LIG_14-3-3_CanoR_1	110	114	PF00244	0.516
LIG_14-3-3_CanoR_1	275	282	PF00244	0.546
LIG_14-3-3_CanoR_1	369	373	PF00244	0.491
LIG_14-3-3_CanoR_1	4	8	PF00244	0.557
LIG_Actin_WH2_2	72	88	PF00022	0.560
LIG_BRCT_BRCA1_1	28	32	PF00533	0.409
LIG_FHA_1	103	109	PF00498	0.696
LIG_FHA_1	110	116	PF00498	0.560
LIG_FHA_1	17	23	PF00498	0.424
LIG_FHA_1	217	223	PF00498	0.563
LIG_FHA_1	295	301	PF00498	0.545
LIG_FHA_1	355	361	PF00498	0.431
LIG_FHA_1	80	86	PF00498	0.449
LIG_FHA_2	175	181	PF00498	0.674
LIG_FHA_2	231	237	PF00498	0.479
LIG_FHA_2	442	448	PF00498	0.604
LIG_LIR_Gen_1	112	120	PF02991	0.413
LIG_LIR_Gen_1	29	39	PF02991	0.447
LIG_LIR_Gen_1	350	360	PF02991	0.455
LIG_LIR_Gen_1	430	439	PF02991	0.520
LIG_LIR_Gen_1	59	66	PF02991	0.639
LIG_LIR_Nem_3	112	116	PF02991	0.417
LIG_LIR_Nem_3	29	35	PF02991	0.444
LIG_LIR_Nem_3	350	355	PF02991	0.484
LIG_LIR_Nem_3	430	434	PF02991	0.552
LIG_LIR_Nem_3	59	64	PF02991	0.631
LIG_SH2_PTP2	113	116	PF00017	0.456
LIG_SH2_SRC	148	151	PF00017	0.412
LIG_SH2_SRC	387	390	PF00017	0.484
LIG_SH2_STAP1	356	360	PF00017	0.422
LIG_SH2_STAP1	421	425	PF00017	0.635
LIG_SH2_STAT5	113	116	PF00017	0.492
LIG_SH2_STAT5	148	151	PF00017	0.412
LIG_SH2_STAT5	356	359	PF00017	0.425
LIG_SH2_STAT5	387	390	PF00017	0.484
LIG_SH3_3	10	16	PF00018	0.513
LIG_SH3_3	257	263	PF00018	0.632
LIG_SH3_3	411	417	PF00018	0.684
LIG_SUMO_SIM_anti_2	112	119	PF11976	0.575
LIG_SUMO_SIM_anti_2	211	216	PF11976	0.378
LIG_SUMO_SIM_par_1	112	119	PF11976	0.410
LIG_SUMO_SIM_par_1	280	285	PF11976	0.468
LIG_UBA3_1	299	306	PF00899	0.506
LIG_WRC_WIRS_1	363	368	PF05994	0.561
LIG_WW_3	64	68	PF00397	0.474
MOD_CK1_1	169	175	PF00069	0.626
MOD_CK1_1	358	364	PF00069	0.487
MOD_CK1_1	403	409	PF00069	0.560
MOD_CK2_1	230	236	PF00069	0.495
MOD_CK2_1	255	261	PF00069	0.527
MOD_CK2_1	362	368	PF00069	0.485
MOD_CK2_1	441	447	PF00069	0.595
MOD_GlcNHglycan	105	108	PF01048	0.671
MOD_GlcNHglycan	127	130	PF01048	0.571
MOD_GlcNHglycan	139	142	PF01048	0.391
MOD_GlcNHglycan	169	172	PF01048	0.642
MOD_GlcNHglycan	173	176	PF01048	0.602
MOD_GlcNHglycan	222	225	PF01048	0.639
MOD_GlcNHglycan	241	244	PF01048	0.361
MOD_GlcNHglycan	247	250	PF01048	0.438
MOD_GlcNHglycan	270	273	PF01048	0.734
MOD_GlcNHglycan	313	316	PF01048	0.749
MOD_GlcNHglycan	327	330	PF01048	0.583
MOD_GlcNHglycan	393	396	PF01048	0.736
MOD_GlcNHglycan	403	406	PF01048	0.589
MOD_GlcNHglycan	435	438	PF01048	0.542
MOD_GlcNHglycan	5	8	PF01048	0.551
MOD_GlcNHglycan	88	91	PF01048	0.538
MOD_GSK3_1	167	174	PF00069	0.746
MOD_GSK3_1	188	195	PF00069	0.637
MOD_GSK3_1	216	223	PF00069	0.585
MOD_GSK3_1	319	326	PF00069	0.584
MOD_GSK3_1	354	361	PF00069	0.435
MOD_GSK3_1	364	371	PF00069	0.483
MOD_GSK3_1	373	380	PF00069	0.434
MOD_GSK3_1	387	394	PF00069	0.484
MOD_GSK3_1	399	406	PF00069	0.659
MOD_GSK3_1	47	54	PF00069	0.607
MOD_GSK3_1	98	105	PF00069	0.574
MOD_N-GLC_1	181	186	PF02516	0.639
MOD_N-GLC_1	216	221	PF02516	0.494
MOD_N-GLC_1	225	230	PF02516	0.555
MOD_N-GLC_2	268	270	PF02516	0.588
MOD_NEK2_1	225	230	PF00069	0.555
MOD_NEK2_1	286	291	PF00069	0.433
MOD_NEK2_1	3	8	PF00069	0.561
MOD_NEK2_1	355	360	PF00069	0.426
MOD_NEK2_2	16	21	PF00069	0.445
MOD_NEK2_2	319	324	PF00069	0.614
MOD_NEK2_2	56	61	PF00069	0.556
MOD_PIKK_1	294	300	PF00454	0.447
MOD_PIKK_1	340	346	PF00454	0.578
MOD_PIKK_1	77	83	PF00454	0.536
MOD_PKA_1	340	346	PF00069	0.581
MOD_PKA_2	109	115	PF00069	0.516
MOD_PKA_2	274	280	PF00069	0.568
MOD_PKA_2	3	9	PF00069	0.517
MOD_PKA_2	340	346	PF00069	0.581
MOD_PKA_2	368	374	PF00069	0.443
MOD_Plk_1	26	32	PF00069	0.408
MOD_Plk_1	361	367	PF00069	0.458
MOD_Plk_2-3	362	368	PF00069	0.485
MOD_Plk_4	109	115	PF00069	0.492
MOD_Plk_4	208	214	PF00069	0.377
MOD_Plk_4	319	325	PF00069	0.637
MOD_Plk_4	355	361	PF00069	0.431
MOD_Plk_4	56	62	PF00069	0.586
MOD_Plk_4	79	85	PF00069	0.453
MOD_ProDKin_1	98	104	PF00069	0.604
MOD_SUMO_rev_2	362	372	PF00179	0.479
TRG_ENDOCYTIC_2	113	116	PF00928	0.404
TRG_ENDOCYTIC_2	356	359	PF00928	0.425
TRG_ER_diArg_1	199	201	PF00400	0.692
TRG_ER_diArg_1	339	341	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILY1	Leptomonas seymouri	48%	100%
A4HK96	Leishmania braziliensis	69%	99%
E9AGV8	Leishmania infantum	100%	100%
E9AV74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
Q4QCA7	Leishmania major	91%	100%