Methionine aminopeptidase 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MG, Family M24

Species:

Leishmania donovani

UniProt:

A0A3S7WWI2_LEIDO

TriTrypDb:

LdBPK_210960.1 , LdCL_210014600 , LDHU3_21.1130

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3S7WWI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWI2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0070084	protein initiator methionine removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0016485	protein processing	5	1
GO:0035551	protein initiator methionine removal involved in protein maturation	6	1
GO:0051604	protein maturation	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004177	aminopeptidase activity	5	12
GO:0005488	binding	1	12
GO:0008233	peptidase activity	3	12
GO:0008235	metalloexopeptidase activity	5	12
GO:0008237	metallopeptidase activity	4	12
GO:0008238	exopeptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0070006	metalloaminopeptidase activity	6	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.665
CLV_C14_Caspase3-7	43	47	PF00656	0.617
CLV_NRD_NRD_1	135	137	PF00675	0.680
CLV_NRD_NRD_1	403	405	PF00675	0.406
CLV_PCSK_KEX2_1	135	137	PF00082	0.586
CLV_PCSK_KEX2_1	141	143	PF00082	0.512
CLV_PCSK_KEX2_1	58	60	PF00082	0.907
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.538
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.907
CLV_PCSK_SKI1_1	141	145	PF00082	0.574
CLV_PCSK_SKI1_1	226	230	PF00082	0.414
CLV_PCSK_SKI1_1	268	272	PF00082	0.413
CLV_PCSK_SKI1_1	456	460	PF00082	0.439
DEG_ODPH_VHL_1	320	333	PF01847	0.491
DOC_MAPK_MEF2A_6	174	181	PF00069	0.526
DOC_MAPK_MEF2A_6	276	284	PF00069	0.406
DOC_MAPK_MEF2A_6	430	437	PF00069	0.526
DOC_PP1_RVXF_1	234	240	PF00149	0.406
DOC_PP1_SILK_1	197	202	PF00149	0.515
DOC_USP7_MATH_1	145	149	PF00917	0.620
DOC_USP7_MATH_1	3	7	PF00917	0.779
DOC_USP7_MATH_1	69	73	PF00917	0.705
DOC_USP7_UBL2_3	10	14	PF12436	0.845
DOC_USP7_UBL2_3	391	395	PF12436	0.455
DOC_USP7_UBL2_3	4	8	PF12436	0.871
DOC_WW_Pin1_4	216	221	PF00397	0.406
LIG_14-3-3_CanoR_1	100	104	PF00244	0.518
LIG_14-3-3_CanoR_1	135	144	PF00244	0.550
LIG_14-3-3_CanoR_1	146	152	PF00244	0.536
LIG_14-3-3_CanoR_1	163	169	PF00244	0.379
LIG_BRCT_BRCA1_1	110	114	PF00533	0.571
LIG_deltaCOP1_diTrp_1	249	256	PF00928	0.406
LIG_FHA_1	105	111	PF00498	0.519
LIG_FHA_1	181	187	PF00498	0.422
LIG_FHA_1	446	452	PF00498	0.411
LIG_FHA_2	100	106	PF00498	0.517
LIG_FHA_2	220	226	PF00498	0.456
LIG_FHA_2	338	344	PF00498	0.468
LIG_FHA_2	452	458	PF00498	0.450
LIG_IBAR_NPY_1	89	91	PF08397	0.547
LIG_Integrin_isoDGR_2	244	246	PF01839	0.422
LIG_LIR_Apic_2	102	106	PF02991	0.519
LIG_LIR_Apic_2	171	175	PF02991	0.406
LIG_LIR_Apic_2	448	453	PF02991	0.563
LIG_LIR_Gen_1	30	40	PF02991	0.679
LIG_LIR_Gen_1	396	402	PF02991	0.485
LIG_LIR_Nem_3	269	275	PF02991	0.528
LIG_LIR_Nem_3	396	400	PF02991	0.405
LIG_LYPXL_yS_3	431	434	PF13949	0.422
LIG_Pex14_1	252	256	PF04695	0.406
LIG_Pex14_2	256	260	PF04695	0.553
LIG_Pex14_2	402	406	PF04695	0.406
LIG_PTB_Apo_2	254	261	PF02174	0.526
LIG_SH2_CRK	397	401	PF00017	0.422
LIG_SH2_SRC	231	234	PF00017	0.383
LIG_SH2_SRC	323	326	PF00017	0.422
LIG_SH2_STAP1	231	235	PF00017	0.383
LIG_SH2_STAP1	397	401	PF00017	0.519
LIG_SH2_STAP1	441	445	PF00017	0.401
LIG_SH2_STAT3	441	444	PF00017	0.376
LIG_SH2_STAT3	98	101	PF00017	0.685
LIG_SH2_STAT5	218	221	PF00017	0.400
LIG_SH2_STAT5	323	326	PF00017	0.441
LIG_SH2_STAT5	441	444	PF00017	0.410
LIG_SH2_STAT5	450	453	PF00017	0.472
LIG_SH3_3	122	128	PF00018	0.670
LIG_SH3_3	75	81	PF00018	0.723
LIG_SH3_3	84	90	PF00018	0.539
LIG_SUMO_SIM_anti_2	178	184	PF11976	0.490
LIG_SUMO_SIM_par_1	105	111	PF11976	0.581
LIG_TRAF2_1	137	140	PF00917	0.557
LIG_TRAF2_1	290	293	PF00917	0.406
LIG_TYR_ITIM	229	234	PF00017	0.406
LIG_UBA3_1	259	268	PF00899	0.553
LIG_UBA3_1	389	395	PF00899	0.406
LIG_WRC_WIRS_1	350	355	PF05994	0.406
MOD_CK1_1	327	333	PF00069	0.453
MOD_CK1_1	396	402	PF00069	0.526
MOD_CK2_1	134	140	PF00069	0.546
MOD_CK2_1	219	225	PF00069	0.524
MOD_CK2_1	337	343	PF00069	0.468
MOD_CK2_1	451	457	PF00069	0.450
MOD_CK2_1	99	105	PF00069	0.529
MOD_Cter_Amidation	56	59	PF01082	0.832
MOD_GlcNHglycan	315	318	PF01048	0.466
MOD_GlcNHglycan	326	329	PF01048	0.400
MOD_GlcNHglycan	5	8	PF01048	0.771
MOD_GlcNHglycan	82	85	PF01048	0.658
MOD_GSK3_1	104	111	PF00069	0.607
MOD_GSK3_1	164	171	PF00069	0.526
MOD_GSK3_1	349	356	PF00069	0.396
MOD_GSK3_1	63	70	PF00069	0.730
MOD_N-GLC_1	313	318	PF02516	0.470
MOD_N-GLC_1	40	45	PF02516	0.827
MOD_N-GLC_1	49	54	PF02516	0.857
MOD_N-GLC_1	63	68	PF02516	0.809
MOD_NEK2_1	353	358	PF00069	0.406
MOD_NEK2_1	365	370	PF00069	0.406
MOD_NEK2_2	445	450	PF00069	0.475
MOD_PIKK_1	23	29	PF00454	0.844
MOD_PKA_1	135	141	PF00069	0.671
MOD_PKA_1	58	64	PF00069	0.901
MOD_PKA_2	134	140	PF00069	0.559
MOD_PKA_2	145	151	PF00069	0.554
MOD_PKA_2	58	64	PF00069	0.868
MOD_PKA_2	99	105	PF00069	0.529
MOD_Plk_1	268	274	PF00069	0.459
MOD_Plk_1	365	371	PF00069	0.406
MOD_Plk_1	445	451	PF00069	0.406
MOD_Plk_4	104	110	PF00069	0.584
MOD_Plk_4	168	174	PF00069	0.392
MOD_Plk_4	175	181	PF00069	0.553
MOD_Plk_4	445	451	PF00069	0.406
MOD_ProDKin_1	216	222	PF00069	0.406
MOD_SUMO_rev_2	137	143	PF00179	0.537
MOD_SUMO_rev_2	184	190	PF00179	0.415
TRG_DiLeu_BaEn_1	105	110	PF01217	0.580
TRG_DiLeu_BaEn_4	139	145	PF01217	0.582
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.465
TRG_ENDOCYTIC_2	231	234	PF00928	0.406
TRG_ENDOCYTIC_2	272	275	PF00928	0.542
TRG_ENDOCYTIC_2	397	400	PF00928	0.422
TRG_ENDOCYTIC_2	431	434	PF00928	0.422
TRG_ER_diArg_1	134	136	PF00400	0.683
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.870

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2W6	Leptomonas seymouri	86%	100%
A0A0S4IME4	Bodo saltans	68%	100%
A0A1X0NXP2	Trypanosomatidae	73%	98%
A0A3Q8IBA7	Leishmania donovani	25%	100%
A0A3R7MCJ4	Trypanosoma rangeli	71%	99%
A1CCP2	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	50%	97%
A1CH02	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	57%	100%
A1CXT5	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	58%	100%
A1CYM1	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	50%	100%
A1DA84	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	51%	100%
A2QAF9	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	49%	98%
A2QHX0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	58%	100%
A4H9X3	Leishmania braziliensis	24%	100%
A4HBT2	Leishmania braziliensis	91%	100%
A4HZM5	Leishmania infantum	100%	100%
A4RDI6	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	55%	100%
A5DR89	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	53%	100%
A5E5I9	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	52%	98%
A6RGC8	Ajellomyces capsulatus (strain NAm1 / WU24)	45%	100%
A6RTU0	Botryotinia fuckeliana (strain B05.10)	57%	100%
A6ZKL2	Saccharomyces cerevisiae (strain YJM789)	54%	100%
A7EZ86	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	57%	100%
A8QBZ2	Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)	52%	100%
B0CRL4	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	53%	100%
B0XTJ7	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	50%	96%
B0Y5N4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	58%	99%
B0YAX5	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	50%	100%
B2B738	Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)	56%	100%
B2VW14	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	46%	100%
B2W1N6	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	56%	100%
B3LNM2	Saccharomyces cerevisiae (strain RM11-1a)	54%	100%
B5VDQ0	Saccharomyces cerevisiae (strain AWRI1631)	54%	100%
B6H5L5	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	47%	100%
B6HTQ4	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	56%	100%
B6Q1N3	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	58%	100%
B6QD96	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	49%	100%
B8LUH2	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	59%	100%
B8M990	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	49%	100%
B8NA06	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	58%	100%
B8NLL0	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	49%	99%
B9WJA2	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	53%	100%
C0NIQ4	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	56%	100%
C0NX86	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	46%	100%
C0SIM8	Paracoccidioides brasiliensis (strain Pb03)	58%	100%
C1GLM4	Paracoccidioides brasiliensis (strain Pb18)	58%	100%
C1HAB2	Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01)	59%	100%
C4JSX6	Uncinocarpus reesii (strain UAMH 1704)	55%	100%
C4R2P3	Komagataella phaffii (strain GS115 / ATCC 20864)	55%	100%
C4Y1F8	Clavispora lusitaniae (strain ATCC 42720)	56%	100%
C4YSA9	Candida albicans (strain WO-1)	54%	100%
C5DE35	Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)	55%	100%
C5FEJ1	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	46%	100%
C5FF46	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	55%	100%
C5GCN0	Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)	57%	100%
C5GLJ6	Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)	46%	100%
C5JW60	Blastomyces gilchristii (strain SLH14081)	57%	100%
C5JYZ5	Blastomyces gilchristii (strain SLH14081)	46%	100%
C5M8M4	Candida tropicalis (strain ATCC MYA-3404 / T1)	55%	100%
C5P8Q4	Coccidioides posadasii (strain C735)	55%	100%
C6HI66	Ajellomyces capsulatus (strain H143)	46%	100%
C7GSF3	Saccharomyces cerevisiae (strain JAY291)	54%	100%
C7YS77	Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)	56%	100%
C7Z7V7	Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)	49%	100%
C8Z3V4	Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse)	54%	100%
C9SB49	Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)	55%	100%
D0A1D9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
D1ZEN1	Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)	59%	100%
D4B2G3	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	55%	100%
D4DE65	Trichophyton verrucosum (strain HKI 0517)	55%	100%
D8PR70	Schizophyllum commune (strain H4-8 / FGSC 9210)	53%	100%
E3L3Q8	Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL)	54%	100%
E3QDQ4	Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212)	47%	100%
E3QW41	Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212)	55%	100%
E3RCY7	Pyrenophora teres f. teres (strain 0-1)	56%	100%
E3RD74	Pyrenophora teres f. teres (strain 0-1)	46%	100%
E4ZYY3	Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)	47%	100%
E5R278	Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)	46%	100%
E5R3Z8	Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)	55%	100%
E5R4J3	Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)	57%	100%
E9AGR8	Leishmania infantum	25%	100%
E9ARW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AV56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
H1UBK1	Caenorhabditis elegans	55%	99%
M1CZC0	Solanum tuberosum	23%	100%
O08663	Mus musculus	58%	97%
O60085	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	59%	100%
P38062	Rattus norvegicus	57%	97%
P38174	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	54%	100%
P50579	Homo sapiens	57%	97%
Q09184	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
Q0C838	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	47%	100%
Q0CL94	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	58%	100%
Q0UTI9	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	55%	100%
Q2GSJ7	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	48%	100%
Q2GYA8	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	55%	100%
Q2U6H2	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	49%	99%
Q3ZC89	Bos taurus	58%	97%
Q4QCC5	Leishmania major	97%	100%
Q4QDK5	Leishmania major	24%	100%
Q4WAY7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	50%	100%
Q4WII3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	50%	96%
Q4WNT9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	58%	99%
Q55C21	Dictyostelium discoideum	59%	100%
Q56Y85	Arabidopsis thaliana	63%	100%
Q59LF9	Candida albicans (strain SC5314 / ATCC MYA-2876)	54%	100%
Q5B4X6	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	57%	100%
Q5BGG1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	49%	100%
Q6BVB8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	55%	100%
Q6CA79	Yarrowia lipolytica (strain CLIB 122 / E 150)	53%	99%
Q6CP80	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	55%	100%
Q7S7L7	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	58%	100%
Q96327	Arabidopsis thaliana	24%	100%
Q9FV49	Arabidopsis thaliana	59%	100%
V5BMW9	Trypanosoma cruzi	71%	98%
V5BS99	Trypanosoma cruzi	26%	100%